Consequences of treating a sore throat: allergy to Grammidin

Lactating women often suffer from various diseases of infectious origin. This is especially true in the cold season. This is not surprising, because the immunity of a nursing mother is still weakened after childbirth. How to eliminate burning pain in the throat or pharynx, relieve inflammation and destroy bacteria?

Grammidin is a local medicine that contains an antibiotic. The drug has antibacterial, antiseptic, and local anesthetic effects. How safe is Grammidin during lactation? More on this later.

Pregnancy and breastfeeding

Grammidin Neo and other varieties are contraindicated for women during lactation.
This is due to the fact that the active components pass into breast milk, and as a result, the baby may experience digestive problems. During the first trimester of pregnancy, there is a complete contraindication for taking a drug containing cetylpyridinium chloride. This medicine is sometimes prescribed in the 2nd and 3rd trimesters. In cases where the benefit of the drug exceeds the possible minimal harm to the fetus. This medicine is prescribed starting from 14 weeks of pregnancy.

But still in medical practice there are cases when doctors prescribe Grammidin to pregnant women in the first trimester.

It is important that such treatment is supervised by a doctor. That is, for pregnant women, treatment of an infection of the throat or mouth with this drug is carried out only if absolutely necessary.

Grammidin at different times

But still, reasonable caution should be exercised with this remedy.

Grammidin itself is completely contraindicated during early pregnancy, for example - in the first 3 months. But in some cases, the doctor may allow it if he decides that the risks of a sore throat are much greater than the negative consequences of taking the medicine. And take the deadline into account. This is quite clearly seen in the table.

As you can see, from the 13th week the drug can be taken, but only with the permission of a doctor.

Pharmacological properties

Gramicidin has a pronounced antibacterial effect. This component actively affects the most common pathogens of infection of the oral cavity and pharynx. Thus, the medicine is able to stop inflammatory processes, eliminate discomfort when swallowing, soreness, and also destroy pathogenic microflora. This is what makes the drug unique.

The antiseptic that is part of “Grammidin” has an analgesic effect and makes it possible to effectively and quickly relieve pain in the mouth and throat. Significant relief occurs almost immediately after the tablet is dissolved.

Drug interactions

As for the interaction of Grammidin with other drugs, the drug is capable of enhancing various effects of many other antibiotics, which are prescribed both locally and systemically.

The drug is produced by a pharmaceutical company in the form of tablets that are either white or white-yellowish in color. One standard cardboard package contains two plastic blisters, ten small tablets each.

The medicine contains the active substance, as well as several additional components. The antibiotic gramicidin C with the addition of cetylpyridinium chloride and oxybuprocaine is the main component of the tablets. Inactive ingredients include: calcium stearate, lactose, sugar and methylcellulose.

What is better: regular Grammidin Neo or Grammidin with anesthetic

The question is incorrect. Each medicine is designed to treat specific forms of the disease.

Let's take a closer look at when you can get by with regular Grammidin Neo, and when is it better to buy Grammidin in a form that includes an anesthetic?

According to the instructions, Grammidin with an anesthetic is indicated when inflammatory processes in the oral cavity are accompanied by severe pain in the throat. This happens primarily with sore throat and stomatitis, but often ordinary pharyngitis can cause not only a cough, but also severe pain.

However, one should immediately make a reservation: the instructions recommend “Neo anesthetic” only when the effect of oxybuprocaine hydrochloride (an anesthetic) is not capable of harm. Therefore, the drug is not suitable for use in patients with individual intolerance to oxybuprocaine.

The least likely factor to influence the choice of Grammidin is price. True, the price of Grammidin tablets with different compositions differs, but only by a few rubles. Therefore, you need to focus on the indications and contraindications for the use of the drug, and not on the price and reviews.

Remember: reviews cannot recommend Grammidin with an anesthetic as a more powerful remedy for the treatment of pharyngitis, tonsillitis and others like them, because it is not such.

A swollen throat and a hacking cough also cannot serve as a reason to choose one drug over another.

But a sore throat is a symptom that may be an indication for prescribing Grammidin with an anesthetic (reviews from patients who have used the drug are clear: the pain goes away already when the first tablet is dissolved).

