Dicloran - dragees, capsules, solution, suppositories, tablets

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Manufacturers: Unique (India)

Active ingredients

Diclofenac

Disease class

Lesions of the lumbosacral plexus
Bile duct stones without cholangitis or cholecystitis
Rheumatoid arthritis, unspecified
Gout
Ankylosing spondylitis
Spondylosis
Sciatica
Other bursopathies
Enthesopathy, unspecified
Rheumatism, unspecified
Other and unspecified abdominal pain
Pain not elsewhere classified
Other constant pain
Renal colic, unspecified
Salpingitis and oophoritis
Inflammatory disease of the uterus, other than the cervix
Parametritis and pelvic cellulitis, unspecified
Other inflammatory diseases of the vagina and vulva

Clinical and pharmacological group

Not indicated. See instructions

Pharmacological action

Anti-inflammatory
Antipyretic
Analgesic (non-narcotic)
Antiaggregation

Pharmacological group

NSAIDs - Acetic acid derivatives and related compounds

Release forms and composition

Pills

1 tablet, coated with a soluble film, contains 50 or 100 mg of diclofenac sodium. Tablets are placed in contour cells of 10 pieces. They go on sale in a cardboard box containing 2 or 10 blisters.

Solution for intramuscular administration

It is a colorless, odorless liquid. The solution for injections is bottled in 3 ml transparent glass ampoules. 1 ml of the drug contains 75 mg of active substance. The package includes 5 or 25 bottles.

The solution for injections is bottled in 3 ml transparent glass ampoules.

Gel for external use

1 g of Dicloran Plus contains 10 mg of diclofenac diethanolamine. The ointment is supplied to pharmacies in tubes of 20 g.

Dicloran oral tablets

Instructions for medical use of the drug

Description of pharmacological action

Dicloran® has anti-inflammatory, analgesic and antipyretic effects. By indiscriminately inhibiting cyclooxygenase 1 and cyclooxygenase 2, it disrupts the metabolism of arachidonic acid and reduces the amount of prostaglandins at the site of inflammation. In rheumatic diseases, the anti-inflammatory and analgesic effect of diclofenac helps to significantly reduce the severity of pain, morning stiffness, and swelling of the joints, which improves the functional state of the joint. In case of injuries, in the postoperative period, Dicloran® reduces pain and inflammatory swelling.

Indications for use

Inflammatory and degenerative diseases of the musculoskeletal system (rheumatoid arthritis, ankylosing spondylitis, osteoarthritis, spondyloarthrosis, etc.), rheumatic diseases of periarticular soft tissues, acute gouty arthritis, pain in the spine, pain and inflammatory syndrome after surgical interventions, gynecological diseases, injuries , renal or biliary colic.

Release form

tablets, coated, soluble in the intestine 50 mg; contour cell packaging 10, cardboard pack 10; tablets, coated, soluble in the intestine 50 mg; contour cell packaging 10, cardboard pack 2; Composition: 1 ml of injection solution contains diclofenac sodium 75 mg; in ampoules of 3 ml, in a box of 5 or 25 ampoules. 1 g of gel for external use - diclofenac 10 mg (in the form of diethylamine); in tubes of 20 g, in a box 1 tube. 1 enteric-coated tablet contains diclofenac sodium 50 mg; 10 pcs in a blister pack, 2 or 10 packs in a box. 1 film-coated tablet, prolonged action - 100 mg; 10 pcs in a blister pack, 2 or 10 packs in a box.

