Full list of Indapamide analogues: Arifon, Veroshpiron, Hydrochlorothiazide, Indap and others

About half of the adult population of our country suffers from hypertension.

Each patient must be treated and take medications prescribed by a specialist.

Indapamide and its analogues are quite often prescribed to hypertensive patients as an effective antihypertensive and diuretic agent.

Letters from our readers

Topic: Grandma's blood pressure has returned to normal!

From: Christina ( [email protected] )

To: Administration otgipertonii.ru

Christina, Moscow

My grandmother’s hypertension is hereditary - most likely, I will have the same problems as I get older.

I accidentally found an article on the Internet that literally saved my grandmother. She was tormented by headaches and had a repeated crisis. I bought the course and monitored the correct treatment.

After 6 weeks she even started talking differently. She said that her head no longer hurts, but she still takes pills for blood pressure. I am sending a link to the article

pharmachologic effect

Manufacturer: Akrikhin, Ozon, Promed, Teva, ALSI, Vertex, etc., Russia
Release form: tablets, capsules

Active ingredient: indapamide

Synonyms: Indap, Arifon, SR-Indamed

The drug belongs to the diuretics (thiazide-like diuretics).

Has a diuretic and antihypertensive effect.

A lasting effect develops a week after continuous use, the drug is cumulative. The therapeutic effect lasts up to 24 hours.

Indapamide - instructions for use

The medicine is taken as prescribed by a doctor once a day in the prescribed dose (2.5 or 1.5 mg) in the morning.

The drug is cumulative. After a single dose, the hypotensive effect lasts up to 24 hours. It is optimal to take the medicine regularly for 4–8 days and monitor your blood pressure. If pressure surges are observed during this time and the therapeutic effect is not enough, you should not stop taking the medicine on your own or increase the single dose. It is necessary to consult a doctor to select a comprehensive treatment - a specialist will select the second component for a diuretic antihypertensive drug.

How to take Indapamide - before or after meals

A common question at doctor’s appointments and at pharmacies is: when to take Indapamide - in the morning or in the evening. According to the instructions for use of Indapamide, the drug is taken in the morning on an empty stomach or after a small breakfast (for example, it is permissible to eat a piece of bread or cheese to prevent nausea).

Indapamide's analogs

Indapamide is a first-line treatment for hypertension. According to studies, it is preferable for older people than drugs from the groups of ACE inhibitors (Enalapril, Perindopril, Captopril, Capoten, etc.) and b-blockers (Concor, Bisoprolol, Nebivolol, Carvedilol, etc.).

Pharmacies offer combination drugs, one of the components of which is Indapamide:

• Noliprel-A – combination with perindopril;
• Triplixam contains amlodipine and perindopril;
• Enzix duo is the second component of enalapril;
• Arifam – combination with amlodipine;
• Co-Perineva and Co-Perindopril are synonyms for Noliprel, which contain perindopril;
• Diroton Plus is a combined analogue containing lisinopril and others.

All substitutes are available by prescription, except for Andipal tablets. This is a cheap analogue of Indapamide without side effects, which has a hypotensive, analgesic, antispasmodic, sedative, and vasodilator effect.

Indapamide analogs and substitutes

Other analogues with diuretic and hypotensive effects:

• Diacarb;
• Tenoric (contains chlorthalidone);
• Triampur etc.

Side effects after taking the medication

Can negative reactions occur after taking the drug Indapamide? This drug has side effects. Let's list them right now.

• Digestive system: gastralgia, nausea, abdominal pain, vomiting, anorexia, constipation, dry mouth, pancreatitis, diarrhea, hepatic encephalopathy.
• Respiratory system: sinusitis, cough, rhinitis and pharyngitis.
• Nervous system: insomnia, asthenia, muscle spasms, nervousness, general weakness, anxiety, headaches, fatigue, vertigo, dizziness, depression, drowsiness, irritability, malaise and tension.
• Urinary system: nocturia, frequent infections and polyuria.
• Heart and blood vessels: arrhythmia, orthostatic hypotension, palpitations, and ECG changes (ie, hypokalemia).
• Allergies: urticaria, rash, hemorrhagic vasculitis and itching.
• Hematopoietic system: thrombocytopenia, hemolytic anemia, leukopenia, bone marrow aplasia and agranulocytosis.
• Laboratory indicators: glucosuria, hyperuricemia, increased plasma urea nitrogen, hyperglycemia, hypercreatininemia, hypokalemia, hypercalcemia, hyponatremia and hypochloremia.
• Other: exacerbation of systemic lupus erythematosus.

Indapamide or Veroshpiron - which is better?

