According to statistics, inflammatory diseases of the uterus and appendages in 20 cases out of 100 lead to persistent female infertility. Most often, the cause of this is adhesions that arise as a result of improper treatment or appear after surgical interventions.
To restore the patency of the fallopian tubes, eliminate congestion and improve blood supply to the pelvic organs, effective anti-inflammatory and resorption therapy is required. One of the modern drugs used for such treatment is Distreptase suppositories. They allowed many women to get rid of reproductive problems and, finally, feel the joy of long-awaited motherhood.
Pharmacodynamics and pharmacokinetics
Distreptase suppositories contain 2 active components:
- Streptokinase is a fibrinolytic enzyme that promotes the transfer from the inactive form of the proenzyme plasminogen to its active form - plasmin , aimed at dissolving fibrin fibers of blood clots.
- Streptodornase is a biocatalyst for the dissolution of pus and other dead cells without negatively affecting the integrity and functioning of healthy cells.
Thus, the drug provides access to antibacterial agents directly at the site of inflammation.
Pharmacokinetics have not been studied.
Indications for use
In what cases is it necessary to use Distreptaza suppositories? The instructions say that the medication is often prescribed after a variety of surgical interventions. The goal of such therapy is to prevent the formation of adhesions and relieve inflammation.
Medicine is often prescribed to women for various diseases of the pelvic organs. Indications for use include adnexitis, salpingitis, metritis and other inflammatory processes. It is worth noting that with timely use, the drug will help to avoid quite serious health problems in the future.
Suppositories are prescribed for inflammation of hemorrhoids of various locations, during the treatment of coccyx cysts, and so on. In men, the composition can be used for inflammation of the prostate and in the complex treatment of diseases of the pelvic organs.
Distreptase suppositories, instructions for use (Method and dosage)
The instructions for Distreptaza involve the rectal use of Distreptaza suppositories with the deepest possible administration.
The dose is calculated depending on the severity of inflammation. Highlight:
- Severe degree with the prescription of 1 suppository three times a day for 3 days, then 1 suppository twice a day for 3 days, and then 1 suppository once a day for 3 days.
- Moderate and mild severity , in which the following regimens are followed: 1 suppository twice a day for 3 days, then 1 suppository once a day for 4 days or twice a day for 2 days.
Dystreptase rectal suppositories. 15000iu 1250iu packaging No. 6
Distreptase Distreptaza International nonproprietary name (INN) Streptokinase + Streptodornase Streptokinaza + Streptodornaza
Dosage form Rectal suppositories.
Composition for 1 suppository: Active substance: streptokinase - 15000 IU 10%, streptodornase - 1250 IU-20000 IU Excipients: liquid paraffin (Paraffin oil) - 0.16 g, neutral fat (Vitepsol H15) - 1.84 g
Information on excipients For the manufacture of suppositories, a candle base is used, consisting of excipients: - neutral fat (Vitepsol H15) - liquid paraffin (paraffin oil).
General characteristics of the drug Physico-chemical properties The shape of cones or torpedoes with a pointed tip; the surface is uniform without spots and bumps, air bubbles, cracks and mechanical damage; color creamy white.
Pharmacotherapeutic group Combined enzyme preparation containing streptokinase. ATS code: B06AA55.
Pharmacological properties of the drug Pharmacodynamics DISTREPTASE in the form of suppositories contains two active ingredients: Streptokinase and Streptodornase. Streptokinase is an activator of the proenzyme plasminogen contained in human blood, which, under the influence of streptokinase, is converted into plasmin, which has the property of dissolving human blood clots. Streptodornase is an enzyme that exhibits the ability to dissolve sticky masses of nucleoproteins, dead cells or pus, without affecting living cells and their physiological functions. DYSTREPTASE suppositories are used as a stand-alone or as an auxiliary drug. The drug can improve access to the site of inflammation of antibiotics and other chemotherapeutic agents. Pharmacokinetics There is no data confirming the systemic absorption of the active components of the drug during rectal administration of DISTREPTASE suppositories
Indications for use of the drug DISTREPTAZE in the form of suppositories is used in adults as part of complex therapy in the following cases: 1. Chronic salpingoophoritis. 2. Postoperative infiltrative changes. 3. Endometritis. 4. Hemorrhoids with acute and chronic course. ; 5. Perirectal abscesses and fistulas with extensive inflammatory infiltrate. 6. Purulent caudal cysts. The effectiveness of DYSTREPTASE in inflammatory diseases of the pelvic organs in women has not been demonstrated in placebo-controlled randomized trials. The use of the drug is based on experience in clinical use.