Pharmacodynamics

Pharmacokinetics

Absorption is rapid and complete; food slows down the rate of absorption. After oral administration of 50 mg of diclofenac, Cmax in blood plasma is 1.5 mcg/ml achieved after 2-3 hours. Plasma concentration is linearly dependent on the size of the administered dose. No changes in the pharmacokinetics of diclofenac are observed during repeated administration and do not accumulate if the recommended interval between meals is observed. Bioavailability – 50%. The binding to plasma proteins is 95-98% (most of it is bound to albumin). Penetrates into synovial fluid; Cmax in synovial fluid is observed 2-4 hours later than in plasma. T1/2 from synovial fluid 3-6 hours, the concentration of the active substance in the synovial fluid after 4-6 hours is higher than in plasma, and remains higher for another 12 hours. Metabolism: 50% of the active substance is metabolized during the “first pass” "through the liver. AUC is 2 times less after oral administration of the drug than after parenteral administration of the same dose. Metabolism occurs as a result of multiple or single hydroxylation and conjugation with glucuronic acid. The P450 enzyme system CYP2C9 is also involved in the metabolism of the drug. The pharmacological activity of the metabolites is lower than that of diclofenac. Systemic clearance is 260 ml/min. T1/2 from plasma - 1-2 hours. 60% of the administered dose is excreted in the form of metabolites by the kidneys; less than 1% is excreted unchanged, the rest of the dose is excreted as metabolites in the bile. Pharmacokinetics in certain groups of patients There was no effect of the patient's age on the absorption, metabolism and excretion of the drug taken orally. In patients with impaired renal function who received therapeutic doses of diclofenac, no accumulation of unchanged active substance was detected. In patients with severe renal failure with creatinine clearance less than 10 ml/min, the excretion of metabolites in bile increases, but no increase in their concentration in the blood is observed. In patients with chronic hepatitis or compensated liver cirrhosis, the pharmacokinetic parameters and metabolism of diclofenac are the same as in patients without liver disease.

Use during pregnancy

Contraindicated during pregnancy. Breastfeeding should be stopped during treatment.

Contraindications for use

Hypersensitivity, bronchospasm, urticaria, rhinitis associated with a history of NSAID use; erosive and ulcerative lesions of the gastrointestinal tract in the acute stage; hematopoietic disorder of unknown origin, pregnancy, breastfeeding, age under 18 years.

Side effects

From the nervous system and sensory organs: headache, dizziness, increased fatigue; in rare cases - tinnitus, irritability, sleep disturbance, anxiety, depression, mental disorders, convulsions, blurred vision, diplopia. From the cardiovascular system and blood (hematopoiesis, hemostasis): in some cases - thrombocytopenia, leukopenia, agranulocytosis, anemia; in isolated cases, chest pain, tachycardia, increased blood pressure. From the gastrointestinal tract: pain and spasms in the epigastrium, flatulence, decreased appetite, impaired liver function, including hepatitis; rarely - erosive and ulcerative lesions with bleeding and perforation, aphthous stomatitis, esophagitis; in some cases - ulcerative colitis, Crohn's disease. From the genitourinary system: rarely - swelling; in some cases - hematuria, proteinuria, interstitial nephritis, acute renal failure, nephrotic syndrome. From the skin: skin rash, urticaria, bullous rashes, eczema, Stevens-Johnson syndrome, Lyell's syndrome, erythroderma, alopecia, photosensitivity. Other: compaction, in some cases - abscess or necrosis at the injection site, redness, burning or tingling sensation when applied topically; rarely - attacks of bronchial asthma, systemic allergic reactions.

Directions for use and doses

IM, orally, locally. IM deep into the muscle at a dose of 75 mg/day (in severe cases, as an exception, 75 mg 2 times a day with an interval of several hours) for no more than 2 days, then switch to oral administration. Orally, without chewing, with a sufficient amount of liquid, preferably before meals (if the stomach is hypersensitive, it can be taken at the end of a meal or after a meal), in a daily dose of 100-150 mg in 2-3 doses. Locally, apply a strip of gel the size of a cherry or hazelnut to intact skin over the painful area and rub in lightly, 3-4 times a day.

Interactions with other drugs

Dicloran® increases plasma concentrations of digoxin and lithium preparations. It has been established that Dicloran® reduces the effect of diuretics. While taking potassium-sparing diuretics, the risk of developing hyperkalemia increases, and therefore regular monitoring of potassium levels in the blood serum is necessary. Against the background of anticoagulants, thrombolytic agents (alteplase, streptokinase, urokinase), the risk of bleeding increases (usually from the gastrointestinal tract). Dicloran® reduces the effect of antihypertensive and hypnotic drugs. Concomitant use with other nonsteroidal anti-inflammatory drugs and glucocorticosteroids increases the likelihood of side effects (gastrointestinal bleeding). Dicloran® increases the concentration of methotrexate and cyclosporine in the blood, which can lead to increased toxicity of methotrexate and increased nephrotoxicity of cyclosporine. Use Dicloran® with caution 24 hours before and after taking methotrexate. Acetylsalicylic acid reduces the concentration of diclofenac in the blood. There is evidence of an increase in the blood concentration of antibacterial drugs of the quinolone group when taken simultaneously with diclofenac. When used together with cefamandole, cefoperazone, cefotetan, valproic acid and plicamycin, the incidence of hypoprothrombinemia increases. Cyclosporine and gold preparations increase the effect of diclofenac on the synthesis of prostaglandins in the kidneys, which is manifested by increased nephrotoxicity. Concomitant use with paracetamol increases the risk of developing nephrotoxic effects of diclofenac. Simultaneous administration with ethanol, colchicine, corticotropin and St. John's wort preparations increases the risk of bleeding in the gastrointestinal tract. There are reports of the development of hypoglycemic or hyperglycemic reactions when diclofenac is used together with hypoglycemic agents. Drugs that cause photosensitivity increase the sensitizing effect of diclofenac to ultraviolet radiation. Drugs that block tubular secretion increase the plasma concentration of diclofenac, thereby increasing its effectiveness and toxicity.

