Amidopyrine - description of the drug, instructions for use, reviews

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Manufacturers: Gulf Pharmaceutical Industries

Active ingredients

• Not indicated. See instructions

Disease class

• Not indicated. See instructions

Clinical and pharmacological group

• Analgesics

Pharmacological action

• Anti-inflammatory
• Analgesic (non-narcotic)
• Analgesic (narcotic)
• Painkiller

Pharmacological group

• Non-narcotic analgesics, including non-steroidal and other anti-inflammatory drugs

Description of the medication

Many consumers often asked doctors about the drug Pyramidon.
They didn’t know what it was, mistakenly thinking that the medicine was a narcotic. Is it really? The active component of the drug was aminophenazone. Probably someone will remember that “Pyramidon” (medicine) was often replaced with a Russian analogue – “Amidopyrine”. The drug can be compared in action to Phenazone. The medicine was produced in tablets. They were sold without medical prescription. Many doctors also prescribed it to patients, including children. If you were born in the 50s and 60s, you probably remember how your parents offered you this cold medicine. Only after some time did experts realize the danger of “magic” pills.

Contraindications to the use of Amidopyrine

Amidopyrine according to the instructions is contraindicated for blood diseases, gastrointestinal ulcers, during lactation, pregnancy, acute gastric and intestinal bleeding, hypersensitivity to the drug. The drug is not prescribed to children under 14 years of age.

Amidopyrine should be used with caution in patients with bronchial asthma or hypersensitivity to other non-steroidal anti-inflammatory drugs.

Amidopyrine solution cannot be combined with salts of organic nitrogen-containing bases and alkaloids, with oxidizing agents, and its powder cannot be combined with menthol, thymol, aspirin, resorcinol, cinchonfen, phenyl salicylate.

November 17, 2013

Contraindications

• ulcerative lesions of the digestive tract (stomach, intestines, duodenum);
• blood diseases (predisposition to the development of hematopoietic pathologies);
• bronchial asthma;
• age restrictions in pediatrics up to 14 years;
• seizure activity;
• stomach bleeding ;
• severe pathology of the hepatic system;
• bleeding disorders;
• individual hypersensitivity.

The drug is recognized as highly toxic and is not used in medical practice in the USA and Europe. With regular use agranulocytosis and hematopoiesis is inhibited.

Amidopyrine preparations

Pirafen - tablets containing amidopyrine and phenacetin, 0.25 g each.

Pyraminal - tablets containing amidopyrine - 0.25 g, caffeine - 0.03 g, phenobarbital - 0.02 g.

Pyramein - tablets containing amidopyrine - 0.3 g, caffeine - 0.03 g.

Novomigrofen is a combination drug containing amidopyrine, phenacetin, caffeine, and citric acid. Used as an analgesic for headaches, neuralgia, and as an antipyretic for colds.

Piranal - tablets containing 0.25 g of amidopyrine and analgin.

Pircofen - tablets containing 0.25 g of amidopyrine and phenacetin and 0.05 g of caffeine.

Amizol - tablets containing 0.3 g amidopyrine and 0.02 g dibazole.

Result of application

The medicine was effective and popular, but only for a certain time. During the years of its active use, the development of medicine did not allow a banal blood test to be performed on every patient. Therefore, even long-term use of the tablets was not prohibited: doctors were unaware of their actual effect.

It later turned out that the medicine was a time bomb. When used, the medicine improved well-being, but at the same time reduced the number of leukocytes in the blood. Regular use of Pyramidon contributed to the development of the immunodeficiency effect. It turns out that one was treated, and the other was crippled. Patients more often suffered from viral and bacterial diseases. And when treated with sulfonamides, severe forms of skin allergies appeared. But no one could have thought that this was the result of long-term use of Pyramidon.

Those children who, at the insistence of their parents, often took this drug, had various bone marrow diseases. This medication was actively affecting him. In some situations, the medicine even caused death. But, we repeat, no one could even think...

History of the creation and prohibition of Amidopyrine

The drug was part of a group of non-narcotic analgesics with analgesic, anti-inflammatory and antirheumatic properties.
It was also produced under the trade names Dipirin, Novoamidon, Pyramidon, etc. Amidopyrine (more precisely, the active substance aminophenazone) was discovered at the end of the 19th century by the German scientist Friedrich Stoltz as a result of the synthesis of another painkiller - antipyrine. By changing just one molecule, the chemist created a new substance that was superior in properties to its predecessor. Subsequently, the substance received another name - pyramidon. The new medicine quickly spread throughout the world, as it was considered very effective in suppressing pain and inflammatory pathologies.

But since the late 70s. In the last century, amidopyrine and its derivatives were withdrawn from sale because it was discovered that the substance promotes the formation in the human body of the carcinogenic compound nitrosamine, which provokes malignant tumors.

Plus, studies have revealed that the medicine affects the bone marrow in children. It was recorded that after treatment with the drug, the level of leukocytes in the blood of patients sharply decreased, and in some patients it was completely absent. As a result of damage to bone hematopoiesis, the incidence of agranulocytosis has greatly increased - a dangerous blood pathology that is practically untreatable and causes fever, necrosis of mucous tissues, contributing to the development of sepsis and bleeding.

Moreover, it turned out that Ampdopirin causes disease regardless of the dosage. That is, the likelihood of a fatal disease occurring is in no way related to the amount of dosage consumed. Amidopyrine provokes a dangerous disease in any dose - minimal or maximum.

Such terrible consequences of treatment with Amidopyrine became the basis for its ban. In Russia, the drug was officially excluded from the register of medicinal products in 1997.

Amidopyrine derivatives that were part of other medications were also recognized as dangerous. Some drugs were withdrawn from sale, while others had their formulations redesigned. So, for example, in Pentalgin a combination of analgin and naproxen (or analgin with paracetamol) was included instead, and in Teofedrine-N - paracetamol.

Properties and price of the drug

"Amidopyrine" is written and sounded in Latin as Amidopyrinum.

