In Russia, approximately a quarter of women and a sixth of men are diagnosed with venous insufficiency of the lower extremities. In every pharmacy you can find effective and not so effective medications for the treatment of CVI.
At stages that do not require surgical intervention, phlebotropic drugs are used, which are used independently and in complex therapy.
Compound
Anavenol contains the following active medicinal components: 0.58 mg dihydroergocristine mesylate , 1.62 mg exulin trihydrate and 32.55 mg rutoside trihydrate .
In addition, the preparation contains such auxiliary compounds as carmellose sodium salt, stearic acid, lactose, stearin, corn starch, povidone, additives E104 quinoline yellow dye and E131 patented blue, E171 titanium dioxide, carnauba and white wax, as well as sodium salt of carboxymethyl starch .
Pharmacodynamics and pharmacokinetics
Considering the specific medicinal properties of Anavenol, experts classify this drug as a group of combined medications that can simultaneously reduce the permeability of vascular walls, have a venotonic effect and restore microcirculation.
dihydroergocristine in the drug which is a semi-synthetic ergot alkaloid and has the properties of alpha-blockers, the arteriole expands, which helps to increase venous tone and improve peripheral circulation when taking the drug.
esculin and rutoside, which are part of Anavenol, an anti-exudative , as well as vasoptective effect on the human body . After taking the drug, about 25% of the drug compounds are absorbed by the stomach, thus binding to the blood plasma. The drug is excreted in bile. Dihydroergocristine, which is part of the drug, can penetrate the placental barrier and also be excreted in breast milk.
Oral
Let's look at the most effective and efficient means for oral administration.
Aescusan
Available in the form of drops and tablets. The product relieves pain, inflammation, swelling. The decongestant effect is provided by horse chestnut extract. The suction restores the contractility of the vascular walls and increases their elasticity.
The conductivity of impulses in the walls of blood vessels improves due to the release of norepinephrine, and venous congestion decreases.
Thiamine stimulates metabolic processes and helps restore blood circulation. In rare cases, nausea, itching, and rash occur. The cost of Escusan drops is 260 rubles.
Troxevasin
Available in capsules, it contains a semi-synthetic substance, troxerutin, which increases the tone of the veins, relieves swelling of soft tissues, and reduces the permeability of the plasma membrane of cells.
The product can be used at any stage of CVI. After treatment, static severity disappears, manifestations of trophic lesions, dermatitis, capillary mesh, and venous nodes decrease.
The effect of the capsules is enhanced when used together with gel or ointment. The cost of troxevasin in capsules is about 350 rubles for 50 pieces, gel 150-200 rubles. The Russian analogue of the drug, Troxerutin, is slightly cheaper.
Both medications are well tolerated and cause allergic skin rashes in isolated cases.
Venoplant
Contains an extract from the fruits and inflorescences of horse chestnut. The natural component enhances the strength of small vessels and improves their tone. The drug quickly relieves symptoms in the early stages of varicose veins.
Many people are interested in whether it is possible to drink Venoplant during pregnancy. Prescription of the drug is possible only in the second and third trimester. The price of Venoplant No. 20 is about 400-450 rubles.
Venosmin
Intended for the treatment of venous insufficiency and hemorrhoids, and can also be used for preventive purposes. The product contains an optimal concentration of hesperidin and diosmin.
Components of natural origin reduce the distensibility of veins and restore the strength of the walls of thin blood tubes. As a result, blood movement through microvessels and lymphatic drainage improves, and the symptoms of CVI and hemorrhoids are significantly reduced.
The drug shows good dynamics at various stages of the disease. Venosmin No. 60 costs about 1000 rubles.
Venza
Reduces swelling, itching, pain, stimulates venous outflow and valve function. The composition includes extracts of herbs, horse chestnut seeds, and Bushmaster snake venom.
The homeopathic medicine is safe. The poison is contained in small quantities and helps thin the blood. Plant components maintain muscle tension in the vascular walls, strengthen blood vessels, and reduce vascular permeability.
Venza costs from 300 rubles, it is recommended in the early stages of varicose veins, as well as hemorrhoids.
Venoruton
Eliminates disturbances in lymphatic drainage and microcirculation, restores the barrier properties of the endothelium, and removes toxic substances. The active component of the drug, rutoside, can cause an allergic rash, heartburn, and nausea.
