pharmachologic effect
A combined drug for the treatment of infectious and inflammatory diseases of the throat and oral cavity.
The drug contains the antimicrobial agent gramicidin C and the antiseptic agent cetylpyridinium chloride. The mechanism of action of gramicidin C is associated with an increase in the permeability of the cytoplasmic membrane of the microbial cell, which disrupts its stability and causes death. Gramicidin C has an antibacterial effect against a wide range of gram-positive and gram-negative microorganisms. Cetylpyridinium chloride is an antiseptic that inhibits the growth and reproduction of pathogens that cause infectious diseases of the mouth and throat. The drug has an antimicrobial effect, reduces inflammation, softens discomfort in the throat, and makes swallowing easier.
Grammidin spray for children 0.03 mg+0.1 mg/dose 112 doses
A country
Netherlands
The country of production may vary depending on the batch of goods. Please check with the operator for detailed information when confirming your order.
Compound
Bottle of 112 doses
of Gramicidin C dihydrochloride 0.0638 mg, cetylpyridinium chloride 0.1 mg per 1 dose. Excipients: ethanol 96% - 19 mg, sucralose - 0.2 mg, glycerol - 33.2 mg, mint flavor - 0.82 mg, citric acid monohydrate - 0.058 mg, sodium citrate - 0.022 mg, polysorbate 80 - 0.4 mg, methyl parahydroxybenzoate (methylparaben) - 0.184 mg, propyl parahydroxybenzoate (propylparaben) - 0.02 mg, purified water - up to 0.2 ml. Spray for topical use dosed in the form of a clear or opalescent, colorless or yellowish solution with a characteristic mint odor.
pharmachologic effect
Combined drug for local use. Gramicidin C is an antimicrobial agent. The mechanism of action is associated with an increase in the permeability of the cytoplasmic membrane of the microbial cell, which violates its stability and causes cell death. Gramicidin C has a pronounced antimicrobial effect against pathogens of infectious diseases of the oral cavity and pharynx. Cetylpyridinium chloride is an antiseptic. Suppresses the growth and reproduction of pathogens of infectious diseases of the oral cavity. The combined drug reduces inflammation, has an antimicrobial effect, softens discomfort in the throat, facilitates swallowing, and when absorbed causes hypersalivation, which promotes mechanical cleansing of the oral cavity and pharynx from microorganisms.
Indications for use
Infectious and inflammatory diseases of the oral cavity and pharynx: - sore throat; - pharyngitis; - tonsillitis; - periodontal disease; - gingivitis; - stomatitis.
Side effects
Possible: in some cases - allergic reactions.
Contraindications
Children under 4 years of age;
I trimester of pregnancy; hypersensitivity to the components included in the drug. Use during pregnancy and breastfeeding Use in the first trimester of pregnancy is contraindicated. If it is necessary to use it during lactation, breastfeeding should be stopped during use.
Mode of application
The method of administration and dosage regimen of a particular drug depend on its release form and other factors. The optimal dosage regimen is determined by the doctor. The compliance of the dosage form of a particular drug with the indications for use and dosage regimen should be strictly observed. For resorption or treatment of the oral cavity. Use 1-4 times a day, depending on the indications, the age of the patient and the dosage form. Immediately after use, you should refrain from eating and drinking for 1-2 hours.
special instructions
If there is no therapeutic effect within 7 days of use, you should consult a doctor.
Interaction with other drugs
Enhances the effects of other antimicrobial agents of local and systemic action.
Directions for use and doses
Locally, by spraying onto the mucous membrane of the mouth and throat. Used after meals.
Dosage for adults: 4 injections per application 3 times a day for 7 days. Immediately after using the drug, you should refrain from eating and drinking for 1 hour.
If there is no improvement after treatment, or symptoms worsen, or new symptoms appear, you should consult your doctor.
Use the drug only according to the indications, method of administration and in the doses indicated in the instructions.
special instructions
Grammidin is for external use only. In this case, spray irrigation in children should be carried out by parents or a treating specialist.
Do not use the drug in the presence of open wound surfaces in the mucous membrane of the mouth or pharynx. It must be taken into account that the solution contains ethanol . In this case, the daily dosage of an alcohol-containing product should not exceed 0.04 g.
The advisability of using the drug during pregnancy or breastfeeding should be discussed by the treating otolaryngologist/dentist, taking into account the potential risks/benefits for both the mother and the unborn child. When using the solution during lactation, it is necessary to stop breastfeeding for the entire period of using the spray.
Analogs
Grammidin is a spray (a separate dosage form is prescribed for children), which, in case of intolerance to the ingredients, can be replaced by other drugs that exhibit a similar therapeutic effect.
Analogues:
- Inhalipt. This pharmacological development is produced at a domestic pharmaceutical plant. Ingalipt is produced in the form of a local spray intended for irrigating the throat. It contains various herbal components, the complex action of which is aimed at relieving infectious and inflammatory manifestations that occur in the mouth and throat. The medicine has a pronounced local antimicrobial and anti-inflammatory effect and is used in the treatment of tonsillitis, pharyngitis, gingivitis, and stomatitis.
