Aksamon solution - official instructions for use

A healthy nervous system is important for the normal functioning of all organs. The current living conditions of a person do not always allow for their preservation. Constant stress, a difficult environmental situation, poor nutrition, taking certain medications - all this affects the nervous system. In addition, there are factors that are more difficult to deal with - age. Deterioration of memory and thinking are inevitable symptoms that accompany aging. However, there are remedies that can improve the patient's condition. More and more often, doctors recommend pills, but they also often prescribe injections with the medicine Axamon.

Medication dosages

The solution is intended for intramuscular and subcutaneous administration.
Aksamon tablets are taken orally. The drug is available with a prescription and is prescribed exclusively by the attending physician. An individual dosage regimen is selected for each patient. The instructions indicate the following dosages:

1. In case of impaired functioning of the peripheral system, the patient is recommended to take 20 mg three times a day.
2. For Alzheimer's disease, the dosage can range from 10 mg to 20 mg. It is recommended to take the medicine 2-3 times a day.
3. If myasthenic syndrome is observed, the patient is prescribed 20-40 mg of medication 4-5 times a day.
4. For intestinal atony, 15-20 mg of the drug should be taken 2-3 times a day for 14 days.
5. The daily dose is no more than 200 mg.

The duration of therapy is determined by the severity of the pathology. It can be 1 month, and sometimes it lasts up to 1 year.

Reviews

The effectiveness of the drug is evidenced by positive reviews from specialists and patients.

Doctors

Arseniy, 37 years old, Moscow: “I prescribe the use of Axamon in most cases at a dose of 5 mg for neurological disorders. The result can be seen after the first dose. The presence of side effects causes the drug to be dispensed with a prescription. For this reason, I recommend not to self-medicate, but to contact a specialist to avoid unpleasant consequences.”

Patients

Varvara, 25 years old, Yaroslavl: “I saw the effect of the drug on my grandfather, who suffered from Alzheimer’s. His memory quickly disappeared, but after taking the medicine for treatment, he could tell a story again. They switched to injections when my grandfather became bedridden and his speech became unintelligible. The effect of the product was observed half an hour or 40 minutes after the injection. Thanks to him, grandfather lived another 9 years.”

Angelina, 44 years old, St. Petersburg: “I started taking the drug after nervous breakdowns caused by stress at work and at home. I went to the doctor when my left arm began to go numb. The effect of the treatment appeared after 5 days. The cost of the drug is high, but I was pleased with the effect, so I recommend it.”

Georgy, 33 years old, Stavropol: “The treatment was prescribed after an examination, when intestinal atony was discovered. The drug caused terrible side effects. Nausea, tinnitus, sweating and vomiting a couple of hours after taking it. Maybe the doctor made a mistake, but he was dissatisfied with the remedy. For that kind of money you can produce high-quality products.”

Side effect

The frequency of adverse reactions that may occur during use of the drug is given in the following classification: very common (>1/10 prescriptions), frequent (1/10-1/100 prescriptions), infrequent (1/100-1/1000 prescriptions), rare (1/1000-1/10,000 prescriptions), very rare (

From the mental side: infrequent - drowsiness.

From the organ of vision: unknown frequency - miosis.

From the side of the heart: frequent - palpitations, bradycardia; unknown frequency - chest pain.

From the gastrointestinal tract: frequent - drooling, nausea; infrequently - vomiting; rare - diarrhea, epigastric pain.

From the liver and biliary tract: unknown frequency - jaundice.

From the skin and subcutaneous tissues: infrequently - itching, rash.

General disorders and disorders at the injection site: frequent - increased sweating; infrequent - general weakness; unknown frequency - hypothermia.

Salivation and bradycardia can be reduced with m-anticholinergic drugs (including atropine, cyclodol, metacin).

If itching or rash occurs, stop taking the drug. In other cases, reduce the dose or interrupt the drug for a short time (for 1-2 days).

Instructions for use Aksamon

The instructions for use indicate that the Aksamon injection solution is administered subcutaneously or intramuscularly. Only a specialist determines the required dosages and sets the duration of the course of therapy. The tablets are taken orally. Therapy for acute conditions should start with the injection form of the drug. Then the transition to the tablet form is carried out.

What is it prescribed for?

The remedy is used to get rid of the following disorders:

• senile dementia;
• Alzheimer's disease;
• intestinal atony;
• neuritis and polyneuritis;
• hyperkinesis and bulbar palsy;
• myasthenic syndrome;
• polyneuropathy and polyradiculopathy;
• lesions of the central nervous system with movement disorders;
• encephalopathy.

The medication is often used for lesions of the peripheral nervous system. Cases with weak labor also apply to taking this drug.

For hemorrhoids

Thanks to the normalization of impulse transmission to the smooth muscles of the intestine, which normalizes its peristalsis, bowel movements are improved and the exacerbation of hemorrhoidal disease is prevented.