The main components of the drug are caffeine benzoate (0.1 g) and amidopyrine (0.25 g). It can be presented in the form of tablets and a white solution.

Amidopyrine is used to combat severe pain, to reduce high fever, and also as an anti-inflammatory or antirheumatic agent. Moreover, its effectiveness is much higher in comparison with other drugs with a similar type of action.

The drug shows excellent results in the fight against joint pain and migraines, so in such cases it is worth choosing Amidopyrine. The price of the drug ranges from 45-70 rubles per package (20 tablets) and differs depending on the pharmacy or region of residence.

Amidopyrine tablets - price of the drug, instructions for use

• Compound
• Indications for use
• Application
• Side effects
• Contraindications
• Price
• Analogs

Amidopyrine, instructions for use: the drug acts as an antipyretic, analgesic and anti-inflammatory agent.

Application

Amidopyrine tablets are taken orally, 0.3 g up to four times a day. If treatment is used during acute attacks of rheumatism, the dosage is increased to 3 g per day. In this case, the dose of a single dose is not increased immediately, but is calculated using a special formula - 0.2 g per year of life. After four doses according to a given scheme, the dosage reaches its maximum value.

Administration to children under 12 years of age is also possible; in this case, the maximum dose per dose is 0.15 g.

The maximum dose for a single dose for an adult is 0.5 g per day; if this is not therapy for acute conditions, no more than 1.5 g can be taken.

In any case, it is not recommended to take the drug on your own; you should consult a specialist before taking it.

Side effects

Treatment that takes a long period of time is always carried out under the supervision of a specialist. Since amidopyrine affects the hematopoietic function of the body, it is necessary to periodically take a clinical blood test.

Inhibition of hematopoiesis may indicate that treatment has been delayed or that the maximum permissible dose of the drug has been exceeded.

In this case, amidopyrine analogues that do not have such side effects on the body can be used.

In addition to the one presented, there may also be other reactions to the drug. Most often, these are skin rashes that go away after discontinuation of the product and a course of antiallergic drugs.

Anaphylactic reactions during treatment with amidopyrine are extremely rare.

Sleep disturbances, swelling.

Price

The price of amidopyrine varies from 45 to 70 rubles per package of 20 tablets. The cost of the drug depends on the region and the pricing policy of medicines.

You can buy amidopyrine here https://www.vse-lekarstva.ru or here https://www.aptekari.com. You can choose the drug, a convenient release form and the number of tablets in the package.

Features of the drug

Composition of Amidopyrine

Amidopyrinum is the Latin name of a drug containing 100 mg of sodium benzoate (caffeine) and 250 mg of dimethylaminopyrazolone, which is the active substance. The chemical formula of the drug Amidopyrine, taking into account two chemical compounds - 2,3-dimethyl-1 -phenyl-4-dimethylaminopyrazolone -5 pyramidone.

Next, the forms and price of Amidopyrine in Russia are considered.

Dosage forms and prices

1. Tableted. Produced since Soviet times in a package of 6 tablets. During Soviet times it was known as “Pyramidon”. Amidopyrine tablets are white or whitish in color with a gray tint.
2. Powder. Crystalline white powder with a mild bitter taste. The powder dissolves poorly in water and quite well in ethyl alcohol.
3. Injection. Ampoules with Amidopyrine solution are produced in different capacities: 10, 5 and 1 ml. The ampoules contain a solution of amidopyrine at 2% or 4% concentration. Ampoules are packed in 10 or 100 pieces in cardboard packs.

Amidopyrine, like Pyramidon, was discontinued in Russian production at the end of the 20th century. On the Russian pharmaceutical market, Amidopyrine is produced in Ukraine. The pricing policy of a marketed drug is determined freely.

Amidopyrine - instructions for use, reviews, indications, analogues - Moscow State Budgetary Institution Polyclinic No. 2

Amidopyrine is a remedy for eliminating headaches, which has been used to lower body temperature and relieve inflammatory processes as a non-steroidal anti-inflammatory drug. Instructions for use in medicine, price of Amidopyrine, reviews and analogues of the drug are discussed below.

Composition of Amidopyrine

Amidopyrinum is the Latin name of a drug containing 100 mg of sodium benzoate (caffeine) and 250 mg of dimethylaminopyrazolone, which is the active substance. The chemical formula of the drug Amidopyrine, taking into account two chemical compounds - 2,3-dimethyl-1 -phenyl-4-dimethylaminopyrazolone -5 pyramidone.

Next, the forms and price of Amidopyrine in Russia are considered.

Dosage forms and prices

1. Tableted . Produced since Soviet times in a package of 6 tablets. During Soviet times it was known as “Pyramidon”. Amidopyrine tablets are white or whitish in color with a gray tint.
2. Powder .
   Crystalline white powder with a mild bitter taste. The powder dissolves poorly in water and quite well in ethyl alcohol.
3. Injection .
   Ampoules with Amidopyrine solution are produced in different capacities: 10, 5 and 1 ml. The ampoules contain a solution of amidopyrine at 2% or 4% concentration. Ampoules are packed in 10 or 100 pieces in cardboard packs.

Amidopyrine, like Pyramidon, was discontinued in Russian production at the end of the 20th century. On the Russian pharmaceutical market, Amidopyrine is produced in Ukraine.

The pricing policy of a marketed drug is determined freely.

https://www.youtube.com/watch?v=mVmrSPVTNyM

The anti-inflammatory effect of Amidopyrine is associated with the expansion of peripheral vessels (mainly cerebral vessels) and improvement of local blood circulation. The value of blood pressure after taking Amidopyrine does not change, since with peripheral vasodilation a slight and unstable narrowing of central vessels is observed.

The analgesic effect is associated with changes in the lumen of blood vessels and the effect of the constituent components of the drug on the nerve centers of the hypothalamus. One of the hypothalamic nuclei is responsible for the release of pyrogenic substances that cause an increase in temperature. Blockade of the excitatory processes of this nucleus leads to the relief of febrile symptoms.

