The drug "Magnelis B6 forte": reviews, instructions for use, analogues

Compound

Magnelis is a safe and effective source of magnesium and pyridoxine .

It is known that when taking foods containing vitamins and microelements, almost half of the substances are not absorbed.

The active components of the drug in question work together much better, providing a high therapeutic result.

The basis of the chemical formula is represented by the following compounds:

• magnesium lactate;
• pyridoxine hydrochloride.

For better absorption, additional ingredients are used in the production of medicines.

There are no toxic substances among them. These are safe chemicals that do not adversely affect the functioning of internal organs and vital systems.

Their list includes:

• acacia gum;
• sucrose;
• Kollidon® SR;
• carmellose sodium;
• kaolin;
• magnesium stearate;
• talc.

The pharmaceutical product is produced in the form of tablets . They can be recognized by their round shape with convex planes and a white shell with a grayish tint.

In the section, a white core with a rough surface is observed.

To make the surface layer, sucrose, beeswax, titanium dioxide, kaolin, acacia gum, gelatin, and talc are used.

Pharmaceutical product packaging options:

• contour packages – 10 pcs.;
• polymer jars - 60, 90, 120 pcs.

dosage form

The drug Magnelis B6 is available in the form of white or grayish-white biconvex, film-coated tablets.

Active components:

• magnesium lactate;
• pyridoxine hydrochloride (vitamin B6).

Each unit of medication contains 470 mg of magnesium lactate and 5 mg of pyridoxine hydrochloride.

Auxiliary components of the tablet core:

• silica;
• sucrose;
• talc;
• gum arabic (Acacia Senegalese gum);
• sodium lauryl sulfate;
• sodium carmellose;
• polyvinylpyrrolidone;
• white clay (kaolin);
• Magnesium stearate.

Shell composition:

• sucrose;
• gum arabic (Acacia Senegalese gum);
• titanium dioxide;
• gelatin;
• white clay (kaolin);
• beeswax.

The product is packaged in cardboard packs of 3 and 5 blisters containing 10 tablets. It is also possible to pack in polymer jars of 60 and 90 medicinal units.

Pharmacology

Magnesium

The substance is present in all tissues of the body.

• Almost all metabolic processes occur with the participation of the mineral. It is part of a chain of stimulants that transmit nerve impulses.
• The microelement has an antiarrhythmic, antiplatelet effect, relieves spasms of the smooth muscles of internal organs and blood vessels.

The main source of the mineral is food. An incorrectly formulated diet, diet and overload provoke a decrease in the concentration of the substance.

Experts identify cases when the need for magnesium increases:

• emotional and physical fatigue;
• pregnancy;
• stress;
• taking diuretics.

Pyridoxine

It is the main engine and regulator of nervous system metabolism.

A low molecular weight organic compound is involved in many metabolic processes and improves the absorption of magnesium from the gastric tract into cells.

Magnesium deficiency is detected using laboratory tests performed on blood serum.

A moderate deficiency of the mineral is reflected by an indicator of 12-17 mg/l, which corresponds to 0.5-0.7 mmol/l. If the value falls below 12 mg/l (0.5 mmol/l), the patient requires maintenance therapy with magnesium-containing drugs.

Which magnesium is better absorbed?

Some people think that it is easy to replenish mineral reserves by eating magnesium-containing foods.
However, not all Mg compounds have high bioavailability. Interesting studies were conducted in the USA in 2003-2006. It turned out that the average daily level of magnesium absorption from food is about 200 mg. And according to experts, to maintain health and physical activity, women should take about 300 mg of magnesium per day, men - 100 mg more. In order for magnesium to be normal you need:

• high bioavailability of Mg compounds,
• a well-functioning system for their transportation from the intestines,
• absence of increased excretion of magnesium by the kidneys.

Pyridoxine (vitamin B6) is needed in almost all of these stages. It participates in the absorption of magnesium and regulates its metabolism. Scientists have proven that the level of magnesium in erythrocytes (red blood cells) significantly increases after just two weeks of taking the daily dose of the mineral along with 1 g of vitamin B6 (keep in mind, this is a high therapeutic dose that requires medical prescription).

While taking vitamins, you may have noticed that magnesium occurs in the form of different chemical compounds: oxide, salts of inorganic acids, salts of organic acids, salts of amino acids.