Pharmacodynamics, pharmacokinetics

As the instructions for use indicate, Aksamon is a reversible cholinesterase inhibitor, which has the ability to block potassium channels in membranes by directly stimulating the conduction of impulses in the neuromuscular synapse and the central nervous system. In addition, under its influence, the influence of serotonin, oxytocin, histamine, adrenaline, and acetylcholine on smooth muscle structures increases.

The drug is characterized by the following pharmacological effects:

1. Improves and stimulates the conduction of impulses in the central nervous system.
2. Improves conductivity in the peripheral parts of the NS in cases of disorders resulting from the action of certain antibiotics, potassium chloride, local anesthetics, due to injury, inflammation.
3. Increases the contractility of smooth muscle structures of organs, which is due to the influence of agonists of serotonin, oxytocin, histamine, acetylcholine, and adrenaline receptors (with the exception of sodium chloride).
4. Improves memory, inhibits the progressive development of dementia.
5. The drug does not have mutagenic, immunotoxic, carcinogenic, teratogenic or embryotoxic effects. It has no effect on the endocrine system.

In accordance with the instructions for use, "Axamon" when used orally is absorbed in the gastrointestinal tract. The maximum saturation of the blood with the active component is observed after an hour. The active substance of the drug binds to plasma proteins by approximately 55%. Half-elimination occurs in 40 minutes. The active substance is metabolized in the liver tissues, excretion is carried out extrarenally and by the kidneys.

When administered intramuscularly, rapid absorption of the substance is observed. The highest concentration is observed after half an hour, the connection with plasma proteins reaches 50%. The drug is metabolized in the liver tissues, excreted by the kidneys and extrarenally. The half-life of parenteral administration is 3 hours.

Let's consider the indications for the use of Aksamon in tablets and solution.

General information

The main active substance in any form of the drug is ipidacrine hydrochloride monohydrate.

According to the instructions for use, the Aksamona tablet contains 15 mg of the active ingredient. The following excipients are used: calcium stearate, ludipress, sodium carboxymethyl starch.

Additional components in the solution are injection water and a solution of hydrochloric acid.

Pharmacodynamics, pharmacokinetics

As the instructions for use indicate, Aksamon is a reversible cholinesterase inhibitor, which has the ability to block potassium channels in membranes by directly stimulating the conduction of impulses in the neuromuscular synapse and the central nervous system. In addition, under its influence, the influence of serotonin, oxytocin, histamine, adrenaline, and acetylcholine on smooth muscle structures increases.

The drug is characterized by the following pharmacological effects:

1. Improves and stimulates the conduction of impulses in the central nervous system.
2. Improves conductivity in the peripheral parts of the NS in cases of disorders resulting from the action of certain antibiotics, potassium chloride, local anesthetics, due to injury, inflammation.
3. Increases the contractility of smooth muscle structures of organs, which is due to the influence of agonists of serotonin, oxytocin, histamine, acetylcholine, and adrenaline receptors (with the exception of sodium chloride).
4. Improves memory, inhibits the progressive development of dementia.
5. The drug does not have mutagenic, immunotoxic, carcinogenic, teratogenic or embryotoxic effects. It has no effect on the endocrine system.

In accordance with the instructions for use, "Axamon" when used orally is absorbed in the gastrointestinal tract. The maximum saturation of the blood with the active component is observed after an hour.

The active substance of the drug binds to plasma proteins by approximately 55%. Half-elimination occurs in 40 minutes.

The active substance is metabolized in the liver tissues, excretion is carried out extrarenally and by the kidneys.

When administered intramuscularly, rapid absorption of the substance is observed. The highest concentration is observed after half an hour, the connection with plasma proteins reaches 50%. The drug is metabolized in the liver tissues, excreted by the kidneys and extrarenally. The half-life of parenteral administration is 3 hours.

Let's consider the indications for the use of Aksamon in tablets and solution.

In what cases is the drug prescribed?

In accordance with the manufacturer's instructions, the medication is indicated for use in the following cases:

• Cerebral circulation disorders.
• Encephalopathy of traumatic, vascular or other origin.
• Alzheimer's disease.
• Bulbar paralysis, paresis, which is accompanied by impaired movement.
• Neuropathies.
• Myelopolyradiculoneuritis.
• Multiple sclerosis.
• Myasthenia, myasthenic syndrome.
• Neuritis.
• Polyneuritis.

Using the product effectively eliminates functional disorders in the nervous system (for example, deterioration of memory and concentration, lability, disorientation). The drug is often used as an element of complex therapy for TBI and demyelinating pathologies.

This is confirmed by the instructions for use for Aksamon.

The drug receives many positive reviews when used to treat children suffering from cerebral dysfunction and learning difficulties. It is noted that the relaxing effect on the muscles makes it possible to use it for intestinal atony and weakened labor.

