Fungal infections of the scalp and dandruff are often diagnosed in both men and women at any age and with different lifestyles. Treatment of such problems usually does not create great difficulties, but it is often protracted and lengthy. Therefore, manufacturers of cosmetic and medicinal care products are trying to invent new drugs to more effectively combat the disease. One of these products is Sebazol shampoo, which, according to the instructions, is characterized by a relatively low cost and a wide range of applications.
Purpose
Shampoo for external use in dermatology and cosmetology. Providing an antimicrobial and antifungal effect, it eliminates not only the symptoms, but also the cause of dandruff.
Sebozol shampoo is designed specifically for removing dandruff (it affects fungal infections of the scalp, face and torso). It can be used for diseases accompanied by the following symptoms: dandruff, seborrheic dermatitis (red-brown plaques with peeling), pityriasis versicolor, seborrheic psoriasis. The shampoo has a pronounced sebostatic and keratolytic-exfoliating effect.
With regular use, it completely prevents the reappearance of dandruff and also improves the condition of sensitive skin.
Suitable for any hair type.
Sebozol
With simultaneous use of ketoconazole with antacids (aluminum hydroxide, histamine H2 receptor blockers, proton pump inhibitors), the absorption of ketoconazole from the gastrointestinal tract decreases. With these combinations, the antifungal activity of ketoconazole should be monitored and its dose adjusted if necessary.
When ketoconazole is used simultaneously with strong inducers of the CYP3A4 isoenzyme, the bioavailability of ketoconazole may decrease, which can cause a significant decrease in its effectiveness. These drugs include isoniazid, rifabutin, rifampicin, carbamazepine, phenytoin, efavirenz, nevirapine. If these combinations cannot be avoided, then the antifungal activity of ketoconazole should be monitored and, if necessary, its dose should be increased.
With simultaneous use of ketoconazole with strong inhibitors of the CYP3A4 isoenzyme (for example, antivirals, including ritonavir, ritonavir-boosted darunavir and ritonavir-boosted fosamprenavir), the bioavailability of ketoconazole may increase. With these combinations, the patient's condition should be monitored to identify symptoms of increased intensity and duration of action of ketoconazole, the concentration of ketoconazole in the blood plasma and, if necessary, reduce its dose.
With simultaneous use, ketoconazole is able to inhibit CYP3A4-mediated drug metabolism, as well as the transport of active substances due to P-glycoprotein. This may lead to increased plasma concentrations of these drugs and/or their active metabolites, causing an increase in the intensity and duration of therapeutic or side effects of concomitantly administered drugs.
The simultaneous use of the following drugs with ketoconazole is not recommended: tamsulosin, fentanyl, rifabutin, rivaroxaban, carbamazepine, dasatinib, nilotinib, trabectedin, salmeterol. If these combinations cannot be avoided, then clinical monitoring of the patient's condition should be provided to identify symptoms of increasing intensity or duration of therapeutic and/or side effects, monitor the concentration of the drug in the blood plasma and, if necessary, reduce the dose of the appropriate drug or suspend its use.
Ketoconazole should be used with caution concomitantly with the following drugs: alfentanil, buprenorphine (IV and sublingual), oxycodone, digoxin, coumarins, cilostazol, repaglinide, saxagliptin, praziquantel, ebastine, eletriptan, bortezomib, busulfan, docetaxel, erlotinib, imatinib, ixabepilone , lapatinib, trimetrexate, vinca alkaloids, alprazolam, aripiprazole, brotizolam, buspirone, haloperidol, midazolam (IV), perospirone, quetiapine, ramelterone, risperidone, maraviroc, indinavir, saquinavir, nadolol, verapamil, aliskiren, aprepitant, budesonide, ciclesonide , cyclosporine, dexamethasone, fluticasone, methylprednisolone, sirolimus, tacrolimus, temsirolimus, atorvastatin, reboxetine, fesoterodine, imidafenacin, sildenafil, solifenacin, tadalfil, tolterodine, alitretinoin (oral dosage form), cinacalcet, mozavaptan, tolvaptan. When used together, careful monitoring of the patient's clinical condition is recommended, if necessary, monitoring the concentration of the drug in the blood plasma and, if necessary, reducing its dose.
In isolated cases, a disulfiram-like reaction is possible when drinking alcohol while taking ketoconazole.
Application
For adults and children over 1 year.
Dandruff.
Apply 5 ml of Sebozol shampoo to clean, damp hair and scalp, lather and leave for 5 minutes. Then rinse thoroughly. Application includes 2 stages: Stage 1 – dandruff removal: apply 2 times a week for 4 weeks. Stage 2 – prevention: once a week or once every two weeks.
Pityriasis versicolor.
When taking a shower, you need to rub Sebozol shampoo into the affected areas of the body, maintaining exposure for 5-7 minutes. Then rinse off the shampoo. Repeat the procedure daily for 14 days.
Seborrheic forms
atopic dermatitis and psoriasis. Use Sebozol shampoo daily for the first 3 days, then every other day. The exposure duration is 5-7 minutes. The course lasts 4-6 weeks.
