Gepasolone in suppositories and ointments is considered one of the affordable and effective ways to get rid of hemorrhoids. The peculiarity of this medication is the insignificant manifestation of side effects on the body.
In pharmacology, there are many different medications for hemorrhoids, in the form of:
- suppository (suppositories);
- gels;
- ointments.
Pharmacodynamics and pharmacokinetics
The drug is applied topically and has anti-inflammatory and venosclerotic effects. Area of application: proctology . Heparin enhances the regeneration of connective tissue, prevents blood coagulation to hemorrhoids, prevents thrombus formation , and has an anti-edematous effect. Thanks to heparin, the number of relapses is significantly reduced. By acting on the vascular endothelium, heparin prevents the formation of edema and a stable fibrin thrombus .
Prednisolone is a glucocorticosteroid of synthetic origin and reduces the activity of inflammatory mediators ( lysosomal enzymes , prostaglandins , kinin and histamine ). Thanks to the vasoconstrictor effect, a decrease in exudation is achieved, the severity of the allergic reaction is reduced (as a result of suppression of cytokines and macrophages ). Lidocaine provides a local anesthetic effect, which is achieved by blocking sodium, voltage-dependent channels, which leads to a decrease in the generation of impulses.
Compound
Lidocaine, which is part of the drug, has an immediate effect. It relieves pain and relieves symptoms of the disease. The effect of the drug lasts for a long period - from 8 to 14 hours. "Gepazolone" only in rare cases causes an allergic reaction in case of individual intolerance to one of the components included in the drug.
The main objectives of the drug are to relieve inflammation, strengthen the walls of blood vessels and prevent the penetration of pathogenic bacteria into anal fissures formed as a result of microtraumas. The effect is achieved due to the presence of the active substance in the drug – prednisolone.
Original packaging of the drug
Another active substance in Hepazolone is sodium heparin. It promotes the resorption of nodes formed outside or inside the rectal canal. This drug promotes accelerated regeneration of damaged cells, which is important against the background of eczema, fissures and other external damage.
The 3 active substances that make up Hepazolone are also used separately in medical practice to quickly eliminate the symptoms of the disease.
The use of Hepazolone for mild hemorrhoids can relieve signs of the disease already on the 4th day of use. In advanced cases in the later stages, up to 14 days of regular use of suppositories may be required. Often, after treatment, the disease recurs only in exceptional cases.
Analogs of candles with similar effects on the market do not contain a similar complex of components, which explains their lack of effectiveness.
Indications for use
The drug is prescribed for fistulas , anal fissures , eczema , itching in the anorectal area caused by an inflammatory process. Instructions for use of Gepazolon it is recommended to use suppositories for thrombophlebitis of hemorrhoidal veins located in the perianal area.
For hemorrhoids (operated, thrombosed), the drug is prescribed as part of complex therapy.
The drug is prescribed before surgical treatment of diseases of the anorectal region.
Interaction with other drugs
The main caveat in using Gepazolon is that it cannot be combined with other medications.
They can also thin the blood, which can lead to a risk of severe bleeding in the rectal area.
The combined use of Hepazolon with hormonal medications is undesirable.
Interaction with this group of drugs involves a sharp increase in the likelihood of pathologies occurring in the adrenal cortex.
Alcohol compatibility
Many people believe that hemorrhoids and alcohol have nothing in common. But this is not so, its use during the course of use slows down the healing process.
May cause worsening of the disease. Alcohol is also a provoking agent for its appearance.
Contraindications
Gepazolon ointment is contraindicated for infectious, fungal, viral and tuberculous lesions of the anorectal area. The medication is not prescribed for functional disorders of the blood coagulation system due to the risk of rectal bleeding .
Gepazolon suppositories are contraindicated in case of intolerance to heparin, lidocaine and prednisolone.
The drug Gepazolon is not used in pediatrics (age limit: 12 years).
During pregnancy and breastfeeding, Gepazolon ointment is contraindicated.
special instructions
People who have had an allergy to selective 5-HT3 receptor blockers in the past have a high likelihood of developing them against the background of ondansetron, which slows down the motility of the large intestine, and therefore a patient with intestinal constipation requires special attention.
Before using Gepazolon ointments and suppositories, it is recommended to follow hygiene rules, if possible, do not lift or carry heavy objects yourself.
Do not chill the anal passage; in case of sedentary work, get up and walk as often as possible.
The use of the drug Gepazolon must be agreed upon with a proctologist. You also need to observe precautions and contraindications.
Conditions for dispensing from pharmacies
Gepazolon is available in all pharmacies without a prescription. Since it is not a narcotic or psychotropic drug.
Storage conditions and shelf life
Gepasolone and all medications must be stored dry and protected from direct light.
The storage temperature should be 25°C and it should be kept out of the reach of children. The shelf life is no more than 2 years from the date of manufacture.
Side effects
Endocrine system: development of Itsenko-Cushing syndrome , functional suppression of the adrenal glands, development of “steroid” diabetes mellitus, decreased sensitivity to glucose.
Cardiovascular system: changes in the electrocardiogram indicating hypokalemia, arrhythmias , increased blood pressure, bradycardia .
Nervous system: dizziness, sleep disturbances such as insomnia .
Metabolism: increased sweating, removal of calcium from the body, formation of hypocalcemia .
All of the above side effects are caused by the action of prednisolone (glucocorticosteroid) and occur when taking the medication for more than 5 weeks.
Hemorrhoidal disease
Hemorrhoids are a very common disease and every year the number of people suffering from this disease is steadily growing. This is due, first of all, to the fact that recently many professions have appeared in which a person spends a long time in a sitting position in front of a computer.
Another cause of the disease may be increased pressure on the pelvic organs and, as a result, poor circulation. This condition occurs during pregnancy or if you are overweight.