All of them have varying degrees of absorption in our body. One experimental study compared the bioavailability of 15 Mg compounds and found that aspartates, citrates, orotates and lactates had the highest levels.

The effectiveness of the magnesium orotic acid salt supplement (Magnerot) is believed to be enhanced because it promotes delivery of the substance across cell membranes. In addition, orotic acid itself is a vitamin-like substance. It is also called “vitamin B13”. Its main role is participation in the synthesis of RNA and DNA.

When we studied the differences between magnesium orotate and magnesium lactate in terms of bioavailability, the following was discovered. It turned out that the level of compensation for magnesium deficiency was almost the same when using both salts. However, if orotate was used in combination with vitamin B6, the therapeutic effectiveness increased by 2.3 times.

So if you are taking Magnerot, getting extra vitamin B6 or sticking to foods rich in pyridoxine (nuts, legumes, fish) during this period will come in handy.

Price

The pharmaceutical product is sold without a prescription. You can buy it at almost any pharmacy.

The average cost is determined by the range - from 480 (90 tablets) to 590 rubles (120 tablets).

Magnelis and Magnelis forte: what is the difference?

The formulas of both products use a combination of pyridoxine and magnesium. This tandem enhances each other's action.

To make regular Magnelis, magnesium lactate is used, and for the forte , magnesium citrate is used.

In the first case, the derivative of the active substance is lactic acid, in the second - citric acid.

Due to the insufficient solubility of lactic acid in water, magnesium from the gastric tract is absorbed by the body by 50%. Citric acid does not have such disadvantages, so the percentage of magnesium absorption is much higher.

Among other differences between regular Magnelis and Forte:

• magnesium content in one tablet - regular drug - 470 mg, forte - 618.43 mg;
• the amount of pyridoxine is in the usual remedy - 5 mg, in the fort - 10 mg.

The compared products differ in packaging options:

• regular drug – 60; 90; 120 pcs.;
• forte – 30; 60 pcs.

The principle of action of both medications is the same. But, given the different derivative substances, the scope of application of the tablets is slightly different:

• A lactate-based composition (regular Magnelis) has proven itself well in nephrology, in particular for the treatment and prevention of urolithiasis arising from oxalate stones.
• Citrate-based products (Forte) are used primarily in gynecology and obstetrics to maintain pregnancy.

The demand for Magnelis does not stop there. Both medications are successfully used in gynecology, nephrology, cardiology, and neurology.

Indications for use

The pharmaceutical product is used to compensate for Mg deficiency, the nature of which is associated with a lack of other substances or this particular mineral.

Why do women take:

• to stabilize the psycho-emotional state during menopausal syndrome;
• reducing irritability;
• restoration of minor sleep disturbances;
• normalization of heartbeat with increased heart rate.

Magnelis helps get rid of gastrointestinal spasms, pain and tingling sensations in the muscles. After a course of therapy, a surge of energy is felt and performance increases.

Instructions for use

The rules for taking the medication are described in detail in the annotation.

For adults

The daily norm corresponds to 6-8 tablets .

This number of tablets should be divided into 2-3 times.

Take the medicine during meals with purified water (at least 150 ml). There is no need to chew the drug.

The duration of therapy is determined individually, taking into account the results of laboratory blood tests (magnesium levels must reach normal limits).

For children

The medication is prescribed to children over 6 years of age whose body weight is more than 20 kg.

The daily norm is 4-6 tablets .

This amount of medication is also divided into 2-3 doses.

Side effects

• During therapy involving taking Magnelis, undesirable reactions associated with allergies to the components of the composition may be observed.
• There are also cases of side effects from the digestive system. This is expressed in pain that occurs in the abdominal area, flatulence, constipation, nausea, and vomiting.

If undesirable reactions intensify, it is recommended to consult a doctor about the possibility of continuing to use a magnesium-containing composition to replenish Mg deficiency in the body.

Restrictions on use

Like all pharmacological agents, Magnelis has restrictions on its use.

You should avoid using this product in the following cases:

• severe renal dysfunction with creatinine clearance <30 ml/min.;
• disturbance of amino acid metabolism leading to the development of mental retardation (with behavioral and cognitive disorders);
• allergy to the components of the composition.

The manufacturer of the product also warns about the age limit. The drug is not prescribed to children under 6 years of age.

If the patient has moderate renal failure, it becomes necessary to consult a doctor about the safety of using the drug. The precaution is due to the risk of developing hypermagnesemia .