Manufacturer: Gedeon Richter-RUS, Russia
Release form: tablets, capsules

Active ingredient: spironolactone

Synonyms: Spironolactone, Verospilactone

Veroshpiron is a potassium-sparing diuretic. When taken orally, the analogue prevents the retention of sodium ions and promotes the excretion of fluid and sodium and chlorine ions. As a result of the diuretic effect, normal blood pressure is lowered and maintained.

Veroshpiron is used according to the recommendation of a cardiologist: 1 or 2 times a day. Indications: arterial hypertension, congestive heart failure, hypokalemia, liver cirrhosis accompanied by ascites and fluid retention. Available by prescription in three dosages - 25 mg tablets, 50 and 100 mg capsules.

Indapamide and Veroshpiron are drugs from the group of diuretics. They differ in their mechanism of action, active substance, indications and contraindications. Analogues are used exclusively as prescribed by a doctor. Moreover, Veroshpiron is an analogue of Indapamide for children from 3 years of age; it is used with caution in old age. Indapamide is not used in pediatrics and is safe in the treatment of the elderly.

Reviews

• Ekaterina, 44 years old. I heard a lot of bad reviews about taking various diuretic medications from friends. Therefore, when I was prescribed Veroshpiron, at first I was even afraid to take it. It seemed that I would not be able to leave the house, I would only be on guard when it took effect. I was pleasantly surprised by the really soft (as I read on the Internet) action. The effect for the most part occurred in the first part of the day, the night passed as usual. There were no allergies or side effects, I was satisfied with the treatment.
• Nina, 56 years old. My husband took Diuver when severe swelling began throughout his body due to ascites (as a result of cirrhosis of the liver). The action began within 2 hours and constantly made itself felt with strong urination. But it was worth it - after a week the swelling noticeably decreased, but Diuver was not canceled; now he drinks it constantly. Potassium supplements were prescribed as part of the complex, as a lot of it was excreted. We are happy with the medicine, we just need it to be prescribed by a doctor.
• Irina, 45 years old. When I started to feel that my legs were swelling during the day, I started using Lasix. I don’t drink it all the time, but when my feet don’t fit into my shoes, I have to. The action is very fast, after 30 minutes an irresistible urge to urinate appears. And after 2 hours the swelling goes away. It suited me, especially since I almost always have high blood pressure. You cannot prescribe this drug yourself; there are many contraindications. I even somehow felt how my blood pressure dropped sharply, and weakness arose. Therefore, it is important that a doctor prescribe it.

Indapamide or Arifon Retard - which is better?

Manufacturer: Servier, France or Russia
Release form: tablets

Active ingredient: indapamide

Indapamide and Arifon Retard are analogues with the same composition. However, the second drug is a controlled-release tablet, so there is a longer lasting therapeutic effect.

The dose of the active substance in Arifon Retard is 1.5 mg. The same content is in Indapamide retard tablets.

Arifon Retard is a higher quality substitute for Indapamide in tablets, with positive reviews. The disadvantage is the high cost.

Indapamide or Indap - which is better, what is the difference

Manufacturer: PRO.MED.CS Prague, Czech Republic
Release form: capsules

Active ingredient: indapamide

Indap is an analogue produced in the Czech Republic and containing indapamide. There is one release form - capsules with a dosage of 2.5 mg.

In fact, Indapamide and Indap are identical, since they contain the same active substance and have the same indications and contraindications. The difference may be in effectiveness and frequency of side effects. The cost of analogues is different - the price for a package of Indap for a month is 100-145 rubles. How much Indapamide costs depends on the manufacturer: the cheapest domestic tablets start from 15 rubles, more expensive are imported or jointly produced tablets (for example, Indapamide-Teva).

Indapamide or Hydrochlorothiazide – which is better?

Manufacturer: Pranapharm, Russia
Release form: tablets

Active ingredient: hydrochlorothiazide

Synonyms: Hypothiazide

Hydrochlorothiazide and Indapamide are drugs with diuretic and antihypertensive effects. They belong to the same group - thiazide and thiazide-like diuretics. Apply once a day.

Hydrochlorothiazide is used for hypertension. The difference is additional indications (edematous syndrome, nephrogenic diabetes insipidus, prevention of complications due to hypercalciuria).

Hydrochlorothiazide is also included in combination drugs for hypertension:

• Lorista N and ND, Lozap Plus (combination with losartan);
• Telsartan N, Telzap Plus (the second component is telmisartan);
• Co-Diroton (combination with lisinopril);
• Valsacor ND (contains valsartan), etc.

