Hofitol

Compound

One Hofitol tablet contains 200 mg of dried aqueous extract of Cynara Scolymus (field artichoke) leaves, as well as pregelatinized corn starch - 22 mg, talc - 3 mg, magnesium trisilicate - 12 mg, magnesium stearate - 3 mg. Shell composition: talc - 16.3 mg, rosin - 1.152 mg, gum lac - 1.152 mg, sucrose - 86.146 mg, gelatin - 0.384 mg, calcium carbonate - 2.2 mg, carnauba wax - 0.082 mg, polysorbate 80 - 0.004 mg, dispersed dye (oxides brown, black and yellow, sucrose), additives E214 and E 218 (ethyl and methyl parahydroxybenzoate).
The composition of the Hofitol solution includes a thick aqueous extract of Cynara Scolymus (field artichoke) leaves at a concentration of 20 g per 100 ml, ethyl alcohol, orange flavor, methyl parahydroxybenzoate, propyl parahydroxybenzoate, glycerol, purified water.

Pharmacodynamics and pharmacokinetics

The medicine Hofitol - its effect?

The pharmacological properties of the drug are due to the action of the complex of biologically active substances contained in the leaves of Cynara Scolymus. Cynarin in combination with phenolic acids has hepatoprotective and choleretic effects. Carotene, inulin, ascorbic acid and vitamins B1 and B2 help normalize metabolic processes.

Hophytol helps to activate bile formation and excretion, reduce the level of urea and cholesterol in the blood.

Pharmacokinetics

Carrying out kinetic observations and identifying metabolites of the drug is not possible, since the effect of Hofitol is the cumulative effect of its active substances.

Effect of the drug

The main indications for use are based on the action of the drug - choleretic. Artichoke extract includes many useful biologically active components - pectin, chlorogenic acid, polysaccharides, caffeic acid. There are also mineral salts, vitamins, potassium, inulin, and cynarin. It is the latter component, in combination with phenolic acids, that provides a choleretic effect - it dilutes bile, preventing the formation of flakes, sediment, and stones. As a result of taking Hofitol, it increases the secretion and flow of bile.

The drug has a hepatoprotective effect, protecting hepatocytes from damage.

With a course of treatment, the functional state of liver tissue is optimized.

Vitamins B, beta-carotene, and inulin also have a noticeable beneficial effect on metabolism. They regulate metabolism, especially fat metabolism. This allows the medicine to produce the following effects:

normalization of cholesterol levels;
reduction of oxidative degradation of lipids;
activation of biochemical processes;
improved digestion;
accelerating the digestion of fatty foods.

Such actions allow the medicine to be used as part of a diet for those who are trying to control fat levels. Due to the presence of inulin, the drug lowers blood sugar. Another effect of Hofitol is diuretic; it removes excess fluid from the body, and along with it, excess urea.

Indications for use of Hofitol

Injection solution, drops and tablets Hofitol - what are they for?

Indications for use of Hofitol:

dyspeptic disorders, manifested by nausea, flatulence, heartburn, a feeling of heaviness in the epigastric region;
chronic non-calculous (calculous) cholecystitis;
chronic hepatitis;
biliary dyskinesia (BDH) of the hypokinetic type (characterized by slowing and sluggishness of bile outflow);
cirrhosis of the liver;
chronic renal failure;
chronic nephritis.

In combination with other drugs, field artichoke preparations can be used to treat:

chronic intoxication (salts of heavy metals, alkaloids, nitro compounds, hepatotoxic substances);
anorexia;
obesity;
atherosclerosis;
uraturia;
urolithiasis.

Contraindications

The drug is not prescribed in case of known hypersensitivity to the components of the tablets/solution (in particular to preservatives E214, E216 or E218) and plants of the aster family (Asteraceae or Compositae).

Other contraindications to the use of Hofitol:

bile duct obstruction;
cholelithiasis;
acute diseases of the kidneys, liver, urinary and biliary tract ( angiocholitis , empyema of the gallbladder , etc.);
children up to six years of age (for the tablet form of the drug).

Instructions for use of Hofitol (Method and dosage)

Hofitol tablets, instructions for use

Patients over the age of twelve are prescribed to take tablets three times a day (before meals), one or two tablets at each dose (daily dose from 600 mg to 1.2 g).

Treatment usually lasts from 2 to 3 weeks. If necessary, the doctor may prescribe a repeat course.

Hofitol solution, instructions for use

The oral solution is shaken and diluted with water before use. A single dose for an adult is 2.5 - 5 ml (1 tsp). Frequency of applications - 3 times a day.

