Ajiflux is a drug (tablets) that belongs to the pharmacological group of drugs used for conditions associated with acidity disorders. This drug is characterized by the following application features:
How to dissolve vascular plaques, normalize blood circulation, blood pressure and forget the way to the pharmacy
- During pregnancy: contraindicated
- When breastfeeding: with caution
- In childhood: with caution
- If renal function is impaired: with caution
Release form and composition
Dosage form – chewable tablets: round in shape, smooth on both sides, white (possible presence of isolated dark inclusions), with a mint smell (in blisters of 10 pcs., 2 blisters in a cardboard pack).
Active substances in 1 tablet:
- Aluminum hydroxide (including aluminum oxide not less than 76.5%) – 400 mg;
- Magnesium hydroxide – 400 mg.
Auxiliary components: povidone, mannitol, isopropanol, sodium saccharinate, sorbitol, sucrose, purified water.
Lubricant composition: magnesium stearate, colloidal silicon dioxide, peppermint leaf oil.
Pharmacological properties
Pharmacodynamics
Fluxum is a direct-acting anticoagulant drug that has antithrombotic properties. Its active substance, sodium parnaparin, is a low molecular weight glycosaminoglycan obtained by the depolymerization of heparin isolated from the mucous membrane of the small intestine of pigs. Its molecular weight can range from 4000 to 6000 Da (dalton).
In vitro and in vivo, parnaparin sodium significantly inhibits coagulation factor Xa, has a minor effect on factor IIa and on the APTT (partial activated thromboplastin time). The drug is characterized by higher anti-Xa than anticoagulant (anti-Pa) activity. If for heparin the ratio of anti-Xa to anti-Pa is 1, then for sodium parnaparin it can reach 1.5–3.
Fluxum does not have a proaggregant platelet effect.
Pharmacokinetics
After subcutaneous (s/c) administration of a single dose, maximum anti-Xa activity in plasma is created within 2–3 hours. Then it gradually decreases, even 12 hours after administration of the dose, anti-Xa activity is still detectable. The bioavailability of the drug is almost 100%, it is assessed by the anti-Xa activity of sodium parnaparin.
When Fluxum is administered at a dose of 3200 anti-Xa ME 2 times a day, a steady state of pharmacokinetics is observed on the third day, at a dose of 6400 anti-Xa ME 1 time per day - on the fourth day.
Parnaparin sodium exhibits linear pharmacokinetics in the dose range from 3200 to 12,800 anti-Xa ME. AUC (area under the concentration-time curve) has a linear relationship with dose.
The pharmacokinetic profile of anti-Xa activity when administered subcutaneously is characterized by a smooth curve with fewer peaks and a slower decrease in activity. Therefore, it is more favorable compared to the profile when administered intravenously (IV).
Parnaparin sodium is metabolized in the liver to form inactive compounds.
It is excreted from the body through the kidneys. The half-life is approximately 6 hours.
Indications for use
- Acute gastritis;
- Exacerbation of chronic gastritis with normal or increased secretory function;
- Peptic ulcer, symptomatic ulcers of the stomach and duodenum;
- Acute duodenitis;
- Acute pancreatitis;
- Chronic pancreatitis in the acute phase;
- Hernia of the diaphragm and esophageal opening;
- Reflux esophagitis;
- Erosion of the mucous membrane of the upper gastrointestinal tract;
- Hyperphosphatemia;
- Putrefactive or fermentative dyspepsia (as part of combination therapy);
- Gastric discomfort, heartburn, gastralgia (due to dietary errors, taking certain medications, drinking coffee, ethanol, nicotine).
Pharmacological properties
Pharmacodynamics
Venarus analogues
Nifuroxazide is a nitrofuran derivative that has an antimicrobial effect.
Shows high activity against Salmonella spp., Campylobacter jejuni, Escherichia coli, Shigella spp., Vibrio cholerae, Clostridium perfringens, pathogenic Vibrions and Vibrio parahaemolyticus, Staphylococcus spp.
Proteus indologenes, Enterobacter cloacae, Citrobacter spp. demonstrate weak sensitivity to nifuroxazide.
Resistant to nifuroxazide: Pseudomonas spp., Providencia spp., Klebsiella spp., Proteus mirabilis.
It is assumed that nifuroxazide blocks the activity of dehydrogenases and inhibits the respiratory chain, the tricarboxylic acid cycle and a number of other biochemical processes in the microbial cell. The balance of intestinal microflora is not disturbed. With the development of acute bacterial diarrhea, it restores intestinal eubiosis.