What else does the instructions for Aksamon tablets and solution tell us?

Contraindications for use

The medication is contraindicated for use if the patient has the following physiological or pathological conditions:

• Pregnancy.
• Lactation period.
• Susceptibility to the components of the drug.
• Vestibular, extrapyramidal disorders.
• Bronchial asthma.
• Severe bradycardia.
• Angina pectoris.
• Epilepsy.
• Age up to 18 years.

Using this drug

The medicine "Aksamon", depending on its pharmacological form, is taken orally, administered subcutaneously or intramuscularly.

For the treatment of lesions in the peripheral parts of the NS, it is recommended to use the medication three times a day, 20 mg.

For the treatment of demyelinating lesions of the nervous system, myasthenic syndrome, myasthenia gravis, it is recommended to take up to 40 mg of the drug five times a day. A maximum of 200 mg per day is allowed.

For the treatment of Alzheimer's disease and other types of dementia, it is recommended to use individually selected dosages. As a rule, it is recommended to take up to 20 mg of Aksamon three times a day. Therapy can have different durations and last from one month to a year.

If a specialist recommends the use of high doses, you should take the drug five times a day with breaks of 3 hours.

For the treatment of intestinal atony, it is recommended to take 15 mg three times a day. Therapy in this case lasts 2 weeks.

Negative effects from the use of medication

Most often, Aksamon tablets and solution are well tolerated by patients. However, in some cases, its use may cause the development of the following side symptoms:

• Cramps.
• Headache.
• Miosis.
• Tremor of the limbs.
• Drowsiness.
• Weakness.
• Increased sweating.
• Reduced temperature.
• Bronchospasm.
• Bradycardia.
• Pain in the area behind the sternum.
• Skin itching.
• Rash on the dermis.
• Ataxia.
• Dizziness.
• Strengthening intestinal motility.
• Decreased appetite.
• Vomit.
• Diarrhea.
• Jaundice.
• Nausea.

If these symptoms occur, you should consult a doctor.

Overdose

If intoxication occurs, the patient experiences the following manifestations: constriction of the pupils, nystagmus, lacrimation, increased sweating, decreased appetite, bronchospasm, conduction disturbances within the heart, jaundice, spontaneous defecation, urination, increased gastrointestinal motility, anxiety, decreased blood pressure, arrhythmia, bradycardia , convulsions, ataxia, general weakness, drowsiness, speech impairment, agitation, fear, anxiety, coma.

Therapy for poisoning consists of gastric lavage, the use of Atropine, Cyclodol, Metacin or another m-anticholinergic agent. In addition, the patient is prescribed symptomatic therapy.

Special instructions for use

During therapy with Aksamon solution and tablets, it is not recommended to take ethanol-containing substances or engage in work that requires quick reactions and increased attention, for example, driving a car.

Patients with pathologies of the cardiovascular system, thyrotoxicosis, ulcerative lesions of the gastrointestinal tract should use the drug only under medical supervision.

Use of the drug during the lactation period and pregnancy

The use of "Axamon" provokes an increase in uterine tone, which may result in premature delivery. Therefore, the use of the drug during this period is prohibited.

https://www.youtube.com/watch?v=5o2jRKqguxA

There is no sufficient data on the safety of the drug during the lactation period, so its use is also prohibited.

Interaction of this drug with other medications

• When combining Aksamon and drugs that can depress the central nervous system, an increased sedative effect may be observed.
• Combined use with other cholinesterase inhibitors and m-anticholinergic blockers significantly increases the effect of Aksamon and its negative manifestations.
• The combined use of Ipidacrine and other cholinergic drugs for myasthenia gravis may increase the likelihood of a cholinergic crisis.
• The likelihood of developing bradycardia increases significantly if Aksamon therapy was preceded by the use of beta-blockers.
• 'Ipidacrine' has the ability to weaken the inhibitory effect of local anesthetics, aminoglycosides, potassium chloride on the conduction of excitation along the nerves of the peripheral nervous system and affects neuromuscular conduction.
• When taking alcohol together with Aksamon, an increase in the negative effects of the drug is observed.

Analogues of "Aksamon"

If there is sensitivity to the components of the drug or contraindications to its use, the specialist may recommend its analogues to the patient. The most popular substitutes are: Neuromidin, Amiridin, Ipidacrine.

It is important to remember that these medications have a number of their own contraindications and can cause the development of negative symptoms. Therefore, the possibility and advisability of replacing the drug should be discussed with your doctor.

The instructions for Aksamon do not indicate the price of the drug.

The cost of this drug

The average price of a package containing 50 tablets is about 700 rubles. A package of 10 ampoules of 5 mg will cost 600 rubles, and 15 mg - 1050 rubles.

