Ginkgo biloba
Medicinal properties of Ginkgo Biloba
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The modern pharmaceutical industry uses both chemical compounds and substances extracted from living plants. One of these incredibly useful gifts of nature is the Gingo tree, from the leaves of which Ginkgo Biloba forte is made.
Instructions for use must be included in each package. But often the manufacturer provides incomplete information; the text may contain complex scientific terms and may be lost from the home medicine cabinet. Let's try to discuss in detail: what kind of medicine Ginkgo Biloba Forte is, its composition, the mechanism of action of the components, the release form, indications and methods of use, and we will also analyze situations when this medicine can harm the body. Let's talk about price and analogues, conditions and shelf life. We read reviews from consumers and doctors.
Release form and composition
Bilobil forte is available in the form of capsules: hard gelatin, size No. 2, with a pink body and cap; contents – light brown or dark brown powder with darker particles, sometimes with lumps (10 pieces in blisters, 2 or 6 blisters in a cardboard package).
Composition per 1 capsule:
- active ingredient: dry extract of ginkgo biloba leaves – 80 mg;
- auxiliary components: corn starch, colloidal silicon dioxide, liquid dextrose, magnesium stearate, lactose monohydrate, talc;
- capsule body and cap: titanium dioxide, black iron oxide dye, azorubine dye, red iron oxide dye, gelatin.
Analogs
Level 4 ATX code matches:
Ginos
Akatinol Memantine
Intellan
Tanakan
Noodzheron
Ginkgo biloba
Memantine
Memoplant
Ginkum
Vitrum Memory
Namenda
Analogs of Bilobil: Vitrum Memory (tablets), Ginos (tablets), Ginkgo Biloba (capsules), Memoplant (tablets), Gingium (tablets), Ginkum (capsules), Tanakan (tablets, oral solution).
Pharmacological properties
Pharmacodynamics
According to the instructions, Bilobil forte is a herbal preparation. It increases the body's resistance to oxygen starvation, especially to hypoxia of brain tissue. The drug stimulates peripheral and cerebral circulation, inhibits the development of toxic or traumatic cerebral edema, and also improves the rheological properties of blood.
Bilobil forte, depending on the dose, affects the vascular wall, increases the tone of the veins and dilates small arteries. The drug prevents the release of free radicals and inhibits lipid peroxidation in cell membranes. Under the influence of Bilobil forte, the release, as well as re-absorption, catabolism and the ability to bind to neurotransmitter receptors (dopamine, acetylcholine, norepinephrine) are normalized. The drug helps improve metabolism in tissues and organs, increase the utilization of glucose and oxygen, accumulate macroergs in cells and normalize mediator processes in the central nervous system.
Pharmacokinetics
Absorption of flavone glycosides occurs in the small intestine. The time to reach maximum plasma concentration is 2 hours, and the half-life is from 2 to 4 hours.
Indications for use
- violation of microcirculation and blood circulation in peripheral organs (including arteriopathy of the lower extremities), Raynaud's disease;
- discirculatory encephalopathy of various origins (arising as a result of traumatic brain injury, stroke or old age), which results in decreased attention, intellectual abilities, weakened memory and disturbed sleep;
- neurosensory disorders (tinnitus, hearing loss, dizziness);
- diabetic retinopathy;
- senile macular degeneration.
Showing
- Cognitive deficit of severe origin (dyscirculatory encephalopathy following a stroke, traumatic brain injury, in a young adult, which is manifested by disorders of respect and/or memory, decreased intellectual abilities, and fear y, impaired sleep) and neurosensory deficiency of various genesis (senile degeneration of the abdominal muscles , diabetic retinopathy);
- intermittent kulgavist in chronic obliterative arteriopathies of the lower ends (II stage after Fontaine);
- the destruction of the dawn of the judgmental genesis, the decline of the evil spirit;
- hearing loss, ringing in the ears, confusion and loss of coordination, most importantly of judicial origin;
- Raynaud's syndrome.
Contraindications
- acute myocardial infarction;
- decreased blood clotting;
- exacerbation of peptic ulcer of the duodenum and stomach;
- erosive gastritis of the stomach (bulbit);
- acute cerebrovascular accidents;
- lactase deficiency, galactosemia, glucose-galactose malabsorption (since the drug capsules contain lactose);
- children and adolescents up to 18 years of age;
- hypersensitivity to any of the components of the drug.
