Release form and composition
Deprim is produced in the form of film-coated tablets: biconvex, round, green (in blisters of 10 pieces, from 3 to 6 blisters in a cardboard box).
1 tablet contains:
- Active ingredient: St. John's wort (dry standardized extract) – 60 mg (including hypericin (general) – 0.3 mg);
- Auxiliary components: magnesium stearate, lactose, talc, microcrystalline cellulose, colloidal silicon dioxide.
Shell composition: carnauba wax, polyethylene glycol, hydroxypropyl methylcellulose, talc, green and blue glaze, titanium dioxide (E171).
Reviews
Arseniy M .: “I started taking Deprim due to the fact that I often have a low mood. I can't say it's depression. More likely, just periodic blues, like the one that happens in the fall. I decided to take a course of the drug. I took it for a month, three tablets a day. I can’t say that I noticed a pronounced effect. My mood, it seemed to me, remained at the same level, but I began to sleep noticeably better. You may need to take Deprim longer to feel the effects.”
Ekaterina A .: “I suffer from increased anxiety, I have many phobias and often have a bad mood. I have been going to see a psychotherapist for a long time. I don’t want to switch to heavy antidepressants, since I lead an active lifestyle, drive and work. The doctor prescribed Deprim for me, and I was pleased with the result. The anxiety disappeared from about the second week of use, in addition, the mood remained at a constant level. Calm - that's how I would describe it. There is no drowsiness or lethargy, I will continue taking the drug.”
Doctor's review : “Deprim is one of those drugs that I would advise prescribing to patients with mild disorders. Mild anxiety, mild depression, non-pathologically low mood. Since taking antidepressants may cause more harm than good in these cases, herbal remedies like Deprima are the medications of choice. This drug has proven itself in the fight against mild forms of depression. My patients experienced virtually no side effects while using it.”
Content
Pharmacological properties
Deprim is a herbal medicine with antidepressant and anxiolytic effects. Its active ingredient - extract of the herb St. John's wort - contains flavonoids, pseudohypericin, hypericin, hyperforin, which improve the functional state of the autonomic and central nervous system. Deprim improves mood and provides greater physical and mental activity.
Pharmacodynamics
The pharmacodynamics of Deprim are currently not well studied.
Pharmacokinetics
There is no information on the pharmacokinetics of the drug.
pharmachologic effect
The action of Deprim is based on increasing the influence of dopaminergic structures and decreasing noradrenergic ones. The fact is that the neurotransmitter dopamine is responsible for a person’s good mood. It is found in nerve cells of the brain, where it is synthesized and participates in signal transmission between neurons. With the help of dopamine, those brain structures that are responsible for happiness and good mood are activated.
This mediator has one more function. It is a precursor to norepinephrine. Norepinephrine, like adrenaline, is a stress mediator. Their concentration in the blood increases when dangerous situations arise and causes a feeling of anxiety. With the help of a specific enzyme, dopamine is converted into norepinephrine in the brain. This contributes to both a decrease in mood and an increase in anxiety.
Deprim blocks the enzyme responsible for the transition of dopamine to norepinephrine. At the same time, the concentration of dopamine increases, since it is less utilized. The concentration of norepinephrine, on the contrary, decreases because it is synthesized less. This mechanism causes two effects: an increase in mood and a decrease in anxiety.
Instructions for use of Deprim: method and dosage
Deprim should be taken orally with water.
Children over 12 years of age and adults are usually prescribed 1 tablet 3 times a day (regularly at the same time). Children 6-12 years old can take the drug 1-2 tablets (in the morning and evening) under medical supervision.
The therapeutic effect appears within 10-14 days from the start of therapy. The optimal effect from regular use of Deprim is usually achieved within several weeks.
If a dose is missed, it should be taken as quickly as possible. You should not take an additional dose to compensate for a missed dose.
Dosage regimen
Regardless of the severity of the pathology, the minimum therapeutic dosage for adults is 180 mg of the active substance, which is divided evenly into three doses. If such therapy is ineffective, the dose can be increased gradually by 60 mg until a sedative effect is achieved.
