Glucosamine chondroitin - main properties, effect on the body, instructions for use, reviews

Hello, my dears! Lovers of dachas, gardens and vegetable gardens will understand me. With the onset of warm days and until late autumn, amateurs like me “rest” only on the ground with a hoe or rake in their hands.

And everything would be fine, but the longer you weed the beds, the more your back and knees hurt. A neighbor in the country advised me to take the drug Glucosamine Chondroitin. It cannot be called a medicine; rather, it is a dietary supplement whose purpose is to nourish joints and bones.

I still can’t determine for sure whether this drug has any effect, but I’ve been taking it every day for the last two months. My back and knees don’t bother me, I just don’t know if the dietary supplements helped or if I stopped going to the dacha.

Dosage forms

There are only two main types of Glucosamine.
Both of these forms are quite effective. Doctors may prescribe drugs containing glucosamine sulfate or hydrochloride to the patient. There are practically no differences between these two types of medicine. However, sulfate products contain several percent less pure glucosamine than hydrochloride products. In addition, the latter are absorbed faster and better when taken orally. Chitin from farmed marine crustaceans is what is commonly used to produce a substance called glucosamine sulfate. Analogues of the drug made on its basis are usually used by people prone to allergies. The fact is that crustaceans are often grown using hormonal supplements. Therefore, many patients, unfortunately, have an allergic reaction to sulfate medicine. Glucosamine hydrochloride is almost completely free of such disadvantages. It is made from corn husks.

Instructions for use of Glucosamine sulfate

The most convenient way to treat osteochondrosis is with an oral solution of the drug. The powder should be mixed in one glass of drinking water. It is necessary to take Glucosamine sulfate according to the instructions at the time of meals to achieve the best effect. The daily dosage of the drug should be determined by a specialist, taking into account the diagnosis, complaints and symptoms manifested in patients.

As a rule, adult patients suffering from osteochondrosis are prescribed one sachet of Glucosamine sulfate per day. The course of therapy lasts approximately 4-10 weeks, depending on the degree of development of the pathology. If osteochondrosis does not completely recede, the doctor may extend the treatment. However, a second course of therapy can be started no earlier than after 2 months.

In addition, you can use Glucosamine sulfate in tablet form. They should also be taken with meals with a glass of water. Typically, adult patients are prescribed one tablet of the drug per day. Therapy can last from three months to six months. The final dosage is determined by the attending physician after a full examination.

It is strictly not recommended to use Glucosamine Sulfate, as well as other chondroprotectors, without a doctor’s prescription. After all, an ill-chosen dosage can harm the body rather than cure it.

special instructions

Glucosamin Chondroitin MSM, reviews of which are considered additional confirmation of the quality of the product, is not effective for patients suffering from advanced forms of osteochondrosis or arthrosis.

This is explained by the almost complete absence of the cartilage layer in this pathology, which does not allow the active components to accumulate in the tissue. However, the medication is used quite often as an auxiliary treatment method.

If mild negative reactions are observed in the first few days of therapy, it is worth reducing the dosage by 2 times. If there is no improvement, treatment should be stopped.

It is important to normalize the diet, include liver, chicken and beef. You should definitely eat seafood, as well as gelatin-based dishes. Compliance with the recommendations will increase the effectiveness of therapy.

What is the remedy

Actually, the substance glucosamine itself is always present in small quantities in the human body. It is produced naturally and helps to increase the extensibility of cartilage tissue. In addition, glucosamine also has an immunomodulatory effect on the human body. That is, it increases resistance to various types of infections.

The drug Glucosamine itself has approximately the same pharmacological effect. In most cases, this remedy is taken by patients in the form of a powder solution. One sachet from the purchased package of Glucosamine medication is simply poured into water (200 ml) and stirred thoroughly. In some cases, this drug may also be used in tablet form. Doctors sometimes use a ready-made solution of Glucosamine for injection. Analogs of this drug that exist on the market are most often available in the form of capsules or tablets.

Once in the human body, a medicine containing glucosamine reduces pain, inhibits degenerative processes in joints, and relieves inflammation. This drug, like almost any other medicine, can, of course, have side effects. However, this happens extremely rarely. Glucosamine is not too expensive. The price for it is only about 350 rubles. for 30 tablets.

Pharmacokinetic parameters

Method of administration: orally.

Absorption : Glucosamine – 25%, Chondroitin sulfate – 12-13% (10% are rapidly decomposing components, 20% are low molecular weight, retaining structure and quickly penetrating into cartilage). The maximum of Chondroitin in the blood is achieved after 3-4 hours.

Distribution : Glucosamine accumulates in cartilage tissue, as well as the liver and kidneys. 30% of the dose is in the bones and muscles for a long time.

Metabolism : Liver enzymes create desulfurization.

Excretion : Glucosamine leaves the body unchanged through urine (a small part in feces). The remaining chondroitin sulfate leaves the body via the kidneys within 24 hours (the half-life is about 5 hours). A halving of Glucosamine concentration is achieved in three days.

