Compound
1 gram of cream contains 1 mg of hydrocortisone butyrate .
Additionally: 72 mg cetostearyl alcohol, 18 mg cetostearyl ether macrogol 25, 60 mg liquid paraffin, 2.8 mg anhydrous sodium citrate, 1 mg propyl parahydroxybenzoate, 150 mg soft white paraffin, 0.5 mg butyl parahydroxybenzoate, 4.2 mg anhydrous citric acid , up to 1 g of purified water. 1 gram of ointment includes 1 mg of hydrocortisone butyrate . Additionally: up to 1 g of ointment polyethylene base containing 5% polyethylene and 95% vaseline oil.
What does the medicine consist of?
Today, Lokoid cream (for children) has only the most positive reviews and is widely used in medical practice. It is produced in Italy and Russia. The drug is intended for external use only. The product "Lokoid" is produced in the form of cream and ointment. It is the cream that is most preferable for children. The main active ingredient of the drug is hydrocortisone butyrate. Macrogol, liquid paraffin, anhydrous sodium citrate, anhydrous citric acid, and purified water are used as excipients.
“Lokoid” (cream) is produced in special aluminum tubes, which make the drug easier to use and also significantly extend its duration. Despite the fact that the drug is hormonal, it is sold in pharmacies without a prescription. Store the cream in a dark place out of reach of children. The drug can be left in the refrigerator, but freezing it is not recommended. The optimal storage temperature is 25 degrees.
Pharmacodynamics and pharmacokinetics
Lokoid in the form of cream and ointment is a synthetic local (external) non-halogenated drug from the group of glucocorticoids . Due to the esterification hydrocortisone molecule with butyrate , the activity of the natural hormone that forms the basis of the drug has radically increased, which explains the rapid onset of anti-edematous , anti-inflammatory and antipruritic effectiveness with local use of Lokoid dosage forms.
The use of recommended therapeutic dosages of Lokoid does not lead to inhibition of the hypothalamic-pituitary-adrenal system. The use of hydrocortisone butyrate in large doses and over a long period of time, especially when applying the drug under occlusive dressings , may be accompanied by an increase in plasma cortisol , which, as a rule, does not affect the decrease in the productivity of the pituitary-adrenal system. When you stop using hydrocortisone butyrate, there is a rapid normalization of endogenous cortisol .
hydrocortisone butyrate accumulates in the epidermis , affecting mainly its granular layer. Systemic absorption of the active ingredient of the drug is insignificant and is characterized by the absorption of a small amount of unchanged hydrocortisone butyrate .
Metabolic transformations of a significant part of hydrocortisone butyrate occur directly in the epidermis and subsequently in the liver with the release of hydrocortisone and other metabolic products.
Excretion of a small part of the unchanged active ingredient of the drug, as well as the products of its metabolism, is carried out through the intestines and kidneys.
Composition and properties
Lokoid cream is a hormonal pharmacological agent, like other forms of the drug. It is based on a glucocorticoid-type hormone that has a modified structure. The name of the active component of the product is hydrocortisone butyrate. This is a hormonal pharmacological substance for external use.
The modified formula of the synthetic hydrocortisone molecule by adding butyric acid enhanced the medicinal properties of the cream. Its therapeutic effect is significantly higher than the properties of hydrocortisone produced by the adrenal glands in the human body.
The action of this drug occurs with the accumulation of active substances on the affected area of the skin. In this regard, a stable effect and hormonal addiction occurs. You should not use this medicine for longer than the period prescribed by your doctor. The course of application should not exceed 14 days.
Indications for use
The use of Lokoid ointment and cream is indicated for the treatment of superficial, non-infected skin diseases sensitive to the effects of local glucocorticoids:
- eczema;
- dermatitis (including seborrheic , contact, atopic );
- psoriasis.
Ointment Lokoid
Lokoid ointment is one of the forms of the drug intended for external use. The ointment is available in 30 g tubes; the drug has a concentration of hydrocortisone butyrate of 0.1%.
