Preparations and medicines with the active ingredient Danazol

Danazol

- a drug, a synthetic androgen.

pharmachologic effect

An antigonadotropic agent, which is a synthetic androgen derived from ethisterone. Suppresses the production of gonadotropic hormones LH and FSH by the pituitary gland in men and women. In women, it inhibits ovarian activity, inhibits ovulation, and causes endometrial atrophy. The action is reversible, devoid of estrogenic or gestagenic effects, in high doses it has weak androgenic activity with a concomitant anabolic effect. In endometriosis, it damages both normal and ectopic endometrial tissue, leading to its inactivation and atrophy. Reduces pain accompanying endometriosis and causes regressive changes in endometriotic lesions. Has an immunosuppressive effect and inhibits lymphocyte proliferation in vitro

. Significantly reduces the level of Ig and the production of autoantibodies in patients with endometriosis. In fibrocystic mastopathy, it promotes the partial or complete disappearance of nodular seals and complete relief of pain. Clinical effectiveness in hereditary angioedema may be due to an increase in the content of the C1 esterase inhibitor (congenital deficiency of which is characteristic of this disease) and, as a result, an increase in the plasma level of the C4 complement component.

special instructions

During the period of use of Danazol, liver function should be regularly examined, including determination of the number of peripheral blood cells and liver enzymes.

It is important to know that the drug affects laboratory parameters of sex hormones (increases testosterone levels, etc.).

Therapy with the drug in patients with thrombosis, kidney or liver disease, migraine, cardiovascular diseases and conditions accompanied by epilepsy, impaired lipoprotein metabolism and fluid retention should be carried out under close medical supervision.

When prescribing Danazol to patients with diabetes mellitus, insulin dosage adjustment is necessary.

It should be taken into account that the drug increases the concentration of glucagon in the blood plasma, enhances the effect of indanedione derivatives and coumarin anticoagulants, as well as:

• Increases the concentration of antiepileptic drugs in the blood and suppresses their metabolism;
• Weakens the effect of oral hypoglycemic drugs and insulin;
• Reduces the effectiveness of antihypertensive drugs;
• Increases the concentration of tacrolimus and cyclosporine in the blood plasma.

Dosage regimen

Inside. Treatment begins on the first day of the menstrual cycle. Adults: 200-800 mg/day in 2-4 doses. For endometriosis, the initial daily dose is 400 mg, subsequently up to 800 mg, the course of treatment is 6 months; as preoperative preparation - 300-400 mg/day 1-2 months before surgery. For benign diseases of the mammary gland - 100-300 mg daily for 3-6 months; for primary menorrhagia and premenstrual syndrome - 100-400 mg/day, course of treatment - 3 months; for gynecomastia in men - 200-600 mg/day. To prevent angioedema, the initial dose is 200 mg, followed by a reduction (in the absence of exacerbations) for 1-3 months. Children: with premature puberty - 100-400 mg daily, depending on the age and condition of the patient.

Instructions for use Danol (Danazol):

Danol (Danazol) is a drug that belongs to the class of sex hormones and drugs that affect the genital area.
The medication suppresses the production of gonadotropic hormones, slows down ovarian function and inhibits ovulation. The active substance reduces the concentration of female sex hormones, as a result of which endometrial malignancy atrophies in the body. Danol (Danazol) destroys ectopic zones, reduces areas damaged by malignant formation. Danol (Danazol) also reduces pain, reduces the formation of new cells and intracellular structures of red blood cells.

You can buy the medicine in the form of film-coated capsules in dosages of 100 mg and 200 mg. The price of Danol (Danazol) depends on the manufacturer and dosage. You can buy the medication on our website.

Side effects

“Vulgar” acne, hypersecretion of the sebaceous glands, fluid retention in the body, hirsutism, “flushes” of blood to the facial skin, profuse sweat, reduction in the size of the mammary glands, deepening of the voice, weight gain, vaginitis, impaired spermatogenesis, virile syndrome, nausea, dizziness , emotional lability, skeletal muscle spasm, headache, increased intracranial pressure, lumbodynia, paresthesia, sleep disturbances, visual disturbances, thrombocytosis or thrombocytopenia, erythrocytosis, leukocytosis, bleeding in patients with hemophilia, skin rash, dysmenorrhea, cholestatic jaundice, hepatitis, alopecia , increased activity of “liver” transaminases.

Overdose

Symptoms

Headache, dizziness, tremor, convulsions, nausea, vomiting.

Treatment

Gastric lavage, symptomatic therapy.

Indications and contraindications:

Prescribed by your doctor for the following problems:

• Benign formations in the breast (fibroadenoma, fibrocystic mastopathy).
• Heavy bleeding during menstruation, also called primary menorrhagia.
• Premature sexual development.
• Enlargement of the mammary gland with hypertrophy of glands and adipose tissue.
• Hereditary angioedema (HAE) is a rare, life-threatening disease that belongs to the group of primary immunodeficiencies. The reason is an insufficiency of the general level or a decrease in the functional activity of the C1 inhibitor of the complement system.

