Flukold tablets: instructions for use, reviews. The drug "Flukold N"

Surely everyone knows the symptoms of colds and flu. Such unpleasant signs appear suddenly. However, with the right approach to treatment, they can also suddenly disappear. To do this, you should consult a therapist who will prescribe medications that help eliminate the symptoms of the disease, as well as quickly eliminate viruses and infections.

The most popular drug against flu and colds is the drug “Flyukold” (tablets). Instructions for use and patient reviews will be described below. You will also learn about what is remarkable about this remedy and whether it has any contraindications.

Pharmacodynamics and pharmacokinetics

The therapeutic effect is achieved through the interaction of Flukold's components.

Paracetamol inhibits cyclooxygenase, which leads to decreased production of prostaglanins , arachidonic acid, thromboxane and prostacyclins . It is a non-narcotic analgesic . It has a slight anti-inflammatory effect, but a pronounced antipyretic and analgesic effect. Reduces the level of prostaglandins in the central nervous system, in the thermoregulation center of the hypothalamus.

Phenylpropanolamine and chlorpheniramine eliminate swelling of the nasal mucosa, fight rhinorrhea and facilitate breathing through the nose.

Chlorpheniramine blocks H1-histamine receptors and has an anticholinergic and sedative effect.

Caffeine is an antipsychotic ; it enhances the therapeutic effect of NSAIDs, improves memory, attention, improves performance, and stimulates the activity of the central nervous system.

Flukold is absorbed into the gastrointestinal tract, metabolites are excreted in the urine. The components of the drug pass through the hematoplacental and blood-brain barriers and enter breast milk.

Pharmacological characteristics

How does the drug "Flukold" (tablets) work? Instructions for use report the following properties of its active substances.

Paracetamol is a non-steroidal anti-inflammatory drug that inhibits the activity of isoforms of the COX enzyme. Due to this effect, this substance reduces the synthesis of prostaglandins from arachidonic acid. As a result, analgesic and antipyretic effects appear in the central nervous system.

The anti-inflammatory properties of this medicine are insignificant, since cellular peroxidases contribute to the inactivation of paracetamol.

Chlorpheniramine maleate is able to block M-cholinergic receptors and H1-histamine receptors. It also has a sedative effect.

It should also be noted that the mentioned substance helps to reduce the intensity of the effects that were caused by histamine. It eliminates swelling of the nasal mucosa and rhinorrhea, and also reduces increased vascular permeability,

Phenylephrine hydrochloride interacts with alpha-adrenergic receptors, helping to reduce the intensity of symptoms of influenza and acute respiratory diseases of various origins.

What role does caffeine play in the drug Flucold? The instructions for use indicate that this is an antipsychotic drug that stimulates the central nervous system, improves physical and intellectual activity, increases strength, as well as heart rate. In addition, caffeine potentiates the effect of NSAIDs.

Side effects

Flukold is well tolerated. Side effects are rare.

Gastrointestinal tract: dyspeptic disorders, epigastric pain, dry mouth , stool disorders.

Cardiovascular system: Increased blood pressure, thrombocytopenia, leukopenia, cardiac arrhythmia, neutropenia, methemoglobinemia .

Central nervous system: limb tremor , migraine , increased excitability, sleep disturbance, emotional lability, dizziness.

Allergy.

Taking medication carefully

You should be extremely careful when prescribing this drug to people suffering from kidney and liver diseases, urinary retention, closed-angle glaucoma, prostatic hypertrophy and obstructive diseases of the gastrointestinal tract.

It is also necessary to say that this medication is recommended with caution to people with epilepsy, severe diseases of the cardiovascular system, chronic alcoholism, as well as the elderly.

In addition, Flukold N should not be prescribed to patients whose work involves driving a car or operating dangerous machinery.

Instructions for use of Flukold (Method and dosage)

Flukold N tablets, instructions for use

Do not chew the Flucold tablet, swallow it whole, and wash it down with water.

The drug is taken three times a day, 1 tablet.