Indications

Remember that the body independently produces the substances it needs. However, due to illness, age, overexertion, injury and other things, synthesis may be disrupted. In these cases, it is best to watch your diet. It is necessary to eat fish (especially salmon), mussels, shrimp, aspic, jellied meat, fruit jelly, and drink rich broth. You can get Glucosamine hydrochloride from animal meat, fish cartilage, poultry and hard cheese. If it is impossible to compensate for the deficiency of substances naturally, then dietary supplements will come to the rescue. They can be taken both for prophylactic purposes and as a supporting agent during therapy.

Indications for use:

• arthrosis of the first degree (not depending on the location);
• periarthritis;
• for athletes;
• people over 50 years old;
• during rehabilitation in the postoperative period;
• increased physical activity;
• excess body weight.

How do combined chondroprotectors work?

When used simultaneously, glucosamine and chondroitin mutually enhance and complement each other's effects. They influence various metabolic processes, which makes their combined use particularly appropriate.

Exogenous HA is actively involved in the synthesis of hyaluronic acid and glycosaminoglycans, prevents the formation of free radicals and enzymes that destroy cartilage tissue, and protects articular cartilage from the destructive effects of non-steroidal anti-inflammatory drugs. Glucosamine has a moderate analgesic and anti-inflammatory effect.

CS stimulates the synthesis of proteoglycans, collagen, hyaluronic acid, suppresses the activity of hyaluronidase, peptidase and elastase - enzymes that destroy cartilage tissue. Chondroitin sulfate maintains the viscosity of synovial fluid, retains moisture in the thickness of cartilage, and has an analgesic, anti-inflammatory, and regenerating effect.

Effects of using chondroprotectors:

• stimulation of chondrocytes - cells that synthesize glycosaminoglycans, collagen, proteinoglycans, hyaluronic acid and other substances necessary for the normal functioning of joints;
• inhibition of the activity of lysosomal enzymes that destroy articular cartilage and accelerate the development of osteoarthritis;
• reducing the intensity of joint pain;
• reduction in the activity of inflammatory processes in the synovium and other joint tissues;
• increasing the resistance of chondrocytes to the negative effects of proinflammatory cytokines, corticosteroids, NSAIDs.

Video from Boris Tsatsouline about the side effects of chondroprotectors:

Benefits of glucosamine

The substance is involved in the construction of the basic substance of the human skeleton. The actions of Glucosamine Chondroitin include:

• inhibits enzymes that disrupt the structure of cartilage;
• accelerates the production of glycosaminoglycan substances;
• improves the metabolism of hyaline tissue;
• prevents compression of connective tissue;
• enhances the secretion of synovial fluid;
• slows down the destruction of bone tissue;
• inhibits the development of osteoporosis;
• reduces the process of calcium loss in bones;
• has the ability to restore damaged bone tissue;
• reduces pain when walking;
• eliminates severe inflammation in joints;
• promotes the synthesis of hyaluronic acid;
• strengthens connective tissue structures.

Benefits of glucosamine. Photo: yandex.ru

Glucosamine Chondroitin complex analogs and description

This medicine is also often prescribed by doctors to patients with joint problems. It is, in fact, another inexpensive analogue of Glucosamine. In this case, both active substances included in the drug harmoniously complement each other, increasing the effectiveness of treatment. Glucosamine is involved in the synthesis of acids necessary for the formation of cartilage tissue, and also contributes to the normal deposition of calcium in the bones. Chondroitin, which is part of the complex, plays the role of a kind of lubricant in the joints.

Both of these components also, by enhancing each other’s action, slow down the destruction of cartilage. Research conducted by experts has shown that together these substances have a much faster and more pronounced healing effect on the human body. The price for the complex drug “Glucosamine + Chondroitin” is also only about 350 rubles. Which, of course, is very inexpensive.

In pharmacies, such a medicine is often sold under the name “Glucosamine Maximum” (its analogues, like the regular, non-strengthened form of the medicine, are numerous and will be discussed below). In addition to the two main active substances, such a medicine most often contains cellulose, calcium carbonate, silicon dioxide, stearic acid, wax and glycerin. There is also a simple product on sale called Glucosamine and Chondroitin, produced by both domestic and foreign companies.

Pharmacodynamics and pharmacokinetics

The pharmacodynamics of the drug has been fully studied. After it enters the body, an active process of absorption of active components into the systemic bloodstream occurs. Chondroitin and glucosamine accumulate in connective and cartilage tissue, as well as synovial fluid of joint joints.

Due to the concentration in tissues in large quantities, the maximum therapeutic effect is achieved in a short period of time. 2-3 weeks after the start of treatment, there is a significant improvement, elimination of acute symptoms of inflammation and a slowdown in the pathological process.

Mobility in the spinal column or affected joints is restored, and pain becomes less pronounced.

Due to the active flow of blood and nutritional components into the affected area, the process of tissue restoration, the formation of chondrocytes and synovial fluid begins. The remedy will not help to completely restore the affected cartilage at an advanced stage of the disease, but it can significantly improve the condition of the tissue.