Danol (Danazol) is contraindicated in case of hypersensitivity to the active substance and its other components. Do not take for breast cancer, porphyrin disease, cancer developing from epithelial tissue cells, androgen-dependent malignancies, vaginal bleeding of unknown origin, renal, liver, or heart failure, pulmonary embolism.

Patients suffering from the following diseases should take it with extreme caution:

• Epileptic convulsions.
• Severe headaches, migraines.
• Pathophysiology of hemostasis.

The drug Danol (Danazol) is not prescribed to women during pregnancy and lactation. The active substance can cause a female fetus to acquire male characteristics. This phenomenon is also called virile syndrome. Before taking the drug, pregnancy must be completely excluded. If the patient becomes pregnant during therapy, the drug is completely excluded from the course of therapy, and the woman is informed of the possible risk to the fetus.

Side effects

The instructions for Danazol indicate that the drug may cause side effects from certain body systems, namely:

• Increased sweating, vaginitis, changes in libido, amenorrhea, acne, reduction in the size of the mammary glands, weight gain, flushing of the face, deepening of the voice, nervousness, spermatogenesis disorders, increased secretion of the sebaceous glands, emotional lability, edema, androgenetic alopecia and minor hirsutism ( endocrine system);
• Tachycardia and arterial hypertension (cardiovascular system);
• Increased activity of liver enzymes, cholestatic jaundice and dysfunction of the gastrointestinal tract (digestive system);
• Tremor, weakness, headache, depression, slight increase in intracranial pressure, sleep disturbances and dizziness (central nervous system);
• An increase or decrease in the number of blood cells (hematopoietic system).

Danazol can also cause skin rashes, muscle spasms or cramps, visual disturbances, back pain and metabolic side effects, namely:

• Increased serum concentrations of LDL cholesterol;
• Impaired glucose tolerance;
• Hyperglucagonemia;
• Decreased serum concentrations of HDL cholesterol.

Symptoms of an overdose of Danazol are convulsions, headache, nausea, dizziness, vomiting and tremor. In such cases, gastric lavage and symptomatic therapy are required.

What is the price of Danol (Danazol)? Where is it profitable to buy the drug in Russia:

The price for an effective hormonal drug on our website is much lower than in other pharmaceutical companies. Do you want to buy an original medication as soon as possible? Call us by phone, follow the “Buy” link, or request a call back.

• The price of the medicine may vary slightly depending on the manufacturer; the exact price is clarified over the phone by our employees.
• You can buy Danol (Danazol) right now, the medicine is always available.

Directions for use and doses

Inside. As a rule, the smallest effective dose is used.

Adults: usually the daily dose is from 200 to 800 mg, divided into 2-4 doses.

Treatment of endometriosis should begin with a dose of 400 mg/day. This dose is increased or decreased as necessary. The duration of treatment is 4-6 months.

For the treatment of benign breast diseases or severe cyclic mastalgia, the recommended daily dose is 100 to 400 mg (usually 300 mg), for 3-6 months.

The dose for primary menorrhagia and premenstrual syndrome is 100-400 mg/day (usually 200 mg) for 3 months.

For gynecomastia, men are prescribed 200-600 mg (usually 400 mg) of the drug/day (for no more than 6 months).

To prevent angioedema, the initial dose should be 200 mg, followed by a reduction (in the absence of exacerbations) over 1-3 months.

Children: can only be prescribed to children with premature puberty at a daily dose of 100 to 400 mg, depending on age and severity of the disease.

Features of application:

All patients taking Danazol should undergo regular liver function tests. If the course of treatment lasts 6 months or more, it is necessary to perform an ultrasound of the liver and pelvic organs.

When treating patients with diabetes, it is necessary to adjust the insulin dosage.

High doses of the drug can prevent ovulation. Small dosages of Danazol do not always affect ovulation, so in this case you need to take care of non-hormonal contraception.

Patients with diabetes mellitus who are undergoing Danazol therapy undergo an insulin dose adjustment. An increased dose of the active component may temporarily stop ovulation.

Contraindications

The use of Danazol is contraindicated in case of hypersensitivity to the components included in its composition. The drug is not prescribed for chronic heart failure, severe liver or kidney dysfunction, breast cancer, porphyria, as well as in cases of:

• Vaginal bleeding of unknown origin;
• Thromboembolic disorders;
• Androgen-dependent tumors;
• Carcinomas;
• Pregnancy and during breastfeeding.

The drug is prescribed with caution to patients with kidney or liver diseases, polycythemia, cardiovascular diseases, diabetes mellitus, lipid metabolism disorders, epilepsy, as well as migraines and disorders of plasma hemostasis mechanisms.

Indications for use of Danazol

Danazol is recommended for the treatment of endometriosis, accompanied by infertility, if it is characterized by the appearance in various organs of tissue areas that are similar in structure to the inner lining of the uterus and undergo cyclic changes in accordance with the course of the menstrual cycle.

The drug is also intended for the treatment of benign formations in the mammary glands, premenstrual syndrome, breast reduction in men and other diseases that are associated with suppression of gonadotropin secretion.