- November 1, 2018
- Other drugs
- Gena Poddubny
Gaynomax suppositories are a topical medicine that produces a pronounced antifungal, antibacterial and antiparasitic effect. This drug is widely used in the field of gynecology and obstetrics.
Release format and composition of the medicinal product
Gaynomax suppositories are produced in the form of suppositories intended for vaginal use. This medicine is an oblong-shaped solid substance with pointed ends on one side. These suppositories are packaged in cell compartments in cardboard packs of seven pieces. The drug is sold complete with special finger pads intended for one-time use. They are supplied for ease of insertion of suppositories into the vagina. The main active ingredients of the drug are tioconazole (100 milligrams per suppository) and tinidazole (150).
Analogs
The drug Gainomax has a sufficient number of analogues with a similar mechanism of action and composition. As substitutes for the drug, it is worth considering other drugs intended for intravaginal use.
Terzhinan
The drug Terzhinan is produced in the form of tablets. Intended for vaginal use. The drug is highly active - after the start of treatment, unpleasant symptoms in patients are quickly eliminated. The composition is active against bacteria, protozoa and fungi. The active component is not absorbed into the systemic bloodstream, so it can be prescribed to pregnant and lactating women, unlike the drug Gaynomax.
Clotrimazole
The drug Clotrimazole is produced in the form of tablets for intravaginal administration. The composition is highly popular because it does not have a high price. The drug is well tolerated and does not cause adverse reactions.
Pimafucin
The drug Pimafucin is considered as an analogue of the drug in terms of pharmacological activity. The product is also produced in the form of suppositories intended for intravaginal use. The composition is able to eliminate the symptoms of vaginal candidiasis after the first use. The drug is well tolerated and does not cause adverse reactions.
Livarol
The drug Livarol is considered a popular formulation used to treat thrush in women. The drug is well tolerated and rarely provokes negative reactions. Before you start using it, you need to consult a gynecologist. The product is contraindicated for use in pediatric practice.
Pharmacological properties of the drug
So, as is already known, Gaynomax suppositories contain two active ingredients in the form of tioconazole and tinidazole. The first is a fairly powerful antifungal drug, distinguished by its synthetic origin, which can exhibit very high therapeutic activity against the yeast-like fungi Candida, as well as gardnerella and some varieties of gram-positive bacteria (be it staphylococci, streptococci and others). This drug can penetrate directly into the pathogen cells and the lesion, which effectively prevents the subsequent progression of the infection.
Tinidazole, which is part of the suppositories, is endowed with great therapeutic activity against such parasites as Trichomonas, Giardia, Gardnerella, Clostridia, Escherichia coli and other pathogenic pathogens. When inserting suppositories into the vagina, the active active ingredients of the drug act locally and practically do not enter the general bloodstream.
Pharmacological group
The drug Gaynomax is a combination of tioconazole and tinidazole. Tioconazole is a synthetic antifungal agent with high activity against yeast-like and other fungi (dermatophytes). It is also effective against bacterial pathogens.
The mechanism of action of tinidazole is not fully understood. Reduction of the nitro group is mediated by the ferredoxin system and the low redox potential produced only by anaerobic bacteria.
When administered intravaginally, both tioconazole and tinidazole are only slightly absorbed. Therefore, the absorption of the two drugs in combination should be low.
Pharmacokinetics
According to the instructions for use for Gaynomax suppositories, after a single administration of 300 milligrams of tioconazole in the form of vaginal suppositories in patients with candidiasis, as a rule, the average concentration of this drug in plasma is 18 nanograms per milliliter.
In most clinical trials, it was found that after a single dose of intravaginally administered tioconazole in the amount of 300 milligrams, its concentration in the vaginal secretion helps to suppress the reproduction of Candida fungi for three days.
