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Manufacturers: Shreya Life Sciences Pvt. Ltd
Active ingredients
- Pancreatin
Disease class
- Dyspepsia
- Functional diarrhea
- Chronic pancreatitis of alcoholic etiology
- Other chronic pancreatitis
- Syndromes of the operated stomach
- Postcholicystectomy syndrome
- Flatulence and related conditions
- Unspecified radiation effects
- Cystic fibrosis with intestinal manifestations
- Diagnosis of gastrointestinal diseases
Clinical and pharmacological group
- Not indicated. See instructions
Pharmacological action
- Proteolytic
- Replenishes pancreatic enzyme deficiency.
- Amylolytic
- Lipolytic
Pharmacological group
- Enzymes and antienzymes
Pharmacodynamics and pharmacokinetics
Taking this medication allows you to compensate for the insufficiency of external secretory function in the pancreas. At the same time, it has a proteolytic, amylolytic and lipolytic effect.
The enzymes that make up Pancreatin , namely lipase, alpha-amylase, chymotrypsin and trypsin , help break down proteins into amino acids, fats into fatty acids and glycerol, starch into monosaccharides and dextrins. The functional state of the gastrointestinal tract also improves, and digestive processes are normalized.
Thanks to trypsin, stimulated pancreatic secretion is inhibited, producing an analgesic effect.
In the alkaline environment in the small intestine, pancreatic enzymes are released from the dosage form because they are protected from the influence of gastric juice in the form of a shell.
The manifestation of maximum enzymatic activity occurs 30-45 minutes after oral administration. Pancreatin is not absorbed into the gastrointestinal tract; the substance is excreted along with the feces.
Description of the drug
The medicine belongs to the enzyme medicines that improve digestion. The active component of the drug is pancreatin. The drug is manufactured in India. The medicine contains the following additional components:
- titanium dioxide;
- lactose;
- povidone;
- starch glycolate;
- talc.
The medicine has a lipolytic and proteolytic effect. The product helps to compensate for the deficiency of the corresponding enzymes. The tablets have an enteric coating. The drug quickly reaches the small intestine. The enteric coating of the tablets is not able to be exposed to gastric juice.
Indications for use of Penzital
Main indications for use:
- carrying out replacement treatment for exocrine insufficiency in the pancreas, for example, in chronic pancreatitis, pancreatectomy , post -dyspepsia , radiation , Roemheld syndrome or gastrocardial syndrome, cystic fibrosis ;
- diarrhea of non-infectious origin, flatulence ;
- impaired absorption of food, for example, after resection of the small intestine and stomach;
- the need to improve the digestion of food in people with normal gastrointestinal function with errors in nutrition - large amounts of food, fatty foods, irregular meals, as well as chewing dysfunction, a sedentary lifestyle and prolonged immobilization;
- preparation for x-ray examination or ultrasound of internal organs.
Side effects
- From the digestive system: nausea, constipation/diarrhea, discomfort in the stomach (however, the cause-and-effect relationship of the development of these effects with the use of Penzital has not been proven, since these reactions are also symptoms of exocrine pancreatic insufficiency);
- Metabolism: with long-term use of the drug in high doses - hyperuricosuria, hyperuricemia;
- Other: allergic reactions.
In patients with cystic fibrosis, if recommended doses are exceeded, fibrous colonopathy (strictures) may develop in the ileocecal portion of the ascending colon.
In children, when taking high doses of pancreatin, irritation of the oral mucosa and the development of perianal irritation are possible.
Penzital - instructions for use (Method and dosage)
The tablets are intended for oral and are best taken before meals . In this case, ordinary water is suitable for drinking. It is contraindicated to use alkaline liquids for this purpose.
According to the instructions for use of Penzital, dose selection is carried out by a gastroenterologist, who must take into account the patient’s diet and the degree of enzyme deficiency. The average daily dosage for adult patients is: 1-2 tablets 3 times . It is allowed to increase the daily dosage to 16 tablets.
When treating small patients, dose selection is performed individually.
The course of therapy is determined by the attending physician and can last for several years.