At least 4 hours should pass between doses.

No more than 4 tablets per day, no longer than a week.

Flukold sachets, instructions for use

The contents of the sachet are dissolved in water.

Take three times a day, but not more than once every four hours.

No more than 4 sachets per day.

The course of treatment should be no more than 3 days.

Packaging, release form and composition

In what form is the drug “Flucold N” produced? The instructions for use state that this medicine can be purchased in tablet form. There are four of them, packed in blisters made of aluminum foil and contained in a paper envelope.

The active components of this product are:

• paracetamol;
• phenylephrine hydrochloride;
• chlorpheniramine maleate;
• caffeine.

The drug also contains various excipients.

Interaction

Ascorbic acid, codeine , propyphenazone , scopolamine enhance the therapeutic effect of the drug Flukold.

Ethanol, sedatives, tricyclic antidepressants, barbiturates increase the half-life of the drug.

It is not recommended to combine with drugs that contain paracetamol.

Contraindications

Which patients are prohibited from prescribing a drug such as Flukold N (tablets)? Instructions for use indicate that contraindications to the use of this medicine are:

• severe impairment of kidney function;
• pregnancy period;
• individual sensitivity (increased) to the substances of the drug;
• breastfeeding time;
• children under two years of age;
• severe disturbances in liver function.

Flukold's analogs

Level 4 ATC code matches: Phenacetin
Combiflu

Chlorphenamine

Coldflu

Calpol

Fervex

Panadol Extra

Panadol for children

Panadol

Solpadeine

Efferalgan

Milistan

Coldrex Maxgripp

Coldrex Hotrem

Coldrex

AntiGrippin

Unispaz

Pentalgin Plus

Rapidol

Maxicold

Analogs include: Coldrex , Adjicold , Lorcold , Neogrip , Radicold .

Drug overdose

What happens if you overdose on Flucold? The instructions for use state that in this case the patient experiences nausea, pale skin, vomiting, tremors of the limbs and pain in the epigastric region. With a subsequent increase in doses, the development of nephrotoxic and hepatotoxic effects of the drug is noted.

It should also be noted that when taking an excessive amount of this drug, glucose metabolism may be disrupted, metabolic acidosis may develop, and methemoglobinemia and coma may occur.

In such cases, gastric lavage, symptomatic treatment and the use of enterosorbents are indicated. In case of paracetamol poisoning, intravenous infusion of N-acetylcysteine ​​is required, as well as oral administration of methionine.

Interaction with other drugs

When this drug is combined with drugs that have a hepatotoxic effect, an increase in the negative effect of these drugs on the liver is observed.

Probenecid and Metoclopramide, taken together with Flucold N tablets, affect the kinetics of paracetamol.

When combining the drug with medications that have a depressant effect on the central nervous system, including sedatives, barbiturates, tranquilizers and tricyclic antidepressants, an increase in the therapeutic effect of the latter is observed.

It should also be incompatible with ethanol.

Flukold (syrup)

Name: Flukold (syrup) Pharmacological action: Flukold is a combined drug with a pronounced analgesic, antipyretic and antihistamine effect. The drug contains two active ingredients - paracetamol and chlorpheniramine maleate. The therapeutic effects and mechanism of action of the drug are based on the pharmacological properties of the active components included in its composition. Paracetamol is a drug from the group of non-selective non-steroidal anti-inflammatory drugs. Paracetamol has a pronounced analgesic and antipyretic effect, the anti-inflammatory effect of the drug is slightly expressed, since paracetamol is inactivated by cellular peroxidases. The mechanism of action of the drug is based on its ability to inhibit the enzyme cyclooxygenase, resulting in a disruption of the metabolism of arachidonic acid and a decrease in the synthesis of prostaglandins, prostacyclins and thromboxane. Reducing the amount of prostaglandins in the thermoregulation center in the hypothalamus helps reduce elevated body temperature. The analgesic effect of the drug is achieved by reducing the amount of prostaglandins in the central nervous system.