Bilobil forte, instructions for use (method and dosage)
Bilobil forte capsules are taken orally, regardless of meal time, with a small amount of liquid. The capsule should be swallowed whole without chewing.
Recommended doses according to indications:
- violation of microcirculation and blood circulation in peripheral organs, Raynaud's disease: one capsule of the drug twice a day (morning and evening);
- dyscirculatory encephalopathy of various origins: one capsule two or three times a day;
- neurosensory impairment, diabetic retinopathy and senile macular degeneration: one capsule twice a day (morning and evening).
The duration of therapy, especially for elderly patients, should be at least 3 months. The effect of the drug begins to appear approximately 1 month after the start of treatment. After consultation with a specialist, it is possible to conduct a repeat course.
Price, where to buy
In Russia, the price of Bilobil No. 20 is 156-211 rubles, the price of Bilobil Forte No. 20 is 273-290 rubles, and the price of Bilobil Intens No. 20 starts at 418 rubles.
In Ukraine, the average prices for these drugs are 99, 152 and 203 hryvnia, respectively.
- Online pharmacies in RussiaRussia
- Online pharmacies in UkraineUkraine
- Online pharmacies in KazakhstanKazakhstan
ZdravCity
- Bilobil capsules 40 mg 60 pcs. KRKA / Krka-Rus / JSC KRKA, d.d., Novo mesto
647 rub. order - Bilobil forte capsules 80 mg 20 pcs. JSC KRKA, d.d., Novo Mesto
RUB 310 order
- Bilobil Intens 120 capsules 120 mg 60 pcs. KRKA JSC, d.d., Novo Mesto
RUB 1,047 order
- Bilobil Intens 120 capsules 120 mg 20 pcs. KRKA JSC, d.d., Novo Mesto
RUR 497 order
- Bilobil forte capsules 80 mg 60 pcs. KRKA/Krka-Rus/AO KRKA, d.d., Novo mesto
RUR 868 order
Pharmacy Dialogue
- Bilobil intense 120 (caps. 120 mg No. 20)KPKA
RUR 556 order
- Bilobil intense 120 (caps. 120 mg No. 60)KPKA
RUB 1,065 order
- Bilobil (caps. 40 mg No. 60)KPKA
RUR 768 order
- Bilobil Forte (caps. 80 mg No. 60)KPKA
RUB 862 order
- Bilobil Forte (caps. 80 mg No. 20)KPKA
RUB 356 order
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Pharmacy24
- Bilobil 120 mg No. 60 capsules KRKA, Slovenia
478 UAH. order - Bilobil intense 120 mg No. 20 capsules KRKA, Slovenia
198 UAH order
- Bilobil 40 mg No. 20 capsules KRKA, Slovenia
93 UAH order
- Bilobil 40 mg No. 60 capsules KRKA, Slovenia
215 UAH order
- Bilobil forte 80 mg No. 20 capsules KRKA, Slovenia
147 UAH order
PaniPharmacy
- Bilobil intensive capsule Bilobil Intens caps. 120 mg No. 60 Slovenia, KRKA dd Novo Mesto
539 UAH. order
- Bilobil forte capsule Bilobil forte capsule. 80 mg No. 60 Slovenia, KRKA dd Novo Mesto
410 UAH. order
- Bilobil capsule Bilobil capsules 40 mg No. 20 Slovenia, KRKA dd Novo Mesto
102 UAH order
- Bilobil capsule Bilobil capsules 40 mg No. 60 Slovenia, KRKA dd Novo Mesto
255 UAH order
- Bilobil forte capsule Bilobil forte capsule. 80 mg No. 20 Slovenia, KRKA dd Novo Mesto
192 UAH order
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Side effects
- gastrointestinal tract: very rarely - vomiting, nausea, loose stools;
- nervous system: very rarely - insomnia, dizziness, headache;
- sense organs: frequency unknown – hearing impairment;
- blood coagulation system: very rarely - decreased blood clotting (in patients who were simultaneously taking drugs that reduce blood clotting, cases of bleeding were observed during long-term treatment with drugs based on ginkgo biloba);
- allergic reactions: very rarely - itching, swelling, redness of the skin.
