Exoderil cream is a medical product with a pronounced antifungal effect for external use. Suppresses the vital activity of dermatophyte fungi, used to treat inflammatory processes in skin and interdigital folds, skin candidiasis, nail fungus, including when a bacterial infection is attached. Used for application to exposed and hairy areas of the skin.
Pharmacodynamics and pharmacokinetics
Pharmacodynamics
Naftifine is a topical antimycotic that belongs to the class of allylamines. The mechanism of its action is associated with the ability to suppress the activity of the enzyme squalene-2,3-epoxidase, and thus inhibit the biosynthesis of ergosterol, which is part of the cell wall of the fungus.
The activity of the drug is manifested in relation to:
- dermatophytes (microsporum, epidermophyton, trichophyton);
- yeast fungi (Pityrosporum, Candida spp.)
- molds (Aspergillus spp.)
- other fungi (for example Sporothrix schenckii).
Naftifine against aspergillus and , and against yeast fungi - depending on the strain of the microorganism, it can exhibit both fungicidal and fungistatic activity.
It has antibacterial activity against Gram (+) and Gram (-) bacteria that can cause secondary infection , as well as an anti-inflammatory effect (which allows you to quickly eliminate the symptoms of inflammation, especially itching).
Pharmacokinetics
After application to the skin/nail, it penetrates well into their various layers and creates stable antifungal concentrations in them. naftifine is used externally, no more than 6% of the substance is exposed to systemic absorption.
The absorbed amount is partially metabolized and excreted in the urine and intestinal contents. T1/2 - 2-3 days.
Form and composition
The active component of the thick white cream is the antimycotic naftifine, concentration - 0.1%, that is, 1 g of the drug contains 10 mg of the main substance. Additional components: alcohols - benzyl, cetyl, stearyl; sodium hydroxide; sorbitan stearate; cetyl palmitate; polysorbate; isopropyl myristate; purified water.
Exoderil is often called ointment, but this is incorrect, since it contains water. Organic alcohols increase the absorption of the active component, and the fatty components form a film on the top layer of the skin that allows air to pass through, but suppresses the activity of pathogenic microorganisms. Packaging: aluminum tubes of 15 and 30 ml. Each is packaged in a cardboard box with instructions for use.
The second form of the drug is an alcohol solution. The concentration of the active substance is the same, 0.1%. It is often prescribed for acute onychomycosis.
Instructions for use of Exoderil (Method and dosage)
Cream Exoderil, instructions for use
When the fungal process is localized on the skin, it is recommended to apply the ointment to the affected area 1 r./day, covering the adjacent areas of healthy skin (approximately 1 cm at the edges of the affected area).
Before applying the cream, the affected area should be thoroughly cleaned and dried.
The duration of treatment for dermatomycosis is usually from 2 to 4 weeks, but if necessary it can be extended to 8 weeks, for candidiasis - 4 weeks.
For nail fungus, apply the cream 2 times a day. Recommendations on how to use the drug for onychomycosis indicate that before the first application of the product, use a nail file or scissors to remove as much of the affected part of the nail as possible. Treatment is long-term – up to six months.
Exoderil solution: instructions for use
For skin mycoses , Exoderil drops are used 1 r./day, for onychomycosis - 2 r./day. The affected area of the skin should be thoroughly washed and dried, the affected area of the nail should be removed as much as possible using a nail file or scissors (to facilitate the procedure, on the recommendation of a doctor, it is allowed to use special emollients).
The duration of therapy for dermatomycosis is up to 4-8 weeks, for fungal infections of the nails - up to six months.
For otomycosis, treatment should last at least 14 days. Treatment is carried out by placing turundas soaked in a solution into the ear. The duration of exposure is 5-8 minutes. You need to repeat the procedure 1-2 times a day.
Additionally
To prevent relapse, Exoderil (both cream and solution) should continue to be used for at least 2 weeks after the clinical symptoms of the disease have resolved.
Nail polish
Exorolfinlac is a drug for nail plate fungi in the form of varnish. The mechanism of action is to disrupt the synthesis of ergosterol, which is part of the cell wall of the pathogen. The active substance is amorolfine from the clinical and pharmacological group of local antimycotics. After covering the nails with this varnish, it penetrates through the plate into the bed within 24 hours.
The peculiarity of Exoderil in the form of varnish is that after a single coating the required concentration of amorolfine is retained in the nail for a week. The varnish can be used both for the treatment and prevention of fungal nail diseases.
The set with varnish, the volume of which is 2.5 ml, includes nail files, spatulas, tampons, and cleaning wipes. The concentration of amorolfine is 5%.