The maximum permissible dosage is 360 mg of active substance per day. This corresponds to 6 Deprim tablets. For children, the minimum dose is 60 mg, the maximum is 120 mg. In the second case, it is divided into two doses. The drug is not prescribed to children under 6 years of age.
Deprim is available in pharmacies without a doctor's prescription.
Overdose
Acute intoxication with Deprim in humans has not been recorded. Signs of overdose include drowsiness, lethargy, general weakness, and greater severity of side effects depending on the dose taken. There are reports of the appearance of confusion and the development of convulsive seizures after taking a dose of Deprim not exceeding 4.5 g daily for 2 weeks and taking an additional 15 g of the drug immediately before admission to the hospital. With significant overdoses, phototoxic reactions sometimes develop.
In this case, the drug is discontinued and activated carbon is prescribed. It is also recommended to avoid sun exposure and UV exposure for 1-2 weeks. Outdoor activities should be limited as much as possible and clothing and/or products that protect the skin from sunlight should be used.
Side effects
Deprim often causes allergic reactions. In addition, in some people it increases the body's sensitivity to animal dander and other allergens. Skin rashes often occur, especially after exposure to the sun.
From the central nervous system, both reactions of excitation (insomnia, anxiety) and depression (drowsiness, fatigue) are possible. In addition, digestive disorders are possible: nausea, vomiting, diarrhea or constipation. Anorexia occurs less frequently. Patients with bipolar disorder may experience a manic episode.
Overall, studies have shown that Deprim has fewer side effects than other antidepressants.
special instructions
If there is no therapeutic effect within 1-1.5 months from the start of treatment, you should stop taking Deprim and consult your doctor.
Patients taking the drug are advised to avoid exposure to the sun and UV radiation (including solariums), and also to refrain from drinking alcohol.
Impact on the ability to drive vehicles and complex mechanisms
There is no reliable information about the effect of Deprim on the ability to drive vehicles or perform complex types of work associated with increased concentration and speed of psychomotor reactions.
Contraindications
Despite the natural origin of the components of the drug, there are circumstances in which its use is strictly contraindicated. These include:
The effect of the drug on the body of a pregnant woman and the fetus has not been studied. There are no data on the effect on breast milk.
Drug interactions
According to the instructions, Deprim should be taken with caution simultaneously with anticonvulsants, antidepressants (serotonin reuptake inhibitors), monoamine oxidase inhibitors, tricyclic antidepressants, anti-migraine drugs (triptans), cardiac glycosides (including digoxin), oral hormonal contraceptives, reserpine, theophylline, indinavir , cyclosporine.
When used together, Deprim may enhance the effect of opioid analgesics and general anesthesia.
Analogs
Analogues of Deprim are products whose active ingredient is St. John's wort extract. These include:
- Deprim Forte;
- St. John's wort;
- Negrustin;
- Life 600 and Life 900;
- Gerbion.
In addition, the antidepressant Venlafaxine is similar in pharmacological action to hypericin. The latter has trade names such as:
- Alventa;
- Velaxin;
- Vipax;
- Deprexor;
- Venlift.
All of the listed analogues have a similar mechanism of action and indications, but may differ in side effects, contraindications and dosages. When changing the drug, you should consult your doctor.
Reviews about Deprima
There are mixed reviews about Deprim among doctors. Many patients self-medicate, taking the drug without consulting a specialist. This often led to a worsening of the symptoms of the disease, as a result of which it was necessary to switch to medications with a more intense effect. Doctors believe that St. John's wort extract may be effective in cases of unstable mood, as well as mild apathy and depression.
Patients respond positively to Deprima. It is taken for seasonal mood swings and anxiety associated with significant life changes or loss of loved ones. It is recommended to use the product regularly over a long period of time. Side effects when taking Deprim are rare. To avoid them, some patients prefer to change the treatment regimen, taking pills not in the morning or afternoon, but at night.
Indications for use
Deprim is the mildest plant-based antidepressant. It does not have strict indications for use. Clinical studies have proven the effectiveness of this remedy in the following cases:
- Mild to moderate depression;
- Subclinical depression;
- Depressed mood due to organic diseases;
- Increased anxiety;
- Decreased mood during premenstrual syndrome in women;
- Asthenovegetative syndrome;
- Meteosensitivity.