With a single intravaginal use, only ten percent of tinidazole is systemically absorbed. Against the background of intravaginal use, tioconazole, like tinidazole, is only slightly absorbed. Therefore, the percentage of absorption of the two ingredients in combination should be low.
instructions for use GAYNOMAX
◊ Vaginal suppositories are yellowish in color, flat with a rounded end in the form of a truncated ellipse.
| 1 sup. | |
| tioconazole | 100 mg |
| tinidazole | 150 mg |
Excipients: vitepsol 2250.0 mg.
7 pcs. – cellless contour packages (1) made of PVC/LDPE, complete with 7 disposable finger pads – cardboard packs.
The description of the drug is based on the official instructions for use and approved by the manufacturer.
Dosage regimen
Intravaginally.
The drug is prescribed 1 vaginal suppository at night for 7 days. Alternative dosage regimen: 1 vaginal suppository 2 times a day (morning and night) for 3 days.
Vaginal suppositories should be inserted deep into the vagina using the disposable finger tips contained in the package.
Elderly patients
When prescribing the drug to elderly patients (over 65 years of age), no change in dosage regimen is required.
Side effect
Side effects according to the results of clinical studies. In clinical studies of the combination of tinidazole 150 mg with tioconazole 100 mg in the form of cream or vaginal tablets, clinical and microbiological parameters were assessed in a total of 348 patients, both dosage regimens (3 or 7 days) were evaluated.
According to the study results, the safety of this combination was assessed as high. The following side effects were observed: allergic reactions (in 3.3-4.5% of cases), local itching (1.9%) and burning sensation (1.7%). In most cases, side effects were moderate, only 0.75% of patients interrupted treatment due to allergic reactions.
Post-marketing experience of use.
In post-marketing practice, the following adverse events were additionally reported:
Local reactions: rarely - swelling, irritation of the vaginal mucosa.
Allergic reactions: rarely - skin rash, urticaria, in some cases - angioedema.
Although no cases of transient leukopenia have been reported with intravaginal use of the combination of tioconazole and tinidazole, cases of this symptom associated with neurological or gastrointestinal symptoms associated with systemic use of tinidazole have been described.
Use during pregnancy and breastfeeding
Tinidazole penetrates the fetoplacental barrier and also into breast milk. The effects of the components of this drug on the development of the fetus and newborn are not known.
Taking Gainomax is contraindicated in the first trimester of pregnancy. During treatment with Gainomax, breastfeeding should be stopped. The use of Gaynomax in the third trimester of pregnancy should be assessed by the attending physician from the perspective of the relationship between potential benefits for the mother and possible risks for the fetus.
Intended use
Gaynomax suppositories can be prescribed to women for the treatment and prevention of the following pathologies:
- If the patient has vaginitis.
- Against the background of the development of colpitis.
- For bacterial vaginosis.
- In case of recurrent vaginal candidiasis.
- As part of complex treatment for trichomoniasis or against the background of gardnerellosis.
- If the patient has vulvovaginitis.
Contraindications for use
According to the instructions, Gaynomax suppositories have a number of different restrictions and contraindications for use, so before starting treatment it is very important to consult a doctor and carefully study the instructions for this drug. Suppositories are contraindicated for women with the following pathological conditions:
- Against the background of individual intolerance to the components included in the suppositories.
- In case of severe disorders of blood functions, exactly as in acute and chronic leukemia.
- In case of pregnancy, especially in the initial trimester.
- During the period of breastfeeding the baby.
- Time before a girl enters into sexual relations.
- For diseases of the nervous system.
Indications for use
The drug Gaynomax is used to treat infectious lesions caused by microorganisms that are characterized by sensitivity to the active component of the drug.
for adults
The drug can be used by patients of this age group who have no contraindications for use. The drug is not used in pediatric practice, and is also not used for patients suffering from dysfunctions of the urinary system.
for children
The use of the drug is contraindicated in children under 18 years of age, as well as in girls who are not sexually active.
for pregnant women and during lactation
Gainomax should not be used in the first trimester of pregnancy. During the period of breastfeeding, as well as during the second and third trimesters, use is possible, but it must be done after consultation with a doctor. Use is carried out exclusively according to the indications of a physician.
