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Manufacturers: Unipharm, Inc. Global Headquarters
Active ingredients
- Naftidrofuryl
Disease class
- Consequences of cerebrovascular diseases
- Raynaud's syndrome
- Peripheral vascular disease, unspecified
Clinical and pharmacological group
- Not indicated. See instructions
Pharmacological action
- Vasodilating
Pharmacological group
- Angioprotectors and microcirculation correctors
pharmachologic effect
Vasodilating agent.
Naftidrofuril has a vasodilating effect, resulting in improved peripheral and cerebral circulation. Causes a decrease in peripheral vascular resistance and increases cardiac output without significantly affecting heart rate and blood pressure. The vasodilating effect of naftidrofuryl is the result of its selective action on 5HT2 receptors in platelets and the smooth muscle layer of blood vessels. As a result of vasodilation caused by the action of naftidrofuryl, there is an improvement in microcirculation in peripheral tissues, the brain and the retina of the eye.
Has an M-anticholinergic effect. Under ischemic conditions, naftidrofuryl causes a decrease in anaerobic metabolism, which leads to an increase in the concentration of adenosiptriphosphate and a decrease in the lactate-pyruvate coefficient. As a result, the resistance of cells (including the brain) to hypoxia increases. The drug improves cognitive function of the brain, reduces episodes of dizziness and headaches, and induces improved sleep. Naftidrofuryl improves blood rheology by inhibiting platelet aggregation and increasing the elastic properties of red blood cells.
What is important to remember when taking
Duzopharm is used to improve blood circulation in diseases and pathological conditions of the brain, muscles, and cardiovascular system, and is available with a doctor’s prescription. It can be used in combination with other drugs, but when introducing it into the course, it is necessary to take into account the peculiarities of the combination. The medication has a relatively small number of contraindications and restrictions, complications and side effects. The advantage is that it can be used in treatment during pregnancy and breastfeeding.
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Directions for use and doses
Inside. The tablets are taken whole with at least a glass of liquid, it is recommended to wash it down with water.
Duzopharm is indicated for long-term oral therapy. For cerebral circulation disorders: it is recommended to take the drug in a daily dose of 300 mg to 600 mg, divided into three doses in a single dose of 100 mg.
For peripheral circulation disorders: it is recommended to take the drug in a daily dose of 400 to 600 mg, in a single dose of 200 mg.
The duration of therapy and dosage are determined by the doctor depending on the clinical condition of the patient. No dose adjustment is required for renal/liver failure.
Duzopharm
Active substance:
Naftidrofuryl*
Pharmgroup:
Angioprotectors and microcirculation correctors
Average price in pharmacies
| Name | Manufacturer | average price |
| Duzopharm 0.05 n30 tablet p/film/coating | Unipharm JSC | 399.00 |
| Duzopharm 0.05 n60 tablet p/film/coating | Unipharm JSC | 657.00 |
| Duzopharm 0.05 n90 tablet p/film/coating | Sopharma JSC | 861.00 |
Analogs for the active substance:No data on synonyms | Application area:Vasospasm/vasoconstriction Vasospastic disorders Varicose ulcer Raynaud's disease Varicose ulcers Ischemic and post-stroke condition Skin ulcer Violation of venous microcirculation Circulatory disorders Peripheral circulation disorder Insufficiency of peripheral circulation in the lower and upper extremities Non-healing ulcers Peripheral artery occlusive disease Occlusive peripheral artery disease in stages III-IV according to Fontaine Residual effects of hemorrhagic stroke Residual effects of ischemic stroke Residual effects of cerebrovascular accident Residual effects of subarachnoid hemorrhage Previous ischemic stroke Previous thromboembolic stroke Peripheral angiopathy Peripheral vascular insufficiency Peripheral vascular lesions Peripheral vascular disorder Consequences of cerebrovascular accident Consequences of insufficient blood supply to the brain Consequences of ischemic stroke Consequences of a stroke Postapoplectic state Post-stroke period Post-stroke syndrome Peripheral circulatory disorder Raynaud's disease Raynaud's phenomenon Raynaud-Leriche syndrome Raynaud's syndrome with trophic disorders Raynaud-Leriche syndrome Condition after stroke Condition after cerebrovascular accident Arterial spasm Vasospasm Trophic ulcer Trophic ulcer of the leg Trophic skin lesions Trophic post-burn ulcers Trophic ulcers Trophic skin ulcers Difficult-to-heal ulcers Functional lesions of peripheral arteries Chronic cerebrovascular insufficiency Chronic obliterating endarteritis Chronic obliterating vascular disease of the lower extremities Chronic occlusive arterial disease Leg ulcer Skin ulcer Trophic skin ulcer Leg ulcer Ulcerative-necrotic skin lesions Leg ulcers Leg ulcers Ulcers of the lower extremities |
Contraindications
- increased individual sensitivity to the drug,
- myocardial infarction (acute stage);
- arterial hypotension;
- hemorrhagic stroke (acute stage);
- epilepsy, increased convulsive readiness;
- chronic heart failure stage II-III. (III-IV according to NYHA - functional classification of heart failure of the New York Heart Association);
- tachyarrhythmias.
- age under 18 years (efficacy and safety have not been established.
Side effects
As a rule, Duzopharm is well tolerated in usual dosages (300-600 mg).
However, undesirable effects may occur in the form of allergies to the drug, as well as sleep disturbances, headaches with dizziness.
Side effects from the digestive system are possible: they can be expressed by decreased appetite, nausea and vomiting, pain in the stomach, diarrhea, intestinal colic.
Reversible increases in the activity of liver enzymes and the occurrence of stomach ulcers are also possible.
Duzopharm is able to increase the severity of the negative cardiotropic effects of beta-blockers, as well as other antiarrhythmic drugs.
Overdose
In case of an overdose, side effects (if any) increase, anxiety may occur, ventricular arrhythmia or bradycardia may also occur, and blood pressure may decrease.
Treatment of drug overdose consists of gastric lavage, it is recommended to take activated charcoal, and it is possible to take laxatives.
Constant monitoring of the patient's condition and maintenance of vital body functions is necessary. A specific antidote for Duzopharma overdose is unknown.
special instructions
Duzopharm does not have a teratogenic effect, but since... There have been no special studies of its safety in pregnant women; it is recommended to prescribe the drug only in cases where the benefit of treatment for the mother outweighs the potential risk to the fetus.
It is not recommended to take the drug during breastfeeding.
At the beginning of treatment, it is recommended to monitor individual tolerability of the drug and monitor possible hypotensive effects in appropriate patients.
The medicinal product contains lactose monohydrate and is therefore not suitable for persons suffering from lactose intolerance, galactosemia or glucose-galactose malabsorption syndrome.
Patients with celiac disease (gluten enteropathy) should be aware that the tablet contains wheat starch.