Using this drug

The medicine "Aksamon", depending on its pharmacological form, is taken orally, administered subcutaneously or intramuscularly.

For the treatment of lesions in the peripheral parts of the NS, it is recommended to use the medication three times a day, 20 mg.

For the treatment of demyelinating lesions of the nervous system, myasthenic syndrome, myasthenia gravis, it is recommended to take up to 40 mg of the drug five times a day. A maximum of 200 mg per day is allowed.

For the treatment of Alzheimer's disease and other types of dementia, it is recommended to use individually selected dosages. As a rule, it is recommended to take up to 20 mg of Aksamon three times a day. Therapy can have different durations and last from one month to a year.

If a specialist recommends the use of high doses, you should take the drug five times a day with breaks of 3 hours.

For the treatment of intestinal atony, it is recommended to take 15 mg three times a day. Therapy in this case lasts 2 weeks.

Indications for use

• Polyneuritis;
• Neuropathy;
• Myasthenic syndrome;
• Myelopolyradiculoneuritis;
• Alzheimer's disease;
• Multiple sclerosis;
• Organic lesions of the central nervous system;
• Organic lesions of the nervous system (paresis, paralysis);
• Weakening of labor.

According to the instructions for Aksamon, the drug is taken orally or given subcutaneous and intramuscular injections. For the treatment of myasthenic syndrome, myasthenia gravis, demyelinating disorders of the nervous system, an increased dose of the drug should be taken - 20-40 mg 5-6 times a day.

The maximum daily dosage for an adult is 200 mg. For the treatment of diseases of the peripheral nervous system, 20 mg is prescribed 3 times a day.

For the treatment of Alzheimer's disease, the dosage is selected by the doctor individually. The course of treatment ranges from one month to a year, depending on the severity of the disease.

When inducing labor, Aksamon is used 20 mg 1-3 times with an interval of 1 hour.

Axamon effectively eliminates functional disorders of the nervous system, such as loss of motivation and initiative, disorientation, lability, poor concentration, and memory impairment.

Axamon is included in the complex therapy of demyelinating diseases and is prescribed for traumatic brain injuries and poisoning with anticholinergic drugs.

There are many positive reviews about Axamon, used to treat children with cerebral dysfunction and learning difficulties.

Axamon is administered intramuscularly, subcutaneously, or taken orally.

For diseases of the peripheral nervous system, take 20 mg three times a day.

To stop a myasthenic crisis, Axamon is administered subcutaneously, intramuscularly at a dose of 5-15 mg once or twice a day.

For the treatment of Alzheimer's disease and other types of dementia, the dosage is selected individually, taking into account that no more than 200 mg of the drug can be administered per day, and the duration of treatment should be no more than 1-12 months.

When prescribing the drug in high doses, it is recommended to take it 4-5 times a day with a break of two or three hours.

To stimulate labor, 20 mg of Aksamon is administered 1-3 times with a break of 1 hour.

Axamon effectively eliminates such functional disorders of the nervous system as: disorientation, poor concentration, lability, memory impairment, loss of initiative and motivation.

Axamon is very often included in the complex treatment of demyelinating diseases, prescribed for traumatic brain injuries, as well as poisoning with anticholinergic drugs.

For myasthenia gravis, myasthenic syndrome and demyelinating disorders of the nervous system, this drug is used in a higher dose: 20-40 mg 5-6 times a day. The maximum permissible dosage is 200 mg.

For diseases of the peripheral nervous system, Aksamon is taken 10 - 20 mg three times a day.

For the treatment of various types of dementia (for example, Alzheimer's disease), the dosage of the above-mentioned drug is selected individually. The maximum daily dose is 200 mg. Duration of therapy is from one to twelve months.

Aksamon injections and tablets: instructions, reviews, analogues and prices

Switches: and published 2017-12-25 - Comments: 1 - Reading: 3 min - Reviews:

A medical product developed for the treatment of nervous system disorders is Axamon.

Instructions for use recommend taking 20 mg tablets for the treatment of multiple sclerosis, paresis, myasthenia gravis, polyneuritis, Alzheimer's disease in children and adults. What else is 'Axamon' used for?

Release form and composition

'Axamon' is produced in the form of tablets and in solution for subcutaneous or intramuscular injection.

The active ingredient in all forms of the drug is ipidacrine hydrochloride in the form of monohydrate. 1 tablet contains 15 mg of active substance. Excipients in the tablets are sodium carboxymethyl starch, ludipress and calcium stearate. The solution contains 0.1 M hydrochloric acid solution and water for injection.

Pharmacological properties

• The drug 'Axamon', instructions for use confirm this, stimulates the transmission of neuromuscular impulses (in case of damage by blocking potassium channels), regulates the process of excitation on nerves and smooth muscle cells, and also enhances the effect of oxytocin, histamine, acetylcholine and serotonin on smooth muscles.
• The drug effectively restores the peripheral nervous system damaged by toxins, inflammation, antibiotics, local anesthetics or trauma.
• Axamon increases contractility and muscle tone of internal organs, reduces pulse, increases salivation, stimulates the central nervous system, improves memory and promotes learning.

