What kind of drug
Diosmin + Hesperidin tablets used in complex treatment of chronic and peripheral venous insufficiency, manifestations of acute hemorrhoids.
They belong to the group of angioprotectors and blood microcirculation correctors.
They are produced by pharmaceutical companies both in the form of drugs and biologically active food additives with different contents of active ingredients.
Where are they kept?
First of all, the active components are found in citrus fruits. They are mostly contained in their peel, but are also present in the pericarp.
Hesperidin is included in the following products:
- orange juice (provided the fruit was sweet);
- in fresh sour oranges (but in very small quantities);
- in tangerine (present in the pulp, but most of all in the peel);
- in hybrid fruits obtained by crossing oranges and tangerines, as well as grapefruit. But the substance content in hybrids is several times less compared to the original.
Hesperidin is found in small quantities in non-citrus plants. First of all, these include snow-white bomeria, aqueous extract of valerian, flowers of codonopsis lacentum and other exotic plants.
Since diosmin is a semi-synthetic product, it is obtained after isolating the flavonoid from citrus fruits.
Pharmacodynamics and pharmacokinetics
The substances diosmin and hesperidin have similar venotonic, angio- and venoprotective effects. Thanks to the pronounced therapeutic effect, the condition of the veins of the lower extremities significantly improves.
When the drug enters the circulatory system, it is evenly distributed in the tissues, improving their blood supply. The maximum concentration in the blood is achieved 3 hours after administration.
With regular use of a combination of substances, you can get rid of many symptoms of venous insufficiency and normalize the condition of the capillaries and lymphatic system.
Hesperidin is also used to prevent bleeding and normalize blood pressure.
Pharmacokinetics have not been fully studied, but the presence of phenolic acids in the urine proves the active metabolism of the drug in the liver.
Basically, it is excreted from the body in feces and, to a lesser extent, in urine.
The half-life is up to 12 hours.
Benefits for the human body
The effect of the active components is due to their positive effect on the vascular walls. Flavonoids have the following properties:
- reduce the extensibility of venous walls by increasing their tone;
- the elasticity of blood vessels becomes higher;
- capillary fragility is reduced. They are less damaged by mechanical stress;
- the activity of the lymphatic system improves, which has a positive effect on the removal of excess fluid from the body;
- substances help fight the release of free radicals;
- congestion occurs in the veins;
- venous pressure decreases, an increase in which is typical for varicose veins;
- hemodynamic parameters become better;
- prostaglandins, which are the main companions of inflammatory processes, are produced in minimal quantities;
- damaged vascular tissues are restored.
Indications for use
According to the instructions for the venotonic Diosmin + Hesperidin in tablet form, the indications for use are:
- symptomatic manifestations of CVI;
- acute and chronic hemorrhoids;
- lymphatic congestion;
- Feelings of fatigue, pain, heaviness in the legs.
It is also advisable to use in the following cases:
- therapy of trophic ulcers;
- preparation and recovery period after surgery to remove hemorrhoids;
- to prevent relapses and accelerate tissue regeneration after phlebectomy and stripping.
The product helps reduce pain, swelling, negative reactions of the body, and accelerates the recovery period.
Contraindications
There are few contraindications to the use of dietary supplements. The list includes:
- excessive sensitivity to active ingredients;
- minor age;
- period of breastfeeding (there is no data on the possible penetration of the drug into breast milk).
If hemorrhoids are in the acute stage, then it is necessary to reduce the duration of treatment so as not to worsen the patient’s condition.
Hesperidin and diosmin work best together. These two active compounds help strengthen the vascular walls and make them immune to injury. First of all, people suffering from varicose veins or hemorrhoids will notice the positive effect of using dietary supplements. One course of drugs helps to significantly improve the condition of patients and prevents the appearance of unpleasant symptoms for a long time.
Directions for use and dosage
According to the instructions for the treatment Diosmin + Hesperidin, the method of use as part of the complex treatment of CVI is 1000 mg / day together with food. The daily dose can be divided into two doses.
The duration of the therapeutic course depends on the severity of the disease and the severity of symptoms. In case of repeated exacerbation of the pathology, the course is carried out a second time.
For acute hemorrhoids, treatment lasts for a week. The daily dose of 3000 mg is divided into three doses and taken for 5 days. The next 2 days, 2000 mg/day.
In case of ineffectiveness, it is necessary to contact a proctologist to correct the treatment regimen. As prescribed by your doctor, a different daily dosage is possible.
What supplements do they contain?
Diosmin and hesperidin are among the numerous dietary supplements designed to combat vascular pathologies. Let's look at the most effective complexes presented on iHerb.
Life Time, Diosmin Hesperidin Complex, 60 Capsules
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This comprehensive supplement includes both beneficial components. The drug contains both diosmin and hesperidin. They perform the following functions:
- act as inotropic agents;
- are compounds that are intended to protect blood vessels;
- help increase the strength of capillaries;
- increase venous tone, and reduce capillary permeability.