The ointment form of the drug is used to treat inflammatory diseases of the skin with characteristic dryness and roughening of the skin. The ointment has a thick consistency that lies on the skin in a dense layer and is poorly absorbed.
It is not used for the treatment of inflammatory processes on the scalp, or for the treatment of dermatological diseases of the face.
Contraindications
Some painful conditions of the human body are incompatible with the use of local hormonal drugs, including Lokoid cream and ointment, for which they are contraindicated in:
- violations of the integrity of the epidermis (including skin wounds and ulcers);
- personal hypersensitivity to hydrocortisone or minor ingredients of the drug;
- neoplastic transformations of the skin ( malignant and benign tumors );
- bacterial skin infections (gram-negative folliculitis , staphyloderma , streptoderma , etc.);
- rosacea (rosacea);
- viral skin infections ( shingles , chicken pox , herpes simplex , etc.);
- perioral dermatitis;
- fungal skin lesions;
- acne (acne);
- parasitic skin lesions;
- syphilitic and tuberculous changes in the skin;
- in the post-vaccination period;
- in infancy up to 6 months.
Pregnant and lactating women require special caution in prescribing Lokoid
Who is contraindicated for Locoid cream?
It is worth remembering that the drug is hormonal. Therefore, it has many contraindications. Lokoid cream is not prescribed for severe forms of acne, infectious skin diseases, fungal infections, or the appearance of tumors on the skin (both benign and malignant). The drug is also not suitable for the treatment of herpes zoster and chickenpox. Its use for the treatment of herpes virus infection is also unacceptable. The patient cannot know in advance what the nature of the rash that appears on the skin is. For those who decide to purchase Lokoid cream, reviews should not become a decisive factor in the choice of medication. You should definitely consult a dermatologist.
You should not use the drug if the integrity of the skin is compromised. Applying cream to ulcers and wounds can only make the problem worse. People with a tendency to allergic reactions also do not take the product.
Side effects
In some cases, when using therapeutic dosages of Lokoid, the formation of negative reactions of a local nature was observed, manifested by skin irritation or other local phenomena characteristic of external therapy with glucocorticoids .
In the case of prolonged use of Lokoid, application of dosage forms of this drug under occlusive dressings and/or on large skin surfaces, side effects characteristic of the action of systemic glucocorticoids .
When using Lokoid externally, the risk of developing local and systemic negative side effects is significantly lower than when using fluorinated steroids .
pharmachologic effect
Pharmacological properties of hydrocortisone butyrate:
- Anti-edematous effect. The effect of hydrocortisone on the skin reduces the permeability of capillary walls, which is formed when histamine is released into the blood. Due to this, excess fluid is removed and swelling in the damaged area of the epidermis is reduced.
- Anti-inflammatory effect. The active component of Lokoid cream relieves inflammatory processes by blocking the release of leukocytes in the inflamed area of the skin.
- Immunosuppressive effects. Due to the suppression of leukocytes, there is an immediate anti-allergic effect and the activity of the body's protective function - the inflammatory process - is reduced. That is why you should not use this product on skin affected by viruses, bacteria and fungi. This will cause further spread of the infection.
- Antipruritic property. Lokoid cream helps eliminate itching and burning caused by various irritants. Its antipruritic effect is lower than that of antihistamines, so comprehensive therapy is necessary to fully treat allergies.
Instructions for use of Lokoid (Method and dosage)
Cream Lokoid, instructions for use
Lokoid cream is intended for local (external) use mainly for the treatment of subacute and acute negative skin processes.
Depending on the location and severity of skin lesions, applying a thin layer of cream to problem areas of the skin 1-3 times a day is recommended. In order to improve the penetration of the cream into the epidermis , its application should be carried out with light massaging movements of the palms of the hands. If positive dynamics of therapy occur, the frequency of use of the cream can be reduced to 2-3 times every 7 days. The total weekly dose of the drug should not exceed 30-60 grams.