Injections, tablets "Axamon": what does the drug help with?

Among the indications for the drug

• Alzheimer's disease and senile dementia of the Alzheimer's type;
• weakness of work activity;
• in the complex treatment of demyelinating diseases;
• intestinal atony;
• diseases of the peripheral nervous system (neuritis, polyneuritis, polyneuropathy, polyradiculopathy);
• myasthenia gravis and myasthenic syndromes;
• bulbar palsy and paralysis;
• recovery phase for organic lesions of the central nervous system, accompanied by motor disorders.

Instructions for use

'Axamon' is absorbed and also administered subcutaneously and intramuscularly.

For myasthenia gravis, myasthenic syndrome and disorders of the demyelinating nervous system, the drug is used in a higher dose: 20-40 mg 5-6 times a day. The maximum permissible dose is 200 mg.

For disorders of the peripheral nervous system, Aksamon is taken 10-20 mg three times a day.

When treating various types of dementia (for example, Alzheimer's disease), the dosage of the above drug is selected individually. The maximum daily dose is 200 mg. Duration of therapy is from one to twelve months.

The solution is taken orally, subcutaneous or intramuscular injections are made. A single dose of the drug is 10-40 mg, maximum volume is 200 mg/day. Ease of administration and duration of treatment depend on the indication.

Contraindications

'Axamon' instructions for use prohibit in the following cases:

• pregnancy;
• lactation (breastfeeding);
• children under 18 years of age;
• hypersensitivity to the ingredients of the drug;
• vestibular tendencies;
• epilepsy;
• bronchial asthma;
• bradycardia;
• angina pectoris;
• extrapyramidal disorders with hyperkinesia.

Side effects

Drugs can have negative consequences. In some cases, patients were observed:

• loss of appetite;
• increased intestinal motility;
• tremor of the limbs;
• nausea;
• rash;
• convulsions;
• drowsiness;
• weakness;
• vomit;
• decrease in body temperature;
• increased sweating;
• miosis;
• itchy skin;
• jaundice;
• diarrhea;
• dizziness;
• headache.
• bronchospasm;
• bradycardia;
• chest pain;
• ataxia.

Analogs

In terms of composition and therapeutic effects, drugs similar to Aksamon include:

1. Ipidacrine tablets - promotes depolarization and blocking of potassium channels in membranes, increases the tone of the smooth muscles of internal organs.
2. Amiridine 20 mg, tablets – enhances the effect of acetylcholine and prevents its fermentation.
3. Neuromidin - enhances smooth muscle contractility under the influence of all agonists except potassium chloride.
4. Ipigrix - stimulates the excitation of synaptic transmission to neuromuscular endings in myasthenia gravis, helps improve memory and attention.

Drug interactions

The drug is allowed to be taken with nootropic medications. When taken together, the effect of potassium chloride, local anesthetics and aminoglycosides is reduced. An increase in sedative effect is observed when interacting with medications that depress the central nervous system.

Ethanol provokes side effects, so it is not recommended to drink alcohol, as there is negative compatibility with alcohol.

In myasthenia gravis, a crisis may occur due to the concomitant use of cholinergic drugs.

Contraindications

Under constant medical supervision, Axamon should be taken by patients with cardiovascular diseases, gastrointestinal ulcers and thyrotoxicosis.

During treatment, it is strictly forbidden to drink alcohol, and it is not recommended to engage in activities that require increased attention and concentration.

Axamon according to the instructions cannot be used for epilepsy, angina pectoris, severe bradycardia, bronchial asthma, extrapyramidal and vestibular disorders, hypersensitivity, during lactation, pregnancy.

Patients with gastrointestinal ulcers, thyrotoxicosis, and diseases of the cardiovascular system should take the drug under medical supervision.

During treatment with Axamon, it is undesirable to drink alcohol or engage in activities that require increased attention and reaction speed.

Axamon should be taken under medical supervision by patients with cardiovascular diseases, thyrotoxicosis and ulcerative lesions of the gastrointestinal tract.

Axamon injections instructions for use, price, reviews, analogs of Axamon in ampoules

Solution for administration as a clear, colorless liquid.

7 8 Excipients: 0.1 M hydrochloric acid solution - up to pH 3.0, water g / - up to 1 ml.

1 ml - colorless glass ampoules (5) - polyvinyl chloride foil (2) - cardboard packaging.

Solution for the administration of m/m and s/c in the form of a clear, colorless liquid.

Excipients: 0.1 M hydrochloric acid solution - up to pH 3.0, g/s water - up to 1 ml.