The drug is actively involved in the metabolism of potassium in the body, therefore it helps strengthen bones and improves the condition of the skin, muscles, and ligaments. After completing the course of therapy, the patient notes not only an improvement in well-being, but also positive changes in the skin, hair and nails.

The pharmacokinetics of the drug begins after its penetration into the digestive tract. The active absorption process occurs in the patient's small intestine. The bioavailability of glucosamine reaches 23-26%, chondroitin - no more than 15%. The components bind rather poorly to blood proteins, but this does not weaken the effectiveness of the medicine.

Processing of active substances occurs in the liver. The period of release of the body from glucosamine lasts up to 6 days. Chondroitin is completely eliminated within 24 hours. The main amount of metabolites are excreted in the urine, a small part is excreted in the feces.

In patients with pathologies of the digestive tract and urinary system, the period of absorption and excretion of components is slightly prolonged, which does not weaken the therapeutic effect.

Price and analogues

According to reviews, “Glucosamine sulfate” is not at all difficult to find, since it is sold in almost every pharmacy. The average cost of the drug ranges from 300-400 rubles. For example, 30 tablets can be purchased for approximately 360 rubles. The powder is sold in 20 sachets for 400 rubles. Capsules can be a more profitable purchase: 60 pieces cost only 350 rubles.

In addition, doctors can prescribe a drug to the patient that has an identical composition and a similar spectrum of action. Analogues of "Glucosamine sulfate":

• "Aponil."
• "Vipratox."
• "Diamax".
• "Pharmaskin".
• "Alite."
• "Heron osteoisi."
• "Ameolin."
• "Elbona".
• "Arthrox."
• "Dona".
• "Negan."
• "Artiflex".
• "Aminoarthrin."
• "Mesulide".
• "Unium".
• "Arotrodar".
• "Nise."
• "Glucosamine hydrochloride."
• "Artron complex".

Conditions of release, storage and sale

This remedy is effective and will help in the treatment of musculoskeletal pathologies. You can buy Chonroxide Glucosamine at any pharmacy. The drug is dispensed strictly according to the doctor's prescription.

To prevent the medicine from losing its medicinal properties ahead of time, it should be stored correctly - in a dark place at a temperature not lower than 15 and not higher than 25 degrees. Chondroxide Glucosamine should be stored out of the reach of children. The shelf life of the product is three years.

You can buy the supplement at any pharmacy or specialized online store. The cost of Glucosamine Chondroitin, analogues of which are also not expensive (Russian production), averages 4,000 rubles. The average cost of a medicine from a foreign manufacturer is 2,000 rubles.

Analogs

Analogue drugs based on the active substance:

1. ARTRA;
2. Chondroxide;
3. Chondrolone;
4. Chondroguard;
5. Larkspur;
6. Kartilag Virtrum;

Chondroprotectors with chondroitin and glucosamine:

• Sofia – cream;
• Chondroitin-Acos – capsules;
• Solgar - tablets;
• Joint Forte – body cream;
• Arthrocin – cream;
• Doppelhertz – capsules;
• Shark oil cream.

External products with chondroitin/glucosamine, vitamins, minerals, and other additives:

1. Smart cream (mummy);
2. Sophia cream (bee venom);
3. Natural Bounty tablets (calcium, vitamin D);
4. Teraflex.

The use of analogues requires consultation with a specialist to avoid side effects and to achieve a better therapeutic result.

Indications for use

Experts prescribe this drug to patients diagnosed with “osteochondrosis” or “osteoarthrosis of the spine.” If during the period of illness a person experiences severe pain in the back and normal joint mobility disappears, then the use of Glucosamine sulfate with chondroitin is considered a mandatory stage of treatment. It must be taken in combination with other medications and physiotherapeutic procedures. Only in this case will the treatment of detected pathologies bring the desired result.

Indications for the use of the drug are usually the following diseases:

• glenohumeral periarthritis;
• spondylosis;
• primary and secondary osteoarthritis;
• chondromalacia patella;
• osteochondrosis.

But any of these pathologies, definitely, cannot be treated with Glucosamine Sulfate alone. In addition to this drug, other medications and procedures must be used.

Overdose

There have been no cases of overdose of the drug when used correctly. But doctors draw patients’ attention to the need to follow treatment rules. When using too large a dosage of the drug at one time, there is a worsening of adverse reactions from internal organs.

The patient may experience increased blood pressure, arrhythmia, and pain in the heart area. The headache intensifies, accompanied by severe nausea and sometimes vomiting.

However, the most pronounced symptoms of overdose are observed on the skin. The rash spreads over large areas, the itching becomes unbearable, and general allergy symptoms appear in the form of watery eyes and runny nose.

If symptoms of overdose appear, you should immediately consult a doctor. Usually the patient's stomach is washed and therapy is prescribed to eliminate the symptoms.