The duration of treatment depends on the nature and characteristics of the course of the disease.

Use of the drug Hofitol oral solution

For oral use. Before use, the solution should be shaken and diluted with water. Adults are prescribed 1 teaspoon (5 ml solution) 3 times a day before meals. Children under 12 months of age: dilute 0.3–0.5 ml of solution (5–10 drops) in 1 teaspoon of water 3 times a day 20 minutes before meals; at the age of 1 year to 5 years - dilute 0.5–1 ml of solution (10–20 drops) in 1 tablespoon of water 3 times a day 20 minutes before meals; at the age of 6-12 years - dilute 2-3 ml of solution (teaspoon) in 1 tablespoon of water 3 times a day 20 minutes before meals; over the age of 12 years - -1 teaspoon of solution, diluted in 1 tablespoon of water 3 times a day 20 minutes before meals. The course of treatment is 2–3 weeks. Repeated courses of treatment are possible after consultation with the doctor.

special instructions

Hofitol should be used with extreme caution in pathologies that could potentially provoke bile duct obstruction , as well as in severe liver pathologies .
The occurrence of abdominal pain and/or diarrhea should be a reason to stop treatment and consult a doctor.
The tablets contain sucrose (0.08 grams/tablet), which should be taken into account in patients with glucose-galactose malabsorption syndrome , fructose intolerance or sucrase-isomaltase deficiency .
The presence of preservatives in tablets and oral solution may cause the development of hypersensitivity reactions (including delayed ones).
The oral solution contains ethanol, therefore, during treatment with Hofitol in this dosage form, it is recommended to avoid drinking drinks that contain alcohol.
Tablets and injection solution do not slow down the speed of reactions and do not impair the ability to concentrate. Drops for oral administration, due to the presence of ethanol in their composition, can affect these parameters, which should be remembered when driving a car and when working with machinery.

Contraindications and side effects

It is forbidden to take the drug if you already have stones, especially when cholelithiasis has led to partial blockage of the bile duct. Any acute pathologies of the kidneys, liver, or other internal organs are also included in the list of contraindications to therapy.

The drug will be harmful in severe liver failure.

Other contraindications include intolerance to the components, deficiency in the body of sucrose, isomaltose (for liquid dosage form).

Tablets are not given to children under 6 years of age; this contraindication does not apply to the solution. During lactation and pregnancy, use is carried out only under the strict supervision of a specialist! Possible adverse reactions include:

allergic reactions;
diarrhea, bloating;
stomach ache;
signs of bowel irritation (rare);
heartburn;
gastrointestinal disorders.

If you take Hofitol for too long a course, diarrhea develops quite often. When this happens, and diarrhea is accompanied by abdominal pain, you should stop taking it. Due to the composition of the auxiliary components, immediate and delayed allergic reactions are possible (within 72 hours). The liquid form includes sucrose in a volume of 0.04 XE/day, which must be taken into account in case of diabetes.

Hofitol's analogs

Similar drugs with a similar mechanism of action: Allohol , Arnica tincture , Berberine , Hepabene , Convaflavin , Leptandra , Olimethin , Tansy flowers , Choleretic collection , Tanacehol , Phytohepatol No. 2 and No. 3 , Flamin , Holagol , Holemaks , Holos , Holosas , Kavechol , Tsikvalon , Rosehip fruits .

A cheap analogue of Hophytol based on the leaf extract of Cynara Scolymus - dragees and tablets for the liver of Artichoke extract (about 220 rubles for package No. 60),

Which is better: Allohol or Hofitol?

Allohol , like Hofitol, is intended for the treatment of pathologies of the liver and biliary tract. Its basis is Activated carbon (enterosorbent), bile, garlic bulbs and stinging nettle leaves.

The drug has choleretic properties (has a cholekinetic effect and causes a moderate choleretic effect), enhances the secretory function of the liver, reflexively increases the motor and secretory organs of the digestive system, improves the digestion process in general and, in particular, the emulsification of dietary fats, reduces the likelihood of cholesterol precipitation from subsequent stone formation.

The active components of Allochol also help to inhibit fermentation processes in the intestinal tract and thereby reduce flatulence.

Allochol is prescribed for the treatment of cholangitis , chronic reactive hepatitis , ADHD , postcholecystectomy syndrome , and atonic constipation .

Choleretic drugs are prescribed only in the absence of signs of inflammation. The choice in favor of a particular drug is made taking into account the type of dysfunction, as well as depending on how quickly you need to get a positive result from therapy.

