"Distreptaza" suppositories: instructions for use, reviews

Currently, many drugs are available in the form of rectal suppositories. Some remedies help cope with inflammation and reduce body temperature, others affect the condition of the blood and blood vessels. Most often, Distreptaza suppositories are prescribed for rectal use. Instructions for using the drug and a detailed summary will be presented to your attention in the article. You can also find out about the reviews that this composition has.

Composition and mechanism of action

Dystreptase suppositories act widely, including the abdominal cavity and urinary system. This effect is due to the components of the drug: streptokinase and streptodornase.

The ingredients have specific enzyme-type characteristics. Their combination allows the medication to carry out a list of actions on the body. Excipients to enhance the effect are paraffin oil and Witepsol N15.

Suppositories are creamy-whitish in color. The surface should be free of any stains, abnormally colored bumps, raised air bubbles, mechanical cracks or other dents.

Thanks to its unique composition, Distreptase has the following effects on the patient’s body:

• Dissolving clots formed in the lymph, which blocks the formation of blood clots
• Breakdown of proteins present in the bloodstream, which stimulates the acceleration of the dissolution of clots
• Stimulates the process of dissolution of formations of keratinized cellular structures
• Elimination of purulent contents formed due to the process of inflammation in soft tissues

The drug has an antithrombotic effect and anti-inflammatory effect. The medication is necessary for the resorption of accumulated fluid of various etiologies; it provides local anesthesia without spreading to the systemic bloodstream.

Pharmacological action of Dystreptase

One of the main enzymes of any human body is Dystreptase, which can destroy the substances of dead cells and pus nucleoproteins. A distinctive feature of this enzyme is that it does not affect the work and functioning of other living cells.

As the instructions for Distreptase show, the main active elements of this drug are streptokinase and streptodornase (promotes successful blood thinning). As for the first fibrinolytic enzyme, it has long been known in thrombolytic treatment. Streptokinase, having an internal and external effect on blood clots that arise in the vessels, destroys them, thereby restoring normal blood flow. Streptokinase causes tissue fibrinolysis. This is due to binding to profibrinolysine. The result of this process is the activation of a proteolytic enzyme that dissolves fibrin fibers in blood clots, which entails the degradation of fibrinogen.

Reviews of Distreptase note that it significantly improves the effect of antibiotics and chemotherapy drugs on various foci of the inflammatory process.

In addition, when using Distreptase suppositories, the diseased area of ​​the body becomes healthier quite quickly, which means the general condition of the body improves.

Indications for use

Treatment with Dystreptase must be carried out as part of a complex treatment.

There are diseases that can be successfully treated with rectal suppositories:

• Chronic adnexitis
• Salpingitis, occurring over a long period of time, listed as chronic
• Endometritis
• Ovarian cyst
• Haemorrhoids
• Advanced salpingoophoritis
• Infiltrative processes after surgery
• Adhesions localized in the abdominal cavity
• Inflammatory process of the tissue that is located around the rectum
• Manifestation of fistulas or intestinal abscesses

Dystreptase is recommended to eliminate swelling during the development of pathogenic processes.

Analogs

Aktilise

Boehringer Ingelheim Pharma GmbH, Germany

Price from 19,000 to 27,899 rubles.

A thrombolytic drug that is used to restore vascular blood flow due to thrombus lysis during myocardial infarction and ischemic stroke. The main component of the drug is alteplase. Available in powder form for the preparation of infusion solution.

Pros:

• Effective for pulmonary embolism
• Fibrin specificity
• Rarely provokes arterial hypotension.

Minuses:

• Expensive
• May provoke arrhythmia
• Contraindicated in neoplasms of the central nervous system.

Biostrepta

Biomed-Lublin, Poland

Price from 952 to 1348 rubles.

Bistrepta is an analogue of Distreptase, the composition of the active components is identical. It is prescribed for the inflammatory process occurring in the pelvis, and is also used in complex therapy of infertility. Available in the form of rectal suppositories.

Pros:

• Helps eliminate benign ovarian cysts
• Rarely causes adverse reactions
• Effective for hemorrhoids.

Minuses:

• Not for children under 12 years of age
• Contraindicated during the 2nd trimester of pregnancy
• Dispensed by prescription.

Instructions for use

Suppositories are prescribed only for rectal treatment. The suppository is inserted as deeply as possible. To carry out the treatment process, the input rate is strictly adjusted by the attending physician based on the diagnosis, the severity of the disease and the personal characteristics of the patient.

