Vaginal suppositories Livarol - instructions for use in gynecology

All information on the site is for informational purposes only and requires additional consultation with your doctor. Livarol - what is it? Medicine related to antifungal (antimycotic) agents. Release form: suppositories for vaginal use. Livarol is used for the treatment of female pathologies. When introducing suppositories (SV), the active component begins to destroy fungi and normalizes the microflora. The action of Livarol also extends to pathogenic fungi. Its components are not absorbed into the blood and do not harm the body.

Description of the drug

Livarol suppositories are an antifungal and antimicrobial drug, the effect of which is directed specifically at the infected parts of the mucous membrane of the vagina and vulva.

1. Suppositories have minimal impact on the functioning of other body systems , since its constituent substances practically do not enter the bloodstream and cannot be carried throughout the body.
2. Ketoconazole, which is part of Livarol, has a fungicidal effect and has an inhibitory effect on harmful fungi, staphylococci and streptococci, which can be the causative agents of thrush.
3. Candles reduce the level of activity of pathogenic microorganisms as much as possible. The essence of the drug’s work is to slow down the formation of ergosterol and changes in the lipid composition of the biological membrane. Under such conditions, the formation of new phospholipids is impossible and destruction of the cell walls of bacteria and fungi with their subsequent death is observed.

Description of candles

The active substance of Livarol is ketoconazole, which is very effective for certain pathologies of the vagina. For example, it is used in the treatment of candidiasis. Livarol suppositories, the instructions for use of which indicate that their use is indicated only from the age of 12.

The description of Livarol contains information that the drug also contains other auxiliary components. Butylated hydroxyanisole prevents tissue damage in fungal-affected areas. Macrogol is the basis for candles. With the help of this substance, the drug is given size and shape.

Properties and action of Livarol suppositories

• The action of the drug is aimed at inhibiting the vital processes and reproduction of pathogens , which are the causative agents of thrush and other diseases of the reproductive system.
• The components of the drug have a negative effect on pathogens , but do not cause disruptions in the functioning of the beneficial microflora of the body.
• Livarol has an inhibitory effect on the vital activity of staphylococci and streptococci, the functioning of which is the root cause of inflammation of the pelvic organs.
• The use of suppositories can provide a complete effect on all foci of inflammatory processes, at the same time and will give a chance to avoid the need to use more drugs to eliminate problems.
• Since the localization of Livarol’s action covers all pelvic organs, the scale of possible treatment and prevention of inflammatory processes is quite impressive.

Livarol for menstruation

When problems with women's health worsen or arise during menstruation, girls have doubts about treating vaginal diseases with suppositories. Livarol suppositories for thrush are often prescribed to girls during menstruation, in whom fungal diseases worsen during this period. The effect of the drug is not reduced due to the presence of resistance to leaching, and the active component of the suppositories does not additionally cause side effects. In this case, the possibility of using Livarol suppositories during menstruation is discussed with the doctor individually.

Indications for use

Before starting treatment, it is necessary to accurately determine whether this drug is suitable for your case.

This can be done by identifying a number of indications for which treatment with Livarol is recommended:

• Prevention of fungal gynecological infections associated with a decrease in the defense capacity of the immune system;
• Candidiasis (vulva and vagina, other urogenital organs);
• Inguinal athlete's foot;
• Dermatophytosis;
• Treatment of mild and progressive forms of thrush;
• Blastomycosis;
• Sporotrichosis;
• Paracoccidioidomycosis;
• The need to maintain the body after antimicrobial therapy, in case of problems in the biocenotic connections of the vaginal microflora;
• Urogenital dysbacteriosis;
• Histoplasmosis;
• The emergence and proliferation of fungal infections, which was provoked by an increase in the activity of streptococci and staphylococci.

Indications

Indications for the use of Livarol are as follows.

• Treatment of fungal vaginal infection. Used for acute and chronic forms as part of monotherapy and combination regimens.
• Prevention of mycoses during the use of drugs. Refers to those that disrupt the normal vaginal microflora (for example, antibiotics) and can provoke vaginal candidiasis and gardnerellosis.
• Complex treatment of cervical erosion. To prevent complications from therapy and for rehabilitation.