A 100 ml bottle is designed for a course of 2-3 months (elimination of dandruff and itching). After 3-4 uses of Sebozol shampoo, the natural function of the scalp is restored and symptoms are eliminated.
In order to carry out a short course of prevention, it is advisable to use 5 ml packets of Sebozol shampoo.
It is advisable to use a 200 ml bottle as a shower gel for long courses and extensive exposures on the scalp and other areas of the body (pityriasis versicolor, seborrheic forms of atopic dermatitis, seborrheic psoriasis).
To record the achieved results, it is advisable to use Ecoderm shampoo 150ml as basic care (daily use).
Composition and release form
Sebozol is also available in ointment form
Sebozol is available in two forms - shampoo and ointment. The active ingredient in any case is ketoconazole.
1 gram of shampoo and ointment contains 20 milligrams of ketoconazole. In addition, the composition contains the following additional components:
- Disodium edetate.
- Sodium laureth sulfate.
- Sodium benzoate.
- Sodium chloride.
- Butylated hydroxytoluene.
Sebozol ointment is available in several dosages - 10, 15 and 20 g. The packaging is equipped with a sprayer, which allows you to accurately control the application of the product to the skin. Sebozol shampoo is produced in volumes of 100 or 200 ml.
Drug interactions
Sebozol should not be used in parallel with steroid drugs
Sebozole is not recommended for use in combination with drugs from the glucocorticosteroid group. The use of Sebozol is prescribed two weeks after complete withdrawal of steroid drugs.
No interactions with other medications were identified. Sebozole has low absorption, so it is safe to use in combination with other drugs.
special instructions
During treatment, blood tests should be performed from time to time to assess the condition of the liver and kidneys.
Sebozole is sold freely and does not require a prescription. But despite this, it is recommended to consult a doctor before use. This is especially true for patients with severe liver and kidney diseases, as well as pregnant women.
In case of elevated levels of liver enzymes or after toxic liver damage, it is recommended to discontinue the use of Sebozol. The use of the drug is advisable only when the expected benefits outweigh the possible risks.
Before starting therapy, it is necessary to assess the condition of the liver and conduct a diagnostic study. This will help exclude possible chronic and acute liver diseases, which the use of Sebozol can significantly aggravate. During treatment, blood tests should be performed from time to time to evaluate the condition of the liver and kidneys.
It is worth considering that acidic drinks enhance the absorption of the active substance - ketoconazole. It is recommended to control the amount of acidic drinks consumed.
How does the ointment affect the body?
How to treat fungus? This is a question many people ask. As already mentioned, the main active ingredient of this medicine is ketoconazole. This component has pronounced antifungal properties. The drug is active against yeast fungi, eumycetes, dermatophytes, as well as some bacterial microorganisms, in particular streptococci and staphylococci.
Ketoconazole inhibits the processes of ergosterol synthesis, and also prevents fungi from forming colonies and threads, which subsequently leads to the death of pathogenic microorganisms. In addition, the drug relieves inflammation, eliminates skin itching and burning.
How much does the drug cost?
Many patients wonder how to treat fungus. Of course, when choosing a medicine, the form of release, the level of safety, and ease of use are taken into account. An equally important factor is the cost of the drug.
It’s worth saying right away that Sebozol is an ointment that is quite affordable. The cost of the drug ranges from 120 to 300 rubles, depending on the volume of the tube. If we are talking about shampoo of this brand, then its price is approximately 300-700 rubles (again, the cost depends on the volume of the jar).
Analogs
Analogues of Sebozole - shampoos Keto Plus, Nizoral, Mycozoral, ointments - Terbinafine, Lamisil, Clotrimazole. Replacement of the drug is carried out only by the attending physician, taking into account the pharmacological properties of external agents. For example, Ketoplus contains, in addition to ketoconazole, zinc pyrithione. This means that this shampoo is not advisable for dry skin.
Clotrimazole is a drug with a similar spectrum of action
Reviews
Anna, 29 years old, Kazan
After reading a lot of good reviews about Sebozole for dandruff, I decided to consult a trichologist. He calculated the required doses and advised me to use shampoo for prevention in the future. The product did its job remarkably well without showing a single side effect.
Angelica
Ekaterina, 52 years old, Nizhny Novgorod
To treat pityriasis versicolor, the dermatologist prescribed me Sebozol ointment. It immediately relieved the unbearable itching, allowing me to finally get a good night's sleep. I followed the instructions, did not take breaks, and did not exceed the dose. And after a month she finally recovered.
Read further:
Mycozoral ointment - instructions for use in the treatment of fungus, composition, review of analogues and reviews
Nizoral cream (ointment): instructions and indications for use, price, review of analogues and reviews
Ketoconazole ointment: instructions and recommendations for use for fungal diseases, effectiveness, analogues and reviews
Viferon ointment: instructions for use for children under one year of age, recommendations and reviews
Cynovit cream gel for acne and acne - instructions for use, price, review and reviews
Sebozol shampoo (review) from 150 rub.
Overall
4.6
- Efficiency
- Price
- Safety
- Availability
Pros
- Efficacy against dandruff
- Economical
- Price
- Smell
Cons
- Addictive
- Possible allergies