Drug interactions

It is also very important to know which medications cannot be taken simultaneously with a chondroprotector. After all, this drug can reduce or enhance the effectiveness of certain medications

• Glucosamine sulfate increases the effectiveness of tetracyclines used to stabilize intestinal function.
• The drug impairs the properties of the antibiotics penicillin and chloramphenicol.
• The medication reduces the negative effect of corticosteroids on damaged cartilage tissue.
• The chondroprotector is compatible with any non-steroidal anti-inflammatory drugs and glucocorticosteroids.

If a patient plans to take Glucosamine and other drugs in parallel, he should definitely consult a specialist. Only a doctor can change the prescribed dose of a chondroprotector so that it does not harm the body.

Price in pharmacies in Moscow, St. Petersburg, regions

The cost of medicine in regional pharmacies, for example, Taganrog, Voronezh or Belgorod, starts from 600 rubles. for 90 tablets. In St. Petersburg and Moscow you can buy it for 800-900 rubles.

Glucosamin Chondroitin MSM is a popular remedy from the group of chondroprotectors, which has a pronounced effect on cartilage, connective and bone tissue.

Reviews from patients confirm the effectiveness of the drug, which allows it to be actively used for the treatment and prevention of many pathologies.

Pharmacological property

Chondroprotectors are used to improve the condition of cartilage and joints. According to the mechanism of action, they belong to the correctors of the metabolism of cartilage and bone tissue. In addition to them, this pharmacological group includes chondraitin sulfate and other glycosaminoglycans - preparations containing hyaluronic acid

Glycosaminoglycans are an important component of the extracellular connective matrix

Most of all, our body contains glycosaminoglycan. It is also the polysaccharide Chondroitin sulfate. The therapeutic effect of the complex is explained by the presence in its composition of the required amount of Chondroitin sulfate and Glucosamine. The latter is a monosaccharide necessary for the connection of glycosaminoglycans. Each component of the complex is effective, but together they enhance the effect. Glucosamine-Chondroitin has a clear chondrostimulating, regenerative and anti-inflammatory effect. In the human body it is necessary for:

• elasticity and strength of fabrics;
• strengthening ligaments and tendons;
• shock-absorbing layer that reduces the load on muscles and joints;
• suppression of the action of enzymes that destroy cartilage tissue;
• obstacles to the leaching of calcium, stabilization of phosphorus metabolism;
• retention of water in cartilage tissue, thereby promoting the recovery process;
• formation of synovial fluid - intra-articular lubrication;
• increasing the amount of type 2 collagen, as well as hyaluronic acid;
• relieving stiffness by slowing down the inflammatory process and reducing pain.

In what cases is Glucosamine-Chondroitin used?

Preparations containing two active components act in several directions at once. Therefore, their use is more preferable than the use of monodrugs. Chondroitin sulfate accelerates the growth of healthy cartilage cells. The benefits of Chondroitin with Glucosamine for joints lie in stimulating chondrocytes in terms of preserving the structure of the matrix. Thus, combined use contributes to:

• slowing down the degeneration of cartilage tissue until destruction is completely avoided;
• protection from exposure to degenerating substances;
• preventing joint wear, muscle age-related changes, as well as dystrophic diseases;
• creating a nutrient medium for joints and additional substances for the growth of a healthy matrix;
• production of synovial fluid in the required maximum;
• relieving pain and inflammation;
• reducing swelling of muscle tissue;
• return to the previous range of motion;
• no need to take glucocorticosteroids and non-steroidal anti-inflammatory drugs, which negatively affect the metabolism in cartilage tissue;
• the body receives Chondroitin sulfate - a ready-made component of cartilage tissue - and Glucosamine - an intermediate component of metabolism.

What other analogues exist?

Of course, Chondroitin is not the only drug that has the same effect on joints as Glucosamine. There are many drugs on the market with the same pharmacological effect. For example, instead of the drug "Glucosamine" in certain cases you can use:

1. "Chondromax Herbal". This product is a natural combination complex that slows down the process of cartilage destruction and improves joint mobility. This drug costs about 370 rubles. per pack of 30 tablets.
2. "Diclovit." This drug is prescribed for degenerative joint diseases, pain after exercise, and migraines. It costs about 200 rubles. (30 tablets).
3. "Arthro-Gran". Used for swelling of joints and stiffness of movement. It costs about 100 rubles (10 g pencil case).
4. "Collagen-Ultra". This medicine is prescribed to improve joint mobility, for fractures, etc. This analogue of the drug "Glucosamine" is quite expensive - about 800 rubles. for 30 pcs.

There are also such well-known analogues of Glucosamine as “Teraflex” and “Arthra”.

Preparations containing chondroitin and glucosamine

Combined drugs belong to the third generation of chondroprotectors. These drugs are effective in the treatment of osteoarthritis, in the fight against unpleasant symptoms and the progressive destruction of cartilage tissue. The first generation of chondroprotectors includes preparations on a natural basis, the second generation includes mono-drugs.

Table 1. Preparations containing glucosamine and chondroitin

Release form and composition of the drug

The drug is available in the form of small oval-shaped tablets with a neutral odor and taste . They are packaged in polyethylene bottles. Each bottle can contain 90 tablets, which are also accompanied by instructions for use.