In case of infection with enterotropic viruses, it blocks the development of bacterial superinfection.
Pharmacokinetics
Nifuroxazide after oral administration is almost not absorbed from the gastrointestinal tract (gastrointestinal tract), as a result of which it does not have a systemic effect. Almost all of it (99% of the dose taken) remains in the intestines and exhibits its antimicrobial effect there. Excreted from the body with feces: 20% - unchanged, the rest - in the form of chemically modified nifuroxazide.
Directions for use and dosage
Ajiflux should be taken orally by chewing or holding the tablets in the mouth until completely dissolved.
Adults are prescribed 2-3 tablets 1-2 hours after meals and at night, for stomach ulcers - half an hour before meals. If the need arises, the single dose is increased to 3-4 tablets. After improvement of the condition, Adzhiflux is recommended to be taken as maintenance therapy, 1 tablet 3 times a day for a course of 2-3 months.
Adolescents over 12 years of age are prescribed 1 tablet 1-2 hours after meals and at night, for stomach ulcers - half an hour before meals.
Side effects
In isolated cases, Adzhiflux causes discomfort:
- nausea and vomiting;
- stool retention;
- distortion of taste sensations;
- with renal failure - thirst, hyporeflexia, decreased blood pressure.
Overdose
When taking Ajiflux, it is necessary to avoid overdose. Violation of the antacid dosage regimen can cause serious pathological conditions. Uncontrolled use of the medication is strictly prohibited for patients with severe liver dysfunction. The consequences of an overdose can provoke irreversible deviations.
The first signs of negative consequences when dosages are exceeded are dry mouth, nausea, constipation and impaired taste.
Other consequences of overdose:
- osteomalacia;
- hypophosphatemia;
- hypermagnesemia;
- hypocalcemia;
- encephalopathy.
Contraindications
Adzhiflux has a number of strict contraindications:
- intolerance to the components of the drug, hypersensitivity to them;
- serious kidney pathologies;
- Alzheimer's disease;
- age restrictions (12 years);
- hypophosphatemia.
During pregnancy
Adzhiflux is prohibited for pregnant women. Nursing mothers should take the drug with great caution.
special instructions
Between doses of Ajiflux and other drugs, a minimum of 2-hour intervals should be observed.
During treatment, it is necessary to ensure sufficient intake of phosphorus salts into the body with food.
Information for patients with diabetes: 1 Ajiflux tablet contains 40 mg of sucrose, which corresponds to less than 1 XE (bread unit).
The drug does not affect the speed of reactions and the ability to concentrate, therefore it can be used to treat people regardless of their field of professional activity.
Patient reviews
Adzhiflux has earned the trust of doctors and patients. Most reviews about the drug have positive connotations. The drug has an affordable price; patients with a modest budget can afford it.
Tablets and suspensions relieve pain very quickly - relief occurs within 15 minutes. It is also convenient that the drug can be taken for prevention. For example, if a certain product causes discomfort, but you cannot get away from it. Side effects are extremely rare if all recommendations are followed, so Ajiflux is safe for health.
Drug interactions
Ajiflux slows down and reduces the absorption of the following drugs: barbiturates (they should be taken 1 hour before or 2 hours after taking an antacid), H2-histamine receptor blockers, indirect anticoagulants, beta-blockers, chenodeoxycholic and ursodeoxycholic acids, salicylates, tetracycline antibiotics and quinolones (grepafloxacin, ciprofloxacin, enoxacin, ofloxacin, norfloxacin, etc.), ketoconazole, itraconazole, digoxin, phenytoin, pivampicillin, azithromycin, rifampicin, chlorpromazine, indomethacin, isoniazid, penicillamine, dipyridamole, diflunisal, cefpodoxime, lan soprazole, zalcitabine, fexofenadine .
M-anticholinergic blockers slow down gastric emptying, thereby enhancing and prolonging the effect of Adzhiflux.