The complex formula is intended primarily to combat the manifestations of varicose veins, swelling, fatigue of the legs, as well as a feeling of heaviness and the appearance of cramps. The nutritional supplement works effectively thanks to the combination of two powerful components. Flavanoids have a positive effect on the condition of blood vessels (regardless of whether they are capillaries or veins).
The dietary supplement includes a complex containing diosmin and hesperidin (500 mg), as well as additional components:
- horse chestnut Contains substances that thin the blood, improve blood flow and strengthen vascular walls;
- dandelion leaf extract. The plant contains tannin, which normalizes the activity of the circulatory system and provides a soothing and relaxing effect;
- gotu kola plant extract enhances blood circulation and accelerates tissue repair.
It is a natural remedy for maintaining healthy legs and strengthening blood vessels, as well as increasing their elasticity. It provides an anti-inflammatory effect and acts as a natural antioxidant.
In the instructions for use, the manufacturer indicates that you need to take 2 capsules twice a day with any meal. Before use, you should consult your doctor in advance.
Garden of Life, Extraordinary Beauty, Beautiful Legs, 30 Vegetarian Capsules
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This supplement contains 600 mg of diosmin per capsule. This drug is prescribed to patients by many doctors in Europe, its effectiveness has been confirmed by various clinical trials involving humans.
The manufacturer advises taking one capsule per day with food, so the package will last you exactly one month.
Doctor's Best, Hesperidin, Methyl Chalcone, 500 mg, 60 Veggie Caps
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This dietary supplement contains a flavonoid that is obtained from citrus fruits. In the form that hesperidin initially has, it is poorly soluble in water, which reduces the effect of its effects. The preparation contains a special form of the substance – hesperidin methyl chalcone. It dissolves perfectly, due to which it is completely absorbed by the digestive tract. Apart from this component, the composition does not include any others. Only plant substances are used to produce vegetarian capsules.
A natural antioxidant that provides support for the vascular system, increases the strength of veins and capillaries, and also has a positive effect on the eyes. With regular use of dietary supplements, venous networks are reduced, swelling of the lower extremities and pain go away. In addition, the drug has a positive effect on blood pressure, which reduces the risk of developing cardiovascular pathologies.
The manufacturer indicates that to improve the condition, you need to take 1 vegetarian capsule 1 – 2 times a day with food. A different appointment schedule is possible if approved by the attending physician.
Life Extension, European Leg Solution, Featuring Certified Diosmin 95, 600 mg, 30 Vegetarian Tablets
See price on iHerb
The natural remedy contains 600 mg of diosmin, which improves the condition of blood vessels and the functioning of the circulatory system. The manufacturer indicates the following features and warnings when using the drug:
- packaging must be stored out of the reach of children;
- if the protective membrane is damaged, the additive cannot be used;
- You should avoid using dietary supplements if you are additionally using anticoagulants or medications intended to prevent the formation of blood clots. Problems with blood clotting are also contraindications;
- It is worth consulting with your doctor in advance for women who are breastfeeding, as well as when using other medications that may interact with the dietary supplement.
The product does not contain dairy products or other potentially dangerous allergens, and therefore does not provoke specific reactions. Daily dose – 1 capsule, which is recommended to be taken during or before breakfast. The course of treatment should last 3 months, followed by a break. Subsequently, you can repeat the course.
Side effects
During clinical trials of the drug, the following adverse reactions were observed.
- Very rarely, angioedema, colitis.
- Rarely: weakness, headache and dizziness, itching and rashes on the skin, localized swelling of the lips or eyelids.
- Often - nausea, vomiting, diarrhea.
Research
- https://www.ncbi.nlm.nih.gov/pubmed/27048768
- https://www.ncbi.nlm.nih.gov/pubmed/29385792
- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6824339/
- https://www.ncbi.nlm.nih.gov/pubmed/22895941
- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6824339/
- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6223991/
- https://www.ncbi.nlm.nih.gov/pubmed/18239868
- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3070018/
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special instructions
When taking the drug as part of a complex treatment of CVI manifestations, the maximum effect is ensured by a combination of:
- wearing compression garments;
- reducing the load on the lower limbs;
- maintenance physical education classes;
- limiting exposure to open sun.
In the treatment of acute hemorrhoids, this drug does not replace the use of specific medications.
Use for hemorrhoids
The effect of the active components is also manifested in the treatment of hemorrhoids. Since the disease is associated with a decrease in the tone of the veins in the anal area, the drug has a positive effect. Elasticity increases, blood vessels return to normal, due to which the patient feels relief after a course of treatment.
The product will be more effective if used in combination with medications prescribed by the doctor. First of all, we are talking about suppositories, creams, as well as following a special gentle diet.
In the acute stage, the drug should be used with caution. Most often, in this case, a reduction in the duration of treatment is indicated.
Analogs
Analogs of the drug Diosmin + Hesperidin according to the active substance are:
- Angiorus;
- Venarus;
- Dioridinvel;
- Venosmin;
- Diovenges.
Taking the drug Diosmin + Hesperidin in tablets and its analogues is recommended after consultation with a phlebologist. Self-administration of medications leads to undesirable consequences.