Special instructions for use

Caution should be exercised when prescribing the drug to patients with bronchial asthma, congestive heart failure, arterial hypertension, edema syndrome, alcoholism, diverticulitis, diabetes mellitus, induced acute hepatic porphyria, in the postoperative period, and the elderly. During treatment with the drug, systematic monitoring of liver function should be carried out. If clinical symptoms of liver disease appear, as well as if abnormalities in liver function tests persist or worsen, the use of Dicloran® should be discontinued. When using the drug, gastrointestinal bleeding may occur or a gastrointestinal ulcer may develop, sometimes complicated by perforation. These complications are not necessarily preceded by warning symptoms or a history of peptic ulcer disease. In those rare cases when patients taking Dicloran® develop these complications, the drug should be discontinued. During the use of Dicloran® tablets, it is recommended to monitor the peripheral blood picture, kidney function, and conduct a stool test for occult blood. Dicloran®, like other non-steroidal anti-inflammatory drugs, may temporarily inhibit platelet aggregation. Therefore, careful appropriate laboratory monitoring is necessary in patients with hemostasis disorders. During treatment with the drug, alcohol consumption is not recommended. Features of the effect of the drug on the ability to drive a vehicle or potentially dangerous mechanisms. Patients taking the drug must refrain from activities that require increased attention and rapid mental and motor reactions.

Storage conditions

List B.: In a place protected from light, at a temperature not exceeding 30 °C.

Best before date

36 months

ATX classification:

M Musculoskeletal system

M01 Anti-inflammatory and antirheumatic drugs

M01A Non-steroidal anti-inflammatory drugs

M01AB Acetic acid derivatives

M01AB05 Diclofenac

pharmachologic effect

Diclofenac belongs to the group of NSAIDs (non-steroidal anti-inflammatory drugs). The action is based on the suppression of the production of prostaglandin synthetase, an enzyme necessary for the synthesis of prostaglandins. The drug eliminates pain, fever, swelling and other signs of inflammation. The active substance prevents platelet aggregation. The analgesic effect is associated with a decrease in the susceptibility of pain receptors to irritating factors. This is achieved by reducing the amount of inflammatory mediators.

Diclofenac belongs to the group of NSAIDs (non-steroidal anti-inflammatory drugs).

Pharmacodynamics

When administered orally, diclofenac is rapidly absorbed into the blood. Eating food can slow down absorption, but does not suppress it. The maximum concentration of the active substance in the blood is reached after an hour. To ensure a therapeutic concentration of the drug in the joint fluid, 120 minutes are required. When applied externally, the analgesic effect occurs within 30-40 minutes.

Pharmacokinetics

When taken orally, the drug penetrates the kidneys and liver, where it is converted into metabolites with less activity. The half-life is 2-6 hours. Diclofenac leaves the body both in urine and feces.

Diclofenac leaves the body in feces.

Dicloran gel

Price from 200 rub.

Non-hormonal anti-inflammatory, decongestant, analgesic drug.

Application – arthritis, radiculitis, myalgia.

Analogues - Voltaren, Clodifen, Dicloran Plus. You can find out more about analogues, their prices, and whether they are substitutes at the end of this article.

Today we’ll talk about Dicloran gel. What is this product and how does it affect the body? What are the indications and contraindications? How and in what doses is it used? What can be replaced?

What kind of gel

Dicloran gel, a drug related to non-steroidal anti-inflammatory drugs.

It is used externally, and when used, pain in soft tissues is reduced, inflammation and swelling are eliminated.