Chlorpheniramine maleate is a H1-histamine receptor blocker. In addition to antihistamine activity, it also has some sedative and M-anticholinergic effects. The drug reduces swelling of the nasal mucosa and facilitates nasal breathing.

The pharmacokinetics of Flukold syrup has not been studied.

Indications for use: The drug is used for the symptomatic treatment of children aged 1 to 12 years suffering from acute respiratory diseases and influenza, which are accompanied by symptoms such as fever, sore throat, headache and swelling of the nasal mucosa.

Directions for use: The drug is taken orally. The syrup should not be diluted, however, after taking the drug you can wash it down with water or tea. The drug should be taken at regular intervals. The duration of the course of treatment and the dose of the drug are determined by the attending physician individually, depending on the nature of the disease and the personal characteristics of the patient. Children aged 1 to 4 years are usually prescribed 5 ml of the drug (1 teaspoon) 4 times a day. Children aged 5 to 8 years are usually prescribed 10 ml of the drug (2 teaspoons) 4 times a day. Children aged 9 to 12 years are usually prescribed 10-20 ml of the drug (2-4 teaspoons) 4 times a day. The duration of treatment should not exceed 3 days.

Side effects: The drug is usually well tolerated by patients, however, in some cases the development of the following side effects was noted when using the drug: From the gastrointestinal tract: nausea, vomiting, pain in the epigastric region, dry mouth. In isolated cases, the development of pancreatitis was noted. From the hematopoietic system: thrombocytopenia, pancytopenia, leukopenia, agranulocytosis. Allergic reactions: skin rash, itching, urticaria, Quincke's edema.

Contraindications: Increased individual sensitivity to the components of the drug. The drug is not used to treat patients suffering from impaired liver and/or kidney function, as well as children under the age of 1 year. The drug should be prescribed with caution to patients with diabetes mellitus, liver and/or kidney diseases, as well as to patients whose work involves operating potentially dangerous machinery and driving a car.

Interaction with other drugs: When the drug is used in combination with codeine, ascorbic acid (vitamin C), scopolamine, propyphenazone and caffeine, an increase in the therapeutic effect of paracetamol is observed. Barbiturates, ethanol and tricyclic antidepressants, when used simultaneously with Flukold, increase the half-life of paracetamol. When used in combination, the drug enhances the effect of drugs that depress the central nervous system, including barbiturates, ethanol, sedatives and benzodiazepine tranquilizers. The simultaneous use of Flukold with other drugs containing paracetamol is contraindicated.

Overdose: When using excessive doses of the drug, patients experience the development of nausea, vomiting, pain in the epigastric region, tremor of the limbs, tachycardia, headache and sleep disturbances. With a further increase in dose, the development of renal and/or liver failure may occur. In case of overdose, gastric lavage, intake of enterosorbents and symptomatic therapy are indicated. In case of paracetamol poisoning, N-acetylcysteine ​​and oral methionine are prescribed. Treatment of a drug overdose should be carried out in a hospital setting under the close supervision of a physician.

Release form: Pink syrup, 25 or 100 ml in bottles, 1 bottle in a cardboard box.

Storage conditions: It is recommended to store the drug in a dry place away from direct sunlight at a temperature of 15 to 25 degrees Celsius. Shelf life – 3 years.

Composition: 5 ml of syrup contains: Paracetamol – 125 mg; Chlorpheniramine maleate – 2 mg; Excipients, including glucose syrup and sugar.

Attention! The description of the drug “ Flucold (syrup) ” on this page is a simplified and expanded version of the official instructions for use. Before purchasing or using the drug, you should consult your doctor and read the instructions approved by the manufacturer. Information about the drug is provided for informational purposes only and should not be used as a guide to self-medication. Only a doctor can decide to prescribe the drug, as well as determine the dose and methods of its use.