Mode of application
Apply varnish according to the instructions 1-2 times a week:
- First, remove the affected parts of the nail using a spatula. If necessary, file down damaged areas.
- Using the cloth from the kit, wipe the nail for mechanical cleaning and degreasing.
- In the future, the procedure should be the same, only remove the previous layer of varnish with a napkin.
- Dip the applicator into the varnish without smearing the product over the neck of the bottle.
- Apply the product to the nail plate in an even layer.
- Wait a few minutes - the product dries quickly.
- Clean the applicator with a clean swab and then discard it.
- Close the bottle of nail polish.
The peculiarity of the product is that after 10 minutes, you can optionally apply decorative nail polish. After all procedures, wash your hands thoroughly with soap. If you used decorative varnish, then the procedures are done in the same way, only the regular varnish is also removed with a napkin.
After the varnish has hardened, you can lead a normal life: use household chemicals, do housework, wash your hands and feet with soap. The treatment is long-term. If the fungus is on the fingernails, then the treatment period is 6 months; on the feet, a longer period is required, from 9 to 12 months.
Lyudmila Sheveleva
Doctor, pharmacist
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Focus on the rate of plate growth. As soon as they become smooth, transparent, uniform, use Exoderil for another two weeks. The doctor will consider you healthy if fungi are not detected during a repeated laboratory test.
It is worth preparing in advance that the process will be lengthy. If after 2-3 months there are no signs of improvement, then you should consult a doctor to adjust the treatment.
A contraindication to Exoderil varnish is an allergy to amorolfine. Under 18 years of age, during pregnancy and lactation, according to the instructions, the product is not recommended for use. This is due to the fact that clinical studies of the safety of varnish in these patients have not yet been conducted.
special instructions
According to the instructions, you should pay attention to the following points:
- A file intended for a diseased nail should not be used on healthy fingers.
- If the work involves contact with solvents, then you need to wear protective gloves to protect the coating.
- You cannot do nail extensions, gel polish, or shellac during the treatment period.
- Since the polish contains ethanol, you should not apply it more than once or twice a week. This can lead to dry cuticles.
- The cleaning cloth included in the set contains substances that must be kept away from fire as they may catch fire.
- The varnish should not get into the eyes or other mucous membranes. If the product gets into your eyes, rinse them immediately with running water.
- If you are allergic to the product, it is recommended to consult a doctor.
- If there are concomitant systemic diseases: diabetes mellitus, HIV, hepatitis, nail plate dystrophy, dermatitis, psoriasis, the product can only be used with the permission of a doctor.
- If the fungus occupies more than 2/3 of the nail area, then you should consult a doctor to prescribe systemic (tablets, pill capsules) antifungal drugs. But most likely, he will insist on surgical removal of the nail.
No cases of drug overdose have been recorded. Store at temperatures up to 25°C in a dark place out of reach of children.
special instructions
Drops and cream are not intended for use in ophthalmology , and therefore contact with the eyes should be avoided.
The medicine does not have a negative effect on the ability to drive a vehicle/mechanics.
What is better - cream or solution?
A special feature of the drug Exoderil is that in addition to the antimycotic effect , it also has antibacterial activity : the drug affects pathogenic microorganisms, often combined with fungal infections.
The solution penetrates well into the nail, being evenly distributed in it and helping to destroy the fungus, relieving inflammation and eliminating itching.
For some diseases (in particular, mycoses of the feet , when both the nail plate and the skin are simultaneously affected), both dosage forms are often used in combination: the nail is treated with a solution in the morning, and cream is applied to the skin in the evening.
In severe cases, in addition to topical therapy, systemic antimycotics (tablets, solution for infusion, powder for the preparation of oral suspension) may be prescribed.
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** The Drug Directory is intended for informational purposes only. For more complete information, please refer to the manufacturer's instructions. Do not self-medicate; Before starting to use the drug Exoderil, you should consult a doctor. EUROLAB is not responsible for the consequences caused by the use of information posted on the portal. Any information on the site does not replace medical advice and cannot serve as a guarantee of the positive effect of the drug.
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** Attention! The information presented in this medication guide is intended for medical professionals and should not be used as a basis for self-medication. The description of the drug Exoderil is provided for informational purposes and is not intended for prescribing treatment without the participation of a doctor. Patients need to consult a specialist!