After using Venoruton, swelling and pain decrease, cramps disappear, the severity of trophic ulcerations and the risk of thrombus formation decrease.
The price of the drug is 800-900 rubles.
Indications for use of Anavenol
The main indications for the use of this drug are: pre-varicose vein syndrome, chronic venous insufficiency, post-thrombotic syndrome.
In addition, the drug effectively helps as part of complex therapy in the treatment of thrombophlebitis, trophic ulcers of the leg, microcirculation disorders caused by injuries, for example, during the period of restoration of motor activity after immobilization of the limbs.
Anavenol tablets
Instructions for medical use of the drug
Description of pharmacological action
Improves microcirculation, has alpha-adrenergic blocking and anti-edematous activity, normalizes vascular permeability.
Indications for use
Chronic insufficiency of venous circulation, pre-varicose syndrome, post-thrombotic syndrome, trophic ulcers of the leg, thrombophlebitis, post-traumatic circulation disorders (for combination therapy).
Release form
film-coated tablets; blister 20, cardboard pack 3.
Pharmacodynamics
Combined drug. It has a venotonic effect, reduces the permeability of the vascular wall, and improves microcirculation. Dihydroergocristine, which is part of the drug, is a semi-synthetic derivative from the group of ergot alkaloids, has an alpha-adrenergic blocking effect, dilates arterioles, slightly increases the tone of the veins, and thereby helps improve peripheral circulation. Rutoside and esculin have a vasoprotective and antiexudative effect.
Pharmacokinetics
After oral administration, about 25% of dihydroergocristine is absorbed into the gastrointestinal tract. Plasma protein binding is about 68%. Excreted in bile. T1/2 is about 14 hours. Dihydroergocristine penetrates the placental barrier and is excreted in milk. The maximum plasma concentration of rutoside after oral administration is reached after 1-9 hours. T1/2 is 10-25 hours, excreted in the form of metabolites and partially in unchanged form. The pharmacokinetics of esculin have not been studied.
Use during pregnancy
Not recommended.
Contraindications for use
- bleeding; - children's age (up to 15 years); - hypersensitivity to the components of the drug. With caution: when prescribing the drug to patients with severe impairment of liver and/or kidney function, heart failure, bradycardia, arterial hypotension.
Side effects
Headache, dizziness, feeling of fatigue, swelling of the nasal mucosa, dyspeptic symptoms, allergic skin reactions.
Directions for use and doses
The tablets should be taken orally, after meals, swallowed whole with a sufficient amount of liquid. The initial dose is 2 tablets. 3 times a day during the first week, then the dose is reduced to maintenance - 1 tablet. 3 times/day.
Overdose
In case of overdose, the manifestations of the side effects described above may increase. If signs of overdose appear, the drug should be stopped, patients should rinse their stomach, and immediately consult a doctor. If necessary, carry out symptomatic treatment.
Interactions with other drugs
Oleandomycin, erythromycin, doxycycline, tetracycline, dopamine, vasodilators, alpha-blockers, beta-blockers can increase, and alpha-blockers, vasopressin and other vasoconstrictors can reduce the effectiveness of Anavenol.
Special instructions for use
During the treatment period, care must be taken when driving vehicles and engaging in other potentially hazardous activities that require increased concentration and speed of psychomotor reactions.
Storage conditions
List B.: In a dry place, protected from light, at a temperature of 10–25 °C.
Best before date
36 months
ATX classification:
C Cardiovascular system
C05 Angioprotectors
C05C Drugs that reduce capillary permeability
C05CX Other drugs that reduce capillary permeability
Side effects
Since this drug can only be prescribed by the attending physician after a comprehensive medical examination, as a rule, Anavenol is well tolerated by patients. Quite rarely, but the following adverse reactions to the drug may occur: allergic skin rashes, headaches, itching, increased fatigue, metrorrhagia and menorrhagia, vomiting, nausea and diarrhea, as well as irritation of the nasal mucosa.
To avoid the development of complications if any side effects occur when taking Anavenol, even those not described above, the patient should immediately stop using the drug and immediately contact your doctor for medical help.