Dicloran contains:

diclofenac diethylamine;
methyl salicylate;
menthol;
linseed oil.

Auxiliary components include:

lemon acid;
monohydrate;
benzyl alcohol;
ricin oil;
carbomer homopolymer.

Pharmacological properties

The components of Dicloran have the following effects:

diclofenac helps eliminate pain;
flaxseed oil helps reduce inflammation;
menthol irritates the nerve endings and through this effect has a local cooling and mild analgesic effect.

The drug helps reduce inflammation and pain in the joints, reduces limited range of motion in the morning, and swelling of the joints.

Pharmacodynamics and pharmacokinetics

Methyl salicylate and diclofenac are NSAIDs. Its action is based on the ability to inhibit the production of prostaglandins and thus reduce the severity of pain in soft tissues, signs of inflammation and swelling.

The active substances of Dicloran are metabolized in the liver parenchyma. The main part of the modified components of the drug is excreted in the urine, the rest is excreted in the feces.

Indications for use

The use of Dicloran is justified in situations where the patient needs treatment:

inflammatory and destructive-degenerative diseases affecting the joint capsule - arthritis, osteoarthritis, radiculitis;
traumatic injury to muscles, ligaments or joints.

Contraindications

Dicloran should not be used if:

hypersensitivity to the components of the drug and other NSAIDs;
third trimester of pregnancy;
diseases caused by the use of components affecting cyclooxygenase.

Directions for use and dosage

The gel should be applied in a thin layer to the entire affected area 2-3 times a day and rubbed in with light strokes.

After using the gel, you should wash your hands.

In childhood, during pregnancy and pregnancy

The instructions for use indicate that Dicloran can be used in the 1st and 2nd trimester of pregnancy under the systematic supervision of a physician. During the third trimester and the period of breastfeeding, you should stop using it.

The drug is used in pediatric practice in children over 14 years of age.

If you use Dicloran for more than 7 days or if the symptoms of the disease intensify, you must inform your doctor.

Side effects

Adverse reactions caused by Dicloran include:

allergic reactions - from the immune system;
itching, burning, urticaria, erythema, hyperthermia - from the skin;
shortness of breath, attacks of bronchial asthma - from the respiratory system.

special instructions

The drug is strictly prohibited from being applied to damaged skin surfaces, wounds or mucous membranes.

Overdose

An overdose of Dicloran is unlikely due to low systemic absorption when the drug is used externally.

Throughout the entire period of use of the gel, no drug overdoses were recorded.

Drug interactions

Drug interactions have not been studied due to its low systemic absorption.

Analogs

Dicloran analogues that are similar to it in active ingredients include:

Voltaren;
Dicklosafe;
Dicloran plus;
Ortofen.

According to the mechanism of action, Clodifen and Diclak gel, Feloran correspond to it.

Source: https://mazikrem.ru/dikloran/

What does Dicloran help with?

The drug is prescribed for:

inflammatory and degenerative processes in joints (osteochondrosis, rheumatoid arthritis, ankylosing spondylitis, spondyloarthrosis);
rheumatic lesions of soft tissues;
gouty inflammatory processes;
back pain;
postoperative pain syndrome;
inflammatory and infectious diseases of the vagina;
post-traumatic pain syndrome (with bruises, fractures, wounds);
biliary and renal colic;
toothaches.

Indications for use

The drug Collargol is recommended for the treatment of ENT diseases. The following situations are identified in which a medication is prescribed for use in the nose:

Protracted chronic rhinitis.
Purulent sore throat, progressing to the chronic stage.
Sinusitis of an infectious nature.
With the growth of adenoids.
Pharyngitis.

Contraindications

The list of contraindications to the use of Dicloran includes:

individual intolerance to the components of the drug;
allergic skin rashes;
allergic rhinitis;
peptic ulcer of the stomach and duodenum;
diseases of the hematopoietic system.

Overdose

It is extremely difficult to provoke an overdose from Dicloran. Because the active components of this drug are extremely poorly absorbed into the skin, it is almost impossible to cause negative consequences.

If you use the gel too much or too often, you are likely to experience a number of side effects.

Most often, patients complain of redness or rashes on the skin, nausea and vomiting. In this case, treatment should be stopped.