Lokoid ointment, instructions for use
Lokoid ointment is intended for local (external) use for the treatment of subacute and chronic negative skin processes, especially with manifestations of infiltration , lichenification , and dryness .
Depending on the location and severity of skin lesions, applying a thin layer of ointment to problem areas of the skin 1-3 times a day is recommended. In order to improve the penetration of the ointment into the epidermis , its application should be carried out with light massaging movements of the palms of the hands. If positive dynamics of therapy occur, the frequency of use of the ointment can be reduced to 2-3 times every 7 days. In cases of insufficient effectiveness of such treatment, for example, with the accumulation of psoriatic formations (dense plaques) on the knee or elbow joints, it is possible to apply ointment under occlusive dressings . The total weekly dose of the drug should not exceed 30-60 grams.
When is Lokoid prescribed?
The drug is most often used to treat the superficial layers of the skin. If a bacterial infection develops and spreads to deeper layers, the cream no longer has the desired effect. The drug can be prescribed for the treatment of eczema, various dermatitis, psoriasis, pruritus, lichen planus, seborrhea and photodermatosis in adults and children.
The drug "Lokoid" is an excellent remedy for relieving itching and redness after insect bites. In rare cases, the drug is used in the treatment of allergic rashes in children. Despite the fact that Lokoid (cream) is available without a prescription, the instructions for use should be studied first. You should not self-medicate, especially when it comes to a child. It is worth consulting a doctor who will confirm the possibility of using this remedy.
special instructions
Due to the risk of glaucoma , you should avoid applying any dosage form of Lokoid to the periorbital area .
In case of systematic contact of the active ingredient of the drugs on the conjunctiva , intraocular pressure may increase .
It is advisable not to use Lokoid in the form of an ointment for the treatment of acute inflammatory processes (especially exudative ones), as well as skin diseases of the scalp. For the treatment of steroid-sensitive skin lesions localized in the area of folds, abundant hair, face and genitals, it is better to use other local dosage forms of the drug Lokoid (Crelo or cream).
atrophic skin changes .
The possibility of systemic and local side effects inherent in hydrocortisone increases with its long-term use, application of the drug under occlusive dressings or on large areas of skin, as well as in childhood.
If there is no effect of therapy with continuous use of Lokoid for 2 weeks, the doctor must clarify the diagnosis.
It is better to limit the duration of use of Lokoid to the shortest possible period, with a course dosage prescribed sufficient to stop the negative skin process.
Side effects
Side effects from the use of the drug can be both systemic and local. The former most often occur with an overdose or when using occlusive dressings. They manifest themselves in the form of menstrual irregularities, darkening and itching of the skin, brittle bones, and a stomach ulcer may develop. Children may experience growth retardation, memory impairment, and night sleep disturbances. When the first side effects appear, it is worth about. The instructions do not describe serious cases of negative reactions. But it’s still worth being safe. The dermatologist will suggest an alternative or reduce the dosage of the drug.
Local side effects can only occur where the cream is applied. They manifest themselves in the form of itching and redness of the skin, an increase in the amount of hair, irritation, dryness, and atrophy. It is worth sounding the alarm if, in the process of using Lokoid cream in children, the skin condition only worsens.
Analogues of Lokoid
Level 4 ATC code matches:
Hydrocortisone
Lokoid Krelo
Lokoid Lipocrem
Analogs of Lokoid cream and ointment are represented by external medicinal agents from the same pharmacological group:
- Afloderm;
- Powercourt;
- Fluorocort;
- Dermovate;
- Polcortolon;
- Cloveit;
- Focourt;
- Triacort.
Cream Lipocream
Locoid cream and Lipocrem are often confused, but these are two different drugs that have differences.
Lipocrem is a form of Lokoid cream that is recommended for the treatment of subacute and chronic dermatological diseases. Lipocrem is prescribed for the treatment of skin pathologies that are accompanied by skin infiltration, dehydration and dryness of the epidermis, as well as lichenification phenomena (thickening, changes in the color of the epidermis and the severity of the skin pattern).
