Pharmacodynamics and pharmacokinetics
The active ingredient, gramicidin C, is an antibiotic of the tyrothricine group , which is active against most Gram+ and Gram- microorganisms that cause infectious diseases in the oral cavity and pharynx. By increasing the permeability of microbial cell membranes for the penetration of inorganic cations, osmotic instability of the cells is achieved. In addition, during the resorption process, salivation increases, which promotes natural cleansing of inflammatory exudate and microorganisms, starting from the throat, oral cavity and ending with the tonsils.
Since gramicidin C is characterized by low systemic absorption, there are no data on pharmacokinetics.
Indications for use of Grammidin
The most effective use of Grammidin is for various infectious and inflammatory diseases of the oral cavity and pharynx:
- Tonsillitis;
- Sore throat;
- Gingivitis;
- Acute pharyngitis;
- Periodontal disease;
- Stomatitis.
For diseases that are accompanied by pain, Grammidin with an anesthetic is indicated.
Grammidin has few contraindications. Having only a local effect, in rare cases it can cause allergic reactions to its constituent components.
According to reviews, Grammidin should be used with caution during pregnancy.
During lactation it is better to avoid using the drug. The drug is not prescribed to children under 4 years of age.
Contraindications
Contraindications include groups of patients who are not recommended to take the drug:
- having hypersensitivity to the components of the tablets;
- pregnant and breastfeeding women, as well as children under 12 years of age.
Milk sugar - lactose is included in Grammidin tablets, which is why they should not be prescribed to people with galactose lactase enzyme deficiency or glucose-galactose malabsorption syndrome .
Instructions for use of Grammidin
According to the instructions, Grammidin and Grammidin with an anesthetic are prescribed two tablets for adults and children (over 12 years old). They should be dissolved one after another within 20-30 minutes after eating. After using the drug, it is not recommended to eat or drink for 1-2 hours. Take 4 times a day. Children under 12 years of age are prescribed 1-2 tablets 4 times a day. Course duration is 5-6 days.
Grammidin NEO is prescribed for adults and children (from 12 years old) 1 tablet 3-4 times a day, and for children from 4 to 12 years old - 1 tablet 1-2 times a day. Course duration – 7 days.
Without any special contraindications, the drug is quite effective in treating a sore throat. According to reviews, Grammidin quickly makes swallowing easier and relieves sore throat. Also, many note its effectiveness in treating children. The drug can be bought at a pharmacy without a prescription, the shelf life is 2 years.
Grammidin's analogs
Matches by level 4 ATC code: Grammidin with anesthetic Neo
Grammidin for children
Grammidin with anesthetic
Grammidin Neo
Bioparox
Gramicidin S
Trachisan
The price of Grammidin analogues ranges from 200-270 rubles, among them are Valenta Pharmaceuticals tablets with different compositions of active ingredients:
- Grammidin Neo (the drug is supplemented with active ingredients - oxybuprocaine and cetylpyridinium chloride ) No. 18 - 210-230 rubles;
- Grammidin Neo with anesthetic (supplemented with the anesthetic lidocaine hydrochloride ) No. 18 – 240-270 rubles;
- Children's with raspberry flavor (with cetylpyridinium chloride ) No. 18 - 180-200 rub.
pharmachologic effect
The active ingredient of Grammidin is the antibiotic gramicidin (Gramicidin C). It acts on almost all pathogens that cause infectious and inflammatory diseases of the oral cavity.
According to the instructions, Grammidin is not addictive. The increased salivation caused by the drug helps cleanse the oral cavity of waste products of pathogenic microorganisms.
An additional active ingredient in Grammidin NEO, Cetylridinium chloride, helps relieve discomfort in the throat.
Grammidin with anesthetic, being a combined antibacterial drug, contains, in addition to the antibiotic lidocaine hydrochloride. Due to this, it also acts as a pain reliever.
Grammidin price, where to buy
The cost of Grammidin tablets ranges from 270 rubles. The price of Grammidin starts from 180 rubles - for children and ends with Neo with Anesthetic (pain reliever) - 280 rubles. The best place to buy the drug is in Moscow pharmacies and other pharmaceutical companies working directly with ValentaPharm.
You can find out how much an analogue of the drug costs and other information on the manufacturer’s official website.