Method of administration and dosage: After removing the suppository from the blister cell, it must be inserted deep into the rectum. The dosage depends on the type and intensity of the inflammatory process. Use as directed by your doctor. In case of severe disease in adults: 1 suppository 3 times a day for the first 3 days; 1 suppository 2 times a day for the next 3 days; 1 suppository 1 time per day for the next 3 days. For mild to moderate severity of the disease in adults: 1 suppository 2 times a day for 3 days; 1 suppository 1 time a day for the next 4 days, or 1 suppository 2 times a day for 2 days. On average, 8-18 suppositories are used per course of treatment. The average duration of treatment is 7-10 days. Any remaining unused product or waste must be disposed of in a manner consistent with local regulations.
Side effects Sometimes allergic reactions, increased body temperature and a tendency to bleed may occur. If any atypical reactions occur, be sure to consult your doctor about the possibility of continuing to use the drug!
Contraindications to the use of the drug: Hypersensitivity to any component of the drug, hemorrhagic diathesis, early period after surgery on the pelvic and rectal organs. The drug should not come into contact with a fresh wound covered with scab, as well as with a freshly applied suture, as this can cause relaxation of the sutures and, as a result, hemorrhage from the wound.
Overdose There are no known symptoms of overdose.
Information about the patient's actions if the next dose of the drug was missed. If the next dose of the drug was missed, do not use a double dose.
Precautionary measures Features of the use of the drug by certain categories of patients (children, pregnant or breastfeeding women, elderly people, patients with certain types of pathologies) DYSTREPTASE in the form of suppositories cannot be used by pregnant women, as well as during breastfeeding. There are no data regarding the specifics of use in persons with impaired liver and kidney function, as well as in elderly patients. Data on the safety and effectiveness of the drug in pediatric practice are limited, therefore its use in children under 18 years of age is not recommended.
Effect of the drug on the ability to drive a car and work with dangerous mechanisms DYSTREPTASE does not affect the ability to drive a car and work with dangerous mechanisms.
Interaction with other drugs DISTREPTAZE should not be used concomitantly with anticoagulants because local bleeding may occur. If you are taking other medications, be sure to tell your doctor!
Conditions and shelf life The place for storing the medicine should be inaccessible and invisible to children. Store at a temperature of 2C - 8C (in the refrigerator). Do not freeze. Shelf life: 3 years. Do not use after the expiration date indicated on the package.
Conditions for dispensing from pharmacies The drug DISTREPTAZE is dispensed with a doctor's prescription.
Packaging 6 rectal suppositories in a blister, 1 blister of 6 pieces. PVC/PE blister in a cardboard box. 5 rectal suppositories in a blister, 2 blisters of 5 pieces. PVC/PE blister in a cardboard box.
Information about the manufacturer BIOMED-LUBLIN" Wytwurnia Surowicz and Szczepionek Spulka Akcyina st. Universitetskaya 10, 20-029 Lublin, Poland Exclusive representative: Alpen Pharma AG Bern, Switzerland
Analogs
Level 4 ATC code matches: Biostrepta
Actilyse
Gemaza
Fibrinolysin
Thrombovazim
Streptokinase
- Aktilise
- Biostrepta
- Metalize
Composition and pharmacological properties
“Distreptaza” suppositories are a combination drug. The main active ingredients of this product are streptodornase and streptokinase, which have special enzymatic characteristics. The combination of these ingredients provides the drug with many specific pharmacological capabilities:
- dissolving blood clots, preventing the occurrence of blood clots;
- splitting proteins contained in plasma and accelerating the process of dissolving clots;
- dissolution of accumulations of keratinized cells and resorption of purulent contents.