Pharmacokinetics

The end products of Amidopyrine are excreted through the urinary system and sweat glands. Urine after consuming Amidopyrine has a bright red tint.

Intermediate products have a toxic effect on liver hepatocytes, where the drug is metabolized. Combined use with sulfonamides leads to allergic skin reactions.

Long-term use of Amidopyrine is fraught with the occurrence of agranulocytosis.

The final decomposition products are rubazonic and methylrubazonic acids, 4-aminoantipyrine and methylaminoantipyrine.

Indications

• pain in the head;
• muscle and joint inflammation;
• high temperature;
• pain associated with nerve topography;
• rheumatic origin of acute joint pain in pediatric patients;
• damage to the joint by rheumatic and inflammatory processes;
• inflammatory process in striated muscles of any etiology;
• chorea syndromes;
• to eliminate hyperthermia in hemorrhagic stroke;
• dyshidrotic eczema;
• inflammation of peripheral nerves.

The antispasmodic effect does not exclude the use of the drug for colic in the intestines and stomach pain.

The following describes the instructions for the use of tablets and other forms of Amidopyrine for children and adults.

Interaction with other medicinal substances

• When using Amidopyrine, one should take into account the inadmissibility of combined use with acid-containing drugs, for example, Acetylsalicylic acid.
• Amidopyrine in the form of injections cannot be used together with metal derivatives of alkaloids due to precipitation of alkaloids in the form of insoluble hydroxides.
• Due to the mutual arrangement of substituent groups in the molecules, Amidopyrine should not be allowed to interact with oxidizing drugs.
• In powder form, the drug is not used in combination with Tsinchonfen, Menthol, Phenyl salicylate, Thymol and Resorcinol due to the formation of eutectic mixtures.
• Do not use with Otirelax drops or Diucifon medicine.

Amidopyrine

Amidopyrine is a pharmacological drug from the group of non-steroidal drugs that has anti-inflammatory and antipyretic properties. In addition, Amidopyrine is a drug with an analgesic and antirheumatic effect.

Release form and composition

Amidopyrine is available in tablet form, each tablet is 0.25 mg or in the form of a two percent solution (one milliliter in an ampoule) and a four percent solution (five or ten milliliters in an ampoule).

The package may consist of six tablets or ten to one hundred ampoules of this drug.

Amidopyrine consists of two main substances: amidopyrine itself and caffeine sodium benzonate.

Directions for use and dosage

Amidopyrine is taken one tablet or 250-300 milligrams up to four times a day.

Acute rheumatism involves taking Amidopyrine in dosages of 1.5 to three grams of the drug per day. In this case, the course of treatment will be quite long until all the symptoms of the acute form of rheumatism disappear. After this, for another two to three weeks in a row, the patient must undergo maintenance therapy with this drug in dosages of 0.6 to 0.9 grams per day.

For children under twelve years of age, Amidopyrine is prescribed in single dosages from 0.025 to 0.15 grams of the drug. A more precise dosage will be determined by the doctor, taking into account age characteristics and the form of the disease.

Properties of Amidopyrine

The drug contains 0.25 g amidopyrine and 0.1 g caffeine benzoate. It looks like a white powder with a crystalline structure and tastes a little bitter. It dissolves very poorly in water, but in alcohol solutions this indicator noticeably improves. Amidopyrine has antipyretic, anti-inflammatory, analgesic, and antirheumatic properties. Numerous reviews from specialists and patients indicate that the effect of Amidopyrine as an antipyretic agent is many times greater than the effect of a similar drug, Antipyrine.

The drug is available in the form of tablets and solution. Amidopyrine analogues are widely known and available. Also, its basic active substance is included in other drugs. There are many analogues of Amidopyrine: Pyrazone, Amidofen, Aminopyrazoline, Amidozon, Amidofebrin, Aminopyrine, Alamidon, Amidopyrazoline, Aneuxol, Pyrazorin, Stellamidon, Anafebrine, Dipirin, Dimethyl-amino-phenazone, Aminophenazone, Novamidon, Amidazofen, Pyramidon, Dimethylamino-antipyrine, Amidozone, Pyramine, Dinapirin. But here are a number of drugs that contain amidopyrine: Pyraminal, Novomigrofen, Piranal, Pirkofen, Amizol, Pyramein.

The action of Amidopyrine is that it blocks the processes of biosynthesis of active prostaglandins. For pain in the stomach or intestines, it has an antispasmodic effect on smooth muscles. The drug is most effective in the fight against acute headaches and joint pain.

How to take Amidopyrine

Treatment of joint diseases is always carried out comprehensively. It works in two directions - it eliminates the cause of the pathology and reduces pain. The treatment regimen is developed by the doctor, and painkillers are prescribed to alleviate the patient’s condition and reduce pain.

Let's look at the instructions for use of Amidopyrine (Pyramidon), an effective drug from the group of potent painkillers.

Compound

“Amidopyrine” is a drug that has been actively used as part of complex treatment of lesions of the musculoskeletal system (MSD) to eliminate pain.

Reference. “Amidopyrine” and “Pyramidon” are often used as synonyms, since these drugs are complete structural analogues, similar in composition, medicinal properties and method of application.

The composition of these medicines is represented by the active ingredient - aminophenazone, as well as caffeine-sodium benzoate.

Reference. Aminophenazone is a strong anesthetic substance obtained as a result of experiments with antipyrine (painkiller).

The chemical formula is as follows:

• C13H17N3O (gross formula);
• 4-dimethylamino-1,5-dimethyl-2-phenylpyrazol-3-one (name of the chemical compound according to the nomenclature of the International Union of Pure and Applied Chemistry).

Pharmacodynamics and pharmacokinetics

The action of the drug is based on the following mechanisms:

• dilation of blood vessels (anti-inflammatory effect);
• normalization of blood microcirculation;
• influence on the hypothalamus and its nerve centers (painkiller effect);
• inhibition of hypothalamic nucleus processes (elimination of febrile symptoms, decrease in temperature).