The bottle and instructions can be placed in a cardboard box. The pharmacological agent contains several active ingredients with various therapeutic properties. The main therapeutic effect is achieved due to the presence of glucosamine and chondroitin, as well as methylsulfonylmethane in the tablets.

Additionally, the composition contains the following ingredients:

• Sodium.
• Potassium.
• Gelatin.
• Magnesium stearate.
• Silicon dioxide.

Additional components do not have therapeutic properties, but are necessary to give the correct form and prevent changes in composition under the influence of various factors.

Glucosamine and chondroitin

I’ll say right away that I have no goal to throw mud at this or that drug. I just want to collect the most objective series of meanings, with the help of scientific research, practice and my reasoning.

First, I’ll tell you about these supplements separately (although they are usually used in combination).

Glucosamine sulfate

Glucosamine

– is one of the most common monosaccharides (the building blocks from which more complex disaccharides, such as glucose, maltose, lactose, OLIGOSACCHARIDES and POLYSACCHARIDES, such as starch, are built).

This aminosaccharide (monosaccharide) is part of polysaccharides such as chitosan (a chitin derivative that absorbs toxic substances and reduces the absorption of fats from the intestines).

There are two forms of glucosamine:

1. Hydrochloride.
2. Sulfate.

We will only talk about SULFATE, because there is practically NO difference between them, and in terms of effectiveness too, because... SULFATE IS CONVERTED IN THE GASTROINTESTINAL TRACT INTO HYDROCHLORIDE.

Whatever you take from these two forms, you will receive the same form in the gastrointestinal tract.

Functions of glucosamine in the body

Glucosamine strengthens and improves:

• Cartilage.
• Tendons and ligaments.
• Synovial fluid (the natural lubrication of our joints).
• Muscle tissue.
• Skin.
• Bone tissue.
• Nails and hair.
• Heart muscle (valves).
• Blood vessels.

Glucosamine is produced naturally in the human body. This is one of the most important building elements of the connective tissues of the osseous-ligamentous apparatus.

Glucosamine helps increase the tensile strength of cartilage (the engineer in me woke up))

I won’t talk separately about its effectiveness now. I’ll tell you a little lower when we talk about chondroitin and glucosamine together.

There are many conflicting studies regarding the positive effects of glucosamine in the prevention and treatment of joints. Some studies claim that glucosamine is absolutely useless, others that it actually helps.

I will draw my conclusions below, but for now let’s talk about chondroitin.

Chondroitin

Chondroitin sulfates

- components of the cartilage of our body, produced by the cartilage tissue of the joints, which are part of the synovial fluid.

The constituent substances of chondroitin are GLYCOSAMINOGLYCANS (part of the intercellular substance of connective tissue, and also found in bones, synovial fluid, and the cornea of ​​the eye).

With a lack of glucosamine in the body, a LACK of chondroitin sulfate is formed in the synovial lubricating fluid, which can cause crunching in the joints.

Functions of chondroitin in the body

• Gives elasticity to cartilage (+ shock absorption), because retains water in tissues (loss of chondroitin in cartilage leads to osteoarthritis).
• Strengthens the strength of ligaments and tendons.
• Suppresses the activity of elastase and peptidase (enzymes that destroy connective tissue).
• Reducing joint pain associated with “cartilage wear.”
• Regeneration of cartilage tissue (weakly expressed).
• Improving the quality of synovial fluid.
• Improving skin properties.

Alternative forms of application

Modern medicine produces glucosamine hydrochloride in the form of a medicinal substance or dietary supplement, equating it to a group of chondroprotectors that better influence the metabolic functions of cartilage tissue.

Glucosamine can be taken as a separate drug, or it can be part of complex products. Available in forms such as gel, balm, ointments, tablets and injections.

Gels and ointments

Although it is generally accepted that glucosamine chondroitin complex is effective when taken orally, formulas have been created for external use containing both components. Thus, you can isolate a gel, the composition of which contains glucosamine sulfate, chondroitin sulfate and additional components (cinquefoil extract, collection of essential oils and D-panthenol).

The gel is prescribed for the following indications:

1. osteoarthritis, affecting the joints and spine;
2. if an injury is sustained (dislocations, bruises, fractures), in order to better restore tissue;
3. increased loads when playing sports;
4. preventive treatment for elderly and frail people.

The combination of glucosamine and chondroitin affects collagen, or rather, its production and strengthening. The gel, penetrating into the tissue, slows down the process of joint destruction and strengthens cartilage. Also, a gel containing glucosamine chondroitin has the advantage that it contains D-panthenol with a wound-healing and conductive effect and essential oils.

If the gel is used for inflammation or injury, the processes of restoration of joint cartilage tissue are stimulated, pain syndrome is reduced, the process of fluid formation in the joint is improved and collagen is strengthened. The course of treatment is calculated from several weeks to 3 months, while applying the gel 2-3 times a day. For the best effect, the complex can be taken orally.

For topical use, you can take a cream-balm that should be rubbed into areas of inflammation and pain. The balm provides joint tissue with active components for regeneration and reduction of inflammation. The balm is also recommended for use as a preventive measure to stop the aging process and destruction of the joint apparatus.