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In combination, the active components of the drug have antithrombotic, absorbable and anti-inflammatory effects.
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Each suppository contains 15,000 IU of streptokinase and 1,250 IU of streptodornase. In addition to these ingredients, Distreptaza suppositories include solid fat and mineral oil.
Distreptase price, where to buy
The price ranges from 1400 to 1600 rubles for 6 suppositories in a blister. The price of Distreptase suppositories is indicated taking into account the dosage of 15,000 IU + 1,250 IU; one course of treatment usually lasts on average 7 to 10 days and requires from 8 to 18 suppositories.
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LuxPharma* special offer
- Dystreptase suppositories rect.
2g N6 2980 rub. order
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- Dystreptase 2 g N6 suppositories Biomed-Lublin Witturnia Surowiec i Szczepionek Spulka Akcijna, Poland
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- Dystreptase suppository Supp.dystreptase rect. 2g No. 6 Poland, Biomed-Lublin
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Contraindications
The drug "Distreptaza" (suppositories) cannot be used if you are hypersensitive to its components. The medicine is not prescribed during pregnancy and lactation. In the latter case, breastfeeding is stopped for the duration of treatment.
It is prohibited to administer the composition to children under 18 years of age without appropriate doctor’s prescription. The drug should not be applied to open wounds or fresh stitches. As you know, the medication promotes the resorption of scabs. This may cause bleeding and suture dehiscence.
Side effects
Negative reactions from using the medication can manifest themselves as:
- allergies;
- increased body temperature;
- intensification of existing bleeding or its development.
If such symptoms occur, you should immediately stop using the drug and consult a specialist.
Candles should be stored in the refrigerator until use. The drug does not reduce concentration and does not affect the patient’s performance and control of vehicles and complex mechanisms.
If there are any contraindications to the use of the product, you should definitely consult a specialist.
Dystreptase in the treatment of adhesions
The substance, entering the body, relieves inflammation and resolves the collected purulent and other types of fluid.
If adhesions are detected within 1 month after their formation, it is recommended to use Distreptase as an independent medicine.
For old adhesions, treatment is carried out comprehensively using additional drugs related to proteolytic effects (Wobenzym).
Medicinal properties
Dystreptase is a drug with a combined composition; its therapeutic effect is due to the specific properties of each of the components. Streptokinase promotes the activation of the proenzyme plasminogen, which is present in human blood; under the influence of streptokinase, transformation into plasmin is observed. It is this substance that has the special property of dissolving blood clots.
Streptodornase is, first of all, an enzyme; it helps to dissolve the accumulation of nucleoproteins, purulent secretions of dead cells, without affecting living cells and their functions.
The drug promotes better penetration of antibacterial drugs and chemotherapeutic drugs to the inflammatory focus.
Interaction with other drugs
Suppositories have the opportunity to be included in the list of medications necessary for complex therapy, therefore their interaction with other medications is revealed as positive, without negative consequences.
The substance specifically contacts with antibacterial medications and preparations, increasing their properties and therapeutic capabilities.
Active substances facilitate the path of antibiotics to the site of inflammation, thereby accelerating the effect and obtaining a therapeutic effect.
Do not use suppositories with anticoagulants at the same time. The combination of drug groups will provoke the formation of local bleeding.
Application in gynecology
Dystreptase shows a positive effect in vaginosis, endometritis, salpingitis, adnexitis, vaginitis.
Bacterial vaginosis
After surgery to remove the fertilized egg from the tube during an ectopic pregnancy, treatment is carried out by installing suppositories. Thanks to therapy, while maintaining the integrity of the pipe, it is possible for it to continue to function normally. Existing adhesions dissolve, which leads to the functionality of the pipe.