However, if treatment with Hydrochlorothiazide or Indapamide alone does not produce the desired results, then combination with the latter is preferable. According to studies, patients experienced a more effective reduction in blood pressure and improved life indicators.

The cost of analogues is affordable. Which is better is determined individually by the doctor. Both drugs are well tolerated and used long-term. A distinctive feature of Indapamide is its direct vasodilatory effect.

Indications for use

The drug is prescribed for:

• Chronic arterial hypertension of various origins
• Hypertension at all stages of development
• For chronic cardiac failure to eliminate water and sodium retention in the body (treatment of edema syndrome).

The latest indications are unregistered, but for these diseases, Indapamide gives a quick and long-lasting positive effect.

You can learn everything about fluid stagnation in the body in the article: body swelling.

Indapamide or Hypothiazide – which is better?

Manufacturer: Hinoin Plant, Hungary
Release form: tablets

Active ingredient: hydrochlorothiazide

Synonyms: Hydrochlorothiazide

Indapamide and Hypothiazide belong to the same group of diuretics and have a diuretic and hypotensive effect. Taken once a day as prescribed by a doctor.

Indapamide additionally has a direct vasodilatory effect.

Analogs are suitable for long-term use and are well tolerated. What to choose is individual and is decided during a face-to-face appointment with a cardiologist.

Indapamide or Torasemide – which is better?

Manufacturer: Pharmproekt, Medisorb, Kanonpharma, Berezovsky FZ, etc., Russia
Release form: tablets

Active ingredient: torasemide

Synonyms: Trigrim, Diuver, Lotonel, Britomar

Torsemide is a new generation analogue of Indapamide with diuretic and hypotensive effects. Belongs to the group of loop diuretics, prescribed for arterial hypertension and heart failure for a long time (at the discretion of the doctor).

Torsemide is not included in the first-line treatment for arterial hypertension indicated in current guidelines for physicians. However, the area of ​​application of the analogue is the treatment of hypertension in hypertensive crises, resistance or intolerance to thiazide and thiazide-like diuretics (Indapamide, Hydrochlorothiazide), and concomitant renal failure.

What to choose – a new generation substitute, Torasemide or Indapamide, individually. Both drugs are available by prescription and have serious contraindications and side effects.

Contraindications

According to the instructions, Indapamide should not be prescribed to patients with:

• Hypokalemia;
• Severe form of renal failure, including anuria, encephalopathy;
• Acute cerebrovascular accident;
• Hypolactasia;
• Galactosemia;
• Hypersensitivity to the main or one of the excipients of the composition.

The use of Indapamide is contraindicated in patients under the age of 18 years, as well as in the case of:

• Concomitant use with medications whose action is aimed at prolonging the intervals of electrical systole of the heart;
• Pregnancy;
• Breastfeeding.

It is recommended to use Indapamide with caution when treating patients with a history of pathologies such as:

• Functional disorders of the liver or kidneys;
• Violation of water and electrolyte balance;
• Hyperparathyroidism;
• Severe form of diabetes mellitus;
• Gout;
• Hyperuricemia.

Indapamide or Furosemide – which is better?

Manufacturer: Borisov Plant (Belarus), Ozone, Update (Russia), Sopharma (Bulgaria)
Release form: tablets

Active ingredient: furosemide

Synonyms: Lasix

Both drugs - Indapamide and Furosemide - have a diuretic and hypotensive effect. The main difference is that the first belongs to the group of thiazine-like diuretics, the second - loop diuretics.

Indapamide is prescribed long-term for arterial hypertension. Taken once a day.

Furosemide is a cheap analogue of Indapamide with a powerful diuretic effect. Used for acute conditions, as well as when traditional therapy for arterial hypertension is ineffective. With long-term use, Asparkam or Panangin is prescribed together to prevent complications and replenish potassium.

The cost of the analogue is low - up to 50 rubles for 20–50 tablets (depending on the manufacturer).

Indapamide or Lisinopril - which is better?

Manufacturer: ALSI, OZONE, Medisorb, Teva, OBL, etc., Russia
Release form: tablets

Active ingredient: lisinopril

Synonyms: Diroton, Lisinoton, Lizoril, etc.

Lisinopril is a drug that can replace Indapamide or supplement it if it is ineffective on the recommendation of a doctor. Belongs to the group of ACE inhibitors used for arterial hypertension. Has the following therapeutic effects:

• hypotensive;
• anti-inflammatory;
• antiatherosclerotic;
• angioprotective;
• cardioprotective.

The analogue does not have a diuretic effect.