1 ml - colorless glass ampoules (5) - polyvinyl chloride foil (2) - cardboard packaging.

The product description is based on the official operating instructions and approved by the manufacturer.

Dosage regimen and duration of treatment

For diseases of the peripheral nervous system, the drug is administered three times a day, one tablet. For myasthenia gravis and demyelinating lesions, the number of doses can be increased to five times a day; in some cases, patients must take two tablets at a time.

The maximum daily dose is 200 mg. To stimulate contractions, one dose of one tablet is usually recommended. If necessary, you can take another 20 mg after an hour. Typical prescription doses for intestinal atony are usually 15-20 mg twice.

The duration of treatment and the number of tablets the patient should take daily depends on the diagnosis and condition of the patient. The doctor who prescribes Aksamon recommends an individual way of taking it.

The use of 'Axamon', which is one of the prescription drugs, is not allowed without prior consultation with specialists and should be taken under the supervision of a doctor.

special instructions

When treating with Axamon, a possible increase in uterine tone should be taken into account. Studies have shown that side effects occur very rarely, occurring in approximately 6.5% of cases. They are usually mild and do not require cancellation

Axamon should be carefully combined with other drugs

Thus, simultaneous use with cholinergic drugs increases the risk of a cholinergic crisis in patients with myasthenia gravis.

Axamon weakens potassium chloride, local antiseptics and antibiotics. When used together with beta-blockers, bradycardia develops more often.

Aksamon enhances the effect of m-cholinomimetics and drugs acting on the central nervous system

Pharmadynamics

Axamon, a reversible cholinesterase inhibitor, directly stimulates the impulse at the neuromuscular junction and the central nervous system by blocking membrane potassium channels. It enhances the effect on smooth muscles not only with acetylcholine, but also with adrenaline, serotonin, histamine and oxytocin.

• Aksamon has the following pharmacological effects:
• – improves and stimulates the conduction of impulses in the nervous system and neuromuscular transmission;
• - improves conductivity in the peripheral nervous system, which is disrupted by injuries, inflammation, exposure to local anesthetics, some antibiotics, potassium chloride and other factors;
• - improves the contractility of smooth muscle organs under the influence of acetylcholine, adrenaline, serotonin, histamine and oxytocin receptors, with the exception of potassium chloride;
• - improves memory, inhibits the progressive development of dementia.

— does not have teratogenic, embryotoxic, mutagenic, carcinogenic and immunotoxic effects; - does not have teratogenic, embryotoxic, mutagenic, carcinogenic or immunotoxic effects. does not affect the endocrine system.

Side effects

• Side effects of the gastrointestinal tract can occur with nausea, vomiting, increased peristalsis and diarrhea, jaundice, anorexia, and hypersalivation.
• Dizziness and ataxia may occur on the central nervous system after repeated use.
• Allergic reactions may manifest as itching or rash. Bradycardia and bronchospasm may occur.
• Axamon is generally well tolerated, side effects occur in 6.5% of cases and usually do not require discontinuation as rapid release prevents drug accumulation and side effects.

Overdose

In case of relative overdose, therapy should be discontinued; m-anticholinergic agents (cyclodol, atropine sulfate) can be recommended.

Contraindications

1. The use of the drug is strictly prohibited for angina pectoris, epilepsy, bronchial asthma, severe bradycardia, hypersensitivity, vestibular and extrapyramidal disorders, during pregnancy and lactation.
2. Axamon should be taken under medical supervision by patients with cardiovascular diseases, thyrotoxicosis and gastrointestinal ulcers.
3. During treatment with Axamon, it is not advisable to engage in activities that require increased reaction speed and attention, as well as drinking alcohol.

Description of the drug

The instructions for use characterize the drug "Aksamon" as a stimulator of neuromuscular transmission. The drug is used to treat various neurological diseases.

A domestic pharmacological medicine is produced. This is a fairly effective remedy. This is evidenced by the instructions for use of the drug "Axamon". The price of the medicine is not exorbitant, unlike its foreign analogues.

The medicine is produced in several dosage forms:

• solution for intramuscular, subcutaneous injection;
• powder;
• pills.

The main component of the medication is the substance ipidacrine hydrochloride. It provides a pronounced anticholinesterase effect.

In addition, the drug has the following properties:

• enhances the functioning of the endocrine and exocrine glands;
• lowers blood pressure;
• increases gastrointestinal motility;
• improves sleep, memory;
• dilates blood vessels;
• provides compression of smooth muscles.

Instructions for use

pharmachologic effect

A reversible cholinesterase inhibitor, prevents the enzymatic hydrolysis of acetylcholine and prolongs its action. Blocks membrane potassium channels and promotes their depolarization. Stimulates synaptic transmission in neuromuscular endings, conduction of excitation in nerve fibers, enhances the effect of acetylcholine and other mediators (epinephrine, serotonin, histamine, oxytocin) on smooth muscles, restores neuromuscular transmission and conduction of excitation in the peripheral nervous system (from for disorders of various origins: injuries, inflammation, the effects of local anesthetics, antibiotics, toxins, KCl).