- Online pharmacies in RussiaRussia
- Online pharmacies in KazakhstanKazakhstan
ZdravCity
- Grammidin children's spray dosage.
for local approx. 0.06 mg+0.1 mg/dose vial. 112 doses Famar Netherlands B.V. Netherlands/ PJSC Valenta Pharm RUR 324 order - Grammidin NEO with anesthetic tablets for rassas. 3mg+0.2mg+1mg 18 pcs. JSC Valenta Pharmaceuticals
RUB 351 order
- Grammidin NEO tablets for rassas. 3mg+1mg 18 pcs. JSC Valenta Pharmaceuticals
290 rub. order
- Grammidin children's tablets for rassas. 1.5mg+1mg 18 pcs. JSC Valenta Pharmaceuticals
RUB 304 order
- Grammidin with anesthetic spray for places. approx. fl. 112doses Famar Netherlands B.V. Netherlands/ PJSC Valenta Pharm
380 rub. order
Pharmacy Dialogue
- Grammidin spray 0.06 mg+0.1 mg/dose 112 doses Valenta Pharmaceuticals OJSC
RUB 339 order
- Grammidin children's tablets d/diss. 4+ No. 18 Valenta Pharmaceuticals OJSC
RUB 332 order
- Grammidin NEO d/diss. No. 18 Valenta Pharmaceuticals OJSC
RUB 310 order
- Grammidin NEO with anesthetic tablets d/rass. No. 18 Valenta Pharmaceuticals OJSC
RUB 339 order
- Grammidin spray for children 0.03 mg+0.1 mg/dose 112 dosesValenta Pharmaceuticals
290 rub. order
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Release form
Available in the form of lozenges:
- Grammidin. Tablets are white, possibly with a yellowish tint. Each tablet contains 1.5 mg of Gramicidin C and excipients (calcium stearate, milk sugar, sugar, methylcellulose). There are 10 pcs in a package, 2 packages in a cardboard box;
- Grammidin NEO. White, round, biconvex tablets with “GR” printed on one side. Each tablet contains 3 mg of Gramicidin C and 1 mg of cetylpyridinium chloride. Excipients – magnesium stearate, colloidal silicon dioxide, acesulfame potassium, talc, mint flavor, sorbitol. 6 pcs in a package, 2-4 packs in a cardboard box, 9 pcs in a cardboard box, 2 packs in a cardboard box;
- Grammidin with anesthetic. Round, biconvex tablets with a menthol odor. Each tablet contains 1.5 mg Gramicidin C, 10 mg lidocaine hydrochloride and excipients: citric acid, eucalyptus oil, aspartame, menthol, mannitol, hydroxypropylcellulose Klucel, calcium stearate. With flavors (raspberry - tablets of white-pink color and raspberry flavor, lemon - white-yellow color and lemon taste, or blackcurrant - white-gray color and blackcurrant taste) or without them - white-cream tablets with inclusions.
Common Questions
1. Can side effects occur while using Grammidin? Undesirable effects are possible. Some people experience allergic reactions, nausea, and diarrhea. When using Grammidin with the anesthetic Neo, the sensitivity of the tongue may be temporarily lost.
2. What medications cannot be used simultaneously with Grammidin and an antibiotic? There are no prohibitions in the instructions for use. The manufacturer only indicated that experts have not encountered cases of clinically significant interactions between Grammidin and any other drugs.
3. Do drugs from the Grammidin line affect the ability to drive vehicles and moving machinery? Medicines do not have such an undesirable effect, so during the treatment period you can do absolutely any business without fear of working.
4. Do I need a prescription to purchase Grammidin? Medicines from this line are classified as over-the-counter drugs. Anyone can buy them in pharmacies.
5. Sprays, tablets “Grammidin with anesthetic Neo”, “Grammidin for children”, “Grammidin Neo” - antibiotics or not? The listed drugs are combination drugs. They combine an antibiotic with an antiseptic, and tablets with an anesthetic also contain an additional local anesthetic component.
Preparations from the “Grammidin” line and active ingredients
The Grammidin line of drugs consists of 5 drugs:
- "Grammidin Neo";
- "Grammidin with anesthetic Neo";
- "Grammidin for children";
- "Grammidin" (spray);
- "Grammidin for children" (spray).
All of the above medicines contain 2 active components - gramicidin C dihydrochloride and cetylpyridinium chloride. The first component is the antibiotic in Grammidin. What effect does it give? When gramicidin C enters the human body, it begins to have an antimicrobial effect. The negative effect of this component on pathogenic microorganisms is to increase the permeability of their cytoplasmic membrane. Due to such exposure, the microbial cell loses its stability and dies.
Cetylpyridinium chloride, another active component, is an antiseptic. It also has a negative effect on pathogens of infectious diseases. The effect of cetylpyridinium chloride in “Grammidin” with an antibiotic is to suppress the growth and reproduction of pathogens.
Side effects
The use of Grammidin in the vast majority of cases is well tolerated by patients and does not cause side effects. Occasionally, allergic reactions may develop due to hypersensitivity to the active or auxiliary components of the drug. If they develop, it is recommended to discontinue drug therapy and consult your doctor to prescribe a drug that has a similar pharmacological effect, but contains other active ingredients.
When treating with Grammidin with an anesthetic, a temporary loss of sensitivity of the tongue is possible due to the action of the anesthetic.