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Analogues of Exoderil
Level 4 ATX code matches:
Mikonorm
Undecin
Gentian violet
Zinkundan
Exiter
Batrafen
Lotseril
Lamisil Dermgel
Lamisil Uno
Lamisil
Salicylic acid
Salicylic ointment
Keto Plus
Exifin
Fungoterbin
Mycoseptin
Thermikon
Nitrofungin
Sulsena
Baziron AS
Ointment analogues: Mikoderil (synonym), Atifin , Batrafen , Lamisil , Mozoil , Terbizil , Fungoterbin , Tebikur .
Analogs of Exoderil in drops: Mikoderil (synonym), Lamisil Uno , Lotseril , Nitrofungin , Nichlorofen , Octicil , Saledez , MC Peel .
Analogs are cheaper than Exoderil
Cheap analogues of Exoderil are domestically produced drugs. Analogues produced by Russian companies may contain the same active ingredient, but their price will be lower in comparison with foreign products.
The first and only substitute for Exoderil in Russia is the drug Mikoderil . A one percent solution of Mikoderil can be purchased from 380 rubles, cream - from 290 rubles.
The price of Russian analogues with a similar mechanism of action is from 60 rubles.
Which is better: Loceril or Exoderil?
Loceryl is an antifungal nail polish whose active ingredient is amorolfine .
Amorolfine is used for fungal nail infections caused by Epidermophyton, Trichophyton, Mycrosporum, Coccidoides, Cryptococcus, Wangiella, Pityrosporum, Candida, Hendersonula, Histoplasma, Sporothrix, Alternaria, Cladosporium, Fonseceae, Scopulariopsis.
naftifine it contains .
Since the drugs differ in composition, it is not entirely correct to judge which is more effective - Exoderil or Loceril .
Loceryl is used to treat nail fungus , its analogue can be used both for the treatment of nail fungus and for the treatment of dermatomycosis . Moreover, the solution penetrates the nail plate better than varnish and acts the same regardless of whether the structure of the nail is damaged or not.
The disadvantages of nail polishes are their inability to penetrate into the channels of the nail plate, as well as into loose and crumbled nail plates.
Reviews allow us to conclude that Exoderil is quite effective against infections caused by the most common fungi today, however, it is powerless against some organisms that its analogue can easily cope with.
Thus, the choice in favor of one or another remedy must be made taking into account the diagnosis, pathogen and degree of damage.
Mikozan or Exoderil - which is better?
The drug Mikozan is a kit for removing fungal infections from the nail. The product is available in the form of a serum and is supplied with disposable nail files and an applicator brush, which makes it easier to apply the medicine to the affected nail.
The active substance of Mycozan is rye enzyme filtrate. When applied to the nail, the drug has a local antifungal effect , while increasing the density of the nail plate, reducing its porosity and creating conditions unfavorable for the growth of pathogenic fungi.
Experts often recommend using Mikozan for prevention, however, patients who have used this drug for treatment speak of it as an effective and really helpful remedy when it comes to onychomycosis .
If the affected area is not limited to the nail, then it is more advisable to use Exoderil to treat adjacent areas of the skin.
Use during pregnancy
Provided that the drug is used in accordance with the recommendations given in the instructions, its effect on the fetus/newborn is unlikely.
The results of teratogenicity studies indicate that there is no risk of any embryotoxic effects.
During pregnancy and breastfeeding, the medicine can be used only after a thorough assessment by the doctor of the expected effect of therapy/risk ratio.
Breastfeeding women should avoid getting the solution/cream on the skin and in the baby's digestive tract.
Reviews about Exoderil
Reviews about Exoderil cream, as well as reviews about Exoderil solution, can be found on forums that are different: for some, this drug helps restore the health of their nails and skin, for others, on the contrary, even after 2-3 months of using the product, there is no improvement notices.
Experts say that you can get rid of nail/skin fungus only if the treatment is carried out correctly.
Since in case of fungal infections of the feet, the pathological process in about half of the cases spreads to the nails, it is considered advisable to combine ointment and drops: for example, the solution for nail fungus is used in the morning, and at night the skin and affected nail plates are treated with cream.
Any external remedies (drops, cream or varnish) against nail fungus should be used regularly and over a long period of time.
At the same time, it is very important (especially during the treatment period) to properly care for your nails/skin (for example, once a week, give your nails a bath with soda and laundry soap), do not forget about personal hygiene and the need to disinfect all surfaces in contact with the fungus.
In severe forms of fungal infection, topical antimycotic drugs (Exoderil or its analogues) are combined with systemic drugs to achieve a positive effect.