When not to take pills

Despite the good results that Magnelis B6 Forte gives for sleep disorders and other diseases, it should not be used if you are hypersensitive to the constituent substances of this drug. A contraindication to the use of tablets is renal failure, which occurs in a serious form when creatinine clearance is less than 30 ml/min. This remedy is not recommended for children under the age of twelve due to the lack of necessary clinical studies.

It is forbidden to take the medicine if you have hereditary galactosemia, lactase deficiency (since the drug contains the component lactose monohydrate), as well as with galactose and glucose malabsorption syndrome. You should not combine levodopa with Magnelis B6 Forte.

The tablets are prescribed with caution for renal failure, which is characterized by moderate severity. There is a possibility of hypermagnesemia

Magnelis B6 Forte can be used during pregnancy (reviews from pregnant women note that the tablets help remove the tone of the uterus, make the stomach softer, and are very soothing), but only as prescribed by a doctor. The product does not have a negative effect on the formation of the fetus. Magnesium can pass into breast milk, so if you use this drug, you should refrain from breastfeeding for a while.

Magnelis b6 during pregnancy

According to clinical studies, the drug in question does not have teratogenic or fetotoxic effects during pregnancy.

Therefore, women in a delicate situation may be prescribed a magnesium-containing composition by their attending physician or obstetrician monitoring the course of pregnancy.

If there is an urgent need for the drug during breastfeeding, it is necessary to interrupt lactation due to the ability of the microelement to penetrate into milk.

Why is vitamin B6 needed?

Vitamin B6 deficiency has almost the same symptoms as magnesium deficiency. Hair falls out, a persistent feeling of fatigue occurs, the skin becomes dry and cracks often appear in the corners of the lips and on the heels, the limbs periodically go numb.

During pregnancy, it is necessary to promptly compensate for the lack of vitamins.

That is why most drugs used as a source of magnesium also contain vitamin B6.

How vitamin B6 is beneficial for the health of the expectant mother and fetal development:

• it is involved in metabolism and energy production in cells;
• improves the absorption of magnesium by body cells after it enters the stomach;
• does not allow blood glucose levels to change sharply;
• helps the body tolerate stress more easily, strengthens the nervous system, and helps to remain calm in difficult situations.

All these properties and actions that Magnelis B6 has make it an almost indispensable drug not only during pregnancy, but also during its planning.

Overdose

If the patient does not have impaired renal function, a magnesium-containing drug does not cause intoxication.

In the presence of renal dysfunction, signs of overdose may appear. Their nature depends on the level of magnesium in the serum. The problem is determined by the following signs: anuria, decreased blood pressure, nausea leading to vomiting, slowed reflexes. Sometimes the patient falls into a coma or cardiac arrest occurs.

To eliminate the consequences of an overdose, doctors use different methods: forced diuresis, rehydration. For kidney problems, hemodialysis/peritoneal dialysis is required.

What's better?

Due to the identical composition, Magnistad and Magne B6 can be called analogues.

Their use is advisable if magnesium deficiency is accompanied by symptoms such as:

• cardiopalmus;
• irritability;
• difficulty falling asleep and other sleep disorders;
• spasms of the intestines and stomach;
• increased fatigue;
• muscle pain, cramps and tingling sensation.

The average course of therapy with these drugs is approximately 1 month. Reception should be discontinued after the level of magnesium in the blood has stabilized. Such drugs taken on an empty stomach can cause diarrhea, so Magne B6 or Magnistad is best taken with food.

If there is a slight deficiency (without the symptoms listed above), you can take a course of vitamins with magnesium to replenish it.

It is difficult to say which is better - Magnistad or Magne B6, since the active substances contained in the first and second preparations are identical. The main selection criterion may be the price, because the cost of 50 Magne B6 tablets is almost 2.5 times higher than the cost of the same number of Magnistad tablets.