Pharmacokinetics: after absorption, the drug is metabolized in the liver. Metabolites are excreted by the sweat glands and urinary system. In this case, the urine turns bright red.

Overdose

If the recommended norm is exceeded, the drug causes an overdose, accompanied by the following pathological conditions:

1. Necrosis of the kidney parenchyma - destruction of kidney tissue with lower back pain, renal colic, nausea, vomiting, and the appearance of blood in the urine.
2. Tonic-clonic seizures are a phenomenon that occurs in two periods. The tonic convulsions phase lasts 20 seconds and is accompanied by spasms of the entire skeletal muscles and rolling up of the eyeballs. Then the period of clonic convulsions lasts 40 seconds, proceeds with phases of spasms and relaxation of the muscle tissue of the body.
3. Heart dysfunction.
4. Pulmonary edema is a pathology in which the fluid content in the lung tissues increases, which leads to a sharp disruption of gas exchange in the lungs.
5. Reducing blood pressure to critical levels.

If such reactions develop, you should immediately go to the hospital where symptomatic therapy will be carried out.

Interaction with other drugs and alcohol

"Amidopyrine" is characterized by the following interactions with other drugs and medicinal substances:

1. Analgesics and antispasmodics. The effectiveness of these medications increases, but at the same time increases the likelihood of developing negative reactions.
2. Zinkhofen, resorcinol, phenyl salicylate, thymol, menthol are not combined with the powder form of the product.
3. Medicines containing acetylsalicylic acid (Aspikor, Aspirin, Cardiomagnyl, etc.) are completely incompatible with Amidopyrine.
4. Alkaloids, salts of organic nitrogen-containing bases, oxidizing agents are not prescribed with the medication in the form of a solution.

During the treatment period, you should avoid any alcoholic beverages, as the likelihood of negative effects on the liver, heart, and kidneys increases.

Price and where to buy

Since Amidopyrine is not in the register of medications, it is not sold in Russia.

But on the territory of Ukraine, where the product is produced today, its average price is 140 UAH, which is approximately 334 rubles at the exchange rate of the Central Bank of Russia. Available in pharmacies with a prescription.

Conclusion

"Amidopyrine" is an effective drug that was actively prescribed for the treatment of lesions of the musculoskeletal system during the Soviet Union. However, at the end of the 20th century, the drug was excluded from the list of registered drugs and discontinued. This is due to the fact that during the tests the toxicity of the drug and its ability to negatively and irreversibly affect vital organs were revealed.

How to replace Amidopyrine

Since the drug itself and other drugs with its derivatives are completely prohibited, there are no direct analogues. However, this does not mean that there was no replacement for Amidopyrine. Today, there are many other NSAID medications that have a similar therapeutic effect, but do not have a dangerous toxic effect on the body.

Based on their chemical structure, drugs are divided into different groups:

Based on acids:

• Salicylates
• Pyrazolidines
• Derivatives of indoleacetic and phenylacetic acid
• Oxycams
• Propionic acid derivatives

Another group includes drugs created on the basis of active substances of non-acidic origin: alkanones and sulfonamides.

Each medicine of one group or another differs in its active substance and effect on the body. Therefore, the selection of the necessary medicine should be made by the doctor, based on the characteristics of the diagnosis and the patient’s health.

Salicylates

ASA-based drugs have anti-inflammatory, analgesic and antipyretic effects. The mechanism of action is achieved through suppression of the process of synthesizing mediators of inflammation, pain, and fever. At the same time, salicylates prevent platelet aggregation, thereby eliminating the threat of blood clots.

The main indications for therapy are:

• Rheumatism and related diseases
• Fever due to infectious and inflammatory pathologies
• Pain of various origins and localization
• Prevention of thrombosis, embolism
• Prevention of myocardial infarction and ischemic blood flow disorders.

Salicylates have an aggressive effect on the mucous tissues of the gastrointestinal tract, so in most cases the drugs are produced under a protective coating or in capsules.

Drugs with ASA: Aspicard, Aspicor, Aspirin Cardio, Acecardol, CardiASK, Sanovasc, Taspir, Thrombo ACC, Thrombopol, Upsarin UPSA.

Pyrazolidines

The effect of drugs is determined by the properties of pyrazolone derivatives. Medicines eliminate pain, high fever, and inflammation by blocking COX activity. The main active substances of this group: phenylbutazone, analgin (metamizole sodium).

Medicines with phenylbutazone

The drugs are prescribed orally or by injection for:

• Rheumatism
• Infectious nonspecific polyarthritis
• Ankylosing spondylitis
• Arthritis (gout, psoriatic)
• Erythema nodosum
• Small chorea.

Medicines for external use are recommended for:

• Dermatitis due to mechanical damage to the skin
• Minor burns
• Insect bites
• Inflammatory infiltrates
• Muscle strains.

Possible side effects:

• Gastrointestinal disorders: dyspepsia, damage to the mucous membranes due to NSAIDs, abdominal pain, nausea, vomiting, bowel movement disorders, ulceration (with a long course), bleeding
• Liver dysfunction
• Increased blood pressure, heart disorders, tachycardia
• Hearing impairment, tinnitus
• Hematopoietic disorders
• Manifestation of allergies: rash, urticaria, bronchospasm, swelling, Quincke's edema.

Contraindications:

• Individual sensitivity
• PUD, duodenum
• Dysfunction of the liver, kidneys
• Pathologies of hematopoiesis
• CHF
• Pregnancy
• For external drugs: ulcers, eczema.

Indoleacetic acid derivatives

Drugs in this group are developed based on the properties of the active substances indomethacin and etodolac. The mechanism of action is achieved by suppressing the activity of COX and subsequent synthesis of prostaglandins.

Indications for use are:

• Joint syndrome
• Spinal pain
• Pain in muscles, joints
• Neuralgia
• Inflammation of soft tissues and joints after injuries
• Rheumatism
• Diffuse connective tissue pathologies
• Painful periods.