Both Allohol and Hofitol are true choleretics, since both increase the secretion of bile and stimulate the formation of bile acids, however, in addition to the choleretic effect, Hofitol also has a protective effect.

Based on this, we can conclude that the use of bile-containing drugs is advisable when it is necessary to carry out long-term course treatment for biliary dysfunction , while the choice in favor of Hofitol is made in situations where the patient is simultaneously diagnosed with liver pathology.

The use of Hofitol in pediatric practice

In pediatrics, solutions for oral/parenteral use are prescribed without age restrictions, tablets are prescribed to children over six years of age.

Indications for use in children are acute or chronic hepatitis , acalculous chronic cholecystitis , fatty hepatosis , motility disorders and decreased tone of the gallbladder and its ducts, increased concentration of acetone in the blood, intoxication (salts of heavy metals, nitrates, etc.), oliguria , chronic renal failure , chronic nephritis , skin diseases ( acne in adolescents, psoriasis , etc.), dyspeptic disorders, obesity, neonatal jaundice.

Children over twelve years of age are prescribed tablets at the same dose as adults. The daily dose of Hofitol tablets for children 6-12 years old is 600 mg (the dose should be divided into three doses).

The optimal dosage form for newborns is drops. According to the instructions for Hofitol, for newborns it is necessary to measure 5-10 drops of the medicine for each dose. The medicine is given on an empty stomach 3 times a day. Before giving the child Chofitol in drops, the required dose is first dissolved in 5 ml of water.

For adolescents over twelve years of age, 2.5-5 ml of solution is diluted in 1 tbsp. l. water. For children under twelve years of age, take 2-3 (depending on age and indications) milliliters of the drug for the same volume of water. The indicated dose should be taken 3 times a day. 20 minutes before meals.

Reviews of Hofitol for children indicate that the drug not only copes with its task very well, but is also very well tolerated by young patients. In addition, the drug is very convenient to use and easy to dose, which is very important when it comes to treating infants.

physiological jaundice for a long period .

An excessive increase in the concentration of bilirubin in the blood during pathological jaundice is dangerous because it can lead to the development of non-infectious damage to brain structures .

Timely use of Hofitol for newborns helps normalize liver function and biotransformation of insoluble toxic indirect bilirubin into non-toxic direct bilirubin. Mothers of young children note that bilirubin decreased on average by the ninth day of life, and by the end of the second or third week, the symptoms of jaundice completely disappeared.

Instructions for the medicine

Tablets are taken by adults and children over 6 years of age. Dosage - 2-3 tablets three times a day. It is enough for children to drink 1-2 tablets in the same regimen. Patients are often interested in whether to take Hofitol before or after meals. Treatment is carried out before meals, the course is 2-3 weeks. It can be repeated if necessary. The solution is drunk 2.5-5 ml three times a day, depending on the pathology, the dose is chosen by the doctor.

In children, the dose of the solution is 1/4 that of an adult. The maximum daily dose is 1.2 g/day for people over 12 years of age. For pregnant women, the optimal dose is 400-600 mg/day. Doctors usually recommend taking tablets that do not contain flavorings (the latter can themselves provoke an allergy). The course for pregnant women is 14 days. In children and adolescents, the main indications for treatment with Hofitol are:

cholecystitis outside the acute phase;
slung syndrome;
stagnation of bile after taking antibiotics or suffering from an intestinal infection;
motor disorders;
low tone of the gallbladder;
poisoning;
acne;
psoriasis;
dyspepsia.

Newborns are given a solution of 5-10 drops/dose three times a day. Dissolve the dose in 5 ml of water or more. Usually the course is 9-14 days, during which time bilirubin, increased due to jaundice, returns to normal.

Chofitol during pregnancy

Why is the drug prescribed to pregnant women?

What is Chofitol for during pregnancy? The instructions indicate that the use of Hofitol in pregnant women is allowed as prescribed by a doctor and provided that the expected result of treatment exceeds the likely risks to the fetus or child.

In the first months of pregnancy, the drug is prescribed for existing risk factors to prevent late gestosis , as well as to alleviate the condition of a woman with early toxicosis . There is evidence that the inclusion of Hofitol in the treatment regimen for preeclampsia helps to improve the clinical course of the disease.

During pregnancy, the drug acts as an antioxidant and hepatoprotector . It reduces the oxidative degradation of lipids under the influence of free radicals, improves fat metabolism, protects the liver and facilitates its work, stimulates the formation and excretion of bile, has a mild diuretic effect, reduces cholesterol in the blood, improves blood condition and blood microcirculation (including in the placenta) .

