Gramicidin C is a drug intended for the treatment of infectious and inflammatory lesions of the mouth and throat. The main indications for use are tonsillitis, stomatitis, gingivitis, periodontal disease and pharyngitis. The active ingredient in the product is represented by the substance of the same name, gramicidin. The medicine belongs to the group of local antibacterial agents. The medication is available for use in children from 4 years of age.
Pharmacodynamics and pharmacokinetics
Gramicidin C is an antibacterial drug. The drug has bactericidal (in high concentrations) and bacteriostatic properties against streptococci , pneumococci , staphylococci , as well as against causative agents of anaerobic infections and other microbes ( gram-positive and gram-negative ).
It increases the degree of permeability of microbial cell membranes to inorganic cations by creating channels in the lipid structures of the membranes. This provokes the development of osmotic instability of cells and leads to their death.
The product is suitable for the treatment of infectious and inflammatory diseases of the mouth and throat. It reduces inflammation, makes swallowing much easier and alleviates discomfort in the throat.
The degree of absorption is low. The drug is characterized by a local effect and is almost not absorbed into the gastrointestinal tract; systemic effects are practically not observed.
Description and composition
The active ingredient in this drug is gramicidin C.
The drug also contains a list of auxiliary substances, including:
- calcium stearate;
- lactose;
- sucrose;
- food flavoring.
Gramicidin tablets are white or as close to white as possible; they are also characterized by flat-cylindricity, chamfer and a notch on one side.
Indications for use
Fat and water solutions are used for:
- purulent wounds;
- burns;
- joint injuries;
- phlegmon , boil , carbuncle ;
- bedsores;
- ulcers;
- osteomyelitis;
- empyema.
An alcohol solution is indicated in case of pyoderma .
As a component of complex treatment, the medicine is used for therapy:
- infected eczema ;
- barley;
- iridocyclitis;
- iritis;
- blepharitis;
- scleritis;
- episcleritis;
- external otitis .
The tablets are indicated for use in the case of infectious and inflammatory diseases of the mouth and throat.
The paste is used for local contraception , as well as for wounds and burns.
Pharmacological group
These buccal tablets have a pronounced local antibacterial effect.
Gramicidin is used for the treatment of infectious and inflammatory diseases that are localized in the mouth and throat.
The principle of action of the drug is due to an increase in the level of permeability of the plasmalemma of the microbial cell. This destroys the cell's resistance and provokes its death.
Gramicidin reduces inflammation, eliminates discomfort in the throat, and makes swallowing easier.
Systemic absorption is practically absent.
Instructions for use Gramicidin S (Method and dosage)
Instructions for use of Gramicidin C indicate that this product is intended exclusively for topical application. intravenously , as this can provoke hemolysis and phlebitis .
An alcohol solution of the drug (2%) is diluted 20-100 times in ordinary just boiled or sterile distilled water.
In addition to aqueous solutions, alcohol and oil solutions are also made. Instructions for use of Gramicidin C indicate that to prepare an alcohol solution, you need to dilute the drug (1 ampoule) with a hundredfold amount of ethyl alcohol (70%). The oil solution is obtained by diluting the contents of the ampoule with the medicine 25-30 times with castor and vegetable (any) oil, as well as lanolin or fish oil.
The prepared solutions are used to wash wounds. They moisten tampons and irrigate bandages. It can also be used for rinsing and in the form of masks in case of suppurating acne.
Two tablets are taken one after the other with an interval of 20-30 minutes. In total, you need to take 4 tablets per day. The course of treatment lasts 5 days.
The paste is applied in a thin layer to the affected areas, then covered with gauze. Such dressings need to be changed every 2-4 days.
As a means of local contraception , the drug is administered into the vagina using a special syringe in a dose of 5-6 g.
Directions for use and dosage
Gramicidin C in the form of lozenges should be administered sublingually (slowly dissolving in the mouth, without chewing), after meals. For 1-2 hours after using the drug, you should refrain from drinking and eating.
The drug is taken 4 times a day. A single dose is determined by age:
- Children 4-6 years old – 1 tablet;
- Children 6-12 years old – 1-2 tablets (no more than 7 tablets per day);
- Children over 12 years old and adults – 2 tablets (within 20-30 minutes, one after the other).
The duration of the therapeutic course is 5-6 days. If prescribed by a doctor, the drug can be used for a longer period.
A solution of Gramicidin C prepared from the concentrate is used externally and locally.
To prepare one rinse, the concentrate should be diluted in 100 ml of drinking water. A single dose of the drug for adults is 10 ml, for children – 5 ml. Procedures should be carried out 2-3 times a day.
To prepare an aqueous solution, the concentrate must be diluted 100-200 times. To do this, add 500-1000 ml of water to the contents of a 5 ml bottle, 10 ml - 1000-2000 ml of water (regular drinking or sterile distilled).
The solution should be applied by irrigation or using well-soaked napkins, on top of which a sterile gauze napkin is applied, and then fixed with a gauze bandage.