Instructions for use of Anavenol (Method and dosage)
Instructions for use of Anavenol prescribe the use of the drug according to the following scheme:
- first week of treatment - the initial dose of the drug should not exceed 2 tablets, which should be taken 3 times a day;
- the next week - the dosage is reduced to 1 tablet (the so-called “maintenance dosage”), which is also taken 3 times a day.
To achieve the greatest medicinal effect, the tablets should be taken whole after meals, they should not be bitten into pieces, and should also be washed down with a sufficient amount of water.
Similar drugs:
- Detralex Oral tablets
- Detralex Oral tablets
- Venarus Oral tablets
- Diovenor 600 Oral tablets
- Aescusan Oral solution
- Pilex Oral tablets
- Diosmin (DIOSMIN) Oral tablets
- Venoplant Oral tablets
- Essaven Gel
- Diosmin (DIOSMIN) Substance-powder
** The Drug Directory is intended for informational purposes only. For more complete information, please refer to the manufacturer's instructions. Do not self-medicate; Before starting to use the drug Anavenol, you should consult a doctor. EUROLAB is not responsible for the consequences caused by the use of information posted on the portal. Any information on the site does not replace medical advice and cannot serve as a guarantee of the positive effect of the drug.
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** Attention! The information presented in this medication guide is intended for medical professionals and should not be used as a basis for self-medication. The description of the drug Anavenol is provided for informational purposes and is not intended for prescribing treatment without the participation of a doctor. Patients need to consult a specialist!
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Interaction
It is worth emphasizing that the combined use of other medications with Anavenol is possible only with the permission of the attending physician. The effect of the drug is significantly enhanced by such medications as: beta-adrenergic agonists, Oleandomycin, alpha-blockers, Erythromycin, vasodilators, Doxycycline, Dopamine, and Tetracycline. , alpha-adrenergic agonists reduce the medicinal properties of the drug.
Anavenol's analogs
Level 4 ATX code matches:
Rutin
Venosmin
Indovazin
Venoruton
Troxevasin Neo
Troxevasin
Detralex
Ginkor Gel
Ginkor Fort
Vasocket
Troxerutin
Askorutin
Antistax
Venarus
At the present time, there are no analogues of this drug that are absolutely identical in chemical composition and pharmacological properties. However, the attending physician may prescribe other medications that will have a similar positive effect on the patient’s body as Anavenol.
During pregnancy and lactation
In the vast majority of cases, the drug is not used in the therapeutic treatment of pregnant women (especially in the first trimester). However, in exceptional situations, the use of Anavenol is possible provided that the positive effect of the drug significantly exceeds the possible harm to the health of the mother and fetus.
It is strictly forbidden to take this medicine during breastfeeding, since the active substances included in the drug penetrate into milk.
External
Anavenol substitutes in the form of gel and ointment are recommended for the prevention and treatment of varicose veins at an early stage. They prevent the development of complications, make the mesh of microvessels less noticeable, and eliminate discomfort in the lower extremities.
Reparil-gel
Normalizes metabolism in the walls of blood vessels, reduces interendothelial pores. After use, the heaviness in the legs, pain, swelling of the feet and legs decreases.
The drug contains the non-steroidal anti-inflammatory drug diethylamine salicylate, it penetrates into the deep layer of muscles and quickly suppresses the inflammatory process, unlike herbal components. Reparil-gel costs approximately 160-180 rubles.
Venitan
Available in the form of a gel and cream, it is recommended for use for the initial signs of varicose veins, sprains, and bruises.
The active component, escin, strengthens the vascular endothelium and smooth muscle cells, helps get rid of sudden cramps, pain, numbness, and a feeling of heaviness. The price of Venitan-gel starts from 220 rubles.
Venolife
For mild forms of varicose veins, this gel eliminates its symptoms, strengthens the muscles of the vascular walls, improves tissue metabolism, elasticity and contractility of capillaries. Venolife accelerates the healing of trophic ulcers in the shallow layers of the skin.
Often pregnant women with signs of venous insufficiency ask the question: “I took pills periodically to strengthen the blood vessels and prevent blood stagnation. What drug will not harm the unborn child and will help improve the tone of the veins?
Venolife will take care of blood vessels during pregnancy, relieve swelling, cramps and discomfort, and protect veins from overload. The price of a 40 gram tube of gel is about 300 rubles.