In any case: when choosing a medicine, you must always rely only on the doctor’s recommendations, as well as on the contents of the instructions.

The average price of Grammidin tablets is from 145 to 170 rubles.

Previous articleNasal drops Grippferon - reliable and safe protection against ARVI.

Grammidin during pregnancy - reviews of the drug

Reviews about treatment with Grammidin during pregnancy are positive. It is important to follow the recommendations for using the drug and not exceed the prescribed dosage.

• Svetlana . I was bothered by acute pain in my throat. The doctor prescribed Grammidin with an anesthetic as the best option for severe pain. The treatment took place during the 6th month of pregnancy for 5 days. I did not notice any negative consequences.
• Zina . I took the drug while treating a sore throat at 8 months of pregnancy. The dosage is reduced to 1 tablet twice a day. She tolerated it well, the treatment helped.
• Catherine . The medicine was prescribed at 16 weeks, so I took it with extreme caution. After 3 days, the acute stage passed, and therapy was continued with safer drugs.

As can be seen from the reviews, Grammidin is successfully used to treat women in the second half of pregnancy.

Grammidin for children

When using Grammidin Neo to treat children, you may encounter certain difficulties. This drug has a menthol flavor, which not all children like.

For effective treatment, the child must completely dissolve the tablets. It is also important that the child swallows saliva, which will be released in large quantities.

Grammidin Neo has quite a lot of analogues. Some of them have the same active substance, and some are similar in action. A cheaper drug with the same antibacterial substance is Gramicidin S.

In turn, with the same mechanism of action there are Bioparox, Hexoral, Faringopils, Tonzipret, etc.

Contraindications

Antiseptic tablets have a pleasant taste due to the presence of flavorings, so there are usually no problems with taking them. But doctors prohibit the uncontrolled use of the medicine, since it has many contraindications. For example, the use of Grammidin tablets is not recommended if you have hypersensitivity to the substances in their composition.

Women should use the drug with extreme caution during pregnancy and breastfeeding. In such a situation, it is necessary to consult a specialist who will select a safe dosage.

While taking the drug, it is best to interrupt lactation, and then resume it.

During pregnancy, Grammidin with an antiseptic is prescribed extremely rarely, since its ingredients can affect the condition of the mother and baby. It is worth keeping in mind that during pregnancy, the medicine can negatively affect a woman’s immunity and provoke allergies.

Tips and tricks

Treatment of an allergy to Grammidin begins with discontinuation of the drug that caused the negative reaction. In some cases, this is enough, and the signs of pathology go away on their own.

But the question arises, what can replace Grammidin, because you need treatment. If therapy cannot be stopped, the doctor selects the appropriate drug after testing for the allergen. After replacement, the substance that caused the negative reaction is gradually eliminated from the body, and allergy symptoms disappear.

To eliminate symptoms such as itching and skin rashes, the doctor prescribes antihistamines - Loratadine, Eden, Suprastin. The latter remedy is considered by many to be the most effective, but it should not be taken during pregnancy or while breastfeeding.

In the first days of developing an allergy to Grammidin, it is useful to take sorbents, for example, activated carbon. If the case is serious, hormonal drugs are prescribed.

Folk remedies can be used as additional measures to treat allergies. Medicinal herbs are considered the most inexpensive, safe and easy to use.

To make the skin rash go away faster, you should prepare a decoction of lemon balm, nettle or yarrow. For 1 tbsp. water take 1 tbsp. raw materials. The mixture is steamed for ten minutes and left to infuse. The resulting liquid is used for rinsing and compresses.

Immunity boosting products will also not be superfluous. You can drink hawthorn tea (50 ml at a time) or celery juice (1 tsp half an hour before meals) for two weeks. Decoctions of chamomile, celandine, and string also help to recover.

Shilajit, from which a solution is prepared, is considered a good antiallergic agent. But before you start treatment with folk remedies, it is better to consult a doctor so as not to worsen the situation.

If you are allergic to Grammidin tablets, diet is of great importance. It helps strengthen the immune system and restore damaged intestinal microflora. To solve the problem faster, you need to drink more clean water. If there are no food allergies, you can drink compotes, fruit drinks and other drinks with the addition of fruits and berries.