Drugs with indomethacin: Indomethacin, Methindol Retard. With etodolac: Nobedolac.

Phenylacetic acid derivatives

Medicines may contain diclofenac or aceclofenac. They have a strong anti-inflammatory, analgesic and moderate antipyretic effect. Suppress the formation of proteoglycan in cartilage tissues, eliminate rheumatic joint pain, and improve mobility.

Preparations containing diclofenac are mainly used externally, so gels, ointments, and rectal suppositories are more widely available. But there are also tablets for oral use.

Drugs containing aceclofenac act in a similar way. Recommended for use in diseases of the musculoskeletal system.

LS: Alenthal, Asinak, Aertal.

Oxycams

This group includes drugs containing oxicam derivatives: piroxicam, meloxicam, lonoxicam, etc.

Substances suppress the activity of COX, which controls the synthesis of prostaglandins in areas of inflammation. They have strong analgesic, anti-inflammatory and antipyretic effects:

• With meloxicam: Arotrozan, Genitron, Movalis, Flexibon, Oxycamox
• With piroxicam: Finalgel, Feldoral, Hotemin, Piroxyfer.
• With tenoxicam: Artoxan, Texared.
• With lornoxicam: Xefocam, Lornoxicam, Zornica.

Preparations with propionic acid derivatives

The drugs are produced with the active substances ibuprofen, ketoprofen, naproxen, flurbiprofen, etc. Like other NSAIDs, they inhibit the functioning of cyclooxygenases and the synthesis of prostaglandins.

The drugs are prescribed for pathologies of the musculoskeletal system, arthralgia, muscle pain, rheumatism, ankylosing spondylitis, osteoarthritis, and arthritis.

Available in oral and parenteral forms, as well as ointments and gels for external use.

Release form and composition

Amidopyrine is produced in tablets of 250 mg in a package of 6 pieces.

Each tablet contains: amidopyrine - 250 mg, caffeine-sodium benzoate - 100 mg.

Amidopyridine analogues are:

• Amidozone;
• Amidazophene;
• Aminopyrine;
• Amidofen;
• Pyradon;
• Pyramin;
• Aminopyrazoline;
• Dinapirin;
• Pyrazone.

According to the instructions for Amidopyrine, it is prescribed for diseases such as:

• neuralgia;
• acute articular rheumatism;
• arthritis;
• chorea (a disease characterized by involuntary movements of the limbs);
• headache;
• feverish conditions;
• myositis;
• joint inflammation;
• muscle inflammation;
• pain syndrome spreading along the nerves.

Amidopyrine is also indicated for acute rheumatic arthritis in children.

The drug should be taken strictly in consultation with your doctor.

Side effects

In some cases, treatment with this drug may be accompanied by side effects, such as:

• nausea, vomiting;
• decreased appetite;
• pain in the epigastrium;
• diarrhea or constipation;
• headache and dizziness;
• state of fatigue and general malaise;
• decreased visual acuity;
• impaired concentration;
• severe drowsiness;
• depressive states.

In rare cases, when using this drug, some disturbances in the ratio of blood components (cellular components and plasma) are observed. It is also possible to develop allergic reactions (for example, rash, urticaria, kidney dysfunction). Cases of anaphylactic reactions have been described (very rare).

Amidopyrine is excreted by the body mainly in the urine, and its breakdown products can sometimes give it a red or dark yellow color.

During long-term therapy with the drug, it is necessary to take a blood test from time to time, since in some cases there is inhibition of hematopoiesis (agranulocytosis and granulocytopenia).

If these adverse reactions occur, use of Amidopyrine should be stopped and contact your doctor for correction in the prescribed course of therapy.

The description posted on this page is a simplified version of the official version of the annotation for the drug. The information is provided for informational purposes only and does not constitute a guide for self-medication. Before using the medicine, you must consult a specialist and read the instructions approved by the manufacturer.

Terms and conditions of storage

Amidopyrine should be stored in a cool, dry place, protected from sunlight.

The shelf life is 2 years.

Information about the drug is generalized, provided for informational purposes and does not replace official instructions. Self-medication is dangerous to health!

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Amidopyrine

05.08.2014

Amidopyrine is a non-steroidal non-narcotic drug with a broad anti-inflammatory effect. It is used to relieve pain syndromes of various types. There are a huge number of Amidopyrine analogues.

Properties of Amidopyrine

The drug contains 0.25 g amidopyrine and 0.1 g caffeine benzoate. It looks like a white powder with a crystalline structure and tastes a little bitter. It dissolves very poorly in water, but in alcohol solutions this indicator noticeably improves.

Amidopyrine has antipyretic, anti-inflammatory, analgesic, and antirheumatic properties.

Numerous reviews from specialists and patients indicate that the effect of Amidopyrine as an antipyretic agent is many times greater than the effect of a similar drug, Antipyrine.

There are many analogues of Amidopyrine: Pyrazone, Amidofen, Aminopyrazoline, Amidozon, Amidofebrin, Aminopyrine, Alamidon, Amidopyrazoline, Aneuxol, Pyrazorin, Stellamidon, Anafebrine, Dipirin, Dimethyl-amino-phenazone, Aminophenazone, Novamidon, Amidazofen, Pyramidon, Dimethylamino-antipyrine, Amidozone, Pyramine, Dinapirin.

But here are a number of drugs that contain amidopyrine: Pyraminal, Novomigrofen, Piranal, Pirkofen, Amizol, Pyramein.

The action of Amidopyrine is that it blocks the processes of biosynthesis of active prostaglandins. For pain in the stomach or intestines, it has an antispasmodic effect on smooth muscles. The drug is most effective in the fight against acute headaches and joint pain.

Indications for use

The instructions for Amidopyrine indicate that the drug effectively relieves fever, symptoms of neuralgia, myositis, acute pain due to articular rheumatism, chorea and arthritis. The drug shows excellent results in the fight against headaches.

This drug is well tolerated and is recommended for acute rheumatic arthritis in children. Amidopyrine helps relieve muscle and nerve pain.