For children
The possibility of using Lokoid in pediatrics is considered from 6 months of age. The area of the skin surface of the child’s body used for applying medications should not occupy more than 20% of the total area. When using Lokoid under occlusive dressings or applying it to the child’s face, the duration of the therapeutic course should be reduced to the minimum possible period.
It should be remembered that in the pediatric age group, suppression of the function of the adrenal cortex may occur more quickly. In addition, local hormonal therapy can cause a decrease in the production of growth hormone . In case of prolonged use of Lokoid in pediatrics, it is necessary to constantly monitor the child’s body weight, growth indicators and plasma cortisol . In studies conducted, children who received 30-60 grams of Lokoid per week for a month, compared with children who received 1% hydrocortisone , did not experience any changes in the functionality of the adrenal cortex .
Reviews
Reviews about Lokoid cream and features of the drug:
Reviews
Valeria, 34 years old, Moscow : “Lokoid cream is beautifully packaged in a cardboard box and tube. The texture of the cream is a little oily, it is colorless and is poorly absorbed, and stains things very much. The smell is neutral. He coped with his task: he eliminated inflammation in allergic dermatitis. I applied the cream once a day for 1 week.”
Olga, 45 years old, St. Petersburg : “Since childhood, I have been struggling with atopic dermatitis. All the remedies that the doctor suggested did not help me at all. I read reviews about this remedy and its effect on blood pressure. I decided to try Locoid cream. I applied it in the evening on the day of purchase. Already in the morning the skin began to look much better. I continued to use it as indicated in the instructions once a day.”
Elena, 38 years old, Adler : “The doctor prescribed this remedy for me for seborrheic dermatitis, he says that the reviews about it are good. The instructions for using Lokoid cream are detailed and understandable. It needs to be applied 2-3 times a day. Please note that the cream is hormonal, so it should only be used as prescribed by a doctor. After 2 weeks of use, it completely solved the problem of dermatitis and reduced the symptoms: itching and burning. The price of the product is not too high, so you can try it.”
Polina, 26 years old, Nizhny Novgorod : “I became familiar with Lokoid cream when strange spots appeared on my skin. The dermatologist said it was an allergy and prescribed pills and this cream. I used the cream for 1 week and everything went away. Now I use it quite often in small quantities. And after a couple of days the allergy subsides. Lokoid is an effective remedy that relieves irritation and burning. The cream has a light texture, the ointment is thicker. Therefore, only cream is suitable for facial skin. The volume of the tube lasts me a long time, and I generally think that it is quite economical.”
Daria, 35 years old, Voronezh : “In this review I will talk about Lokoid cream. It was recommended to me by a dermatologist I know. It helps against dermatitis, psoriasis, eczema. On the plus side, I note that it can also be used for children. The cream is hormonal, but it works very effectively. It cannot be applied to the skin just like that. Read the instructions carefully. The doctor prescribed me Lokoid for eczema. It did a good job with the itching and burning of the skin, which really bothers me. The product does not contain fragrances. »
During pregnancy and lactation
Prescribing Lokoid to pregnant and lactating women requires special caution.
Since glucocorticoids tend to penetrate the placenta , it is possible that they may affect the fetus, especially when the drug is applied to large areas of skin.
The exact amount of hydrocortisone found in breast milk has not been established, and therefore it is not possible to determine the extent of its effect on the infant.
Therapeutic effect
What kind of medicine is this - "Lokoid"? The cream is a hormonal drug that is applied externally. The glucocorticoid hormone under the influence of butyric acid becomes more active, thereby enhancing the therapeutic effect of the drug. "Lokoid" belongs to the group of synthetic drugs. The main component has a strong anti-inflammatory effect. Unpleasant symptoms such as skin itching, swelling and flaking go away. The modified glucocorticoid has another positive property. The human body does not get used to the hormone. Thanks to this, Lokoid (cream) is approved for use in children over 6 months of age.