Lean fish and meat, as well as fermented milk products, are allowed in small quantities. All smoked meats, sauces, canned food, fatty and fried foods are completely prohibited. The amount of salt in food should be minimal.

When Grammidin will not help, and when it will cause harm

Sometimes the only reason a patient refuses treatment with Grammidin tablets is reviews.
Having read information on forums in which reviews of the drug sometimes differ in the most dramatic way, a person suffering from chronic pharyngitis flatly refuses to take such a controversial medicine. He refuses completely in vain. And not at all because the reviews about Grammidin are not true. Quite the contrary, in most cases, reviews of the drug are not embellished or discredited; each person simply talks about whether the drug helped him or not. And here everything depends on the competence of the doctor who prescribed the pills, the type of disease and the ability to carefully read the instructions in the instructions.

Price in pharmacies

The cost of the drug depends on the dosage form sold, as well as the pharmacy chain that sells the drugs. You can purchase the drug at any private or public pharmacy located near your place of residence.

Before using lozenges, you must consult a specialist and read the official instructions for use of Grammidin. Additionally, it is recommended to study reviews of patients who took the product.

Rules for taking the drug

Despite the fact that doctors most often prescribe Grammidin Neo to children over 12 years of age, they can still be given to children after 4 years of age. In this case, it is recommended to take 1 tablet 1-2 times a day. And from 12 years of age and adults, the frequency of administration should be increased to 3-4 times.

The course of treatment is the same for both age groups – 5-6 days. If after this time there are no changes, then the drug is discontinued.

Grammidin Neo tablets are intended for resorption. In this case, the tablet should dissolve completely; you should not bite or chew it. After it has completely dissolved, you should not eat or drink for 1-2 hours. For a pronounced therapeutic effect, it is recommended to ensure that the active substances of the drug act on the mucous membrane of the mouth and throat for a long time. Therefore, you need to take the medicine after meals.

Indications for use

Grammidin (lozenges have a high therapeutic effect) should be used based on the indications noted in the instructions for use. The medicine is prescribed in the complex treatment of infectious and inflammatory diseases in the pharynx and mouth caused by the influence of pathogenic microorganisms.

Indications:

• acute course of tonsillitis;
• development of pharyngitis;
• angina;

  
  Grammidin lozenges are prescribed for bacterial tonsillitis

• presence of gingivitis;
• inflammatory processes in the gums and gingival tissues – periodontitis;
• inflammatory reactions in the area of ​​the oral mucosa - stomatitis.

The product is intended for the symptomatic treatment of infectious and inflammatory diseases in the mouth. For the clinical cure of diseases, complex therapy is prescribed, which includes taking various groups of drugs.

Grammidin antibiotic

This medicine contains an antibiotic – gramicidin. It belongs to antibacterial drugs that inhibit most strains of pathogenic flora.

In particular, the antibacterial component of Grammidin exhibits high activity against staphylococci and streptococci, which are the most common cause of infectious processes in the oral cavity.

These bacteria actively multiply in the mucous membrane of the larynx, causing a sore throat, pain, swelling and cough. The antibacterial effect of the drug leads to their death, as a result of which the manifestations of the disease quickly disappear.

In high concentrations, the antibiotic included in Grammidin has a bactericidal effect (destroys bacteria), and in small concentrations it has a bacteriostatic effect (prevents their reproduction).

The same antibiotic is included in some other medications used to treat a wide variety of diseases. However, these products do not treat throat and cough, and therefore they are not worth buying. In addition, Grammidin’s “analogs” do not include other important components of the drug.

In addition to the antibiotic, Grammidin contains an antiseptic with a different biochemical structure and mechanism of action - cetylperidinium chloride (this substance neutralizes bacteria resistant to the action of gramicidin).

And in Grammidin with an anesthetic an additional local anesthetic substance (oxybuprocaine hydrochloride) was added.

Thanks to this combination of active substances, both types of medicine not only quickly and completely eliminate the cause of the disease, but also contribute to significant relief of the patient’s condition immediately after the start of treatment: the throat stops hurting, swelling goes away, and the cough calms down.