Deprim
Release form, composition and packaging
Green film-coated tablets, round, biconvex. 1 tab. dry, standardized extract of St. John's wort (Hypericum Perforatum) 60 mg incl. hypericin (general) 300 mcg. excipients: lactose, microcrystalline cellulose, talc, magnesium stearate, colloidal silicon dioxide. Shell composition: hydroxypropyl methylcellulose, polyethylene glycol, talc, carnauba wax, dyes: quinoline yellow (E104), indigotine (E132), titanium dioxide (E171).
Deprim forte
Capsules are hard, opaque, gelatinous, green; the contents of the capsules are compact granules, greenish-brown or grayish-brown in color with a characteristic odor, size 0.1 tablet. dry, standardized extract of St. John's wort (Hypericum Perforatum) 425 mg incl. hypericin (generic) 1 mg. Excipients: lactose monohydrate, cellulose, calcium hydrogen phosphate dihydrate, colloidal silicon dioxide, magnesium stearate, talc, gelatin, sodium lauryl sulfate, water, dyes (titanium dioxide E171, chlorophyll-copper complex E141), purified water.
Clinical and pharmacological group: Herbal medicine with antidepressant activity.
pharmachologic effect
Sedative herbal medicine. The main active substances of St. John's wort - hypericin, pseudohypericin, hyperforin and flavonoids - improve the functional state of the central and autonomic nervous system. Deprim improves mood, normalizes sleep, increases mental and physical activity.
Pharmacokinetics
Data on the pharmacokinetics of the drug Deprim are not provided.
Indications
- decreased mood;
- depressive states of mild to moderate severity, accompanied by anxiety (including those associated with menopausal syndrome);
- increased sensitivity to weather changes.
Dosage regimen
Adults and children over 12 years of age are prescribed 1 tablet. 3 times/day or 1 capsule 1 time/day (regularly at the same time); if necessary, the dose can be increased to 2 capsules/day (in 2 divided doses).
Children aged 6 to 12 years - under medical supervision, 1-2 tablets/day in the morning and afternoon. The optimal effect is achieved by taking the drug regularly for several weeks. The therapeutic effect of the drug Deprim appears 10-14 days after the start of administration. If you miss one dose, the drug should be taken as soon as possible. If it is time for your next dose, do not take an additional dose to make up for the missed dose. You should not take two doses of the drug at the same time. The drug should be taken orally with water.
Side effect
- From the digestive system: nausea, vomiting, constipation.
- From the side of the central nervous system: feeling of fatigue, anxiety.
Allergic reactions: hyperemia of the skin, itching.
Dermatological reactions: in persons with increased sensitivity to sunlight, simultaneous use of the drug and sunbathing may cause burns (photosensitization).
Contraindications
- severe depression;
- children under 6 years of age (for film-coated tablets);
- children under 12 years of age (for capsules);
- hypersensitivity to the components of the drug.
Pregnancy and lactation
Despite the lack of data on the harmful effects of the drug, taking Deprim during pregnancy and lactation is possible only if the expected benefit to the mother outweighs the potential risk to the fetus or child.
special instructions
The patient should be warned that if there is no therapeutic effect within 4-6 weeks after the start of treatment, you should stop taking Deprim and consult your doctor.
Patients taking the drug should avoid exposure to the sun and UV radiation (including solariums). Patients taking Deprim should avoid drinking alcohol.
Overdose
Symptoms: increased described side effects, general weakness, lethargy, drowsiness.
Treatment: drug withdrawal, activated carbon. No acute poisoning with St. John's wort has been observed in humans.
Drug interactions
Deprim activates microsomal oxidation (cytochrome P450), so the drug should be prescribed with caution while taking anticonvulsants, antidepressants (serotonin reuptake inhibitors), tricyclic antidepressans, MAO inhibitors, anti-migraine drugs (triptans), oral hormonal contraceptives, cardiac glycosides (including including digoxin), theophylline, cyclosporine, indinavir, reserpine.
When used simultaneously, Deprim may enhance the effect of general anesthesia and opioid analgesics.
Storage conditions and periods
The drug should be stored out of the reach of children at a temperature not exceeding 25°C. Shelf life: 3 years.