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The standard dosage regimen is presented in the table.

On average, the treatment process is carried out in 7-18 dosages. The course is designed for 1-1.5 weeks.

Mode of application

How to use the medicine "Distreptaza" correctly? Suppositories are inserted exclusively into the rectum. In this case, it is necessary to first perform an act of defecation. If there is no stool for several days, it is recommended to perform an enema. The drug must be pushed as deep as possible into the anus.

The dosage of the medication is chosen by the doctor and depends entirely on the severity of the disease and accompanying symptoms. Suppositories are prescribed one at a time for administration. The frequency of application of the composition can be from one to three times a day. Duration of therapy is 5-10 days. If necessary and if there are appropriate indications, the course of treatment can be repeated after a certain period of time. This decision is made by the doctor.

Interaction with other drugs

Suppositories have the opportunity to be included in the list of medications necessary for complex therapy, therefore their interaction with other medications is revealed as positive, without negative consequences.

The substance specifically contacts with antibacterial medications and preparations, increasing their properties and therapeutic capabilities.

Active substances facilitate the path of antibiotics to the site of inflammation, thereby accelerating the effect and obtaining a therapeutic effect.

Do not use suppositories with anticoagulants at the same time. The combination of drug groups will provoke the formation of local bleeding.

Active components and active substances

For endometriosis, suppositories should contain:

1. Diclofenac. The substance can have anti-inflammatory, analgesic and antipyretic effects, as well as reduce the likelihood of blood clots and rheumatism. It is more active than ibuprofen and butadione. Contraindicated in pregnancy and lactation, heart failure and kidney and liver diseases.
2. Propolis. The natural glue produced by bees is included in many medicinal preparations. Suppositories with propolis for endometriosis will relieve inflammation, eliminate bacteria and infections, reduce temperature, and restore the regenerating and wound-healing function of cells. They are used in combination with other drugs. Despite the fact that you can prepare such a medicine yourself, it should only be used as prescribed by a doctor.
3. Ichthyol. The substance in the medicine is useful not only for endometriosis, but also for other diseases associated with inflammation. Ichthyol normalizes blood circulation, gets rid of infections and germs, and has an analgesic effect.
4. Sea ​​buckthorn . The berry contains many vitamins, carotenoids, oils and glycerin, which have a positive effect on the female reproductive system. Sea buckthorn suppositories (tampons soaked in oil) heal wounds, strengthen blood vessels, disinfect mucous membranes, regulate hormonal levels, and reduce the risk of tumor development. The medicine can be used to treat inflammation of the uterus, colpitis and for prevention, but only after consulting a gynecologist.
5. Progesterone. The substance and its analogues are part of hormonal drugs and are actively used during pregnancy. Accumulating in the uterus, the substance resumes the functioning of the endometrium, stimulates the accumulation of nutrients and restores reproductive function.
6. Longidaza. The component reduces swelling and inflammation, prevents new adhesions from forming, smoothes existing scars, prepares tissues for the penetration of nutrients and increases the effectiveness of hormonal therapy. Used in combination with other drugs, does not cause allergies.
7. Celandine. In folk medicine, this plant is used to eliminate inflammation and relieve pain. It contains an alkaloid, organic acid and tannins. The dosage is prescribed by a doctor, and violation of the recipe leads to allergic reactions, poisoning, etc.
8. Ismagen (woolly panzeria). The herb can dilate blood vessels and remove toxins. For endometriosis it will be an effective analgesic, anti-inflammatory and diuretic.

Modern drugs combine various active substances for greater effectiveness.

Application in gynecology

Dystreptase shows a positive effect in vaginosis, endometritis, salpingitis, adnexitis, vaginitis.

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After surgery to remove the fertilized egg from the tube during an ectopic pregnancy, treatment is carried out by installing suppositories. Thanks to therapy, while maintaining the integrity of the pipe, it is possible for it to continue to function normally. Existing adhesions dissolve, which leads to the functionality of the pipe.

Contraindications for the use of suppositories

In order to avoid side effects and worsen the situation, you must remember about contraindications to the use of suppositories. Insertion of suppositories vaginally or rectally is prohibited in the presence of the following factors:

• pregnancy;
• disturbances in the functioning of neuromuscular transmission;
• hematopoietic disorders;
• kidney or liver dysfunction;
• lack of normal tone of skeletal muscles and internal organs due to lack of general nutrition;
• heart failure;
• tachycardia;
• glaucoma;
• intolerance to components.