Flukold instructions and frequently asked questions

Stock

dyuchi speeches:

1 tablet contains paracetamol 500 mg, caffeine 30 mg, phenylephrine hydrochloride 5 mg, chlorpheniramine maleate 2 mg;

additional speeches:

corn starch, sodium starch glycolate (type A), talc, gelatin, magnesium stearate, sorbitol rosechin (E 420), Povidone K-30, sodium benzoate (E 211), Ponceau barberry 4R (E 124), purified water.

Medicine form Tablets.

Main physical and chemical authorities:

Round, uncoated tablets, rye-colored with dark rye-colored inclusions.

Pharmacotherapeutic group

Analgesics and antipyretics. Paracetamol, combinations without psycholeptics.

ATX code N02B E51.

Pharmacological authorities

Pharmacodynamics.

The pharmacological activity of the drug is determined by the properties of paracetamol, caffeine, phenylephrine hydrochloride and chlorpheniramine maleate, which are included in the drug. Paracetamol

repair antipyretic, pain-relieving and anti-fever treatment. The mechanism of action is due to the inhibition of prostaglandin synthesis.

Caffeine

create a stimulating effect on the central nervous system, mainly on the cerebral cortex, the dycholic and vascular centers, promotes mental and physical performance, reduces drowsiness, as a result, it weakens the functions that suppress comfort the central nervous system.

Phenylephrine hydrochloride

perform a nasal-sound procedure that relieves swelling of the mucous membrane of the nose and paranasal sinuses.

Chlorpheniramine maleate

carry out antihistamine and anticholinergic action. Blocking

H1 receptors, have a protiallergic effect, change the penetration of the mucous membrane of the upper ducts of the respiratory tract, change lacrimation, itching in the eyes and nose.

Pharmacokinetics.

Wasn't followed up.

Clinical characteristics

Showing

Symptomatic colds and flu are accompanied by elevated body temperature, chills, headaches, nasal congestion, coughing, aches and pain in the body.

Contraindicated

Increased sensitivity to the components of the drug, other similar xanthines (theophylline, theobromine). Chronic obstructive illness. Emphysema. Severe cardiovascular illnesses, including impaired conductivity. expressions of atherosclerosis, severe form of ischemic heart disease. Acute myocardial infarction. Thrombosis of peripheral arteries. Decompensated heart failure. Shlunochkova tachycardia. Hyperthyroidism. Severely impaired liver function and/or poor functioning. Hostria pancreatitis, hepatitis. Stenozuvalnaya virazka schluk and duodenum. Congenital hyperbilirubinemia. Severe arterial hypertension. Prostate adenoma with difficulty in sechovypushka. Obstruction of the neck of the mikhur. Poisoned blood (anemia, leukopenia), hyperthyroidism. Pyloroduodenal obstruction. Pheochromocytoma. Blood diabetes. Bronchial asthma. Postcutaneous glaucoma. Glucose-6-phosphate dehydrogenase deficiency. Alcoholism. Increased wakefulness. Disturbed sleep. Epilepsy. Immediately stagnation with monoamine oxidase inhibitors (MAO) and for 2 days after their stagnation. Immediate treatment with tricyclic antidepressants and β-blockers. Summer age of the patient (over 60 years).

The period of pregnancy or breastfeeding. Children's age up to 12 years.

Interactions with other medicinal drugs and other types of interactions

Liquidity of soaked paracetamol

may increase when taken with metoclopramide and domperidone and change with cholestyramine. With one-hour ingestion, the anticoagulant effect of coumarins (such as warfarin and other coumarins) is enhanced due to an increased risk of bleeding as a result of prolonged, regular ingestion of paracetamol. Taking single doses does not show any significant effect. Barbiturates alter the antipyretic effect of paracetamol. Anti-seizure drugs (phenytoin, barbiturates, carbamazepine), which stimulate microsomal liver enzymes and isoniazid, can enhance the hepatotoxicity of paracetamol due to the advanced stage of the drug's transformation into hepatotoxic metabolites . Paracetamol reduces the effectiveness of diuretics.

Don't hang out with alcohol all at once.