Most drugs that are intended to treat skin diseases provide only a temporary effect. This cannot be said about a product like Lokoid. The cream, which includes strong anti-inflammatory components, eliminates the problem for a long time. After the end of treatment, remission does not occur.
When the drug is applied to the skin, the active hormone accumulates in the deep layers of the epidermis. Only a small part of the drug is absorbed into the systemic circulation. The medication is completely utilized in the liver.
Reviews about Lokoid
Reviews about Lokoid ointment left on the Internet divide patients who have ever used this drug approximately equally, where some note the high effectiveness of the ointment, the speed of its action and the absence of side effects, while others evaluate the effect of the drug “exactly the opposite.” Reviews about Lokoid cream are more positive. In this case, the number of people who were satisfied with the effects of the cream far exceeds the number of patients with a negative opinion about its effect. This may be due to the use of ointment or cream to treat non-specific skin conditions. In any case, the use of even external hormonal drugs requires a thorough approach with an accurate diagnosis and selection of a therapeutic agent.
The same trend in assessing the effectiveness and safety of Lokoid can be seen when used in pediatrics, regardless of the dosage form of the drug, including cream or ointment. Whether or not the basis of a local medicinal drug is hormonal or not, the possibility of its use for children can be determined exclusively by a pediatrician, considering each individual pathological case on an individual basis.
Use by pregnant women and children
The drug is not prohibited for use during pregnancy and lactation. For children in the first year of life, the medication can also be prescribed. The dosage used is the same as for the treatment of adult patients. The only difference is that pregnant women and children must be constantly under medical supervision. The use of Lokoid cream in pregnant women is justified only when the expected benefit to the pregnant woman outweighs the possible harm to the fetus.
Before using Lokoid cream or ointment to treat children, you should consult a pediatrician. In patients under three years of age, the drug is most often used to treat chronic pathological processes that are not amenable to more gentle therapy. For children, the drug can also be prescribed for the treatment of skin. The dosage and other nuances of treatment should be discussed with a dermatologist.
Lokoid price, where to buy
The price of Lokoid ointment varies between 300-340 rubles. The price of Lokoid cream fluctuates around 320-370 rubles.
- Online pharmacies in RussiaRussia
ZdravCity
- Lokoid Lipocrem cream 0.1% 30g Temmler Italy/Astellas
RUR 309 order - Lokoid Crelo emulsion for external use. approx. 0.1% 30g Temmler Italy/Astellas
162 RUR order
- Lokoid cream 0.1% 30g Temmler Italy S.r.L.
RUB 267 order
- Lokoid ointment 0.1% 30g Temmler Italy S.r.L.
290 rub. order
Lokoid cream. Price issue
The drug "Lokoid" is hormonal, so it is not cheap. The final cost depends on the release form. The most preferred cream for children is Lokoid cream. The price of the drug in pharmacies averages 290 rubles. The product can be stored in a cool place for no more than three years.
Lokoid ointment can be stored at a temperature of 25 degrees Celsius for up to five years. The cost of this form of the drug is 300 rubles. The least popular is the Lokoid emulsion. The medicine is stored for no more than two years, but is cheaper. At the pharmacy you will have to pay 230 rubles for it.
Which is better: Locoid ointment or cream
Lokoid ointment and cream.
Photo: vchemraznica.ru Dosage forms of the drug Lokoid differ in the composition of excipients, and accordingly there is a difference in texture. The cream form is applied to non-wetting skin lesions with bright redness; it is lighter in consistency. The mazefu form is used in cases where skin damage is accompanied by roughness, severe dryness, cracks with itching, redness, and rash.
Both forms can be prescribed to children from 6 months.
Description of the drug
Lokoid is a transparent ointment with a jelly-like consistency that does not have a specific odor. Its active ingredient is quickly absorbed and penetrates directly into pathological lesions.