Pregnancy and lactation

The drug is used intravaginally and has a local effect on the body. Therefore, Livarol should not be prescribed during pregnancy, especially in the first trimester. Ketoconazole can inhibit the production of sex hormones in the fetus, and this risks negatively affecting the process of its formation.

In the second and third trimesters, the drug is used with caution if the expected benefit to the expectant mother is higher than the possible risk to the child. During lactation, Livarol suppositories can be used, but it is better to do this as prescribed by a doctor.

The drug practically does not penetrate into milk, so during treatment you can adhere to the usual breastfeeding regimen.

During lactation, Livarol suppositories can be used, but it is better to do this as prescribed by a doctor. The drug practically does not penetrate into milk, so during treatment you can adhere to the usual breastfeeding regimen.

Mode of application

Before using the drug, it is recommended to carefully read the rules for its use and consult with a gynecologist.

1. It is better to administer suppositories in the evening a few hours before bedtime.
2. The introduction of suppositories into the body is carried out after preliminary removal of the contour packaging in a supine position. Suppositories should be inserted into the vagina with the sharp end forward.
3. After this, it is recommended to spend an hour or an hour and a half in bed so that the components of the medication have time to dissolve and penetrate the mucous membrane of the genital organs.
4. During the initial stage of thrush, which is accompanied by slight pain and an unpleasant burning sensation when urinating, the drug is recommended to be used for one to three days.
5. In the chronic form, therapy will take ten days.

The progression of the chronic form of candidiasis can be determined by a number of symptoms such as:

• Feeling of severe itching in the groin area;
• Observation of swelling of the external genitalia;
• Painful sensations in the lower abdomen;
• The appearance of discharge of a cheesy consistency with an unpleasant sour odor.

If you have the entire list of these problems, it is recommended to immediately consult a doctor to subsequently determine the course of therapy.

Use during pregnancy and lactation

The use of Livarol in the first trimester (first twelve weeks) of pregnancy is prohibited.
Even a small fraction of the substance ketoconazole that enters the bloodstream can have an undesirable toxic effect on the process of formation and subsequent development of the fetus in the prenatal period.

As a result, malfunctions and mutational changes in the embryo may occur, followed by the formation of a number of serious complications and diseases of the unborn child.

The use of suppositories in the subsequent months of pregnancy should be strictly agreed with the attending physician, but even in this case, the use of Livarol should not be long-term.

During pregnancy, there is a high risk of side effects and exacerbation of allergic reactions. The use of the drug during lactation also requires precautions.

Using candles for more than five to seven days is strictly prohibited.

If this period is exceeded, a number of unpleasant symptoms may occur for both mother and child. A possible manifestation of an allergy that will negatively affect the chemical composition of milk.

With constant use of the drug, there is a possibility of absorption of the active component into milk with its subsequent transfer to the child, which is not desirable.

Use in childhood

Since the effect of the constituent components of the drug on the body of a child under 12 years of age has not been studied, Livarol is not prescribed to children under 12 years of age, since it is unknown what the effect on the child’s body will be.

The effectiveness and safety of Livarol in this case remains unknown.

The drug is prescribed to children aged 12 to 15 years in accordance with medical indicators. Only a doctor can prescribe its use. Self-medication at this age is unacceptable and dangerous.

Livarol during pregnancy

Vaginal candidiasis during pregnancy occurs in 75% of women, but due to the danger of miscarriage and damage to the fetus that it carries during this period, treatment of the fungal disease is mandatory. Due to the active component of the suppositories, their use is possible in the last trimesters of pregnancy. For pregnant women in the first trimester, vaginal suppositories are contraindicated. The duration of the course of treatment is not reduced, but occurs in the same way as for other girls. The entire period occurs exclusively under the supervision of the attending physician with monitoring of health status.

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Contraindications

Contraindications for use in gynecology can be absolute or relative.

Absolute contraindications:

• If the patient has acute sensitivity to the components of the drug. The reasons for this may vary, but most often such hypersensitivity is due to malfunctions of the immune system. That is why, before using suppositories, it is necessary to determine the level of personal susceptibility of the constituent components, in particular ketoconazole.
• If the body rejects the constituent elements of the suppositories, it is recommended to consult your doctor to prescribe the optimal analogue of treatment. If this rule is not followed, there is a risk of severe chain reactions of the immune system. This can lead to serious and hazardous complications;
• The use of suppositories is prohibited in the first twelve weeks of pregnancy. The first trimester is the period of formation of all organs and systems of the fetal body and the active substance, which is one of the constituent elements of the drug, may have an undesirable effect on this process;
• Liver or kidney failure.