In rare cases, Dicloran components enter the body. In this case, it is necessary to call an ambulance as soon as possible. Specialists will lavage your stomach and then give you the required amount of activated carbon.

Additionally, diuresis is performed to cleanse the blood of accumulated toxins. If necessary, symptomatic therapy is carried out.

Directions for use and dosage of Dicloran

The injection solution is injected into the gluteal muscle. The daily dose is 75 mg. In case of severe pain, it is increased by 2 times. Injections are given every 12 hours. On the third day they switch to taking tablet forms of Dicloran. The tablet is swallowed whole, washed down with plenty of boiled water. It is recommended to take the drug before meals. The daily dose (150 mg) is divided into 3 applications. The ointment is applied to clean skin over the affected areas 3-4 times a day in an amount of 1-2 g.

Collargol nasal drops: instructions for use for adults and children, analogues

The pharmacy sells a large number of antiseptics. One of them is Collargol - drops recommended for instillation into the nose for various diseases in otolaryngology, as well as dermatology and for the treatment of pathologies of the organs of vision. Before use, it is recommended to read the instructions and clarify the indications for use and contraindications.

Collargol is a drug that belongs to the group of antiseptics. It contains albumin and colloidal silver.

The drug is sold in powder form, which must be dissolved in liquid before use. Only after this a colloidal solution of Collargol is formed. It has a weak balsamic aroma and a transparent consistency, without impurities or a specific shade.

You can buy pre-prepared drops at the pharmacy. But before purchasing, the pharmacist will need to explain for what purpose the medicine is needed: to treat the organs of vision or for instillation into the nose for ENT diseases. This is necessary to dilute the powder to the desired consistency.

Silver preparations are effective antiseptic (disinfecting) agents.

The medicine Collargol®, which belongs to the colloidal silver solution, is often used as part of complex therapy for erysipelas, inflammation of the outer eye membranes (conjunctivitis), chronic inflammation of the lacrimal sac (dacryocystitis), soft chancre, paraproctitis, adenoiditis and sinusitis (Collargol nasal drops ® can be buried even for children), etc.

Collargol® for newborns is often prescribed as part of complex therapies for dacryocystitis.

Collargol® is an effective bactericidal antiseptic.
In undissolved form, Collargol® is produced in the form of black-green or black-blue small plates, characterized by a pronounced metallic luster.
Upon contact with water, Collargol® dissolves and forms colloidal solutions of silver.

At the same time, Collargol® plates swell and gradually dissolve, leading to the formation of rapidly collapsing sols.

In this regard, Collargol® solutions are never prepared in reserve.

The shelf life of Collargol® in solution does not exceed thirty days.

Collargol® solution is quite easy to prepare (provided that high-quality plates are used). Sometimes, to speed up dissolution, the plates are first ground in a mortar.

Solutions for external use are filtered through cotton wool. Solutions for washing wounds, microenemas, etc., are passed through filters made of ash-free paper or through glass filters.

Collargol® composition

In prepared solutions of Collargol® for microenemas, rinses, drops, etc. contains seventy percent silver and thirty percent protective albumins (sodium salts of protalbic and lysalbic acids).

Albumins are added to Collargol® solutions to keep silver molecules in an active state, since the resulting sols are easily destroyed in the presence of acids or salts of heavy metals.

Most often, prepared solutions are prescribed in the form of 1-2% of drugs for instillation into the eyes, nose, or douching. According to indications, more concentrated solutions of the drug can be used.

For younger patients, the solution is used in concentrations of up to two percent.

The prescription for the medicine is written by the attending physician. It must be remembered that solutions for external use cannot be used for eye infections or for douching.

Rp.: Sol. Collargoli 0.2 percent, one hundred milliliters

DS Clean wounds.

Rp.: Sol. Collargoli three percent, ten milliliters D.S. 5 drops each. into the nasal passage, twice a day.

The product is available in the form of small plates or powders. Subsequently, other dosage forms of the drug are made from the raw materials, according to the prescription prescribed by the doctor.

Most often, the drug is used in the form of:

eye drops (two, three, five percent solution);
ointments at five and fifteen percent;
solutions for rinsing, nasal instillation and external use in the form of 0.2, 1.2% solution.

1-3 percent solutions can be used in the form of ophthalmic drops. The product is used one to two drops at a time. every six to twelve hours.

In ENT practice, they can use a 1-3 percent solution of five drops twice a day or two or three drops. every six to eight hours.