The balm with chondroitin and glucosamine has a composition with additional components, including sea buckthorn and eucalyptus oils; it also contains menthol, camphor, St. John's wort and other components. The product should be taken topically and it is better to consult a doctor about the duration of treatment and the number of applications to the skin.

Complex for sports

Sports nutrition is on par with visiting the gym for real athletes. That is why complexes containing chondroitin glucosamine are also designed to support the ligamentous apparatus in athletes and people with an active lifestyle.

It is not uncommon for former athletes to begin to suffer from pathologies of the joints and spine with age due to numerous injuries and overloads throughout their lives.

This is due to the fact that during exercise, collagen, vitamins and minerals are lost, and tissue metabolism is disrupted. Thus, doctors have created an ultra-complex containing glucosamine and chondroitin for sports nutrition.

It is better to take the complex in a course, this will better preserve the integrity of the joints. In addition, sports nutrition additionally contains chondroitin complex plus zinc and methyl sulfatemethane. If you take the complex, you can observe the following effect:

• swelling decreases when joints are stressed;
• the frequency of pain after exercise and injury is reduced;
• joints cope better with the load;
• Collagen is produced in sufficient quantities.

It is the complex of all substances that allows for a better effect on the human body, and the product is safe to take. The norm per 100 g of fat and protein is zero, calories - up to 131 kcal, and carbohydrates - up to 52.4 g.

Meals are taken twice a day by mixing the contents of a measuring spoon into a glass of water. If desired, you can help the production of collagen by consuming foods such as jelly, jellied meat, and jellies.

Side effects

It is a safe dietary supplement, has high tolerability, and does not have a negative effect if the dosage is observed.

At higher doses, as well as in case of increased duration of administration, the following are possible:

• allergies (rash);
• flatulence, constipation, diarrhea, other stomach disorders;
• headache;
• sleep problems;
• swelling;
• pain in connective tissues;
• weight loss;
• increase in heart rate.

If you simultaneously take tetracyclines, the solubility of the dietary supplement increases.

When taken simultaneously with penicillin, the bactericidal properties of the additive are weakened.

Description

The main active ingredient of this remedy is an aminosaccharide, which gradually accumulates in the cells of the musculoskeletal system. It is then used as a building material to form articular ligaments, heart valves, nail plates and cartilage.

Glucosamine sulfate is a substance that also affects metabolic processes in cartilage tissue. It replenishes the natural deficiency of the substance, promotes the activation of the production of proteoglycans, synovial fluid and hyaluronic acid.

In addition, glucosamine sulfate increases the permeability of joint capsules and normalizes enzymatic phenomena in the cells of synovial membranes and articular cartilage. In addition, this element promotes the fixation of sulfur during the production of chondroitinsulfuric acid and simplifies the natural deposition of calcium in bone tissue. In addition, glucosamine sulfate prevents the progression of degenerative processes in the joints, normalizes their functions and eliminates pain.

The bioavailability of the main active ingredient of the drug with proper oral administration is approximately 25% due to the first pass effect directly through the liver. The highest concentration of the component is detected in this organ, as well as in the kidneys and articular cartilage. The processed ingredient is excreted unchanged mainly in urine and only partially in feces.

pharmachologic effect

Chondroitin Complex is a drug that has a pronounced chondroprotective effect. The drug contains two active components - glucosamine hydrochloride and sodium chondroitin sulfate. The drug prevents degenerative changes in joint tissue, its active components take part in the synthesis of connective tissue, stimulate the synthesis of collagen, proteoglycans and hyaluron.

In addition, chondroitin sulfate inhibits the activity of hyaluronidase and reduces the breakdown of hyaluron. The drug regulates phosphorus-calcium metabolism. The use of the drug in complex therapy of degenerative-dystrophic diseases of the musculoskeletal system makes it possible to reduce the dose of non-narcotic analgesics.

Sodium chondroitin sulfate is involved in the construction of cartilage tissue, is able to reduce the activity of enzymes that destroy joint cartilage, and stimulates its regeneration. Sodium chondroitin sulfate in the early stages of inflammatory processes can reduce its activity, slowing down degenerative changes in cartilage tissue.

Reduces the severity of pain, improves the functional state of joints, reduces the need for non-steroidal anti-inflammatory drugs for osteoarthritis of the hip and knee joints.

Glucosamine hydrochloride eliminates the deficiency of glycosamines in the body, has chondroprotective properties, and is involved in the biosynthesis of proteoglycans and hyaluronic acid. Glucosamine hydrochloride exhibits affinity for cartilage tissue, initiating the process of sulfur fixation during the biosynthesis of chondroitinsulfuric acid.

Selectively acting on articular cartilage, glucosamine hydrochloride is a specific substrate, a stimulator of the synthesis of proteoglycans and hyaluronic acid, suppresses the formation of enzymes and superoxide radicals that predetermine damage to cartilage tissue (phospholipases, collagenases), prevents the destructive effect of glucocorticoids on chondrocytes, disruption of glycosaminoglycan production, induced by non-steroidal anti-inflammatory drugs.