Relative contraindications:

• In the 2nd – 3rd trimester of pregnancy, suppositories can be used only as prescribed by the attending physician. The negative impact of the medication on the condition of the fetus during this period is minimized, but with its systematic and long-term use, there is a possibility of allergic reactions in the mother, which can have a bad effect on the child’s well-being;
• During lactation, allergies may occur with a subsequent impact on the level of milk quality;
• If there are open wounds or ulcers in the vaginal area, use should be extremely careful. Ideally, it is recommended to use vaginal tablets only after the wounds have healed. Otherwise, there is a possibility of pathogenic infections entering the body at the time the suppository is inserted. It is also possible that the amount of ketoconazole entering the bloodstream will be exceeded.

Side effects

When inserting suppositories into the vagina, ketoconazole enters the body in very small concentrations. Therefore, this amount causes almost no side effects. The use of the drug can cause mainly only local reactions. Side effects:

1. Copious vaginal discharge. After the introduction of suppositories, mucus and cheesy masses, which consist of dead microorganisms, may begin to actively secrete. This effect is observed in most women. Therefore, the use of sanitary pads is recommended during treatment.
2. Partner's reactions. During treatment it is necessary to use condoms, otherwise the partner may become infected during sexual intercourse. Redness of the penis appears. The peak risk of infection occurs in the first six hours after using suppositories. The prohibition of sexual intercourse during treatment is not included in the contraindications of Livarol.
3. Allergic reactions mainly appear against the background of intolerance to the drug or its individual components. If negative signs appear after the first administration, then repeated use of suppositories may cause a stronger reaction of the immune system. They mainly manifest themselves in the form of redness and swelling of the vagina, which is almost invisible against the background of the inflammatory process. With a more aggressive reaction of the immune system, burning, itching and pain appear. In the most severe cases, skin rashes appear in the perineum. Anaphylactic shock occurs extremely rarely. At the first negative manifestations, the administration of suppositories should be stopped.
4. In addition to these side effects, a relapse of the infection may occur. It is caused by short courses of treatment. After this, the fungus can survive and begins to multiply on the vaginal mucosa. As a result, the disease recurs.

To avoid relapses, suppositories should be used for at least five days if there is an acute form of the disease and 10 days if there is a chronic form. These courses must be followed even if the symptoms have disappeared after several times of administering the suppositories.

Dosage

The dosage of the medicine depends on the degree of complexity of the disease, its form and stage:

1. Most often, treatment is carried out with the frequency of introducing one suppository per day for 3 - 4 days.
2. The exception is clinical forms of diseases , in this case the course of therapy is 10 days with the frequency of administering one suppository per day.
3. In case of acute vaginal candidiasis or thrush , it is recommended to use one suppository per day for 5 days. The dosage of the active substance should be 400 mg per suppository.
4. In chronic or recurrent forms of thrush, it is recommended to administer one suppository per day. The course of therapy is ten days.
5. Preventive therapy for thrush is 5 days, during which it is recommended to administer one suppository per day.

The start of a course of treatment or prevention is possible the next day after the end of menstruation. During menstruation, the use of suppositories is undesirable, since the active components of the drug are removed along with the blood and the positive effect of the treatment is negated.

If the need arises, the course of treatment can be repeated monthly, subject to prior consultation with a gynecologist.

Mechanism of action of SV

The description of the mechanism of action is reduced to the main component. The antifungal effect is achieved using the active substance. After inserting the candle, it begins to gradually melt. The composition of the medication covers the vaginal mucosa. The active substance Livarol penetrates pathogenic fungi and disrupts the synthesis of ergosterol in them, from which cell walls are formed. As a result, without protection, the fungus quickly dies.

When used, Livarol has a fungicidal and static effect. For humans, ketoconazole is harmless, since there is no ergosterol in cell membranes.

Side effects

A large number of positive reviews from women about the action of the drug Livarol are clear confirmation of its effectiveness.

According to statistics, vaginal suppositories showed the best results in 97% of treatment examples.

An extremely safe and easy-to-use drug, it rarely caused side effects.