When treating soft chancre, erysipelas or lymphangitis, Collargol® ointments can be applied to the affected area every 12-24 hours.

When treating purulent wounds, 0.2-2% solutions are used; for microenemas and instillations of the bladder, 0.2-2% solutions of the drug are used.

The medicine Collargol, which belongs to the colloidal silver solution, is often used as part of complex therapy for erysipelas, inflammation of the outer eye membranes (conjunctivitis), chronic inflammation of the lacrimal sac (dacryocystitis), soft chancre, paraproctitis, adenoiditis and sinusitis (Collargol nasal drops can even children can bury themselves), etc.

Collargol for newborns is often prescribed as part of complex therapies for dacryocystitis.

Collargol is an effective bactericidal antiseptic.

In undissolved form, Collargol is produced in the form of black-green or black-blue small plates, characterized by a pronounced metallic luster.

Upon contact with water, Collargol dissolves and forms colloidal solutions of silver.

At the same time, Collargol plates swell and gradually dissolve, leading to the formation of rapidly collapsing sols. In this regard, Collargol solutions are never prepared in reserve.

The shelf life of Collargol in solution does not exceed thirty days.

Special instructions for Dicloran

In some cases, the dosage of the drug is adjusted. Sometimes the use of Dicloran is abandoned.

During pregnancy and lactation

Diclofenac may have a negative effect on the development of the fetus, so it is not prescribed to pregnant patients. If treatment is necessary during lactation, breastfeeding is temporarily suspended.

Is the drug suitable for children?

Medicines containing diclofenac are contraindicated in patients under 18 years of age.

What to do if Dicloran gets into your mouth?

In this case, the oral cavity is washed with plenty of water. In case of accidental ingestion, consult a doctor.

Effect on concentration

People undergoing treatment with Dicloran should refrain from driving a car or operating complex machinery.

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Rheopolyglukin Solution for infusion
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** The Drug Directory is intended for informational purposes only. For more complete information, please refer to the manufacturer's instructions. Do not self-medicate; Before starting to use Dicloran, you should consult a doctor. EUROLAB is not responsible for the consequences caused by the use of information posted on the portal. Any information on the site does not replace medical advice and cannot serve as a guarantee of the positive effect of the drug.

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** Attention! The information presented in this medication guide is intended for medical professionals and should not be used as a basis for self-medication. The description of the drug Dicloran is provided for informational purposes and is not intended for prescribing treatment without the participation of a doctor. Patients need to consult a specialist!

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Side effects and overdose

The following undesirable consequences may occur during the use of Dicloran:

neurological disorders (headaches, dizziness, chronic fatigue, irritability, insomnia, depressive and mental disorders, double vision);
cardiovascular disorders (decrease in the number of platelets and leukocytes, chest pain, rapid heartbeat, arterial hypertension);
signs of damage to the gastrointestinal tract (stomach pain, increased gas formation, non-infectious hepatitis, ulceration of the intestinal walls, intestinal spasms, aphthous stomatitis);
dysfunction of the excretory system (edema, presence of blood and protein in the urine, nephrotic syndrome);
skin manifestations (rashes such as urticaria and erythema, bullous rash, eczema, increased sensitivity to sunlight, baldness);
other side effects (infiltrates at injection sites, redness and burning of the skin when using the cream, asthmatic attacks, anaphylactic shock).

Precautionary measures

In order for the patient to experience exceptionally positive changes from the use of Dicloran, treatment should be approached with extreme caution. Adhere to the following rules:

Do not apply the medicine to open wounds - this will cause a serious allergy;
Make sure that the active ingredients of the medicine do not come into contact with your eyes, nose or mouth. If this happens, rinse the cavities with copious amounts of water;
Please note that the composition contains propylene glycol. This substance can cause a mild allergic reaction;
You should not make a bandage or compress from this gel;
If rash or itching occurs, therapy should be stopped immediately;
After applying the medicine, wash your hands thoroughly;
Please perform a sensitivity test before use.

To prevent the development of side effects, it is not recommended to use Dicloran simultaneously with other non-steroidal anti-inflammatory drugs. This can cause toxic effects on the body.

It is also prohibited to use Dicloran while taking any anticoagulants - taking the drug significantly increases the risk of bleeding.

Before using the drug, you should definitely consult with your doctor.