Dystreptase in the treatment of adhesions

The substance, entering the body, relieves inflammation and resolves the collected purulent and other types of fluid.

If adhesions are detected within 1 month after their formation, it is recommended to use Distreptase as an independent medicine.
For old adhesions, treatment is carried out comprehensively using additional drugs related to proteolytic effects (Wobenzym).

Pharmacy candles

You should not try to find the right drug yourself. Only a doctor can select and prescribe effective suppositories for such a disease.

Antican-endometrin

These suppositories are prescribed by the attending physician as part of general therapy for the treatment of endometriosis and hormonal disorders, to restore menstruation and prevent adhesions. During pregnancy, Antican is used to prevent miscarriage.

The preparation contains natural substances: celandine, sea buckthorn, calendula, elderberry, wormwood and lacunex.

Effect of use:

• elimination of bleeding;
• tissue healing;
• infection prevention;
• resorption of endometriosis foci;
• reduction of adhesions;
• relieving pain, spasms and inflammation.

Contraindicated for people allergic to bees and honey. Compatible with other drugs. The approximate course of treatment is from 1 to 2 months. Administered at night in the supine position.

ASD-2 (Dorogov candles)

Dorogova's antiseptic is used in alternative medicine to relieve symptoms such as:
The drug also supports the immune system and promotes tissue regeneration. Side effects include gastrointestinal disorders and local allergic reactions. Despite the fact that the medicine is classified as homeopathic, you should not prescribe your own dosage.

Suppositories for rectal use are white-yellow in color and about 10 mm in size. Basic properties:

• stimulation of immunity;
• fight against viruses;
• preventing the formation of tumors;
• elimination of pathogenic microorganisms;
• relieving inflammation.

Due to the fact that the drug contains cocoa butter, the suppositories are easy to administer and quickly dissolve. They are prescribed to pregnant women after 14 weeks, and there are no restrictions during lactation. Side effects include local allergies in the form of rash and itching. Combines well with antibiotics and chemotherapy drugs.

Suppositories have immunomodulatory and anti-inflammatory activity and are used as part of hormonal therapy.

• pregnancy and lactation;
• age up to 6 years;
• individual intolerance;
• allergy to lactose.

Before inserting suppositories, you must first empty your intestines. Although the drug is available without a prescription, it should not be used without consulting a specialist. When antibiotics are used together, the effectiveness of the latter decreases.

The medicine contains walnut extract and cocoa butter. Contains a complex of vitamins, organic acids and tannins.

• antibacterial;
• restorative;
• antisclerotic;
• astringent;
• hemostatic;
• wound healing and restorative.

Contraindicated for pregnant women, breastfeeding women and people with hyperthyroidism. It is used to treat various diseases, including gynecological ones. Suppositories reduce pain and normalize blood function.

Diclofenac

Suppositories contain the active substance diclofenac sodium. They have a cylindrical-conical shape and are white in color.

Prescribed by a doctor for pelvic inflammatory processes. It is prohibited to use when:

• any ulcerative lesions of the gastrointestinal tract;
• bronchial asthma;
• rectal bleeding;
• heart and kidney failure;
• liver diseases;
• hyperkalemia;
• under 16 years of age;
• pregnancy and lactation.

Side effects

The suppositories are well tolerated without causing side effects. But if the patient does not adhere to a certain dosage or does not take into account contraindications, the drug can negatively affect his well-being.

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The following side effects are identified:

• Increase in body temperature
• Possibility of bleeding
• Allergic reactions in the form of skin rash, severe itching and excessive redness of the drug injection area

If a symptom is identified or prerequisites for the formation of a reaction are detected, treatment with rectal suppositories is immediately stopped. After this, consult a doctor as soon as possible.

Side effects

In most cases, the use of Dystreptase is well tolerated by patients, side effects rarely develop. The most common side effects are:

• Dizziness;
• Allergic reactions;
• Inhibition of the blood anticoagulant system;
• Increased body temperature.

Patients should note that Distreptase may increase the likelihood of bleeding.

To date, there have been no cases of overdose with Distreptase.

Contraindications

The product can be used only after the presence or absence of contraindications has been determined. If the latter are detected, use of the product is strictly prohibited.