Contraindications
Absolute:
- thrombocytopenia induced by sodium parnaparin (including medical history);
- conducting regional anesthesia in patients using Fluxum for therapeutic purposes;
- diseases or conditions complicated by bleeding;
- increased risk of bleeding or predisposition to bleeding: hemostasis disorders (except for consumption coagulopathy not caused by heparin), period of exacerbation of erosive and ulcerative lesions of the gastrointestinal tract and gastric and duodenal ulcers, chorioretinopathy, angiodysplasia, hemorrhagic stroke;
- acute bacterial endocarditis (except prosthesis endocarditis);
- severe traumatic brain injury in the postoperative period;
- severe uncontrolled arterial hypertension with blood pressure (BP) more than 180/100 mmHg;
- combination with ticlopidine when using high doses of parnaparin sodium;
- simultaneous use of salicylates and other non-steroidal anti-inflammatory drugs (NSAIDs), antiplatelet agents (including clopidogrel, dipyridamole), sulfinpyrazone;
- breast-feeding;
- age under 18 years;
- hypersensitivity to heparin and pork products;
- individual intolerance to the components of the drug.
Fluxum should be prescribed with caution in case of renal and/or liver failure, mild to moderate arterial hypertension, gastric and duodenal ulcers and a history of erosive and ulcerative lesions of the gastrointestinal tract, heparin-induced thrombocytopenia, thrombocytopenia caused by other low molecular weight heparins (including anamnesis), a history of chorioretinopathy, diseases of the brain and spinal cord in the postoperative period, a history of diseases or conditions that may be accompanied by bleeding; when used simultaneously with indirect anticoagulants, dextrin (for parenteral use) or systemic glucocorticosteroids (GCS); in combination with ticlopidine at low doses of parnaparin sodium. During pregnancy, the use of Fluxum is allowed only in case of emergency and under the supervision of a doctor.
During pregnancy, the use of Fluxum is allowed only in case of emergency and under the supervision of a doctor.
Interaction of Adzhiflux with other drugs
M-anticholinergics potentiate the effect of the antacid by reducing gastric motility.
The combined drug reduces and inhibits the absorption of salicylates, indirect anticoagulants, barbiturates, β-blockers, antihistamines, antibiotics from the group of tetracyclines and quinolones, Azithromycin, Penicillamine, Rifampicin and Isoniazid.
Price
The drug is a cheaper analogue of Almagel and Maalox. A package (20 pcs.) of chewable tablets will cost only 130 rubles, and suspensions - from 250 rubles.
On the territory of Ukraine, the cost of tablets varies from 55 hryvnia, suspensions - from 100 hryvnia.
Video on the topic: The work of the pancreas, the causes of diabetes, pancreatitis
https://youtube.com/watch?v=hZoN4-peQQA
Adzhiflux has more expensive and cheaper analogues:
There are many drugs of this pharmacological group on the market, each of them has its own characteristics of action. When choosing the right one, you need to be guided by medical recommendations and the sensations of your body.
Adzhiflux analogues and prices
A total of 30 analogues of Adzhiflux were found. All analogues of Adzhiflux were selected according to the international drug classification system ATC (anatomical-therapeutic-chemical classification). Active ingredients: A simple combination of salts Enter your exact address to buy Adzhiflux at the nearest pharmacy Classification of the drug Adzhiflux
Analogues in composition
The Ajiflux analogues listed below have the same ATC codes. Analogues are selected according to the chemical structure of the drug and are the most suitable substitutes. Same composition, indications for use, doses of active ingredients may differ.
Analogues by indication and method of use
The analogs are the same according to the ATC level 4 code. Medicines that have different compositions, but may be similar in indications and route of administration.
Analogues according to the ATC code of the 3rd level
The analogues are the same according to the ATC level 3 code. Medicines that have different compositions, but may be similar in indications and method of administration.
Almox A
All Adzhiflux analogues are presented for informational purposes only and are not a reason for making an independent decision about replacing the drug. Before using the drug, consult your doctor and read the instructions for use.
Conditions for storage and release from pharmacies
You do not need a doctor's prescription to purchase the combination antacid drug.
It is recommended to keep chewable tablets in a dry place, shielded from direct sunlight at a temperature not exceeding +25° C.
The shelf life of this drug is 60 months from the date of release indicated on the factory packaging.
Keep away from children!
Properties of the product and effect on the body
This is a combination medicine that can weaken the negative, damaging effects of various factors on the delicate mucous membrane of the stomach. Thus, the composition of the drug actively interacts with gastric juice and hydrochloric acid, the drug is able to be evenly distributed throughout the entire mucosal area, which provides the patient with long-term gastroprotection, without activating the secondary process of hypersecretion of gastric juice.
Adzhiflux does not provoke metabolic disorders, electrolyte balance, and also does not provoke the development of alkalosis. In addition, the drug is activated almost instantly after administration, because within 4 minutes its therapeutic effect begins, which lasts more than 1 hour.