But doctors warn about the possibility of, in rare cases, problems such as:

• Nausea and vomiting;
• Acute diarrhea;
• Severe migraine and dizziness, possibility of fainting;
• Sleep disturbance;
• Allergic reactions - skin rash, hives, fever;
• Redness of the skin in the groin area and vaginal mucosa;
• Feeling of burning and itching in the perineum and vaginal area.

If one of the listed problems occurs, it is recommended to immediately seek help from a doctor in order to choose a lighter analogue of the drug.

Livarol price

You can purchase Livarol vaginal suppositories in city pharmacies or online stores that sell pharmacy products. The latter option is more convenient due to the ability to select the appropriate price, study customer reviews and choose a delivery method. Whatever method of purchasing the drug you prefer, information on prices for Livarol suppositories is presented below:

Analogs

There are a number of more gentle analogues of Livarol on the domestic market:

• Sebozol,
• Fluomizin,
• Nizoral,
• Clotrimazole,
• Ginezol and others.

Fluomizin

Clotrimazole

Nizoral

Ginesol

Livarol drug for the treatment of fungal diseases

Have you been fighting thrush for many years without success?

Head of the Institute: “You will be amazed at how easy it is to cure thrush by taking it every day...

Livarol is a medicine that is widely used to treat fungal infections in women caused by yeast or yeast-like fungi. The drug is not used in men and young children (under 12 years of age due to the lack of research on the safety of treatment).

Livarol contains the active ingredient ketoconazole (additionally includes macrogol 1400, 1500). The only form of release is vaginal suppositories (suppositories) containing 400 mg of active ingredient.

Short description

Brief description of Livarol: the drug belongs to the group of imidazoledioxolane derivatives, which acts on the synthesis of ergosterol. A substance that is part of the cell wall of fungi and bacteria. Ketoconazole inhibits the synthesis of erogosterol, disrupts the restoration of cell membranes, and increases their permeability. This leads to a gradual disruption of metabolic processes in the cell and its death. Due to this, Livarol acts on dermatophytes (Trichophyton spp., Microsporum spp.), yeast fungi (Candida spp., Pityrosporum spp.). Affects streptococci and staphylococci (not used as an antibiotic).

Indications for use of Livarol

• Acute and chronic vaginal candidiasis,
• Prevention of thrush recurrence;
• Prevention of repeated fungal infections of the vagina that develop with primary or secondary immunodeficiency or long-term use of antibiotics that disrupt the bacterial landscape of the vagina;
• Intolerance (allergy) to the components of the drug (even in the past)
• Pregnancy (first trimester)

Contraindications

Relative contraindications:

• Pregnancy (second and third trimesters)
• Breastfeeding (lactation period)
• Patient age (children under 12 years old)

Side effects

Livarol is used exclusively in the form of vaginal suppositories; its side effects rarely become systemic or lead to overdose.

In rare cases, the drug may cause:

• Local reactions (itching, redness, burning, slight swelling of the genitals)
• Nausea
• Dizziness

special instructions

1. The simultaneous use of Livarol with alcohol is not recommended: when combined, it can cause disulfiram reactions (sharp increase in heart rate, decreased blood pressure, redness of the skin, possible fainting), and also increases the risk of toxic damage to the liver.
2. During treatment, it is recommended to completely avoid sexual activity. During unprotected sexual intercourse, the medicine can cause local allergic reactions to the skin of the partner’s genital organs. When using condoms or a diaphragm, there is a decrease in their contraceptive properties.

Doesn't cause addiction. Dispensed from the pharmacy with a doctor's prescription. Shelf life: 2 years in a dark place away from children. , Russian Federation.

How to use Livarol for thrush

In the treatment of acute candidiasis vulvitis and vulvovaginitis (damage to the vestibule of the vagina and the vagina itself), the use of Livarol is possible only in complex therapy (the use of systemic fungicidal drugs is added to the treatment regimen).

Diagnosis of sexually transmitted diseases is carried out; dysbiosis, diseases of the gastrointestinal tract; diseases of the endocrine system (diabetes mellitus, etc.), disorders of local and systemic immunity.

The typical dosage in such cases is 400 mg of ketoconazole in suppositories (suppositories) for 10 days in the evening. If Livarol is used during menstruation, suppositories are not used until the end.