Use for the treatment of pregnant women and children
The safety of the drug during pregnancy has not yet been fully studied. During clinical trials, it was established that Penzital had no teratogenic effect. But when using the medication, the potential risk to the fetus should be taken into account.
During breastfeeding, the use of the medication is extremely undesirable.
Tablets are given to children mainly for indigestion. In this case, the duration of the treatment course is 2 weeks.
If you abuse fatty foods, the duration of treatment for a child is 2-3 days. The optimal dose of medication for children is 1000 units/kg body weight per day (in terms of lipase activity).
Interaction
The simultaneous use of Penzital and antacid drugs with aluminum, calcium or magnesium ions can significantly reduce its effect. Iron supplements can reduce iron absorption.
Combination therapy with this drug with antithrombic drugs and acetylsalicylic acid reduces their effectiveness.
When treatment is prescribed simultaneously with non-selective monoamine reuptake inhibitors, the development of dangerous lethargy can be expected; with M-anticholinergic blockers, an increase in anticholinergic effect is noted, and alkaline liquids disrupt the pharmacodynamics of Penzital.
Penzital in combination with Pancreatin
The activity of pancreatin enzymes is higher in Penzital. In some cases, Pancreatin is used after completing a course of treatment with Penzital. The latter drug is used to eliminate digestive disorders as active therapy. After normalization of the patient's condition, it is recommended to use a weaker Pancreatin.
The medicine activates the production of pancreatic enzymes. Pancreatin helps improve liver and small intestine function. The medicine contains excipients such as magnesium stearate, macrogol, microcrystalline cellulose, titanium dioxide.
Indications and contraindications
Pancreatin is effective for digestive problems that occur during pregnancy or a sedentary lifestyle. The medicine is used for intestinal bloating and deterioration of pancreatic function. Pancreatin can also be prescribed in the presence of a chronic inflammatory process in the area of the gallbladder or stomach. The drug is also taken after resection of the digestive tract.
According to the instructions, Pancreatin should not be taken if individually tolerated. The medicine is contraindicated if the patient has acute pancreatitis. In addition, it is not recommended to exceed the recommended dosage of the medication. Otherwise, an increase in the concentration of uric acid in the blood plasma may occur.
Symptoms of acute pancreatitis
If a patient has acute pancreatitis, it is better not to self-medicate. With this pathology, severe pain in the abdominal area of various localization occurs. Acute pancreatitis may also be accompanied by a feeling of dryness in the mouth, elevated body temperature, nausea, and severe vomiting.
The severity of the symptoms of the disease depends on the degree of damage to the gland. In mild forms of acute pancreatitis, one-time vomiting and moderate pain in the abdominal area may occur. With severe damage to the pancreas, painful vomiting occurs and sharp pain appears.
Analogs
Level 4 ATC code matches:
Digestin
Creon
Pancitrate
Mezim
Festal
Pankreoflat
Pancreazim
Enterosan
Panzinorm Forte
Panzinorm
Micrasim
Enzistal P
Pancreatin
Pangrol
Hermital
Abomin
The main analogues of this drug are represented by such drugs as: Gastenorm Forte, Creon, Mezim, Micrazim, Pangrol 10000, PanziKam, Panzinorm, Panzim Forte and others.
Also drugs with a similar effect are: Pancrelipase, Pancitrate Festal, Enzistal-P, Ermital and so on.
What's the harm?
The drug "Penzital", reviews of which are mostly positive, has a number of side effects. As a rule, they are all associated with gastrointestinal disorders. Undesirable consequences of taking this medication may include nausea, constipation, or, conversely, intestinal disorders, as well as an increase in the level of uric acid in the blood. In patients suffering from cystic fibrosis, fibrous nodes may form, which will lead to intestinal obstruction
Therefore, you need to be careful when taking Penzital.
It’s not difficult to guess what this medicine is for when you see the active ingredient pancreatin in its composition. But you shouldn’t self-medicate, even though many experts agree that negative symptoms are not necessarily a consequence of taking the medicine, they can appear due to the disease itself.