Side effects

In most cases, Grammidin does not cause any side effects. However, some patients sometimes experience signs of allergic reactions.

In addition, this drug has a fairly strong anesthetic effect, which can cause temporary loss of sensitivity in the tongue.

"Grammidin" is contraindicated for people who are allergic to one or another component contained in the medicine.

Antibacterial medication is not recommended for use in the treatment of women carrying a child. It is also better to avoid Grammidin during lactation.

Overdose

Cases of overdose with a pharmacological drug have not been described. However, the use of tablets can lead to problems in the gastrointestinal tract - the development of nausea, vomiting, and problems with stool.

If signs of overdose occur, including those not noted in the official instructions, it is recommended to stop taking the drug and seek advice from your doctor. It is possible to prescribe symptomatic therapy and completely discontinue the drug. In severe cases, it may be necessary to prescribe sorbent drugs or perform gastric lavage.

INSTRUCTIONS for medical use of the drug Grammidin

Registration number: P N002878/01-250411 Trade name of the drug: Grammidin International nonproprietary name: Dosage form: lozenges.

Composition per tablet: One tablet contains: gramicidin C dihydrochloride (in terms of gramicidin C) – 0.0015 g (1500 IU); sucrose (sugar) - 0.28825 g, mannitol 0.28825 g, hyprolose - 0.004 g, calcium stearate - 0.018 g.

Description: Tablets of white or white with a yellowish tint, with a characteristic odor, flat-cylindrical shape with a chamfer and a score. Pharmacotherapeutic group: antibiotic of polypeptide structure. ATC code: [R02AB30]

Pharmacological properties

Antibacterial drug for local use in the oral cavity and pharynx. Has a pronounced antimicrobial effect. In high concentrations, it has a bactericidal effect on most gram-positive and gram-negative microorganisms - causative agents of infectious diseases of the oral cavity and pharynx. Increases the permeability of the microbial cell membrane, which disrupts its stability and causes death. The drug is practically non-addictive to microorganisms sensitive to it. When absorbed, it increases salivation, helping to cleanse the oropharynx of microorganisms and inflammatory exudate. Due to low systemic absorption, data on the pharmacokinetics of Grammidin are not available.

Indications for use

Infectious and inflammatory diseases of the mouth and throat: acute pharyngitis, acute tonsillitis (tonsillitis), periodontal disease, gingivitis, stomatitis.

Contraindications

Hypersensitivity to the components of the drug, lactation period, children under 4 years of age (for this dosage form), sucrose/isomaltase deficiency, fructose intolerance, glucose-galactose malabsorption.

Carefully

Pregnancy.

Use during pregnancy and lactation

Pregnant women should consult a doctor before using the drug. The use of the drug is possible if the potential benefit to the mother outweighs the possible risk to the fetus. Breastfeeding should be stopped during treatment.

Directions for use and doses

Grammidin tablets are taken after meals, by dissolving in the mouth without chewing. Immediately after using the drug, you should refrain from eating and drinking for 1-2 hours. Children from 4 to 6 years old: 1 tablet 3-4 times a day. Children from 6 to 12 years old: 1-2 tablets 3-4 times a day (but not more than 7 tablets per day). Children over 12 years of age and adults: 2 tablets (one after the other for 20-30 minutes) 4 times a day. Course of treatment: 5-6 days. If there is no therapeutic effect within 6 days of taking the drug, it is recommended to consult a doctor.

Release form and composition

Grammidin with anesthetic is available in the following dosage forms:

• dosed spray for topical use: a colorless or yellowish solution with slight opalescence or transparent, with a characteristic mint odor (112 doses each in aluminum bottles equipped with a push-type dosing device and a folding cannula; in a cardboard box there is 1 bottle and instructions for the drug);
• lozenges: biconvex, round; no taste – white with a creamy tint and a menthol smell; raspberry - white-pink, interspersed, with a bitter raspberry taste and menthol smell; lemon - white with a yellowish tint, interspersed, with a bitter lemon taste and menthol smell; blackcurrant - light gray, interspersed, with a bitter blackcurrant taste and menthol smell (10 pcs. in blisters, in a cardboard pack 1 or 2 blisters and instructions for the drug; 10 or 20 pcs. in polymer jars, in a cardboard pack 1 jar and instructions for using Grammidin with anesthetic).