Despite the fact that the drug is not a special gynecological or obstetric drug, it is used to improve the condition of liver pathologies , atherosclerosis , and inflammatory diseases of the urinary tract.

The use of Hofitol also improves the general well-being of asthenic pregnant women. A woman is much less likely to be bothered by weakness, dizziness, mood swings, drowsiness, and her central nervous system excitability decreases.

One of the problems of pregnant women is fluid retention in the tissues. As a result, pregnancy is often complicated by quite serious pathologies. Chophytol improves the functioning of small vessels and kidney function, thus preventing the development of edema and dropsy.

However, it must be borne in mind that the drug does not have antiseptic and antibacterial properties. Therefore, if a blood test reveals signs of inflammation, Hofitol alone is not enough. Along with it, you should take uroseptic drugs .

Reviews about Chofitol during pregnancy are often good. Most women claim that the drug helped them well with toxicosis, heartburn and swelling. However, there are also reviews that note that the result was not noticeable even after completing the full course.

What dosage is considered optimal during pregnancy?

How to take Hofitol during pregnancy? The optimal dosage of tablets during pregnancy is 500 mg/day. The medicine is usually taken for three weeks.

In the form of an oral solution, Hofitol is taken three times a day, a teaspoon (5 ml). The course of treatment is usually about two weeks.

The duration of the course is determined by the doctor individually.

Use of Chofitol during lactation

Data on the safety of use of the product during breastfeeding are not provided.

Chophytol is a choleretic herbal preparation made from field artichoke. The mechanism of its action is due to a set of biologically active substances contained in the leaves of the field artichoke. The combination of cynarin + phenolic acids exhibits a choleretic effect and allows the use of Hofitol as a hepatoprotector. The thiamine, riboflavin, ascorbic acid and inulin contained in artichokes normalize metabolism. In addition, Hofitol has a diuretic effect and promotes the removal of urea from the body. The multicomponent composition of the herbal medicine makes it impossible to conduct pharmacokinetic studies, because The biologically active substances contained in artichoke leaves cannot be traced in the body using traditional markers or biological studies. Available in tablets and solution for oral use. The recommended duration of pharmacotherapy is 2-3 weeks. Repeated courses are possible, the need for which is determined by the doctor on an individual basis. With prolonged use of the drug in submaximal doses, the development of dyspeptic disorders is possible. Hofitol has proven itself in the treatment of patients suffering from various liver pathologies (hepatitis, cirrhosis) and diseases of the biliary tract (cholecystitis, dyskinesias). The plant nature of the drug gives it a number of advantages over synthetic drugs. It causes virtually no clinically significant side effects. The bioflavonoids, biogenic amines, terpenoids, vitamins and minerals included in its composition give the drug a mild hepatoprotective and antioxidant effect. Hophytol is practically non-toxic, which allows it to be included in long-term drug courses in patients of any age without increasing the risk of side effects.

The drug is suitable for use in outpatient settings. Clinical studies have shown the versatility of its pharmacodynamics. In addition to choleretic, antioxidant and hepatoprotective, it has a detoxifying, mild diuretic and hypocholesterolemic effect. Hofitol can be used as part of complex treatment or as monotherapy. An improvement in the general condition of patients is observed, as a rule, already in the second week of treatment: their sleep is normalized, their appetite improves, their mood improves, and the severity of epigastric pain decreases. A month after the start of treatment, the improvement in the condition of 85-90% of patients is supported by both objective indicators and subjective assessments. In 10-15% of patients, clinical symptoms of the disease persist, but they become much less pronounced. The drug can also be used in patients with cholestasis syndrome, because Hophytol, unlike individual hepatoprotectors, does not aggravate their condition. It is important that the normalization of the processes of formation and excretion of bile observed when taking Hofitol helps to improve digestive function in general, because The hepatobiliary system is in close contact with the gastrointestinal tract. Pregnancy and breastfeeding are not direct contraindications to the use of Hofitol, but drug therapy in such cases should be carried out under mandatory medical supervision. The drug should not be used in patients with biliary obstruction, during exacerbation of kidney disease, or in children under 6 years of age. The liquid form of Hofitol contains small amounts of ethanol.

Reviews about Khofitol

Hofitol is intended to enhance the motility of the gallbladder and restore normal bile flow in case of dysfunctional disorders of the biliary tract .