The drug can be taken strictly in consultation with your doctor.

Instructions for Amidopyrine

The drug is prescribed only by a doctor after examining the patient and based on test results. But the instructions for Amidopyrine indicate the following dosage regimen:

• Usually 1 tablet (0.25 g) is prescribed, 3-4 times a day. The maximum effect is achieved after the patient takes the drug 4 times;
• For acute rheumatism, the dosage is increased to 2 g and taken 2-3 times a day. This treatment regimen can be very long; the medicine should be taken until the symptoms of acute rheumatism disappear completely. After symptoms are relieved, you should adhere to maintenance therapy for two to three weeks and take the drug 0.6 g per day;
• For migraine and hypertension, use 1 tablet 2 times a day as a vasodilator;
• Children over 12 years of age are prescribed 0.025-0.15 g once a day. When treating a child, only a doctor can prescribe a dosage depending on the type of disease and the condition of the child’s entire body.

Amidopyrine enhances its effect in combination with drugs such as Analgin, Phenacetin, Phenobarbital and Caffeine. The maximum dosage for an adult is 0.5 g at a time. For acute conditions, 1.5 g is allowed.

Pharmacological action of Amidopyrine

The drug has analgesic, antipyretic and anti-inflammatory effects. After taking it, the urine turns an intense red color.

Amidopyrine slightly dilates blood vessels (mainly in the brain) and relaxes their smooth muscles. Due to this, headaches are well relieved. The medicine does not affect blood pressure, since when the peripheral vessels expand, the central ones narrow.

In addition, Amidopyrine causes slight sweating and acts on the brain centers responsible for fever, resulting in a decrease in body temperature. The analgesic effect of the drug is also associated with its effect on the centers of the brain.

Indications for use

The medication is used for symptomatic treatment of various pathological conditions:

1. Myositis is a group of diseases characterized by inflammatory damage to skeletal muscles.
2. Arthritis is an inflammatory lesion of the joints.
3. Neuralgia is a lesion of peripheral nerves, which is accompanied by pain in the area of ​​innervation of the affected nerve fiber.
4. Migraines are a neurological pathology that manifests itself as regular, severe attacks of pain in one or both halves of the head.
5. Articular rheumatism in the acute period is a systemic inflammatory pathology of connective tissue.
6. Fever syndrome is a biological process that occurs as a reaction of the body to an infection and is expressed by an increase in body temperature.
7. Infectious diseases, the course of which is accompanied by high body temperature.
8. Headache.

Use for colic and spasms in the intestines and stomach is not excluded, since the drug has a pronounced antispasmodic effect.

Contraindications

Contraindications for the use of the medication include:

1. Individual intolerance to components.
2. Peptic ulcer of the stomach, intestines, duodenum is a pathology of the digestive system, which is accompanied by a defect in the mucous membrane and the tissues located underneath it.
3. Children and teenagers up to 14 years of age.
4. Gastric bleeding is the entry of blood from damaged vessels into the lumen of the stomach. Accompanied by weakness, dizziness, vomiting “coffee grounds”.
5. Liver disorders.
6. Seizure activity is the body's predisposition to sudden seizures.
7. The period of pregnancy and breastfeeding.
8. Bronchial asthma is a chronic inflammatory pathology of the respiratory system. Its main manifestation is bronchospasm (narrowing of the lumens of the bronchi).
9. Blood pathologies and the tendency to develop hematopoietic diseases.

Side effects

The medication provokes the development of systemic side effects:

• inhibition of the hematopoietic process;
• swelling;
• rash, itching on the skin;
• sleep disturbance;
• anaphylactic reaction is a rapidly developing manifestation of systemic allergy;
• allergic reactions.

With long-term and regular use, the development of agranulocytosis is possible - a decrease in the number of leukocytes in the blood due to granulocytes and monocytes.

Amidopyrine: instructions for use, price and formula – Website about hernias and their treatment

The article is a practical guide (instructions) for Amidopyrine, a drug from the NSAID group.

After reading the article, the reader will learn how to use this drug correctly, what are the indications and contraindications for taking it, in which cases the medicine will help and in which it will not.

The article will be useful for both buyers and medical professionals and pharmacists.

At the beginning of the 18th century, scientists obtained the first anti-inflammatory non-steroidal drug, salicylic acid, from willow bark.

Since then, NSAIDs have firmly taken their place in medicine and began to be used to treat various diseases that are accompanied by inflammation and pain. Since then, many types of drugs belonging to this group have been produced.

One of them is Amidopyrine.

Manufacturer

Ukrainian pharmacological.

Chemical formula

The formula of the drug is C13-H17-N3-O (4-dimethylamino-1,5-dimethyl-2-phenylpyrazol-3-one + sodium benzoate).

Release forms

Amidopyrine is found in retail pharmacies in the following forms :

• tablets with a dosage of 0.25 g, intended for oral administration;
• 2% solution for injection in glass ampoules of 2 ml and 4% solution in ampoules of 5 ml and 10 ml;
• concentrated powder 0.25 g.

Indications

The medicine is prescribed for the symptomatic treatment of the following pathologies:

• inflammatory damage to skeletal muscles of various etiologies (myositis);
• migraine;
• acute and chronic rheumatism of the joints;
• arthritis;
• neuralgia;
• infectious diseases accompanied by inflammation and pain;
• fever;
• muscle pain (myalgia);
• chorea;
• spasms and colic of the gastrointestinal tract;
• pain syndrome of various origins.

Pharmacology

The drug has a pronounced analgesic, anti-inflammatory and antipyretic effect . Clinical trials have shown that its analgesic properties are not inferior to Phenazone. At the same time, the therapeutic effect of Amidopyrine is achieved faster due to the addition of caffeine and it lasts longer.

Due to caffeine, this NSAID also has a mild psychostimulant and cardiotonic effect.

It has a stimulating effect on the central nervous system, increases reflex excitability of the spinal cord, increases mental performance, dilates blood vessels, and increases heart rate.