The drugs Indapamide and Lisinopril contain different substances and belong to different pharmacological groups. This indicates a difference in indications, mechanism of action, contraindications and side effects. What is suitable for a particular person depends on many factors - age, other diseases, medications taken, financial capabilities, previous therapy and its effectiveness, etc. The drug is prescribed by a doctor.

Note! If monotherapy is ineffective, an analogue based on two substances - Lisinopril and Indapamide - can be selected, or prescribed together. Combined drug – Diroton plus.

special instructions

Against the background of incorrect dosing or long-term use of Indapamide, hyponatremia, hypochloremic alkalosis, and hypokalemia may develop in patients with severe liver dysfunction and chronic heart failure. Elderly patients, those with coronary heart disease, and diabetes mellitus are also at risk of developing side effects.

To prevent the negative effects of the drug, treatment should be carried out under the control of changes in the concentration of electrolytes, glucose, and uric acid in the blood. The first laboratory test is recommended to be carried out after seven days of taking Indapamide.

If laboratory abnormalities are diagnosed, the patient should take more fluids to prevent the development of acute renal failure.

If simultaneous treatment with angiotensin-converting enzyme inhibitors is necessary, the patient should temporarily stop taking the diuretic or prescribe a low dose of inhibitors.

According to the instructions for Indapamide, during therapy it is recommended to exercise extreme caution when driving, especially at the beginning of taking the drug.

Indapamide or Amlodipine - which is better?

Manufacturer: Ozone, Prana, Teva, Kanonpharma, etc., Russia
Release form: tablets

Active ingredient: amlodipine

Synonyms: Amlotop, Norvasc, Normodipin, Cardilopin, Kalchek, Amlorus, etc.

Amlodipine is another antihypertensive drug classified as a calcium channel blocker. The analogue is prescribed long-term for hypertension and angina pectoris. Has a number of actions:

• hypotensive;
• antianginal;
• vasodilating.

The disadvantage of the analogue is side effects in the form of allergic manifestations and swelling. Used to reduce and maintain blood pressure, reduce cardiovascular risks (stroke, heart attack, atherosclerosis).

The drugs Indapamide and Amlodipine are analogues that differ in composition, pharmacological group and action. The first remedy is a diuretic, taken for a long time in the morning. If the therapeutic effect is insufficient, it can be taken together with Amlodipine, which is often prescribed at lunch. Both analogues are prescription and cannot be used without a doctor's prescription.

The advantage of Indapamide is its diuretic effect. The drug regulates water-salt metabolism, the disruption of which is a common cause of arterial hypertension.

Indapamide Retard analogues

An imported analogue of Indapamide Retard with the same dosage is the drug Arifon Retard from the company Servier. The cost of the substitute is several times higher. It features higher-quality raw materials, the presence of clinical trials, and fewer side effects.

A significant difference between the analogue is the release form. The tablets are coated with a controlled release coating. This ensures that a uniform hypotensive effect is observed throughout the day. Indapamide Retard is in the form of ordinary tablets, the active substance is released unevenly. Depending on the manufacturer, a strong effect may be observed within 3-4 hours after administration, then the therapeutic effect will not be enough to stabilize blood pressure.

Composition of the medicinal product and its release form

In what form is this drug marketed? In the pharmacy it can only be found in the form of biconvex tablets coated with a white film coating.

What active ingredient does Indapamide contain? Analogs of this drug (most of them) and the drug itself contain such an active component as indapamide. As for the excipients, the tablets include the following elements: lactose monohydrate, crospovidone, povidone K-30, magnesium stearate, talc and sodium lauryl sulfate.

Answers on questions

Is indapamide a diuretic or not?

Yes, the drug is a diuretic.

Does indapamide increase or decrease blood pressure?

The medicine lowers blood pressure and maintains optimal levels when taken regularly.

Which is better - Indapamide capsules or tablets?

The effectiveness of the two forms is approximately the same. What to choose depends on individual preferences.

Does indapamide remove potassium or not?

Yes, to a small extent.

What can replace Indapamide if you are intolerant to it?

This issue is resolved in person at a doctor’s appointment. Preparations containing this substance are not suitable.

Reviews from specialists and patients about the drug

Now you know what the drug Indapamide is. Reviews and the price of this medication will be presented right now.

Experts say that this medicine copes well with its task. It effectively lowers blood pressure and also acts as a diuretic.

Reviews of the drug "Indapamide" indicate that after its use, left ventricular hypertrophy decreases, and its hypotensive effect is manifested even in those patients who are on hemodialysis.

As for negative statements about the mentioned remedy, most often they are associated with the manifestation of a large number of adverse reactions. However, it should be noted that such effects are observed only in those who exceeded the prescribed dosage of the drug or took it despite existing contraindications.