Interaction with phenylephrine hydrochloride

With MAO inhibitors it causes a hypertensive effect, with tricyclic antidepressants (amitriptyline) it increases the risk of cardiovascular side effects, with digoxin and cardiac glycosides it leads to arrhythmia. Myocardial infarction. Phenylephrine with other sympathomimetics increases the risk of adverse cardiovascular reactions and may reduce the effectiveness of β-blockers and other antihypertensive drugs (reserpine, methyldopa) due to increased risk of arterial hypertension Terial hypertension and adverse cardiovascular reactions.

Phenylephrine may cause adverse reactions when taken for one hour with indamethacin and bromocretin (severe arterial hypertension). Congestion of phenylephrine hydrochloride with sympathomimetic amines increases the risk of arrhythmia and myocardial infarction.

Rauwolfia alkaloids alter the therapeutic effect of phenylephrine hydrochloride.

Significantly increase the depressant effect of chlorpheniramine maleate

You can immediately take the drug with: drugs, barbiturates, sedatives, neuroleptics, tranquilizers, anesthetics, narcotic analgesics, alcohol. Chlorpheniramine maleate enhances the anticholinergic action of atropine, antispasmodics, tricyclic antidepressants, and antiparkinsonian drugs.

Caffeine

enhances the effect (reduces the bioavailability) of analgesics-antipyretics, potentiates the effects of similar xanthines, α- and β-adrenergic agonists, psychostimulants.

The immediate ingestion of caffeine with MAO inhibitors can cause an unsafe increase in arterial pressure.

Cimetidine, hormonal contraceptives, isoniazid enhance caffeine.

Caffeine reduces the effect of opioid analgesics, anxiolytics, anesthetics and sedatives, and is an antagonist of anesthetic drugs and other drugs that depress the central nervous system, a competitive antagonist of adenosine drugs, ATP. With one-hour infusion of caffeine and ergotamine, the absorption of ergotamine in the scolio-intestinal tract is enhanced, and in thyroid-stimulating conditions, the thyroid effect is promoted. Caffeine reduces the concentration of lipid in the blood.

Features of stastosuvannya

Do not overdo the prescribed dose.

The difference between one-hour ingestion and other drugs used for symptomatic treatment of colds and flu, medicinal methods that replace paracetamol.

In Denmark, it is not recommended to use sedatives, drugs or drinks to replace alcohol.

The drug is prescribed as a medicine only after assessing the cardiovascular risk/measles in the following types of illness: arterial hypertension; disruption of heart rhythm; razladi sechovipuskannya. If the doctor recommends using the drug throughout the treatment period, it is necessary to monitor the functional state of the liver and peripheral blood patterns.

When the drug is frozen, there is no trace of over-the-counter infusion of kava, medicinal tea, other tonic drinks and medicinal preparations that replace caffeine. This can cause problems with sleep, tremors, tension, restlessness, and heart palpitations.

Before taking the drug, you should consult with your doctor if the patient is taking warfarin or similar drugs that may have an anticoagulant effect.

It is necessary to check with your doctor about the possibility of administering the drug to patients with impaired liver and liver function.

Be aware that in patients with alcoholic liver disease, the risk of hepatotoxicity from paracetamol increases; The drug can be combined with blood glucose and sechoic acid based on laboratory results. In patients with severe infections, such as sepsis, which are accompanied by a decrease in glutathione levels, when taking paracetamol, the risk of developing metabolic acidosis increases. Symptoms of metabolic acidosis include severe, accelerated or difficult breathing, boredom, vomiting, loss of appetite. It is important to consult a doctor once these symptoms appear.

Patients who take analgesics every day for mild arthritis should consult a doctor.

If you don’t know the symptoms, you have to go to the doctor.

As soon as the headache becomes permanent, it is time to go to the doctor.

The doctor's purpose is to use sorbitol of roschin (E 420). If the patient has an intolerance to certain medicinal products, it is necessary to consult a doctor before taking this medicinal remedy.

It is advisable to remove Ponceau 4R (E 124), which may cause allergic reactions.