In chronic forms of candidal vulvovaginitis, vulvitis (thrush), treatment tactics consist in accurately identifying the cause that provokes the re-development of thrush. Livarol is prescribed at a dose of 400 mg daily in suppositories for 10 days. Afterwards - repeated anti-relapse preventive treatment according to the scheme: 5 days of 400 mg of livarol in the form of suppositories once a month for 3 months. Drinking alcohol does not affect the effectiveness of the drug.

The treatment regimen, duration of the course and frequency of dosing are prescribed only by the doctor.

Interaction with other drugs

During experimental official testing of the drug’s compatibility with other medications, no acute adverse reactions were found. Incompatibility is minimized due to the reduced ability of ketoconazole to dissolve in the blood.

Therefore, the concurrent use of any other medications is not prohibited. Ketonazole is not transported through the circulatory system and cannot actively interact with other drugs.

The only exception is drugs containing alcohol. Interaction with ethyl entails a number of serious consequences.

Interaction with alcohol

Drinking alcohol during treatment is extremely undesirable.

The combination of even the small amount of active components of Livarol that penetrate the body and alcohol can cause disulfiram reactions, which include:

• A sharp decrease in blood pressure;
• Increased heart rate;
• Dizziness followed by fainting;
• Redness of the skin.

In addition, there is a serious risk of liver damage from toxic substances.

The combination of the constituent components of the drug and alcohol increases the level of sulfonylurea production with the subsequent development of hypoglycemia.

In addition, corticotropin has an inhibitory effect on the adrenal glands with the necessary stimulating effect, increases the level of toxicity of phenytoin, lowers the level of acidity of gastric juice and increases the content of digoxin, methylprednisolone, indirect coagulants and other substances in the blood plasma.

Reasons for prescription and features of the drug

Also find out about suppositories for thrush in the 1st and 2nd trimester of pregnancy and read reviews about Pimafucin suppositories during pregnancy.

For the treatment of fungal diseases

Risks and side effects

If during the study no critical side effects on the fetus occurred, then specialists often prescribe livarol during pregnancy. But, nevertheless, the possibility of the following manifestations after taking the drug is noted:

• toxic effect of the drug on the liver: taking into account the fact that in a pregnant woman she works with double load, since she cleanses not only her body, but also the child’s body, if there is a direct release of a toxic substance into the blood, this can aggravate the condition of the liver;
• possible disruption of the gastrointestinal tract: some experience nausea, vomiting, constipation, diarrhea, sometimes there may be bloating, usually all these symptoms already bother a woman during pregnancy (starting from the middle of the 1st trimester), the drug Livarol can aggravate her condition ;
• possible disorders of the nervous system - headaches, dizziness, a feeling of goose bumps: a woman may feel sleepy or, on the contrary, suffer from insomnia, some experience increased excitability, anxiety, fatigue, fainting, weakness, in rare cases there is an increase in intracranial pressure, therefore, if such symptoms occur, you should stop taking the medication and consult a specialist.

A woman may have an allergic reaction - itching, burning, inflammation. The use of the medicine is prohibited until 12 weeks. In case of individual intolerance to the components of the drug. You should also not take Livarol while breastfeeding.

It has been used in obstetrics and gynecology for a long time. If the instructions are followed, side effects are observed in a small percentage of women during pregnancy, and the price of the drug is acceptable.

Correct use of the drug

10 pieces per pack

Instructions for use.

1. Candles are prescribed as a course of treatment. Usually it ranges from 3 to 5 days (can be up to 10 days). Depending on the severity or form of the disease, the doctor prescribes an individual medication.
2. It is necessary to use 1 suppository per day (also determined by the gynecologist).
3. Lying on your back, you need to insert the suppository deeply into the vagina.
4. After administration, it is better not to get up for at least half an hour, do it at night. The candle melts and part of it flows out.
5. It is better to carry out treatment in parallel with a partner to achieve greater effect.