Increases the tone and contractility of the smooth muscles of internal organs, incl. gastrointestinal tract and bronchi (up to bronchospasm), reduces heart rate, increases the secretion of the salivary glands, the contractile activity of the myometrium, and the tone of skeletal muscles. Has a stimulating effect on the central nervous system in combination with individual manifestations of sedation; helps improve learning and memory.

Hypersensitivity, epilepsy, extrapyramidal disorders with hyperkinesis, angina pectoris, bradycardia, bronchial asthma, tendency to vestibular disorders, pregnancy, lactation. With caution. Peptic ulcer of the stomach or duodenum (acute stage), thyrotoxicosis, cardiovascular diseases.

Application and dosage

Inside, s/c, i/m. For lesions of the peripheral nervous system - 20 mg 3 times a day.

For myasthenia gravis, myasthenic syndromes, demyelinating lesions of the nervous system, the dose can be increased to 20-40 mg 5-6 times a day. The maximum daily dose is 180-200 mg. Relief of myasthenic crisis - 5-15 mg 1-2 times a day subcutaneously or intramuscularly.

For Alzheimer's disease and other forms of dementia, individual selection of the dosage regimen is required. The maximum daily dose can reach 200 mg; duration of appointment – ​​from 1 to 12 months. If it is necessary to use in high doses, it is advisable to use 4-5 times a day with an interval of 2-3 hours.

To stimulate labor - 20 mg 1-3 times with an interval of 1 hour. For the treatment and prevention of intestinal atony - 15-20 mg 2-3 times a day for 1-2 weeks.

special instructions

During treatment, ethanol intake should be avoided.

During the treatment period, care must be taken when driving vehicles and engaging in other potentially hazardous activities that require increased concentration and speed of psychomotor reactions.

Interaction

Reduces the inhibitory effect on neuromuscular transmission and conduction of excitation along peripheral nerves of local anesthetics, aminoglycosides and KCl.

Strengthens the sedative effect of drugs that depress the central nervous system, incl. ethanol, the effect of other cholinesterase inhibitors and m-cholinergic stimulants.

Against the background of other cholinergic drugs, the risk of cholinergic crisis in patients with myasthenia increases.

Beta-blockers increase the severity of bradycardia.

Atropine and methocynium iodide reduce the severity of overdose symptoms.

Axamon

Release form and composition

The drug is available in the form of tablets and solutions. The package contains 5 tablets of 10 tablets (20 mg). For subcutaneous and intramuscular administration, prepare a solution of 5 ampoules in 1 ml packaging.

One tablet of the drug Aksamon contains: 20 mg of ipidacrine hydrochloride monohydrate, which is the active substance. Excipients: 1 mg calcium stearate, 65 mg Ludipress, 14 mg sodium carboxymethyl starch.

pharmachologic effect

• The drug stimulates the transmission of neuromuscular impulses (if they are damaged by blocking potassium channels), regulates the process of excitation on nerves and smooth muscle cells and enhances the effect of oxytocin, histamine, acetylcholine and serotonin on smooth muscle.
• Axamon effectively restores the peripheral nervous system damaged by toxins, inflammation, antibiotics, local anesthetics or trauma.
• Axamon increases contractility and muscle tone of internal organs, reduces pulse, increases salivation, stimulates the central nervous system, improves memory and promotes learning.

Indications for use

How does Axamon help you? Prescribed tablets and injections:

• senile dementia;
• intestinal atony;
• lesions of the central nervous system with motor disorders;
• swallowing, chewing and speech disorders (bulbar palsy);
• Alzheimer's disease;
• myasthenia gravis and myasthenic syndrome;
• demyelinating diseases;
• neuritis, polyradiculoneuropathy, polyneuritis and polyneuropathy.

Drug overdose

Like any medicine, this medication should be taken only according to the regimen prescribed by a specialist. Deviation from this recommendation can provoke the development of quite unpleasant consequences.

The following symptoms of overdose indicate drug abuse:

• arrhythmia;
• vomit;
• lacrimation;
• feeling of anxiety, incomprehensible panic;
• feeling of fear;
• spontaneous defecation and urination;
• decrease in pressure;
• coma;
• constriction of the pupils;
• general weakness;
• nystagmus;
• impaired intracardiac conduction.

If the symptoms described above occur while taking the medication, the patient should initially rinse the stomach. In case of overdose, doctors prescribe symptomatic therapy and include m-anticholinergic drugs in the treatment: Atropine, Metocinium iodide, Trihexyphenidyl.