Suspension during pregnancy or breastfeeding.

Contraindicated.

This is due to the fluidity of the reaction during treatment with vehicles or other mechanisms.

During treatment with Flucold®-N, avoid treatment with transport means, robots with mechanisms and other unsafe types of activity.

Method of congestion and dosage

For adults and children over 12 years of age, take 1 tablet every 3-4 years, or no more than 4 tablets per day. The interval between doses should be no less than 4 years. The triviality of the treatment signifies the doctor. The maximum period of treatment without consulting a doctor is 3 days.

Do not take paracetamol at the same time as medication.

Children.

The drug should be given to children over 12 years of age.

Overdose

Symptoms of paracetamol overdose.

In the first 24 years of age, pallor, tiredness, vomiting, anorexia and abdominal pain appear. When taking large doses, disturbances in orientation, arousal, confusion, disturbances in sleep, heart rate and pancreatitis may occur. In some cases, acute nitric deficiency was reported due to tubular necrosis, which manifests itself as pain in the transverse region, hematuria, proteinuria; nephrotoxicity (nic colic, interstitial nephritis).

In severe cases, liver failure can progress to encephalopathy, hemorrhage, hypoglycemia, and even death.

Taking 10 g or more paracetamol, especially with alcohol, over 150 mg of paracetamol per 1 kg of body weight in children can lead to hepatocellular necrosis with the development of encephalopathy, hepatic coma and death. The first clinical signs of hepatonecrosis may appear 12-48 years after overdose. Impaired glucose metabolism and metabolic acidosis may be to blame.

Cardiac arrhythmia and pancreatitis were also diagnosed.

When the drug is used in large doses, aplastic anemia, pancytopenia, agranulocytosis, neutropenia, leukopenia, thrombocytopenia may develop in the side of the hematopoietic organs. When taking large doses, side effects of the central nervous system include confusion, psychomotor restlessness and impaired orientation; on the side of the thyroid system – nephrotoxicity (nirconic colic, interstitial nephritis, capillary necrosis).

In case of overdose, medical assistance is required. The patient should be immediately taken to the doctor for early symptoms of overdose. Symptoms may be between nausea and vomiting, or may not reflect the severity of overdose or the risk of organ damage. The following was examined for the treatment of active vugillas, since an overdose of paracetamol was taken within 1 year. The concentration of paracetamol in blood plasma should disappear after 4 years or later after administration (higher early concentrations are not reliable). Treatment with N-acetylcysteine ​​can be continued for 24 years after taking paracetamol, but the maximum dry effect occurs when administered for 8 years after taking paracetamol. The effectiveness of the antidote sharply decreases after this hour. If necessary, the patient is given internal traces

N-acetylcysteine ​​is suitable for establishing dose overflow. If vomiting is present, methionine can be taken orally as an excellent alternative in remote areas of the patient's body.

In case of overdose of phenylephrine hydrochloride

Hyperhidrosis, psychomotor restlessness or depression of the central nervous system, headache, confusion, drowsiness, impaired fluid speed, arrhythmias, tremor, hyperreflexia, seizures, boredom, vomiting, drowsiness, restlessness, arteries may occur. alna hypertension.

In case of overdose of chlorpheniramine maleate

Atropine-like symptoms may be avoided: mydriasis, photophobia, dry skin and mucous membranes, increased body temperature, intestinal atony. Suppression of the central nervous system is accompanied by respiratory disorders and dysfunction of the cardiovascular system (changes in pulse rate, changes in arterial pressure, even to vascular insufficiency).

Large doses of caffeine

may cause pain in the epigastric region, vomiting, diuresis, rapid breathing, extrasystole, tachycardia and cardiac arrhythmia, flow to the central nervous system (confusion, sleeplessness, nervous agitation, fatigue, anxiety, anxiety, tremor, suedi). Clinically important symptoms of caffeine overdose are also associated with liver damage caused by paracetamol.

Likuvannya.

For the first 6 years after a suspected overdose, it is necessary to wash out the tube and then hospitalize the patient.