The following situations are identified in which the use of Distreptase is prohibited:

• Individual intolerance to active substances or hypersensitivity to one of them
• Diathesis of hemorrhagic type
• If a short period of time has passed after surgery on the pelvic organs and intestinal tubes
• During pregnancy, especially in the first weeks after conception
• During the period of natural feeding
• Childhood and adolescence, up to 18 years of age

The product must be used with caution when detecting hemorrhoids, both external and internal. The medication should also not be used if there are fresh scars or only healed wounds. Minor trauma provokes bleeding.

If the patient is prone to bleeding of any nature, the treatment process using Dystreptase should be discontinued.

During the therapeutic effect of rectal suppositories, the consumption of alcoholic beverages is strictly prohibited. The interaction of active substances and alcohol can lead to serious health consequences.

Dystreptase rectal suppositories (suppositories) 2g N6

Dosage form

Rectal suppositories, 6 pieces per pack.

Compound

1 suppository contains

Active substances: streptokinase 13,500 – 16,500 IU, streptodornase 1250 – 20,000 IU.

Excipients: vitepsol N15, paraffin oil.

Pharmacotherapeutic group

Other hematological drugs. Enzyme preparations.

Pharmacological properties

The drug contains two active substances: streptokinase and streptodornase. Streptokinase is an activator of the proenzyme plasminogen contained in human blood, and under the influence of streptokinase it is converted into plasmin, which has the property of dissolving human blood clots. Streptodornase is an enzyme that has the ability to dissolve sticky masses of nucleoproteins, dead cells or pus without affecting living cells and their physiological functions. The drug facilitates the access of antibiotics or chemotherapeutic agents to the site of inflammation.

Indications for use

- chronic salpingophoritis

— postoperative infiltrative lesions of the pelvic organs

- endometritis

- acute and chronic hemorrhoids

- perirectal abscess and fistula with extensive inflammatory infiltrate

- purulent caudal cysts

Directions for use and doses

Remove the suppository and insert deeply into the rectum.

The dosage depends on the type and degree of intensity of the inflammatory process.

In severe cases of the disease in adults:

• 1 suppository 3 times a day for the first 3 days;
• 1 suppository 2 times a day for the next 3 days;
• 1 suppository 1 time per day for the next 3 days.

For mild to moderate severity of the disease in adults:

• 1 suppository 2 times a day for 3 days;
• 1 suppository 1 time per day for the next 4 days,
• or 1 suppository 2 times a day for 2 days.

On average, 8–18 suppositories are used per course of treatment.

The average duration of treatment is 7 - 10 days.

Side effects

Sometimes

- allergic reactions

- increase in body temperature

- tendency to bleed

If any atypical reactions occur, be sure to consult your doctor about the possibility of continuing to use the drug!

Contraindications

- hypersensitivity to any component of the drug

— early period after operations on the pelvic and rectal organs

- hemorrhagic diathesis

- pregnancy

Drug interactions

Enhances the penetration of antibiotics and chemotherapy drugs into the site of inflammation.

Should not be used simultaneously with anticoagulants, as local bleeding may occur.

If you are taking other medications, be sure to tell your doctor!

special instructions

The drug should not come into contact with a fresh wound or suture, as this can lead to relaxation of the sutures and, as a result, bleeding from the wound.

While being treated with Dystreptaza, do not take any other medications (including those available without a prescription) without first consulting your doctor. Uncontrolled treatment can harm your health.

Use in pediatrics

There is no experience of use in children, because Clinical studies have not been conducted, so the drug is not recommended for use in children and adolescents under 18 years of age.

Pregnancy and lactation

There is no experience of use in pregnant and lactating women, because Clinical studies have not been conducted, so pregnant and lactating women are not recommended to use the drug.

Features of the effect of the drug on the ability to drive a vehicle or potentially dangerous mechanisms

Does not affect.

Overdose

Not identified.

Storage conditions

Store at temperatures from 2o C to 8o C (in the refrigerator).

Do not freeze!

Keep out of the reach of children!

Shelf life

3 years

Do not use after the expiration date stated on the package.

Conditions for dispensing from pharmacies

On prescription.