Drug interactions

With other drugs

The combined use of Dicloran and other non-steroidal anti-inflammatory drugs is not recommended. Simultaneous administration of the drug with anticoagulants increases the likelihood of bleeding and hemorrhage. The drug increases the toxicity of cardiac glycosides. Diclofenac slows down the excretion of water and sodium, reducing the effectiveness of diuretics. The simultaneous use of Dicloran with cyclosporines can lead to kidney damage.

Alcohol compatibility

The administration of the drug cannot be combined with the consumption of alcoholic beverages.

Interaction with other tools

Collargol does not have the ability to be absorbed and does not penetrate into the systemic circulation. Locally it does not react with other drugs. It is undesirable to instill Collargol when using sodium chloride, novocaine, hexamethylenetetramine, iodides, and aocaloid salts. Collargol is also not used with medications containing electrolytes, ethyl alcohol, and adrenergic agonists. In case of simultaneous treatment with other drugs in the form of eye drops or ointments, an interval of 15 minutes should be observed between their instillations.

Conditions for dispensing from pharmacies

Is it sold without a prescription?

Tablets and injections based on diclofenac are not available without a prescription. The ointment can be purchased without a prescription.

Dicloran gel can be purchased without a prescription.

What is the price?

20 g of gel for external use costs 270 rubles. 20 tablets will cost 150 rubles. The average price of 5 ampoules of injection solution is 190 rubles.

Reviews from doctors

Valeria, 35 years old, Kaluga, therapist: “This gel is an effective non-hormonal anti-inflammatory agent containing diclofenac. The drug quickly eliminates joint pain, relieves swelling and a feeling of stiffness. For joint diseases, I recommend using the ointment together with tablet forms of the drug.”

Natalya, 43 years old, Elabuga, orthopedist: “I often prescribe Dicloran tablets for injuries and diseases of the musculoskeletal system. They have a prolonged effect and help quickly get rid of pain. Due to the presence of a large number of side effects, I do not recommend using them for more than a week.”

Buying Collargol: where and which one?

Due to the relatively short shelf life, not exceeding 30 days, pharmaceutical companies cannot establish industrial production of Collargol. If in the story with Protargol, experts nevertheless found a loophole, coming up with a solid, stable form of silver proteinate, and releasing ready-made Sialor protargol, then with Collargol there is no such possibility. Due to the too high concentration of highly active ionized silver, this drug is doomed to be prepared extemporaneously, that is, exclusively in pharmacies. Therefore, you need to specifically look for Collargol solution or ointment in those pharmacies that, even in our difficult times, have preserved the traditions of prescription drug manufacturing. Depending on the purpose, several forms of the drug are available:

To wash wound surfaces, 0.2–1% Collargol solutions are used externally.
For local use in urological and ENT practice, drugs with a concentration of 1–2% are prescribed. They are also used in pediatrics, for the treatment of diseases of the nasopharynx (adenoiditis or bacterial rhinitis);
In ophthalmology, the most concentrated solutions are used. Depending on the severity of the disease and the age of the patient, 2, 3 or even 5% Collargol eye drops can be used;
In dermatology, as well as for lymphangitis, Collargol ointment is prescribed; its standard concentration is 15%.

When ordering Collargol at a pharmacy, pay the pharmacist's attention to the concentration of the medicine or indicate how you will use it. This will avoid mistakes and may even prevent side effects that occur when using the drug with incorrect dosages.

Particular caution should be exercised by those purchasing eye drops. The fact is that all ophthalmic forms must be sterile.

It is strictly forbidden to replace Collargol eye drops with a solution for external use.

When purchasing a drug for the treatment of ophthalmic diseases, pay attention to the label. It should indicate the form - “eye drops”, as well as the indication “sterile”.

Patients' opinions

Anastasia, 40 years old, Sevastopol: “I suffer from chronic osteochondrosis, so back pain occurs every 3 months. They are especially strong after exercise. In such cases, a gel based on diclofenac helps. I apply it morning and evening, it helps get rid of the unpleasant sensations that interfere with working during the day and sleeping at night.”

Dmitry, 33 years old, Yaroslavl: “Despite my young age, I often experience lower back pain. I work at a construction site, and discomfort occurs after carrying heavy objects. Mom recommended a gel with diclofenac, which saves her from joint pain. I apply it at night, after which I cover my back with a woolen scarf. By morning the discomfort goes away.”