The only limitation to its use is high sensitivity to the ingredients included in Inhalipt. The daily dosage is 1-2 injections 3 to 4 times. The duration of the therapeutic course may vary depending on the nature of the inflammatory process and is determined by the treating ENT specialist or dentist. This drug is available over-the-counter. The price of the drug varies between 73-120 rubles. per bottle. - Hexoral. The production and release of this drug is carried out by a Russian pharmacological company. The medication is produced in the form of a local aerosol for irrigating the throat. Its active substance is hexetidine, a component that exhibits high antimicrobial and antiviral properties. The drug also has a pronounced antifungal effect. Scope of application of the aerosol: infectious, inflammatory and fungal diseases occurring in the mouth and throat area, preventive treatment after surgery or injury. The medicine is also used as a hygiene product to help eliminate bad breath. 1 irrigation is prescribed per day. The procedure is carried out no more than 2 times a day. It is prohibited to use the aerosol in the presence of erosions in the oral cavity, in children under 3 years of age, as well as in the presence of allergies caused by the activity of the main ingredients that make up Hexoral. The drug is available without a prescription. The cost of a bottle in pharmacies ranges from 267 to 346 rubles.
- Angilex. This pharmacological drug is being developed on the basis of hexetidine, an active element of the drug that has a pronounced anti-inflammatory and antibacterial effect. Angilex is manufactured in two medicinal versions - in the form of a local spray and a solution for external use. It has a high therapeutic effect against gram-positive and gram-negative microflora, while also having a bactericidal effect. Thanks to additional components, analgesic and bactericidal effects are noted. Indications for the use of Angilex are: inflammatory diseases occurring in the pharynx and mouth, including dental pathologies - gingivitis, stomatitis, periodontitis. Restrictions on taking the drug include allergic symptoms and children under 2.5 years of age. The daily norm is one installation from 4 to 6 times. The maximum period of use of the spray is no more than 5 days. Further use of the medication must be agreed upon with the treating otolaryngologist. The price of the drug ranges from 155 to 210 rubles.
- Anginovag. This pharmaceutical development is made from several active elements and belongs to the category of local anti-inflammatory drugs of combined action. The dispensed dosage form is a local spray intended for irrigation of the mouth and throat. The action of the main elements is aimed at combating pathogenic microflora, eliminating inflammatory processes, and reducing pain or discomfort. The main indications for taking the medicine: diseases of an infectious or inflammatory nature occurring in the oral cavity or pharynx. Anginovag is also used for the occurrence of inflammatory diseases in dentistry - gingivitis, periodontitis, stomatitis, glossitis. The oral form of the drug is prohibited for use if you are allergic to the composition, as well as in children under 13 years of age. In the first 2 days of therapy, 1-2 injections are prescribed every 2-3 hours. Subsequently, the dosage is 1 irrigation every 6 hours. The duration of the course should not be more than one week. The price of the spray in pharmacies starts from 450 rubles. per bottle.
- Agisept. The manufacturer of this drug is an Indian pharmaceutical company. The product is manufactured in tablet form based on 2 active elements - amylmetacresol and dichlorobenzyl alcohol. These components fight the action of pathogenic microflora in the oral cavity and pharynx. Additional components are various flavoring fillers and aromas. Indications for taking tablets are the following processes: inflammation or infections occurring in the oral cavity and pharynx - the occurrence of tonsillitis, pharyngitis, stomatitis, the development of gingivitis, periodontitis. It is prohibited to use the medication in the presence of high hypersensitivity reactions provoked by the action of the main components of the drug, as well as in children under 5 years of age. Children over 5 years of age are prescribed 1 capsule every 4 hours per day. The duration of treatment should be determined by the treating otolaryngologist. Adjisept is available over-the-counter. The price of a package in pharmacies in Moscow and the Moscow region ranges from 62 to 120 rubles.
- Anzibel. This drug is produced by a Turkish pharmaceutical company. Anzibel is produced in the form of lozenges (tablets) for resorption. Their active ingredients are the following substances: chlorhexidine, enoxolone and benzocaine. The combined effect of the drug is aimed at reducing pathological processes occurring in the area of the mouth and pharynx. The main indications for taking lozenges are: infectious and inflammatory lesions of the oral cavity and pharynx, provoked by the negative influence of external factors. The product relieves swelling. Eliminates inflammatory reactions, reduces pain. It is forbidden to use Anzibel in case of high reactions of intolerance to the composition, as well as in the presence of phenylketonuria. Children from 6 to 12 years old are prescribed 1 lozenge every 2-3 hours. However, the permissible dosage should not be exceeded - more than 8 lozenges. Children over 12 years old should take 1 lozenge every 2-3 hours. The maximum period of use of the medicine is no more than 7 days. Its cost in pharmacies is 95 to 190 rubles.
Grammidin is a spray for children, which should be replaced with similar drugs only after prior consultation with a specialist. Independent selection of analogues may cause the development of side effects or other negative reactions.