Reviews about Penzital
This drug is especially popular not only among patients suffering from various gastrointestinal diseases, but also in need of a cure for overeating. Therefore, reviews of Penzital are found everywhere. This drug is often prescribed during pregnancy , since during this period its quickly effective effect, which practically does not cause side effects, may be required. For example, it is actively used by women who feel severe heaviness in the stomach or nausea .
In addition, the drug can be prescribed to this group of patients to improve digestion and normalize the functions of the digestive tract. Although many ladies don’t even know exactly why Penzital helps during pregnancy. Therefore, you often find detailed explanations from specialists who tell you why Penzital tablets help best, how and when they should be taken.
In general, as reviews show, this drug is quite effective. However, despite the fact that it is enzymatic and, according to some, safe for the body, it is not recommended to take it without a doctor's prescription.
Use of medication for intoxication
Intoxication can be caused by eating low-quality food or taking medications. Malaise also occurs after inhalation of harmful substances that are toxic. In some situations, intoxication can be caused by an insect bite. In case of poisoning, the following symptoms occur:
- pain in the abdominal area;
- vomit;
- nausea;
- increase in body temperature.
The use of Penzital tablets for intoxication is indicated if the poisoning is caused by the consumption of low-quality products. In other cases, other treatment is indicated. For intoxication caused by an insect bite, Penzital is ineffective.
Penzital price, where to buy
This drug in enteric-coated tablets can be purchased at any Russian pharmacy. At the same time, the price of Penzital for 20 pieces can vary between 51-60 rubles.
- Online pharmacies in RussiaRussia
ZdravCity
- Penzital tablets p.p.o.
enteric solution 80 pcs. Shreya Life Sciences Pvt, Ltd, 167 RUR. order
Release form and composition
Dosage form – tablets, enteric film-coated: round, convex on both sides, white (10 pieces in strips, in a cardboard box from 1 to 12 strips).
The active ingredient of the drug is pancreatin, its content in 1 tablet is 212.5 mg, which corresponds to the enzymatic activity:
- Lipase – 6000 IU FIP;
- Amylase – 4500 IU FIP;
- Proteases – 300 IU FIP.
Additional components: sodium starch glycolate, microcrystalline cellulose, povidone, titanium dioxide, methacrylic acid copolymer, colloidal silicon dioxide, diethyl phthalate, talc, lactose.
Brief information about Pancreatin
This drug is designed to compensate for the deficiency of enzymes, which under normal conditions are produced in sufficient quantities by the pancreas. With the help of “Pancreatin”, more successful and rapid breakdown and absorption of food occurs, which leads to the normalization of the digestive process. The dosage of the drug is usually calculated in terms of the lipase enzyme; depending on the manufacturer and form of release, it is 25-50 IU.
"Pancreatin" is mainly used in complex therapy in the treatment of diseases of the pancreas; the course of treatment can range from several weeks to several years. As a rule, the drug is well tolerated, without any side effects.
Allergic reactions to one of the components of the drug (for example, lactose or pork) are relatively rare; it should also be taken into account that long-term use can provoke the development of anemia. Therefore, “Pancreatin”, when it comes to a long course of treatment, is always prescribed in combination with iron supplements.
Contraindications to taking Pancreatin are acute pancreatitis and exacerbation of the chronic course of the disease, hypersensitivity to the components of the drug, as well as the patient’s age under three years. If we are talking about taking the medicine by a pregnant woman, then it is permissible only on the recommendation of the doctor managing the pregnancy.
Features of dosing, undesirable effects and symptoms of overdose
Drugs containing pancreatin are most often well tolerated by patients.
Sometimes they cause side effects in humans such as:
- intestinal dysfunction (constipation, diarrhea);
- discomfort in the epigastric region;
- nausea;
- allergic manifestations.
Long-term use of large doses of Penzital can provoke hyperuricemia and hyperuricosuria in the patient. In children, using the product for a long period may cause irritation of the anus and mucous membranes in the mouth.
In case of an overdose of Penzital, death is unlikely. As a result of significantly exceeding the dose of the drug, the patient may complain of constipation, and hyperuricemia or hyperuricosuria may develop. In case of drug overdose, symptomatic therapy under the supervision of a specialist is recommended.