Method of administration and dosage of the drug
Gaynomax suppositories are intended for vaginal use. According to the instructions, women are prescribed one suppository of the drug twice a day for three days for the treatment and prevention of a particular gynecological infection. In the presence of a mild clinical picture of the pathology or as part of maintenance treatment, this drug is indicated for one suppository once a day immediately before bedtime for a week.
To insert the suppository into the vagina, the patient must take a comfortable position, then she must put on the disposable fingertip included in the medicine kit and insert the drug inside as deeply as possible. After the medication administration procedure, it is recommended to lie down for forty minutes to achieve an even distribution of the active ingredients of the medication.
Applications and dosages
The regimen of medicinal use, course duration and dosage are directly dependent on the form of release of the medication and the nature of the disease. The selection of the optimal dosage and method of use is carried out by a doctor.
for adults
Patients in this age group can use medications if there are indications for use. The suppositories are inserted deep into the vagina. Dose adjustment is required for elderly patients.
for children
The use of the drug by children under 18 years of age is prohibited.
for pregnant women and during lactation
The possibility of using a medication during pregnancy and breastfeeding is determined on an individual basis. The drug is not recommended for use in early pregnancy. The drug can be used in the second and third trimester. It is not recommended to use the composition during breastfeeding. Such an action can provoke the appearance of various complications that affect the development of the fetus.
Using suppositories during pregnancy
The active ingredients of these suppositories can easily penetrate the placental barrier, just like into the breast milk of nursing mothers. Considering that the effect of the drug on the child’s body and fetus during lactation has not been fully studied, treatment with these suppositories is not prescribed to pregnant and lactating women. If a treatment course with this drug is necessary, a woman should consult a doctor in search of the safest and alternative medicine.
Analogues of Gaynomax are easy to find.
Side effects
During therapy with this drug, women may develop the following side effects:
- The appearance of burning and itching in the vagina immediately after insertion of the suppository.
- The occurrence of discomfort when urinating.
- For allergic reactions.
- Against the background of a drug overdose.
It is worth saying that to date, no cases of overdose with this drug have been recorded in medicine, however, in order to prevent the above adverse reactions, it is still not recommended to exceed the doses given in the instructions.
special instructions
During treatment with Gaynomax, it is forbidden to drink alcohol, since in such a case the risks of developing adverse reactions from tinidazole sharply increase. During therapy with suppositories of this medicine, it is not recommended to engage in sexual contact, and also to use during this period certain barrier means intended to protect against unwanted pregnancy (we are talking about vaginal caps, condoms, and so on). The fact is that the constituent ingredients of suppositories can have a negative effect on the latex base of contraceptives.
Price, conditions of release and storage measures for the drug
This drug in the format of vaginal suppositories is dispensed in pharmacies without a prescription from a doctor. The candles in question must be stored in a cool place, but not in the refrigerator. This drug should also be kept away from children. The shelf life of the described suppositories is, as a rule, two years from the date of their production. The average price for the drug "Gaynomax" in pharmacies is currently one thousand one hundred rubles per package. Next, we’ll find out what the reviews say about these candles.
Gaynomax instructions for use of suppositories
Latin name: gynomax ATC code: G01AF20 Active ingredient: Tioconazole, tinidazole Manufacturer: Embil Pharmaceutical, Turkey Dispensing conditions from the pharmacy: By prescription
Gynomax suppositories are prescribed for the treatment of infectious and inflammatory processes in gynecology in women.
Composition of the drug
Active ingredients: ticonazole - 100 mg in one suppository and tinidazole - 150 mg in one suppository. The auxiliary component is vitepsol.
Medicinal properties
The active ingredients in the suppositories provide a wide therapeutic complex and fight against many infectious pathogens. Tioconazole works best against fungal structures, especially against yeast-like and bacteria, which also includes thrush.
The active substance inhibits the activity of Gardnerella vaginalis, Trichomonas and Bacteroides; the list also includes gram-positive pathogenic microorganisms. The therapeutic effect is triggered by tioconazole disrupting the integrity of the membrane structures of the fungus, as well as suppressing the synthesis of ergosterol, which is necessary to maintain the life of the fungus.