Dystreptase analogues

The following medications with a similar spectrum of action are distinguished:

• Aktilise
• Gemaza
• Wobenzym
• Lidaza
• Metro-Adnex-Inyel
• Galavit
• Fibrinolysin
• Metalize
• Biostrepta
• Longidaza
• Streptokinase
• Phlogenzyme
• Thrombovazim

All these medicines tend to repeat the effects of the original. And only one drug has identical active ingredients - Biostrepta.

Only the attending physician selects analogues. The patient cannot independently choose medications.

Patient reviews

Most patients (approximately 65-70%) respond positively to Distreptase. The remaining patients indicate that the effect is insufficient. Most often, such reviews are based on the fact that patients used the medication incorrectly, which caused side effects and negative treatment results.

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Valentina, 28 years old: The doctor prescribed Distreptase suppositories to me after I was admitted to the hospital for treatment for an exacerbation of salpingoophoritis and adnexitis. I had severe pain. I was prescribed to put suppositories in the morning and evening for 3 days, and then for another 4 days, 1 suppository per day. After just 2 days, the pain went away, and by the end of the treatment all discomfort ceased. I am pleased with the results, the effect of the treatment is still noticeable.

Elizaveta, 34 years old: Both of my pregnancies ended in caesarean sections. After the second, there were complications that affected my health. After a while, my cycle was disrupted, my periods began to come out brown and in smaller volumes. The doctor, after conducting an examination, discovered a thickening of the suture and prescribed 1 suppository for treatment with Distreptase suppositories for 10 days. I did not notice any side effects during the entire treatment period. The subsequent cycle was of normal volume, without painful syndrome. So far I am satisfied with the results of the treatment.

Anna, 27 years old: This winter I caught a cold on my ovary. I was treated for inflammation, the tests were normal, but I was constantly tormented by heaviness in the lower abdomen and pain. An ultrasound scan revealed adhesions. The doctor recommended Distreptase suppositories to me. My treatment lasted for 6 days, 1 suppository rectally. Having placed them, I gradually forgot about the pain. I am satisfied with the result of the therapy, it helped me.

Purposes of using suppositories for endometriosis

Due to pathological hormonal changes, the internal mucous layers of the uterus spread to nearby areas and into the organ cavity itself. This can lead to problems in the body and loss of reproductive function.

To prevent disease, candles are used, which differ in the method of exposure and purpose of use.

Vaginal suppositories are not always prescribed. In some cases, it will be more effective:

• rectal suppositories - placed in the anus;
• sticks inserted into the cervix or ureter.

All suppositories are completely absorbed within an hour, which is much faster than the tablet form of the drug. An allergic reaction occurs rarely. In addition to the medication, hormone therapy is prescribed in tablets or injections. Candles are:

1. Relieving inflammation. During endometriosis, prostaglandins are actively produced. These are biologically active lipid substances that stimulate the process of inflammation and cause pain. In order to suppress the work of prostaglandins, anti-inflammatory suppositories are used. They also have an anesthetic effect. One of the components of such drugs is indomethacin. It can have an analgesic effect, reduce temperature and increase tissue permeability.
2. Strengthening the immune system. The human body is capable of fighting inflammatory processes on its own if it functions correctly. But with a weakened immune system, the damage that occurs is not eliminated. Therefore, along with other medications, women are prescribed immunomodulatory suppositories. In order to produce the necessary proteins that can stop the development of the disease and eliminate the source of inflammation, suppositories containing interferon are prescribed.
3. Eliminating adhesions. Uterine adhesions, or intrauterine synechia, are fusions of the uterine walls that disrupt menstruation and lead to infertility. It is formed as a result of endometriosis and requires separate treatment. There are drugs whose action is aimed at destroying existing adhesions and preventing the formation of new ones. Such suppositories are prescribed vaginally or rectally, depending on the characteristics of the development of the disease.
4. Supporting hormone levels. The complex of general therapy may include hormonal suppositories. When used, hormones increase within 6 hours, and pathologies in the uterus caused by endometriosis are suppressed.

Price in Russia, where to buy

It is not possible to purchase the medicine on the territory of Russia; it is not registered. Pharmacy chains from Ukraine provide delivery services. Under such acquisition conditions, the cost of packaging will be on average 800-1400 rubles.

The table shows where and at what cost you can purchase Distreptase suppositories.

Thus, to neutralize painful discomfort in diseases of the reproductive system and organs located in the abdominal cavity, Distreptase suppositories are used. Only correct use and timely diagnosis will provide a positive therapeutic effect.

Aug 30, 2018Violetta Lekar