The therapeutic properties of the drug appear a few minutes after its application to the affected epidermis. Therefore, it is used for acute and chronic diseases of the skin surface.
What does Lokoid ointment help with:
- eliminates swelling of the skin, promotes the resorption of extensive edema;
- relieves inflammatory processes of various localizations and at any stage of the course;
- reduces the intensity of itching, burning, pain;
- stimulates rapid healing of damaged tissues;
- eliminates small and large allergic rashes.
The active ingredient of the drug is hydrocortisone butyrate. This compound is obtained by reacting butyric acid with one carboxyl group on the glucocorticosteroid. The substance obtained as a result of a chemical reaction has pronounced therapeutic activity.
Clinical and pharmacological group
Lokoid is a representative of the clinical and pharmacological group of drugs for external use containing glucocorticosteroids. According to its therapeutic effect, the ointment is classified as an anti-inflammatory, anti-exudative, and analgesic agent.
Patients often ask dermatologists whether Lokoid is a hormonal ointment or not. The active ingredient of the drug is an improved synthetic analogue of hydrocortisone.
This hormone is produced by the adrenal cortex when the body is exposed to external or internal negative factors. Therefore, when using Lokoid, it is necessary to take into account the specifics of hormonal therapy.
pharmachologic effect
Lokoid cream exhibits complex therapeutic activity due to the pharmacological properties of the glucocorticosteroid.
Compliance with the dosage regimen recommended by the doctor allows you to avoid suppression of the functioning of the adrenal glands. The drug does not disrupt the functioning of the structures of the pituitary gland and hypothalamus, which regulate the activity of the endocrine and nervous systems. Even with a certain decrease in the biosynthesis of endogenous cortisol, its production normalizes after completion of therapy.
Hydrocortisone is characterized by the manifestation of diverse therapeutic activity:
- inhibition of cyclooxygenase, which stimulates the biosynthesis of prostaglandins and bradykinins. The use of the product allows you to quickly stop both acute and sluggish inflammatory processes;
- preventing the accumulation of macrophages and leukocytes in damaged tissues. When using a hormonal drug, the release of pathological exudate and the resorption of edema are accelerated;
- normalization of blood circulation in inflammatory foci. Together with the blood flow, substances necessary for cell restoration penetrate into them. Metabolism accelerates, and, consequently, regenerative processes.
The glucocorticosteroid begins to transform in the epidermis, and final metabolism occurs in hepatocytes (liver cells).
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An effective analogue of Lokoid ointment Dermovate is a drug for the treatment of inflammatory skin pathologies.
Release form and composition
The Lokoid therapeutic line includes ointment, cream and emulsion with a liquid consistency. Dosage forms have identical therapeutic effects, but differ in the composition of auxiliary ingredients. The Italian manufacturer produces ointment in 30 g packaging.
Primary packaging is a hermetically sealed aluminum tube of bright yellow color. It is enclosed in a cardboard box along with instructions for use. The Lokoid ointment base contains ethylene polymer and petroleum jelly. A small amount of additional ingredients reduces the likelihood of local systemic manifestations.
Doctors recommend various dosage forms of Lokoid to patients. What is the difference between ointment and cream:
- the ointment penetrates into the deepest layers of the epidermis, instantly providing an anti-inflammatory effect;
- The cream is evenly distributed in the upper layers of the skin and exhibits prolonged therapeutic activity.
One of the differences is the thicker consistency of the ointment. The difference between ointment and cream lies in the range of medications used. The cream is often prescribed to patients with chronic skin pathologies. And the ointment is recommended to eliminate severe symptoms of acute diseases.
Storage conditions and periods
Lokoid is intended to be stored in a dark place at room temperature. The shelf life of the drug is 5 years. If the seal of the tube is broken, it is limited to 3-4 weeks. Storing the ointment with the primary packaging open for a long time leads to its delamination. It also changes color and has an unpleasant foreign odor. This product cannot be used for treatment.