Side effects

Negative consequences resulting from the use of this drug occur extremely rarely. According to statistics, 6.5% of patients taking the medicine "Axamon" experience side effects.

The instructions for use warn of the following possible manifestations:

1. Mental disorder. Sometimes patients develop increased drowsiness.
2. Nervous system. Taking the medication may be accompanied by dizziness, tremor, convulsions, and headache.
3. Cardiac system. Patients complain of bradycardia, palpitations, and chest pain.
4. Organs of vision. Miosis may occur.
5. Respiratory system. Taking the medication can lead to increased secretion of bronchial secretions.
6. Gastrointestinal tract. May develop drooling and nausea. In some cases, vomiting, epigastric pain, and diarrhea are observed.
7. Biliary tract and liver. While taking the medication, jaundice may develop.
8. Subcutaneous tissues and skin. Patients may experience itching and rash.
9. General disorders. Sometimes patients experience increased sweating and general weakness. Hypothermia may occur.

Pharmacological effects

By preventing the enzymatic hydrolysis of acetylcholine, Aksamon prolongs its action. By blocking membrane potassium channels, the drug promotes their depolarization. By exerting a stimulating effect on synaptic transmission in neuromuscular endings and the conduction of excitation in nerve fibers, the drug is able to enhance the effect of acetylcholine and other mediators (including epinephrine, serotonin and others) on smooth muscles. The active substance "Axamona" restores neuromuscular transmission and conduction excitation in the peripheral nervous system, which can be disrupted due to the influence of various factors, in particular inflammatory diseases or injuries. The drug also increases the tone and contractility of the smooth muscles of the internal organs, including the gastrointestinal tract and bronchi (up to bronchospasm), reduces the heart rate, increases the contractile activity of the myometrium, increases the tone of skeletal muscles and the level of secretion of the salivary glands. “Axamon” has a stimulating effect on the central nervous system in combination with individual manifestations of sedation. Under the influence of this drug, memory can improve and manifestations of dementia slow down. The drug does not have teratogenic, mutagenic, carcinogenic or embryotoxic effects, and also does not affect the functions of the endocrine system. The drug is characterized by fairly rapid absorption. The maximum level of concentration in the blood of the active substance can be recorded within twenty-five minutes after taking the tablet, with about half of the volume bound to blood proteins. Ipidacrine quickly penetrates the tissues and is quickly metabolized in the patient’s body. The half-life of Aksamon is 0.7 hours. The drug is excreted through the kidneys and other routes.

special instructions

During treatment with Axamon, patients should avoid drinking alcohol, as alcohol increases the likelihood of side effects.

The doctor must strictly monitor the treatment process for patients with peptic ulcers of the gastrointestinal tract, excessive production of thyroid hormones, and pathologies of the heart and blood vessels.

Drug interactions

Axamon can be used in combination with nootropic drugs without any problems.

The medication is able to reduce the inhibition of neuromuscular transmission and the conduction of excitation reactions along peripheral nerves, which are provided by local anesthetics, aminoglycosides, and potassium chloride.

The sedative effect of medications that depress the central nervous system (tranquilizers, neuroleptics, antidepressants, sedatives, hypnotics, antimanic drugs) is enhanced when taken simultaneously with Axamon.

Efficiency increases, but along with it the likelihood of developing complications characteristic of ipidacrine increases with the combined use of drugs similar to it in pharmacological action, m-cholinomimetics (Pilocarpine, Aceclidine) and ethanol.

Taking Axamon together with cholinergic drugs can provoke a cholinergic crisis.

Beta-blockers, which the patient took before starting to use Axamon, increase the likelihood of developing such an unpleasant symptom as bradycardia.

The simultaneous use of the described drug with sodium thiosulfate does not cause complications.

Vehicle management

With driving a car, as well as working with complex mechanisms that require high concentration of attention from the patient, it is better to wait until drug therapy is completed.

Use during pregnancy and lactation

It is strictly forbidden to administer Aksamon to women expecting a baby, since the drug increases the tone of the uterus, thereby provoking miscarriage or premature birth. But during the process of childbirth, the medication can help if the woman in labor does not have contractions or they are very weak.

Clinical studies of the safety of using the medication during breastfeeding have not been conducted, therefore, if treatment with Axamon is necessary, breastfeeding will have to be completed.

Prescription in childhood

The description of the drug states that it cannot be prescribed to patients under 18 years of age. However, there is data on the use of ipidacrine in pediatrics. Axamon has proven effective in treating children with cerebral disorders and learning problems. It is important to remember that the decision to prescribe this or that medication can only be made by a specialist, especially when it comes to children.

Release form and composition

Aksamon is available in tablets of 0.02 g in blister packs and in glass bottles of 50 pieces.

In the form of a solution for intramuscular and subcutaneous injections. The drug is sold in glass ampoules (1 ml each), placed in blister packs of 5 pieces.