Take only on the advice of a specialist

special instructions

The use of drug suppositories requires compliance with a number of special instructions:

• Regular monitoring of peripheral blood patterns , kidney and liver function;
• According to the instructions, to prevent re-infection by the disease, it is recommended to carry out a simultaneous course of therapy for the sexual partner;
• During the treatment period, it is recommended to abstain from sexual intercourse. There is a possibility of an allergic reaction to the constituent elements of this drug in a partner. When using contraceptives, a decrease in protective ability has been recorded as a consequence of the effects of the components of the drug;
• It is recommended to eliminate or limit the consumption of baked goods and foods with high carbon levels. The diet should include, for the most part, foods of dairy or plant origin;
• During therapy, it is recommended to give preference to breathable cotton underwear and completely avoid lace;
• A candle that has fallen on the floor cannot be used for its intended purpose, as there is a high probability that it was contaminated with bacteria and microbes;
• Using a candle after its shelf life has expired is unacceptable;
• The use of Livarol does not have a negative effect on the speed of psychomotor reactions and does not cause a decrease in the level of concentration;
• The break between the end of treatment of skin diseases with glucocorticosteroids and the use of vaginal suppositories should be at least two weeks;
• The candle should be used immediately after it has been removed from the packaging. It is not recommended to hold it in your hands for too long or cause any mechanical damage;
• Use of the drug by adolescents requires special caution.
• If frequent relapses of thrush occur, it is necessary to systematically take a smear both during treatment and after its completion. This will help determine how effective the drug is and, if therapy does not give the desired result, will help you select a similar drug.

Instructions for use of Livarol suppositories

When using, the candle is carefully removed from the package and inserted deep into the vagina (the woman should lie on her back). The medicine is used at night, since after taking Livarol, vaginal discharge increases. During the therapy period, it is useful to use daily sanitary pads. Schemes of use are presented in the table.

Table - Treatment of thrush with Livarol (acute and chronic)

If the symptoms of colpitis have disappeared after the first or second suppository, you cannot interrupt the prescribed course yourself. The decision about this must be made by the doctor, having received confirmation of recovery by laboratory tests. Treatment can be repeated if the desired result is not achieved.

You should not take Livarol during menstruation. If more than ten days have passed since ovulation, postpone treatment until the next cycle. If the “critical days” come unexpectedly, it is better to interrupt the course until the discharge ends.

Price

The average cost of the medicine will depend on the number of suppositories.

One contour package of Livarol contains five candles, the price of which in Russia in Moscow is 400-500 rubles per piece . As a result, you will have to pay twice as much for a cardboard box of suppositories.

In Belarus, the cost of Livarol is 120-190 thousand rubles ; in Ukraine, the drug can be purchased at a price of 65-140 hryvnia.

Cost of analogues

If you cannot find Livarol on sale, you can use analogues of the drug, such as:

• Candide cream , the price of which in the capital's pharmacies is 250 rubles ;
• Candide B6 - in the form of candles, a cheaper analogue. A pack of six candles will cost the buyer 80 rubles ;
• Metrogyl cream priced for one package – 250 rubles ;
• Lomexin cream will cost 490 rubles , and a pack with 2 suppositories will cost 360 rubles ;
• Ketoconazole in the form of an ointment costs 60-100 rubles or in the form of suppositories for 400 rubles .

Candide

Candide B

Ketoconazole

Lomexin

Metrogil

Cost, methods of purchasing and storing candles

The price of the medicine depends on the number of suppositories in the package and the area where the medicine is sold, as well as on the manufacturer and methods of sales. In Moscow, Livarol radar is sold from 373 to 566 rubles, in St. Petersburg - 474-644 rubles, in Perm - 464-633 rubles. You can also purchase the drug on the official website of the RLS company.

Each package contains instructions for use and the price of Levarol suppositories. Vaginal suppositories are available without a prescription. However, the use of SV during pregnancy is allowed only on the recommendation of a gynecologist. The shelf life of the drug is 2 years. Vaginal suppositories should be stored in a dark, dry place, out of reach of children, at a temperature not exceeding 25 degrees.

Livarol

Active substance:

Ketoconazole*

Pharmgroup:

Antifungal agents

Average price in pharmacies

Effect of the drug

Ketoconazole is the main active substance of Livarol, an imidazoledioxolane derivative. It has two different effects on the infection: fungistatic (suppresses the growth of fungal cells and their division) and fungicidal (completely destroys them). This effect can be achieved by suppressing the synthesis of ergosterol in the cells of microorganisms, without which the cell wall of fungi cannot form normally.

Livarol successfully fights dermatophytes and yeast fungi, as well as streptococcal and staphylococcal bacteria.