The drug has hepatoprotective and diuretic properties, which makes it possible to use it not only for ADHD and chronic pathologies such as nephritis , hepatitis or cholecystitis , but also during pregnancy (to reduce the severity of symptoms of early toxicosis and treat late gestosis ), for neonatal jaundice and for weight loss as part of obesity treatment programs (as an adjuvant).

If we study the reviews of doctors about Chofitol, we can conclude that the drug is effective for chronic cholecystitis and, in addition, “works” well for liver dysfunction. As a hepatoprotector , the drug is most often used to eliminate the consequences of toxic liver damage (including drug-induced).

Reviews of Hofitol for toxicosis , as well as the results of a number of studies confirm that after a course of use of the drug, the symptoms of toxicosis completely cease in approximately 25% of patients, and in another 35-50% (according to various sources), the general condition noticeably improves.

The forums also often discuss the feasibility, safety and effectiveness of prescribing Hofitol for children (in particular, for newborns). For older children, the medicine is prescribed for the treatment of diseases of the biliary tract and gall bladder, as well as for the elimination of dyspeptic symptoms , and for newborn children - for the treatment of physiological jaundice .

Most mothers leave good reviews about the drug, since it has a natural composition, is well tolerated by children and is easy to use. However, there are also reviews that mention side effects during treatment (the cause of complaints is most often diarrhea), and also that in some cases the medicine did not alleviate the child’s condition at all.

To be fair, it is worth noting that negative reviews about Hofitol are rare. Mostly they are left by people who are dissatisfied with the fact that the medicine did not completely rid them of the disease, but only temporarily removed the symptoms.

Hofitol price, where to buy

How much do tablets and solution cost in Russian pharmacies?

The price of Chofitol in drops is 500 rubles. You can buy tablets from 390 rubles for package No. 60 and from 890 rubles for package No. 180. The cost of the oral solution is 390-400 rubles.

Cost of Hofitol in Ukraine

The price of Hofitol in tablets is from 120 to 300 UAH (for 2 blisters of 30 tablets, 5 blisters of 12 tablets or 6 blisters of 10 tablets). Buy syrup in Kyiv, Odessa, Dnepropetrovsk and other large cities - 230 UAH.

Online pharmacies in RussiaRussia
Online pharmacies in UkraineUkraine
Online pharmacies in KazakhstanKazakhstan

ZdravCity

Hofitol tablets p.p.o.
60 pcs. Rosa-Phytopharm 406 rub. order
Hofitol tablets p.p.o. 180 pcs Rosa-Phytopharm
RUB 892 order
Hofitol solution internal 120ml n1Rosa-Phytopharm
RUR 556 order

Pharmacy Dialogue

Hofitol (oral solution 120 ml)Lab. Rosa-Phytopharma
RUR 559 order
Hofitol (tab.p/vol. No. 60)Lab. Rosa-Phytopharma
RUR 414 order
Hofitol (tab. p/o No. 180)Lab. Rosa-Phytopharma
RUR 971 order

Pharmacy24

Chophytol 120 ml No. 1 solution Laboratory Rose-Fitofarm, France
205 UAH order
Hofitol No. 180 tablets of the Rose-Phytopharma Laboratory, France
329 UAH. order
Hofitol No. 60 tablets Laboratories Rosa-Phytopharma, France
113 UAH order

PaniPharmacy

Hofitol tablets Hofitol tablets. p/o 0.2g No. 60 France, Lab. Rosa-Phytopharma
118 UAH order
Hofitol tablets Hofitol tablets. p/o No. 180 France, Lab. Rosa-Phytopharma
341 UAH. order
Hofitol liquid Hofitol solution per/approx. 120ml France, Lab. Rosa-Phytopharma
201 UAH order

Description of the medicine

Hofitol is produced in France by the company Rosa-Fitofarm, and is available in two forms - tablets and a solution for internal use. The price of the medicine is 350 rubles/60 tablets, 390 rubles/120 ml of solution.

The composition contains artichoke extract - an extract of phyto-raw materials.

This remedy belongs to the group of choleretic drugs of natural origin. In addition to 200 mg of extract (one dose for both forms), there are also additional ingredients:

starch;
gummilk;
talc;
rosin;
magnesium stearate and trisilicate;
gelatin;
polysorbate;
sucrose and others.

The tablets are round, convex on both sides, brown (coated). The solution has an original smell, which is achieved through the introduction of orange flavor, as well as the natural aroma of artichoke extract. Tablets are sold in 60/180 packs, in blisters - 12-30 pieces. The syrup is sold in a dark glass bottle.