Pharmacokinetics

Data on the pharmacokinetics of this NSAID in clinical practice are not provided.

Where to buy, how much does it cost?

The medicine is freely available in Ukraine. Rarely found in Russian pharmacies.

The approximate cost for it is from 319 to 340 rubles per package.

How to use?

• The treatment regimen is selected taking into account the form of release of the medication.
• Pills
• Take one tablet orally up to four times a day , washed down with a sufficient amount of boiled water.
• Note:

• For patients with acute rheumatism, the dose may be increased to 3 g per day. The daily dose is evenly divided into 3-4 doses throughout the day. According to this scheme, the drug is taken for 10-14 days, and then transferred to a maintenance dose of 0.6-0.9 g per day.
• For children, the daily dose is from 0.025 to 0.15 g. More precisely, the dose is selected by the doctor taking into account the individual characteristics of the child (body weight, physical condition, type and severity of the disease, age). As a rule, a single dose is calculated according to the scheme: 0.2 g for each year of life. The maximum dosage is achieved in four doses. Note! The daily dose of amidopyrine for children should not exceed 0.15 g.
• For patients with impaired renal function, dosage adjustment is required.

1. Powder
2. The dose is selected taking into account the same as when taking the medication in tablets.
3. Solution

Adult patients are prescribed 1-2 injections per day. Treatment can be combined with taking oral tablets.

The duration of treatment is determined individually.

Note

• The drug is not prescribed for children in this release form.
• When administering the drug via injection, the risk of adverse reactions from the gastrointestinal tract is reduced.

Drug interactions

Before starting treatment, the patient should pay attention to the peculiarities of drug interactions between Amidopyrine and other medications:

• It enhances the effect of antispasmodics and painkillers, significantly increasing the risk of adverse reactions.
• The tablets are not compatible with acetylsalicylic acid preparations (Aspirin, Upsarin Upsa, ASA-cardio, Aspicor).
• Injections are not prescribed together with alkaloids due to the possible risk of sedimentation.
• The powder is not prescribed with medications containing menthol, resorcinol, cinchonfen, thymol.

Side effects

While using the medicine, the patient may experience the following adverse reactions :

• increased fatigue;
• insomnia;
• swelling;
• allergic reactions;
• inhibition of the hematopoietic system with the risk of developing agranulocytosis with leukopenia;
• decrease in leukocytes in the blood.

The medication has increased toxicity, so the risk of developing side effects while taking it is quite high.

In pediatrics

The medicine is prescribed to children with caution. If possible, it is better to choose another complex anti-inflammatory and analgesic drug that would have less toxicity. If the prescription of a medication is vital, it should be taken under the strict supervision of a doctor, without exceeding the recommended dosage.

During pregnancy

Not used during pregnancy .

Interaction with alcohol

During treatment, you should avoid drinking any alcoholic beverages to reduce the risk of harmful effects on the liver, kidneys and heart.

In what cases will the remedy not help?

The medicine must be taken strictly as prescribed. For other pathologies, its effectiveness has not been clinically proven.

In addition, some people may experience intolerance to this medication, which is manifested not only by the occurrence of allergic or adverse reactions, but also by the lack of a therapeutic effect.

Storage

Store in a dry, dark place at a temperature of 15 to 25 degrees.

Release from pharmacies

Dispensed as prescribed by a doctor.

Similar drugs

Currently, you can find many different medications on sale that differ in composition from this medication , but have a similar therapeutic effect. Let us give examples of the most popular of them.

1. Ibuprofen is a Russian pharmacological NSAID, available in the form of tablets for oral administration, ointments and suspensions. The main active ingredient is ibuprofen. Ibuprofen is one of the popular NSAIDs used for diseases of the musculoskeletal system. Prescribed for rheumatism, arthritis, ankylosing spondylitis, etc. The price of Ibuprofen ranges from 30 to 114 rubles.
2. Nise is an Indian medicine produced by. The main active ingredient is nimesulide. Nise is commercially available in the form of oral tablets, oral granules, suspension and gel. Prescribed for injuries, radiculitis, osteochondrosis, arthritis, ankylosing spondylitis. The average price for it ranges from 190 to 310 rubles.
3. Ketanov is an NSAID based on ketorolac, produced by the Indian Pharmacological Company in the form of tablets for oral administration and a solution for intramuscular injection. Ketanov is prescribed for the relief of acute pain syndrome of various origins (trauma, toothache, sciatica, postoperative period). Dispensed strictly according to a doctor's prescription. The cost for Ketanov ranges from 67 to 212 rubles.
4. Indomethacin is a Russian NSAID, available in the form of rectal suppositories and tablets. Indomethacin is prescribed for the treatment of joint pain, osteoarthritis, gout, spondylitis, rheumatism, dysmenorrhea and other pathologies accompanied by pain and inflammation. The average cost for Indomethacin is from 67 to 200 rubles.

Note to the reader

Amidopyrine is a synonym for aminophenazone, a drug from the pyrazolone group. These medicines are made on the basis of the same chemical formula, which means they are identical in composition.

Aminophenazone was first obtained by the German chemist Philene at the end of the 18th century. Clinical studies have proven its high effectiveness as an antipyretic, anti-inflammatory and anti-neuralgic agent. It quickly hit the shelves of pharmacies and became very popular in pharmacology. However, the demand for the drug did not last long.

Half a century later, a decision was made to withdraw aminophenazone from free sale due to numerous patient complaints about side effects, including agranulocytosis. Doctors conducted a repeated clinical study, during which a high risk of developing agranulocytosis was proven (in approximately 15-20% of subjects taking aminophenazone).

Despite the ban, pharmaceutical companies continued to produce this medicine, but with a change in the chemical formula.

Currently, aminophenazone is included in some combination NSAIDs, including Amidopyrine.

Although new drugs are more modern and less toxic, complaints about side effects while taking them are received quite often. It is noteworthy that such combination drugs are produced only in Russia and some CIS countries (Ukraine, Georgia).