If unwanted side effects occur, treatment with the drug should be stopped and consult a doctor.
Interactions with other medicinal drugs and other types of interactions
The patient should not take the drug, since it often contains acetylsalicylic acid, warfarin or thiazide diuretics.
When the drug is ingested for one hour with medications that inhibit blood coagulation (such as phenprocoumon and acetylsalicylic acid), the remaining effect may be enhanced - the risk of bleeding is increased.
The immediate use of ginkgo bean extract with low-intensity medicinal methods is particularly noticeable:
- Ginkgo whites are highly metabolized by antiepileptic drugs, which are metabolized by the CYP2C enzyme system. With concomitant therapy, anti-epileptic drugs (valproate, phenytoin) can change the seizure threshold, which increases the likelihood of an epileptic attack.
- The interaction of ginkgo bean extract with drugs that are metabolized by the cytochrome P450 enzyme system cannot be completely turned off (inhibition or induction of certain isoenzymes is possible).
special instructions
If hypersensitivity reactions occur, the drug should be discontinued. The patient should inform the doctor about the use of Bilobil forte before any surgical operation.
If there is a sudden deterioration or loss of hearing, as well as the reappearance of tinnitus and dizziness, you should immediately consult a doctor.
Patients receiving anticoagulant drugs, as well as persons with bleeding diathesis, should consult a specialist before using Bilobil forte.
The body and cap of the gelatin capsules of the drug contain the dye azorubine, which can cause bronchospasm or allergic reactions in patients with increased individual sensitivity.
Impact on the ability to drive vehicles and complex mechanisms
During treatment with Bilobil forte, care must be taken when engaging in potentially hazardous activities that require a high concentration of attention and quick reaction (for example, driving a car, working as a dispatcher and operator).
Side effects
In case of stagnation, the following side reactions may occur:
On the side of the grass tract:
sort out the etching; dyspepsia; diarrhea; abdominal pain; tediousness, vomiting.
On the side of the immune system:
hypersensitivity reactions, including angioedema, urticaria, buttocks.
On the side of the nervous system:
headache; confused; innocence (including vasovagal).
From the side of the skin:
singed skin, blistering, bumps, visip, itching, eczema.
In isolated cases of ingestion of drugs containing ginkgo biloba extract, especially in case of one-hour infusion with anticoagulants and non-steroidal anti-inflammatory drugs (such as phenprocoumon and acetylsalicylic acid), hemorrhage may occur intestinal, ophthalmic, cerebral). The cause of these episodes has not been established.
The drug contains barberry azorubin (E 122), which can cause allergic reactions in some cases.
In case of any unexpected reactions, the traces of the drug will become stagnant and will inevitably lead to the doctor.
Reports of suspected adverse reactions.
Reports of suspected adverse reactions following drug registration are of great importance. This makes it possible to carry out continuous monitoring of the relationship between the blood and the risks associated with medical treatment. Health professionals are responsible for reporting any suspected adverse reactions to the national reporting system.
Reviews about Bilobil forte
The effectiveness of the drug Bilobil forte is confirmed not only by positive reviews from patients and doctors, but also by studies according to which ginkgo biloba extract is practically the only known remedy that helps improve cognitive function in elderly patients.
According to reviews, Bilobil forte helps fight fatigue, absent-mindedness, lethargy, attention and memory disorders. Patients note that after the course of treatment, their performance, resistance to stress and overall well-being increased. The advantages of the drug also include its natural composition, a well-known and trusted manufacturer and the absence of side effects. Patients who have taken Bilobil forte are most often satisfied with its effect and in the future begin to use the drug for preventive purposes.
Unique miracle tree
Ginkgo is a gymnosperm dioecious plant with fan-shaped leaves measuring up to 5 - 7.5 cm. Homeland of growth: China. Interesting Facts:
- Ginkgo trees have incredible resistance to air pollution, so they “get along” well in large cities.
- Six plants came to life within a one and a half kilometer zone from the explosion site after the nuclear bombing of Japan.
- In France it is grown specifically for pharmaceutical processing.
- Near temple buildings in China and Japan, Ginkgo trees grow up to 30 meters high; scientists say their age exceeds several thousand years.
The highest content of active components (bioflavonoids) is found in the leaves, which begin to acquire a yellowish color in early autumn.