Since the enzyme ergosterol stops being synthesized, the fungal pathogen stops multiplying and soon dies altogether.
The second active component of Gainomax tinidazole suppositories is active against protozoal and anaerobic microorganisms. These include: Giardia lamblia, Enteroamoeba histolytica, Eubacterium species, Bacteroides fragilis, Trichomonas vaginalis, Peptostreptococcus, Bacteroides, Clostridia, Veillonella.
The combined composition based on tioconazole and tinidazole is powerful, so in 90 - 100% of cases there is a rapid disposal of pathogenic pathogens in the gynecological area. With intravaginal administration of the drug, a persistent therapeutic effect occurs in approximately 85 out of 100 cases.
Mode of application
The average cost of the drug in Russia is 1030 rubles per package.
Gaynomax is easy to use - insert suppositories deep enough into the vagina using thin rubber medical gloves once a day before bed for a week, or 2 times a day for 3 days in a row.
Parallel therapy of the sexual partner is mandatory, even if he does not exhibit negative manifestations of the disease, otherwise the treatment result may be poor.
After administration during the daytime, it is advisable to lie down for 40 minutes so that the drug is well distributed along the walls of the vagina.
During pregnancy and breastfeeding
Not prescribed, since the active components penetrate the systemic bloodstream and can cause harm to the fetus or child through breast milk.
Contraindications and precautions
Contraindications include:
- Individual intolerance to active components, allergic reaction or hypersensitivity
- History of organic lesions of the central nervous system
- Leukemia
- Age before adulthood
- Presence of hymen
- Periods of breastfeeding and pregnancy in the patient
- Hematopoiesis is impaired.
Gaynomax should be hidden away from children.
Cross-drug interactions
You cannot drink alcohol during treatment with medication, otherwise there will be extensive toxic effects - vomiting and nausea will begin, the skin will turn red, and colic will begin in the intestines.
Side effects
Rarely occur, but are usually accompanied by local reactions - burning in the vagina or itching, which indicates an allergy. Systemic adverse reactions occur even less frequently - migraine, swelling, rash, dark urine and irritability.
Ornisis
Abdi Ibrahim, Türkiye
The average cost in Russia is 200 rubles per package.
Ornidazole is an antibiotic with an antiprotozoal effect. Used in urology, gynecology and gastroenterology. It has a wide spectrum of action, is active against Trichomonas, Giardia, amoebae, Gardnerella and other anaerobic mycobacteria. Available in tablet form and as a suppository for intravaginal administration.
Pros:
- Compatible with alcoholic drinks
- It's inexpensive.
Minuses:
- Not suitable for everyone
- Not suitable for pregnant women.
Reviews about the drug
Reviews about Gaynomax candles are mostly positive on the Internet. Their effectiveness in the treatment of vaginitis is noted. There are practically no reports on the development of adverse reactions. In the comments there are sometimes some complaints about the cost of this remedy. But in general, even despite the fairly high price, patients are satisfied with the results of the treatment.
For example, it is reported that this medication perfectly helps women cope with the presence of vaginitis against the background of the development of colpitis, bacterial vaginosis and the appearance of recurrent vaginal candidiasis. In addition, the effectiveness of these suppositories is also reported in the case of complex treatment for trichomoniasis or against the background of gardnerellosis, just as in the case of vulvovaginitis.
Thus, this medication is recommended for women with various infectious inflammations of the vaginal mucous membranes caused by Candida fungi. Most reviews (including medical ones) emphasize that this medication helps perfectly in the presence of vaginal candidiasis, and it can also be successfully used for vulvovaginitis, which is caused by Trichomonas vaginalis. The effectiveness of the drug is especially praised in the treatment of vaginitis and diseases of the genitourinary organs that arise as a result of the activity of certain pathogenic microorganisms.
We reviewed the instructions for use for Gaynomax candles and reviews.