For the first 8 years after overdose - oral administration of methionine or internal administration of cysteamine or N-acetylcysteine; symptomatic therapy; in case of severe arterial hypertension – use of α- and β-blockers.

Adverse reactions

On the side of the immune system:

anaphylaxis; hypersensitivity reactions, including skin itching, visip on the skin and mucous membranes (cause generalized visip, erythematous, urticaria), angioneurotic swelling; exudative erythema multiforme (including Stevens-Johnson syndrome); toxic epidermal necrolysis (Lyell's syndrome).

On the side of the nervous system

: headache, confusion, psychomotor restlessness, disorientation, restlessness, nervousness, fear, twitchiness, sleep disturbance, insomnia, drowsiness, confusion, hallucinations and, depression, tremors, tingling and heaviness in the ends, noise in the ears, epileptic attacks, anxiety; in several episodes – coma, seizures, dyskinesia, changes in behavior, mental weakness.

On the side of the dichotomy system:

bronchospasm in patients sensitive to acetylsalicylic acid (aspirin) and other non-steroidal anti-inflammatory drugs.

From the side of the organs:

impaired vision and accommodation, mydriasis, internal eye pressure, dry eyes.

On the side of the grass tract:

fatigue, vomiting, burning, dry mouth, discomfort and pain in the epigastric region, diarrhea, constipation, flatulence, hypersalivation, decreased appetite, acute viral illness.

On the side of the hepatobiliary system:

impaired liver function, increased activity of liver enzymes, usually without development of hepatitis, hepatotoxicity, hepatonecrosis (with high doses).

On the side of the endocrine system:

hypoglycemia, right up to hypoglycemic coma.

On the side of the blood system:

anemia, including hemolytic; thrombocytopenia, agranulocytosis, neutropenia, pancytopenia, leukopenia, sulfhemoglobinemia and methemoglobinemia (cyanosis, adhesions, heart pain), sinus or bleeding.

On the side of the thyroid system:

nephrotoxicity, interstitial nephritis, papillary necrosis, impaired secretion, dysuria, secretion, aseptic pyuria, nitric colic.

On the side of the cardiovascular system:

arterial hypertension, tachycardia or reflex bradycardia, arrhythmia, shortness of breath, heart pain, heart failure.

Inshi:

decreased creatinine clearance, increased excretion of sodium and calcium, nasal congestion; Possible decrease in sechoic acid in the blood, as determined by the Bittner method; slight increase in 5-hydroxyindoloctic acid, vanillylmygdalic acid and catecholamines in the cell.

A one-time use of the drug in recommended doses with products that replace caffeine may increase the side effects associated with caffeine, such as confusion, restlessness, insomnia, restlessness, anxiety, irritability, headache, destruction of the side of the scolio-intestinal tract and accelerated heart rate.

Term of attachment 4 rocks.

Umovi sberіgannya

Store in a dry, dark place out of reach of children at a temperature not exceeding 25 ºС.

Package

No. 4 – 4 tablets per strip in a paper envelope;

No. 12 – 4 tablets per strip, 3 strips per cardboard box;

No. 200 – 4 tablets per strip in a paper envelope, 50 envelopes per cardboard box.

Release category

No. 4; No. 12 – without a prescription, No. 200 – with a prescription.

Virobnik

Sketch Pharma Pvt. Ltd.

Location of the distributor and addresses of the location of its activities

Syorvey No. 110/A/2 Amit Farm, Jane Upasrya, near the Coca Cola plant, N.H. No. 8, Kajipura - 387411, Kheda, India.

Special Recommendations

Now you know how to use the drug "Flukold" (4 tablets). The instructions for use state that if, after taking the medication, the patient’s body temperature does not decrease for three days or more, and the pain does not subside within five days, then it is necessary to consult a doctor.

This medicine is prescribed with extreme caution to people with diabetes.

The drug "Flukold N" reduces the speed of reactions.