Composition for 1 dose of spray:

• active ingredients: gramicidin C (in the form of gramicidin C dihydrochloride) – 0.06 mg; cetylpyridinium chloride – 0.1 mg; oxybuprocaine hydrochloride – 0.15 mg;
• auxiliary components: sucralose, citric acid monohydrate, polysorbate 80, ethanol 96%, sodium citrate, propylparaben, methylparaben, glycerol, mint flavor, purified water.

Composition for 1 lozenge:

• active ingredients: gramicidin C – 1.5 mg; lidocaine (in the form of lidocaine hydrochloride) – 10 mg;
• auxiliary components: citric acid, hydroxypropylcellulose, eucalyptus oil, calcium stearate, aspartame, menthol, mannitol; for tablets with raspberry, lemon or blackcurrant flavors, respectively - raspberry, lemon or blackcurrant flavoring.

Grammidin's analogs

Many drugs have a similar effect, are similar in composition and are even more affordable. You can easily choose an analogue of Grammidin if the pharmacy does not have the required product. If the antibiotic is simple, then it can be replaced:

• aerosol Bioparox;
• Faringosept;
• Angi Septom;
• Strepsils with eucalyptus, vitamin C, menthol;
• Yox spray;
• Neo-Angin;
• Spray Stopangin;
• Lugol.

Neo and Children's can be replaced with the following analogues:

• Askoseptom;
• Bicarmint;
• Hexalize;
• Dekamin;
• Lariprontom;
• Lysobacter;
• Novoingalipt;
• Septolete.

The drug with anesthetic is replaced with the following analogues:

• Anti-Sore throat;
• Agisept;
• Astrasept;
• Hexaspreem;
• Hexoral;
• Gorpils;
• Drill;
• Inhaliptom;
• Kameton;
• Coldact Lorpils;
• Rinza Lorsept;
• Stopangin 2A;
• Suprima-ENT;
• Terasil.

Antibiotic Neo with anesthetic can be replaced:

• Gorpils;
• Drill;
• Dorithricin;
• Septolete;
• TeraFlu Lar.

Grammidin for children

The list of contraindications includes age 3-4 years. Grammidin is allowed for children with an anesthetic from three years of age. Other types are allowed from 4 years. The dosage for children is the same as for adults, so their presence in the line is an advertising ploy by the manufacturer to increase sales, as reviews say. When giving your baby Grammidin for a sore throat, make sure that he dissolves the lozenges and does not swallow them. Feeding tips for babies:

1. Ordinary throat tablets Grammidin are more suitable for the treatment of bacterial diseases, children - for viral ones, with an anesthetic - have an effect for severe pain.
2. Do not treat for longer than a week.
3. Give capsules after meals and prohibit eating and drinking for an hour.
4. If your baby needs two lozenges, give them one at a time.

Instructions for use of Grammidin, dosage

The drug must be taken immediately after meals. The tablets are kept in the mouth until completely dissolved; they cannot be chewed. After each dose of the drug, you should refrain from drinking and eating for 1–2 hours.

Dosage of Grammidin tablets with anesthetic, according to the instructions for use - 1 tablet \ 3 or 4 times a day. For severe symptoms of the disease, the permissible dosage for adults is 2 tablets up to 4 times a day (tablets are taken one after the other with a break of 20-30 minutes).

Dosage of Grammidin for children:

• Children over 12 years of age and adults - 2 tablets (they are dissolved directly one after another within half an hour) 4 times a day.
• Children under 12 years of age – 1-2 tablets 4 times a day.

The average duration of therapy is 5-6 days. If symptoms of the inflammatory process continue, you should consult a doctor.

Instructions for use Grammidin NEO

The drug is prescribed to adults and children (from 12 years old) 1 tablet 3-4 times a day.

Children from 4 to 12 years old – 1 tablet of Grammidin NEO \ 1-2 times a day.

Course duration – 7 days. If there is no therapeutic effect within 7 days of taking the drug, you should consult a doctor.