After oral administration, the active components of the drug are well absorbed in the gastrointestinal tract. The bioavailability of chondroitin sulfate is 13%, glucosamine – 25%. The peak concentration of chondroitin in the blood plasma is observed 3-4 hours after taking the drug.

The active components are metabolized in the liver. The half-life of glucosamine is about 68 hours, chondroitin sulfate sodium is completely eliminated from the body within 24 hours. The active components of the drug are excreted primarily by the kidneys; a small part of glucosamine hydrochloride is excreted by the intestines.

Instructions for use

Chondroitin's instructions for use contain recommendations regarding the duration and frequency of administration. The doctor must determine the specific duration and daily dose, depending on the pathology. To achieve a lasting therapeutic result, the chondroprotector is taken for a long time (from 1.5 to 3 years), with time intervals of 2 weeks to 1 month.

The ointment is applied to a dry, clean area in the morning, in the evening - in the place where the pain is felt. Rub it over the skin using massaging movements without pressure for 2-3 minutes.

The duration of taking the gel is 14-60 days, the ointment is 21 days.

Chondroitin with glucosamine for joints is used 2-3 times a day for 4-12 weeks.

Due to the lack of data on the effect of the external agent on the fetus, its use during pregnancy is not recommended.

Good absorption of the chondroprotector into the skin and penetration into the bloodstream can have negative consequences during breastfeeding. Nursing mothers are advised to stop lactation during treatment.

The ointment enhances the effect of medications (external and oral) that affect blood clotting:

• antiplatelet agents;
• fibrinolytics;
• indirect coagulants.

Concomitant use may cause increased bleeding.

The drug promotes better absorption of tetracyclines, reduces susceptibility to penicillins and the antibiotic Chloramphenicol.

For children, the drug is prescribed upon reaching 15 years of age.

The ointment and gel must be stored in places inaccessible to children, protected from light, at temperatures up to 20 degrees.

The shelf life of the gel is 24 months, the ointment is 36 months.

Features of the use of the drug

Glucosamine + Chondroitin is prescribed for the treatment of those patients diagnosed with degenerative diseases of the spine and joints. In particular, the drug is indicated for patients with osteoarthritis and osteochondrosis.

This remedy, as well as other drugs with similar active ingredients (Glucosamine-Chondroitin Plus, Glucosamine + Chondroitin + MSM, etc.) are also prescribed if necessary to provide an additional source of these substances.

Indications for use

The drug is prescribed for the purpose of prevention and additional auxiliary therapy of degenerative-dystrophic diseases of the joints, for the restoration of joints in people who have suffered sports injuries and fractures.

Capsules can also be included in sports nutrition. The drug Chondroitin Complex is used in complex therapy of degenerative-dystrophic diseases of the joints and spine:

1. glenohumeral periarthritis;
2. osteoarthritis;
3. osteocondritis of the spine;
4. fractures (to accelerate the formation of callus).

Contraindications

Although this product is a supplement, it belongs to medicines and, along with its indications for use, it also has contraindications. The drug Chondroitin Complex is contraindicated for:

• individual hypersensitivity to glucosamine hydrochloride, sodium chondroitin sulfate, as well as auxiliary components (croscarmellose sodium, sodium starch glycolate, low molecular weight medical polyvinylpyrolidone, magnesium stearate, Aerosil);
• thrombophlebitis;
• bleeding tendency;
• severe kidney/liver dysfunction;
• diabetes mellitus;
• phenylketonuria;
• during pregnancy;
• during breastfeeding.

The use of Glucosamine Chondroitin Complex is not recommended for people with individual intolerance, as well as for women during pregnancy and breastfeeding. The drug Chondroitin Complex is not used in pediatric practice.

Only a qualified specialist can prescribe the drug, its dosage, frequency of administration and course duration, and only taking into account the individual characteristics of the body and the patient’s age. In addition, before you start taking the medicine, you should read the instructions and make sure there are no contraindications.

Directions for use and dosage

The dosage, regimen and frequency of use of the medication are selected by the doctor. When using Glucosamine Chondroitin, the instructions for use indicate that the optimal duration of the therapeutic course is a month. Three or four courses can be conducted per year.

The drug is intended for oral use. It is recommended to swallow the capsules whole, without chewing or crushing, with a sufficient amount of liquid. The drug is taken 30 minutes before meals. The duration of the course of treatment and the dose of the drug are determined by the attending physician individually for each patient.

Adults and adolescents over the age of 15 years are usually prescribed 1 capsule of the drug 2 times a day. 3 weeks after the start of drug therapy, switch to a maintenance dose of 1 capsule of the drug 1 time per day.

The duration of treatment is usually at least 2 months. To achieve a sustainable therapeutic effect, it is recommended to take the drug for at least 6 months.

The daily dose is 1500 mg. It should be divided into two or three doses. The use of the supplement can be combined with taking steroids and other anti-inflammatory medications.