Pharmacological properties of the drug Flukold tablets and powder for oral use

The pharmacological activity of the drug is determined by the properties of the components included in its composition. Paracetamol has an analgesic and moderate antipyretic effect. The mechanism of action is associated with inhibition of prostaglandin synthesis. The antipyretic effect is mediated by the effect on the regulatory centers of the hypothalamus. Phenylephrine belongs to the group of sympathomimetics, its action is primarily associated with direct stimulation of adrenergic receptors and is partially mediated through the release of norepinephrine. Chlorphenamine (chlorpheniramine) maleate belongs to the group of histamine H1 receptor blockers. Has a moderate sedative and M-anticholinergic effect. Inhibits the biological effects of histamine: reduces the severity of symptoms of allergic rhinitis, sneezing, rhinorrhea, irritation in the pharynx. Phenylpropanolamine hydrochloride helps reduce hyperemia and swelling of the mucous membrane of the upper respiratory tract and paranasal sinuses. Caffeine stimulates the central nervous system, cardiac activity and increases the strength of myocardial contractions. Ascorbic acid (vitamin C) plays an important role in increasing the body's nonspecific resistance to infections. The pharmacokinetic properties of Flukold are determined by the pharmacokinetics of each ingredient of the drug. Paracetamol is quickly and almost completely absorbed from the gastrointestinal tract. The maximum concentration in blood plasma is reached 2 hours after administration, is metabolized in the liver and is excreted mainly in the urine in the form of glucuronide and sulfate conjugates. Less than 5% of the drug is excreted unchanged. The half-life ranges from 1 to 4 hours. The drug is evenly distributed in all body fluids, about 25% is bound to blood plasma proteins. Chlorpheniramine maleate is quickly absorbed from the gastrointestinal tract and distributed throughout all tissues of the body. About 25% binds to blood plasma proteins. Phenylpropanolamine is easily absorbed after oral administration, the maximum concentration in the blood plasma is reached after 1–2 hours; The average half-life is 2–3 hours, undergoes significant metabolism in the body, and is excreted primarily in the urine. Caffeine is rapidly absorbed from the gastrointestinal tract and distributed throughout all tissues and fluids of the body, including the central nervous system, fetal tissue and breast milk. It is quickly metabolized and excreted in the urine. The half-life in blood plasma is about 3 hours. 70% of the dose is excreted in the urine.

Interactions of the drug Flukold tablets and powder for oral use

It is not recommended to use Flukold simultaneously with other drugs for the symptomatic treatment of colds, vasoconstrictors for the treatment of rhinitis and with drugs containing paracetamol. The effect of paracetamol is enhanced when combined with codeine, ascorbic acid, scopolamine, chlorphenamine, propyphenazone and caffeine. With the simultaneous use of barbiturates, tricyclic antidepressants, and alcohol, the half-life of paracetamol may increase. Long-term use of anticonvulsants may reduce the effectiveness of paracetamol.

Composition of Flukold

The drug is available in the form of tablets and sachets for the preparation of syrup:

Special instructions for the use of the drug Flucold tablets and powder for oral use

If the high temperature persists for 3 or more days or occurs again, and the pain does not stop for more than 5 days, it is necessary to reconsider treatment tactics. Use with caution in patients with impaired liver and kidney function, coronary artery disease, diabetes mellitus, and the elderly. During breastfeeding, it is used only if the expected benefit to the mother outweighs the potential risk to the child. When using the drug, you should not drive vehicles or work with potentially dangerous mechanisms.

Consumer fears and doubts

There are other consumer opinions about the medicine. Many patients are afraid to take this medication because it contains antihistamines. It is generally accepted that they are addictive. After all, many vasoconstrictor drugs for the nose can be used for no more than three days in a row. All doubts should be dispelled: if you use the medication in an age-appropriate dosage and do not take it for more than a week in a row, then nothing bad will happen. The medicine will not cause any addiction to you. It is only important to remember that the components have a sedative effect. If you have important work to do, you should discuss with your doctor the possibility of changing the medication to another.