Side effects

The instructions warn about the possibility of developing the following side effects when prescribing Grammidin:

• allergic reactions;
• temporary loss of tongue sensitivity.

Contraindications

It is contraindicated to prescribe Grammidin in the following cases:

• 1st trimester of pregnancy;
• children under 4 years of age;
• hypersensitivity to the components of the drug.

If it is necessary to use the drug during lactation, the issue of stopping breastfeeding should be decided.

Overdose

Cases of overdose have not been registered or described. Possible increased adverse reactions.

Folk remedies and methods of prevention

Algorithm for preparing a solution for rinsing from honey and soda:

1. Boil 500 milliliters of water, cool to a temperature of approximately 40 degrees.
2. Add 1 teaspoon each of baking soda and honey.
3. To stir thoroughly.
4. Cool to an acceptable temperature.
5. Rinse 2-3 times a day after eating.

Algorithm for preparing a compress based on onions and honey:

1. Grate the onion until smooth.
2. Add honey to the mixture.
3. Place the mixture on cellophane.
4. Apply to the sore throat and insulate with a towel.
5. Keep for about 30 minutes.

You can use a small blanket, but you need to take into account the fact that the fabric will be saturated with the smell of onions and it is unlikely that it will be washed until it is perfectly clean.

Prevention methods

It is always much easier to prevent a disease than to get rid of it. It is necessary to adhere to general rules to avoid a sore throat:

• Take vitamin complexes recommended for consumption by pregnant women.
• Ventilate the room regularly, bringing fresh air into the room.
• Dress for the weather. You shouldn't overcool, but you shouldn't overheat either.
• Avoid large crowds of people.
• During periods of pandemics, when leaving the house, it is necessary to lubricate the nostrils with oxolinic ointment.

Grammidin is a good remedy for pregnant women in the 2nd and 3rd trimester , helping to cope with a sore throat.

However, you should consult a specialist before use. You should not self-medicate, as this may affect the baby’s health. Take care of yourself and your child!

Analogs

Today, many pharmacological companies produce drugs that are similar in action to Grammidin. Its analogues include the following medications:

• oral tablets "Pancef";
• Nitroxoline tablets;
• solution for topical use "Furacilin";
• substance-powder “Furadonin”;
• aerosol "Bioparox";
• lyophilisate for the preparation of oral solution “Lactobacterin dry”;
• suspension for oral use "Ersefuril";
• granules for the preparation of Pancef oral suspension;
• solution for oral use "Sextafag";
• suspension for oral use "".

special instructions

Grammidin with anesthetic does not have any effect on reaction and concentration. That is, you can control transport and other complex mechanisms while taking this medicine.

If, during complex treatment, a person takes another antibacterial drug, then gramicidin C enhances its effect. Especially if it is also a topical remedy.

Although gramicidin C is an antibiotic, combining it with alcohol is not as dangerous as when drugs are absorbed through the gastrointestinal tract. In this case, alcohol usually provokes accelerated absorption, and thereby increases the concentration of the active substance in the blood. Grammidin is a topical agent, which means that a negligible part enters the bloodstream. Accordingly, alcohol does not have an excessively destructive effect on the therapeutic effect.

It is important to store the drug correctly. Namely, that the tablets should be hermetically sealed and stored in a dry place with a temperature of no more than 250C. If all the rules are followed, the drug remains effective for 2 years.

Let's talk about risk

Of course, expectant mothers are interested in the issue of risk. So, what is the danger of Grammidin during pregnancy in the 1st trimester? The fact is that during the first 3 months, all the main organs of the child are formed. This is why doctors prohibit taking all fairly serious drugs, especially antibiotics, for which there is no accurate data on exactly how they affect. To be safe, it is best to abstain.

But what to do in cases where the drug was prescribed for various reasons? Not all patients carefully read the instructions. Sometimes there are situations like “I didn’t know I was pregnant and took Grammidin.” What to do in such cases? Get tested, do screening and don’t worry.

As a rule, at the very beginning of bearing a child, the risk of intrauterine death increases, rather than the birth of a baby with anomalies. The fruit is so small that anything that affects it kills it. In addition, do not forget that we are talking about a local remedy. This means that the effect on the fetus is reduced compared to other antibiotics.