Hemorrhoidal disease is very often accompanied by inflammation of the hemorrhoidal node as a result of its thrombosis in the anal area. This usually manifests itself in an acute form and causes pain, rectal bleeding, burning, unpleasant itching and discomfort in a person.
Instructions for use of Gepazolon (Method and dosage)
Gepazolon suppositories, instructions for use
Treatment of internal hemorrhoids: Gepazolon suppositories are administered 1-2 times daily into the rectal cavity.
Treatment of external hemorrhoids: insert the suppository into the anus so that the base of the suppository can be felt from the outside. Until the suppository completely melts, it is recommended to hold the anus area with a gauze pad for 3 minutes. Otherwise, the therapeutic effect is not achieved due to the suppository “falling through” into the rectal cavity.
Duration of therapy – 1 week. Treatment can be extended up to 2 weeks if necessary.
Instructions for Gepazolon ointment
The ointment is used if hemorrhoids have already fallen out. In this case, they need to be lubricated up to 3 times a day.
Release form
The official drug "Gepazolone" is available in the form of suppositories. Pharmacies sell cream, gel, wax and ointment with the same name, but from different manufacturing companies. But suppositories have become particularly popular in the treatment of hemorrhoids, thanks to their gentle and effective elimination of the disease at any stage.
The manufacturer produces candles in a package of 5 pieces, in a cardboard box with oblong cells.
Hemorrhoids significantly reduce the quality of life, so they must be treated in the early stages
Analogs
Level 4 ATC code matches: Betiol
Olestezin
Proctosedyl
Ultraproct
Relief
Anuzol
Posterisan Forte
Posterisan
Bezornil
Procto-Glyvenol
Glivenol
Proctosan
Analogs include the following drugs: Betiol , Anuzol , Relief Advance .
Treatment of hemorrhoids
To treat this disease, pharmacologists combined the three main active components of the drug in one small rectal suppository: heparin, prednisolone, lidocaine.
Each of the components of the drug has its own special pharmacological effect on hemorrhoids, but their combined use can cure the disease and prevent its further progression.
The action of heparin is aimed primarily at preventing the formation of blood clots. When this medicine is applied topically, blood clots in the varicose veins of the rectum gradually dissolve. Heparin relieves tissue swelling. When treating cracks and abrasions of the rectum with the drug, tissue in the anal area is restored.
These suppositories contain another very important component - prednisolone. It is a synthetic hormone and its action is directed directly to the rectal mucosa. It is practically not absorbed into the general bloodstream and does not have a systemic effect on the body. Its main effect is aimed at reducing the severity of inflammation, reducing itching in the rectal area, discomfort and burning . The hormone prednisolone has good vasoconstrictor properties, which also appear only at the level of the distal intestine.
Lidocaine in the rectum provides a local analgesic effect. It is simply irreplaceable in the acute form of the disease , when a person suffers from severe pain.
It is the combination of these three important components that allows you to deal with hemorrhoids very quickly and successfully.
When treating an acute form of the disease at an early stage, the effect of using Hepazolon occurs approximately on the fourth day. After a week, the nodes and veins are completely reduced, the pain and swelling of the tissues and damaged vessels disappear. The patient’s mucous membrane of the distal intestine is gradually restored.
Gepazolon is a Russian combination drug. Its action is aimed at alleviating the symptoms of the disease and eliminating the causes of its occurrence. The article (see below) provides reviews of the use of hepazolon suppositories for hemorrhoids.
Conditions for dispensing from pharmacies
How to purchase the drug
Hepazolon suppositories are actively discussed on forums and medical websites. Patients confirm the high effectiveness of the drug in the treatment of hemorrhoidal disease with positive reviews. The drug has undergone clinical trials, but it cannot be taken as a completely safe medicine. The medication has serious contraindications, as well as the ability to cause an allergic reaction.
This explains the fact that the drug must be prescribed and prescribed by the treating proctologist, since the drug is dispensed in a network of pharmacies upon presentation of a prescription from a doctor. Independent use of Gepazolon as a therapeutic antihemorrhoidal agent is prohibited. Prescriptions are carried out on an individual basis, taking into account the characteristics of the body and existing additional pathologies.
If you do not take into account individual intolerance, then some component after the introduction of a suppository for treatment purposes can provoke a complication. If such a phenomenon occurs, medical care and consultation are necessary with interruption of the use of Gapazolone. When prescribing a treatment regimen, doctors treat pregnant patients and nursing mothers with special care, since not every drug is allowed to be used for this group of patients.
Reviews
After pregnancy and childbirth, I developed hemorrhoids. This is a terrible condition. It was painful to sit, and the thought of the toilet generally made me tremble. After defecation, I noticed that droplets of scarlet blood were being released. I went to see a doctor at a local clinic. He said that I had started the disease and “what were you thinking before?” that now only surgery will help me. But I didn’t know that everything was so serious, especially since I have a baby, I’m very tired and didn’t notice that the bumps in the anus had greatly increased in size. The doctor advised me to buy Gepazolon suppositories at the pharmacy. I agreed, they are inexpensive. A week after the treatment, I came to the appointment, and the doctor said that now everything is much better. The veins and nodes are practically invisible, the swelling has gone, the crack has healed.
Valentina, 31 years old, Moscow.
I got hemorrhoids because my work is closely related to the computer. I sit on average 12 hours a day. Recently, the pain in the anus has intensified, and a burning sensation has appeared. At the pharmacy, the pharmacist advised me to buy Gepazolon suppositories. 5 days after using it, I forgot about the disease. Now I live and enjoy life. But just in case, I bought 2 more packages of candles and put them in the refrigerator.
Konstantin, 42 years old, Yalta.