To dilute the concentrate to obtain a fat solution, you can use castor oil, lanolin or fish oil in a ratio of 125-150 ml of any of these products for 5 ml of concentrate, 250-300 ml for 10 ml of concentrate. The resulting fat solution of Gramicidin C is applied using soaked napkins, a sterile gauze napkin is placed on top, and then fixed with a gauze bandage.
To prepare an alcohol solution, the concentrate must be diluted 100 times with 70% ethanol (5:500 or 10:1000). The drug is used in the treatment of pyoderma, lubricating the skin 2-3 times a day.
Gramicidin S price, where to buy
The price of Gramicidin in tablets 1.5 mg is about 130 rubles. The medicine in the form of a concentrate costs about 200 rubles. The price of Gramicidin S in the form of a paste may vary, but in general it does not differ significantly from the prices for other forms of the drug.
- Online pharmacies in RussiaRussia
ZdravCity
- Gramicidin C sublingual tablets.
1.5 g 20 pcs. AO Update PFK 104 rub. order
Release form and composition
Gramicidin C is available in the following dosage forms:
- Lozenges: flat-cylindrical with a bevel, white with a yellowish tint or white, scored on one side, marked “R” on the other, or without it (20 pcs. in polymer cans, 1 can in a cardboard pack; 10 each pcs. in blister packs, 2 packs in a cardboard box);
- Concentrate for preparing a solution for local and external use, alcohol 2%: solution from yellow to light yellow (5 or 10 ml in bottles, 1 bottle in a cardboard box).
1 tablet contains:
- Active substance: gramicidin C – 1.5 mg;
- Auxiliary components: milk sugar (lactose) – 441.69 mg; calcium stearate – 6 mg; food flavoring – 1.98 mg; sugar (sucrose) – 148.2 mg; sodium saccharinate (soluble saccharin) – 0.63 mg.
The composition of 1 ml of concentrate for the preparation of a solution for local and external use includes:
- Active substance: gramicidin C – 20 mg;
- Auxiliary components: ethanol (ethyl alcohol 95%) – up to 1 ml.
Analogs
If it is impossible to take the drug Gramicidin S, there is a need to find substitutes for the drug. The pharmaceutical market has a number of analogues of this medicine.
Falimint
The product is a local anesthetic and antiseptic. Falimint is available in the form of lozenges. The medication is used to treat inflammatory diseases of the oral cavity, inflammatory diseases of the respiratory tract, as well as reflex cough. The safety of use during pregnancy and lactation has not been fully confirmed. The active component of the product is acetylaminonitropropoxybenzene.
Neo Angin
This medicinal product contains 2,4-dichlorobenzyl alcohol, amylmetacresol and levomenthol as active ingredients. Sales are carried out in the form of lozenges. Neo Angin acts locally. Among its properties: antimycotic, anesthetic and antiseptic. Used for the prevention and treatment of infectious and inflammatory lesions of the mouth and throat. Age under 6 years is a contraindication.
Stomatidin
Stomatidin is sold in the form of a solution for topical use. The active component is hexethidine. The medication has a pronounced antiseptic effect. The main indications for use are inflammatory and infectious diseases of the oral cavity and pharynx. Use is contraindicated for children under five years of age.
Storage conditions
The drug Gramicidin C is intended for dispensing from pharmacies without the need to provide a prescription from a doctor.
The drug should be kept in a place reliably protected from moisture and direct sunlight. The medication should not be stored in a place accessible to children. The storage temperature should not exceed 25 °C.
The period during which the drug still retains its therapeutic properties and is considered suitable for use is 36 months. Do not use the medicine after the specified period has expired.
Contraindications
There are a number of contraindications to the use of the drug Gramicidin. The presence of any of the items listed below necessitates the need to stop using the product. The medicine cannot be used if you have an individual sensitivity to one or more components of the drug. Also, use is prohibited for children under 4 years of age and women who are breastfeeding.
The medication should be used with caution in pregnant women and patients aged 4 to 12 years.
Overdose
In case of intentional or unintentional taking of a dose of medication significantly higher than the recommended one, undesirable clinical effects may occur, meaning intoxication.
Among the symptoms of an overdose of Gramicidin C:
- vomit;
- nausea;
- diarrhea.
If clinical manifestations of an overdose are detected, you must contact a medical facility.
To avoid such negative situations, you should not exceed the dosages specified in the instructions or indicated by your doctor.
special instructions
Since this medication is indicated for sublingual and buccal use, chewing or swallowing it is unacceptable.
Patients who suffer from diabetes should pay attention that each unit of the drug contains 0.05 XE.
Gramicidin does not have the slightest effect on the ability of patients to drive vehicles, as well as to work with mechanisms and devices that require careful handling, and interaction with which involves increased use of cognitive abilities and attentional resources. Also, the medication does not impose restrictions on the ability to engage in extreme sports and activities recognized as potentially dangerous.