The combined use of the drug with magnesium, potassium or other minerals has a beneficial effect on the condition and functioning of the musculoskeletal and muscular systems.

As indicated in the annotation, the dose of the drug should be selected taking into account body weight. People weighing less than 50 kg are prescribed 1000 mg of glucosamine and 800 mg of chondroitin, 50–90 kg - 1200 mg of chondroitin and 1500 mg of glucosamine, more than 90 kg - 1600 mg of chondroitin and 2000 mg of glucosamine.

Patients receiving therapy with Chondroitin Complex are advised to refrain from drinking alcoholic beverages and also reduce the amount of sugar in the diet.

Side effects

As a rule, the drug is well tolerated by patients. Side effects when consuming Glucosamine Chondroitin Complex are rare. The occurrence of unpleasant symptoms may be due to abuse of the supplement (more than 3000 mg).

When taking products whose active ingredients are glucosamine and chondroitin (Weider Glucosamine Chondroitin Plus MSM, Glucosamine Chondroitin MSM, Ultimate Nutrition Glucosamine Chondroitin MSM, etc.), the following undesirable effects may develop:

• stool disorders;
• periodic pain in the epigastric region;
• flatulence;
• dizziness, headache;
• swelling;
• pain in the limbs;
• tachycardia;
• allergic manifestations;
• disruption of biological rhythms.

If such symptoms appear, you should refrain from further use of the product, rinse your stomach, take the sorbent, and then seek the help of a qualified specialist.

Glucosamine is considered a safe supplement. During the studies, subjects took it at a dosage of 1500 mg per day for three years.

Studies in which glucosamine was taken for more than twelve months indicate that glucosamine sulfate itself continues to provide long-term benefits for health and joint pain, but the effectiveness of glucosamine/chondroitin and other combination supplements gradually decreases .

Most glucosamine as a supplement ingredient is obtained from organic seafood components. Therefore, before starting consumption, it is recommended to make sure whether you are allergic to seafood. If this is a problem for you, don't worry - there are special glucosamine supplements from plant sources that are marketed as vegetarian.

In the early stages of glucosamine research, there was some concern that glucosamine might negatively impact insulin resistance. However, several newer studies have concluded that taking glucosamine has no effect on it.

Overdose

The drug is well tolerated and cases of overdose are practically not described. Abuse of the drug, exceeding the dosage, as well as independent extension of the course of treatment with Glucosamine Chondroitin according to the instructions for use, is fraught with the appearance of:

1. pain in the epigastric region;
2. nausea and vomiting;
3. flatulence;
4. constipation;
5. diarrhea;
6. pre-fainting states;
7. headaches;
8. drowsiness;
9. dermatitis;
10. redness of the dermis;
11. swelling;
12. rash;
13. increased fatigue;
14. sleep disorders.

If such symptoms occur, you must stop using the products and always seek the help of a qualified specialist. In case of overdose, symptomatic therapy is usually carried out.

Special instructions for taking the drug

Glucosamine-Chondroitin (complex) is considered one of the safest medications. These capsules are easy to drink, they are easily absorbed and rarely cause side effects. But you still need to know the features of their use and combination with other medications:

• if there is no improvement two weeks after starting treatment, you should consult your doctor about the possibility of replacing the drug with its analogues - “Arthra”, “Teraflex”, “Chondroflex” and others;
• this drug impairs the absorption of penicillin antibiotics;
• Tetracycline drugs begin to be absorbed more quickly and may cause side effects;
• The complex combines well with non-steroidal anti-inflammatory drugs and glucocorticosteroids, enhancing their effect;
• During treatment, you need to completely eliminate alcoholic beverages and limit sugar consumption.

If side effects are observed during therapy, in particular, dysfunction of the digestive system, it is necessary to halve the dose of the drug. If side effects persist, therapy should be discontinued.

For a more pronounced effect during treatment, you should include in your diet foods containing glucosamine, chondroitin, and collagen. These are beef, chicken, sea fish, etc. A specialist will tell you in more detail about which products contain the substance the body needs.

Drug interactions

The Glucosamine-Chondroitin complex in combination with tetracyclines can lead to an increase in the absorption of the latter. When the drug interacts with lemomycetin and semisynthetic penicillins, on the contrary, their degree of absorption decreases.

This medication reduces the need to take NSAIDs, corticosteroids and painkillers. Treatment with this drug becomes more effective when the patient’s diet includes foods with vitamins C and A, as well as salts of copper, manganese, selenium, zinc and magnesium.

Contraindications to the use of glucosamine

The drugs are contraindicated for:

• individual intolerance;
• bleeding tendency;
• thrombophlebitis.

Prescribe medications with caution to patients with:

• severe liver and kidney failure;
• endocrine pathologies;
• metabolic disorders.

If side effects and allergic reactions occur, the course of treatment is stopped. Do not apply ointments and gels to open wounds or if you are prone to allergic reactions (rash, itching, swelling). Do not prescribe injection drugs that contain lidocaine to patients with cardiac conduction disorders, acute heart failure, convulsions, epilepsy, severe kidney pathologies and liver, children under 12 years of age.