In the USA, Canada, Poland and other economically developed European countries, drugs based on aminophenazone are completely withdrawn from sale.

FAQ

On specialized websites and forums, readers often share their opinions about this tool and ask questions. We have posted the most interesting and popular ones in our article.

• Are Amidopyrine and Butadione the same thing?
• No, these are two completely different drugs, although they both belong to the group of NSAIDs and pyrazolones.
• Is it possible to take this NSAID with analgin?

Source: https://nrb2.ru/diety/amidopirin-instruktsiya-po-primeneniyu-tsena-i-formula.html

Contraindications and possible side effects from the use of the drug

"Amidopyrine" slightly inhibits the blood circulation in the body, so it is necessary to monitor the state of the blood during the entire course of therapy. In addition, it can provoke allergic reactions, which will manifest themselves in the form of rashes, redness, itching, hives, etc.

There are some contraindications to the use of the drug:

• presence of blood diseases;
• diseases of the gastrointestinal tract in the form of ulcers;
• the presence of intestinal or stomach bleeding.

In addition, the use of the drug is contraindicated in the presence of hypersensitivity to the components of the drug, as well as during pregnancy and breastfeeding.

The drug is not prescribed to children under 14 years of age.

In addition to the main contraindications for use, there are some additional points. For example, Amidopyrine solution should not be taken together with Aspirin, Thymol, Resorcinol and other medications that contain alkaloids, salts of organic nitrogen-containing bases and oxidizing agents.

Side effects may occur if the maximum dosage of the drug is exceeded

They can manifest themselves in the form of nausea, diarrhea or constipation, weakness throughout the body and loss of strength, severe headaches, fatigue, blurred vision, and loss of the ability to concentrate on anything. In some cases, a state of oppression and depression may occur

So, from all of the above, we can draw short conclusions: “Amidopyrine” is a strong pain reliever, but its use without the knowledge of a doctor is prohibited (since only an experienced doctor will be able to prescribe the necessary dosages). The drug cannot be combined with some medications and in case of overdose can cause side effects.

Amidopyrine – Methods and means of treating diseases

The tablet contains 250 mg of the active substance dimethylaminopyrazolone and 100 mg of sodium caffeine benzoate.

Amidopyrine formula: C13-H17-N3-O.

Release form

The medication is available in tablet form, in the form of a crystalline white, slightly bitter powder without a particular odor, in the form of a solution. The crystals dissolve easily in an alcohol solution and slowly in an aqueous solution.

Tablets are available in packs of 6 pieces. Ampoules of 1.0, 5.0 and 10.0 ml contain a solution of 2% or 4% of the active substance. Each cardboard package contains 10, 100 ampoules.

pharmachologic effect

Analgesic, antipyretic, anti-inflammatory agent. According to the mechanism of action, the active component is similar to Antipyrine, but has more pronounced activity. Amidopyrine is considered the strongest analgesic in its pharmacological group. The therapeutic effect of the drug develops more slowly in comparison with Antipyrine, but lasts longer.

When taking Analgin, Phenacetin, Caffeine and Phenobarbital simultaneously, the severity of the analgesic effect of the drug increases.

The anti-inflammatory effect of Pyramidon is more pronounced than that of Antipyrin.

In relation to smooth muscle muscles, an antispasmodic effect is manifested, which makes it possible to prescribe the drug for colic and spasms of the intestines and stomach.

https://youtube.com/watch?v=q8dusqjN_7E

In the treatment of acute rheumatic arthritis in pediatric practice, preference is given to Amidopyrine due to better tolerability of the drug by the child's body compared to other sodium salicylates.

Instructions for use of Amidopyrine (Method and dosage)

The tablets are intended for oral administration. The drug can be taken up to 4 times a day in a single dosage of 0.3 g. The daily dosage can be increased to 3 g (to relieve acute attacks of rheumatism).

A single dose is calculated according to the following scheme: 0.2 grams for each year of life. After 4 doses according to the described scheme, the maximum dosage of Amidopyrine is achieved.

Instructions for use of Amidopyrine for children

For an adult patient, the maximum dose taken at a time is 0.5 g per day.

Interaction

Amidopyrine enhances the therapeutic effect of most analgesics and antispasmodics. The use of the drug as part of combination therapy leads to an increase in the severity of negative side reactions.

Inactivation and complete incompatibility are recorded for Aspirin and other drugs that have an acidic environment.

special instructions

The drug can inhibit hematopoiesis, which can lead to the development of leukopenia (decreased number of white blood cells) with agranulocytosis.

Powder forms are incompatible with resorcinol, menthol, acetylsalicylic acid, Tsinchonfen, Thymol, Phenyl salicylate (eutectic mixtures are formed). The medicinal product is excluded from the register of medicinal products of the Russian Federation.

Amidopyrine analogues

Level 4 ATX code matches:

• Amidozone;
• Pyramidon;
• Pyrazone;
• Amidofen;
• Alamidon.

In pediatric practice, Amidopyrine can be used only in exceptional cases to relieve an acute attack of rheumatism.

Amidopyrine price, where to buy

The price of Amidopyrine in Ukraine is 139.95 UAH.

The medicine is not commercially available in the Russian Federation.

PLEASE NOTE! Information about medications on the site is for reference and general information, collected from publicly available sources and cannot serve as a basis for making a decision on the use of medications in the course of treatment. Before using the drug Amidopyrine, be sure to consult with your doctor.

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** The Drug Directory is intended for informational purposes only. For more complete information, please refer to the manufacturer's instructions. Do not self-medicate; Before starting to use the drug Amidopyrine, you should consult a doctor. EUROLAB is not responsible for the consequences caused by the use of information posted on the portal. Any information on the site does not replace medical advice and cannot serve as a guarantee of the positive effect of the drug.

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** Attention! The information presented in this medication guide is intended for medical professionals and should not be used as a basis for self-medication. The description of the drug Amidopyrine is provided for informational purposes only and is not intended for prescribing treatment without the participation of a doctor. Patients need to consult a specialist!

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