Interaction

• Absorption of magnesium from the gastric tract is significantly reduced when Magnelis is taken simultaneously with medications containing calcium salts or phosphates.
• When prescribing tetracycline during the use of a magnesium-containing drug, it is recommended to separate the medication intake with a three-hour break. The caution is associated with decreased absorption of tetracycline under the influence of magnesium.
• Pyridoxine reduces the activity of levodopa.
• Magnesium neutralizes the effect of thrombolytic drugs and prevents the body from absorbing iron.

special instructions

The instructions for use of the drug contain a special instructions section, which should be studied especially carefully, since it contains important information:

• the tablets contain sucrose, so you need to be careful when prescribing them to patients with diabetes;
• with concomitant calcium deficiency, the magnesium deficiency should first be eliminated, and then treatment with calcium preparations should be started;
• there is no evidence that the drug impairs concentration or the speed of psychomotor reactions, so it can be prescribed when driving or driving dangerous mechanisms;
• If after a month of treatment there is no result, it is not advisable to continue therapy.

Reviews

Regina, 49 years old:

Women over 45 know the condition when hot flashes are felt, sleep is disturbed, and anxiety worsens. After an examination, the gynecologist prescribed a number of medications, including Magnelis. The specialist explained that my symptoms were due to a lack of magnesium in the body. To replenish it, it is necessary to carry out therapy using this remedy.

I purchased a pack of 90 tablets. I drank almost everything before completing the treatment. No side effects were observed while using the medication.

Valeria, 28 years old:

During the period of bearing my second child, the doctor prescribed Magnelis B6 to compensate for the microelement deficiency. Before using the pills, I carefully studied the instructions and consulted with other specialists.

The product is truly safe and does not cause any unwanted reactions. The result is noticeable after taking the drug for a week according to the tests sent the day before. The medication fully copes with its functions, so I confidently recommend it for use.

Anastasia, 34 years old:

Magnelis b6 was prescribed by a doctor when test results revealed a magnesium deficiency. She turned to a doctor for help after she began to increasingly notice fatigue and an unreasonable decrease in mood. According to a specialist, my condition is associated with hormonal imbalance. Therefore, comprehensive treatment was recommended.

It only took 2 weeks to replenish magnesium in the body. Then I used hormone replacement medications. The only disadvantage of Magnelis is the high price.

Taking the drug for neuroses

One of the most important functions of Magnelis B6 for VSD is that it serves as an anti-stress factor. This occurs due to the fact that Magnelis B6 slows down the processes of excitation of the central nervous system and because of this the patient ceases to respond too sharply to external stimuli.

The nervous system is extremely sensitive to magnesium deficiency. A decrease in it in the body is manifested by nervousness, unreasonable fears and anxiety, insomnia and fatigue, and frequent headaches.

Magnesium, together with vitamin B6, normalizes the nervous system during stress, depression and tense conditions. Any stress significantly increases the body’s daily need for magnesium, which is why patients need to take Magnelis B6 for VSD.

Analogs

A structural analogue of the drug in question is the drug Magnelis in 6 forte.

Among other pharmaceutical products with identical properties, the following items are popular:

• Magne B6 – 580 rub.;

• Perfectil – 695 rub.;
• Vitrum – 1706 rub.;

• Duovit tablets for women – 300 rubles;
• Magne Express – 540 rub.;

• Magnesium Chelate Evalar – 933 RUR;
• Magnerot – 516 rub.

You should not select a magnesium-containing drug yourself.

Each medicine contains a different amount of the mineral. In addition, the composition includes other components, the replenishment of which is not necessary.

Only a qualified specialist can prescribe adequate treatment.

Magnicum

This is an analogue of Magnelis B6.

This medication is also a source of magnesium for the body. The composition also contains vitamin B6, or pyridoxine hydrochloride. These two components work well together. Magnicum is used for deficiencies of magnesium and vitamin B6.

For the purpose of prevention, it is also used for:

• Chronic physical and mental fatigue.
• Irritability.
• Stress.
• Depression.
• Sleep disorder.
• Myalgia.
• Atherosclerosis.
• For the purpose of preventing myocardial infarction.

A person who smokes for a long time and abuses alcohol has hypomagnesemia. The use of laxatives, oral contraceptives, and diuretics can also affect the amount of magnesium in the body.

For heart disease, arterial hypertension, heart failure, osteoporosis, and after bone fractures, magnesium is prescribed.

It is enough to take two tablets once a day or one tablet twice a day.

Do not use the drug in case of hypersensitivity to its components, severe renal failure, hypermagnesemia, vitamin B6 hypervitaminosis, AV blockade, myasthenia gravis, Parkinson's disease, severe arterial hypotension, diarrhea.

The price of the drug is about 300 rubles.

What other analogs exist for the drug Magnelis B6?