Instructions for use

Active ingredients

Gramicidin C + Cetylpyridinium chloride

Release form

Pills

Compound

1 tablet contains:

active substances:

gramicidin C dihydrochloride - 3.20 mg (in terms of gramicidin C - 3.00 mg)

cetylpyridinium chloride monohydrate - 1.05 mg (in terms of cetylpyridinium chloride - 1.00 mg)

Excipients:

colloidal silicon dioxide -5.00 mg, talc -60.00 mg, acesulfame potassium -15.00 mg, mint flavor -25.00 mg, sorbitol -1065.75 mg, magnesium stearate -25.00 mg.

Pharmacological effect

A combined drug for the symptomatic treatment of infectious and inflammatory diseases of the throat and oral cavity. The drug contains the antimicrobial agent gramicidin C and the antiseptic agent cetylpyridinium chloride. The mechanism of action of gramicidin C is associated with an increase in the permeability of the cytoplasmic membrane of the microbial cell, which violates its stability and causes death. Gramicidin C has an antibacterial (bactericidal) effect against a wide range of gram-positive and gram-negative microorganisms. Cetylpyridinium chloride is an antiseptic, inhibits the growth and reproduction of pathogens of infectious diseases of the oral cavity. The drug has an antimicrobial effect, reduces inflammation, softens discomfort in the throat, and facilitates swallowing , when absorbed, causes hypersalivation, which promotes mechanical cleansing of the oral cavity and pharynx from microorganisms.

Pharmacokinetics

The drug has a local effect and is practically not absorbed in the gastrointestinal tract, which determines the almost complete absence of systemic effects.

Indications

Infectious and inflammatory diseases of the mouth and throat: acute pharyngitis; tonsillitis; tonsillitis; periodontal disease; gingivitis; stomatitis.

Contraindications

Lactation; hypersensitivity to the components of the drug.

Precautionary measures

Keep out of reach of children, protected from light.

Use during pregnancy and breastfeeding

Pregnant women should consult a doctor before using the drug. The use of the drug is possible if the potential benefit to the mother outweighs the possible risk to the fetus. Breastfeeding should be stopped during treatment. Directions for use and doses

It is used after meals, by dissolving in the mouth without chewing.

Immediately after using the drug, you should refrain from eating and drinking for 1-2 hours.

Dosage for adults and children over 12 years of age: 1 tablet 3-4 times a day.

Dosage for children from 4 to 12 years: 1 tablet 1-2 times a day.

If there is no therapeutic effect within 7 days of taking the drug, it is recommended to consult a doctor.

Side effects

In some cases, allergic reactions to the components of the drug are possible.

Overdose

Symptoms: taking the drug in doses higher than recommended may cause gastrointestinal disorders due to changes in the bacterial microflora: nausea, vomiting, diarrhea. Treatment: you should stop taking the drug and consult a doctor.

Interaction with other drugs

Currently, there are no cases of clinically significant interactions with other drugs.

special instructions

Grammidin for children should not be taken in the presence of open wounds in the oral cavity, since cetylpyridinium chloride slows down the healing of wounds. Effect on the ability to drive vehicles and operate machinery The drug does not affect the performance of potentially hazardous activities that require special attention and quick reactions (driving a car and other vehicles means, work with moving mechanisms, work of the dispatcher and operator, etc.).

Contraindications, side effects and overdose

Contraindications are mainly related to individual intolerance to the components. As for side effects, they boil down to typical manifestations of allergies. And if you take an anesthetic compound, your tongue may partially lose sensitivity for some time. But it comes back quickly, you don’t even need to do anything special for this. Cases of overdose have not been studied by science.

Separately, it is worth noting that Grammidin interacts quite well with other drugs; it is periodically prescribed as part of complex therapy. But if the medication is used together with other antibiotics of similar, that is, local action, then their effect can be additive. And not only positive, but also negative. In addition, there is a risk of an autoimmune reaction or an excessive increase in immune status, which is not always positive during pregnancy. Therefore, if you are taking several drugs with a similar effect at the same time, it is better to consult your doctor in advance.