Indications and contraindications
The drug is prescribed for fungal infections of skin folds, open areas of the epithelium and nails. It has been proven effective against ringworm, microsporia, epidermophytosis, trichophytosis, onymychoses, cutaneous candidiasis, pityriasis versicolor, mycoses of the ear canal, dermatomycosis, including the addition of a bacterial infection.
Contraindications include:
- hypersensitivity to the main or auxiliary components - naftifine or propylene glycol;
- pregnancy;
- open wounds or violation of the integrity of the skin in the form of microtraumas - cuts, scratches or abrasions.
Experience of use in pediatric practice is limited, so the drug is used in young patients with caution, and only under the supervision of a physician. To prevent the development of allergic reactions, it is recommended to conduct skin tests first. To do this, apply a little cream to the elbow, rub in, and leave for 40 minutes - 1 hour. If there are no warning symptoms - swelling or redness - you can treat the problem area.
Read more Instructions for using drops against the fungus Exoderil
How much does Exoderil cost?
Cost of the drug in Ukraine
The price of Exoderil in Kyiv is from 117 UAH. Ointment in tubes of 15 g can be bought for an average of 130 UAH. The price of Exoderil 10 ml in Ukraine is from 150 UAH, the medicine in 20 ml bottles in Dnepropetrovsk, Kharkov, Odessa or Zaporozhye costs 305-310 UAH.
Cost of the drug in Russia
You can buy Exoderil in Moscow at a price of 425 rubles: the price of Exoderil cream 15 g is 425-530 rubles, 30 g is 770-830 rubles; the price of Exoderil solution 10 ml is 510-710 rubles, drops in 20 ml bottles cost 860-1020 rubles.
Systemic agents (tablets, solution, etc.) are not produced under the Exoderil brand. You can treat nail fungus using both dosage forms of the drug according to the scheme: cream in the evening, solution in the morning.
- Online pharmacies in RussiaRussia
- Online pharmacies in UkraineUkraine
- Online pharmacies in KazakhstanKazakhstan
ZdravCity
- Exoderil solution for external use.
approx. 20ml Globopharm Pharmaceuticals Products/Sandoz GmbH RUB 1,018 order - Exoderil solution for external use. approx. 1% 30ml Globopharm Pharmaceutical Products/Sandoz GmbH
1320 rub. order
- Exoderil cream 1% 30gSandoz GmbH
RUR 686 order
- Exoderil cream 1% 15gSandoz GmbH
460 rub. order
- Exoderil solution for external use. approx. 1% 10ml Globopharm Pharmaceutical Products/Sandoz GmbH
RUR 514 order
Pharmacy Dialogue
- Exoderil cream (tube 1% 30g)Merck KgaA
RUB 849 order
- Exoderil solution 1% 10mlSandoz
RUR 623 order
- Exoderil solution (vial 1% 30ml)Sandoz
RUB 1,354 order
- Exoderil cream tube 1% 15gMerck KgaA
RUB 506 order
- Exoderil solution (vial 1% 20ml)GloboPharm
RUB 1,129 order
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Pharmacy24
- Exoderil Nail polish medicinal 5% 2.5 ml solution Lek pharmaceutical company d.d., Slovenia
327 UAH.order - Exoderil 1% 20 ml cutaneous solution Globofarm Pharmaceutical Products und Gandelsgesellschaft mbH/Sandoz GmbH, Austria/Austria
283 UAH order
- Exoderil 1% 10 ml cutaneous solution Globofarm Pharmaceutical Products und Gandelsgesellschaft mbH/Sandoz GmbH, Austria/Austria
179 UAH. order
- Exoderil 1% 15 g cream Merck KgaA & Co. Werk Spittal, Austria/Sandoz GmbH, Austria/Salutas Pharma GmbH, Nimecchina
128 UAH order
PaniPharmacy
- Exoderil nail polish 5% fl. 2.5 ml No. 1
366 UAH order
- Exoderil liquid Exoderil solution for external use 1% 10ml Austria, Sandoz
222 UAH order
- Exoderil cream Exoderil cream for external use 1% 15g tube Austria, Sandoz
142 UAH order
- Exoderil liquid Exoderil solution for external use 1% 20ml Austria, Sandoz
297 UAH order
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Acquisition and storage
The product can be purchased at a pharmacy; you do not need to present a prescription. You do not need to put it in the refrigerator; it should be stored at room temperature, out of the reach of children and pets. Heating above +25°C should be avoided. Shelf life: 5 years from the date indicated on the package. If the color changes, an unpleasant odor appears, or the structure delaminates, do not use it.
Produced by the Austrian company Sandoz, price - from 418 rubles. per tube of 15 g, from 690 rub. - for 30 g.
