TOP 12 analogues of the drug Triderm: list of inexpensive ointments and creams

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Triderm is a combined hormonal drug for external use. Belongs to the group of corticosteroids for the treatment of skin diseases for external use - highly active corticosteroids in combination with other drugs (D07XC01). Active ingredients: Betamethasone, Gentamicin, Clotrimazole.

The drug Triderm has anti-inflammatory, antipruritic, antiallergic, antibacterial, antifungal effects. The cream form relieves acute inflammation, and the ointment form relieves chronic inflammation. Dispensed without a doctor's prescription!

Triderm does not contain parabens.

Compound

• 1 gram of Triderm ointment contains 10 mg of clotrimazole , 1 mg of gentamicin , 0.5 mg of betamethasone . Additional components: liquid paraffin, soft paraffin.
• 1 gram of Triderm cream also contains 10 mg of clotrimazole , 1 mg of gentamicin , 0.5 mg of betamethasone . Additional components: propylene glycol, petrolatum, liquid paraffin, cetostearyl alcohol, benzyl alcohol, macrogol cetostearate, phosphoric acid, sodium dihydrogen phosphate dihydrate, water, phosphoric acid.

Pharmacodynamics and pharmacokinetics

Pharmacodynamics

Multicomponent product for external use. Combines the antipruritic, anti-inflammatory, antiallergic and antiexudative effect of betamethasone with the antifungal effect of clotrimazole and the antibacterial activity of gentamicin .

Clotrimazole has an antifungal effect due to its ability to inhibit the biosynthesis of ergosterol , which is an important structural unit of the fungal cell membrane. Effective on Epidermophyton floccosum, Trichophyton rubrum and mentagrophytes, Candida albicans, Microsporum canis, Malassezia furtur.

Gentamicin has a wide spectrum of effects. Exhibits a bactericidal effect and provides local treatment of bacterial skin lesions. Effective on:

• gram-negative bacteria – Proteus vulgaris, Pseudomonas aeruginosa, Escherichia coli, Klebsiella pneumoniae, Enterobacter aerogenes;
• gram-positive bacteria – Staphylococcus aureus.

Pharmacokinetics

There is no data on the pharmacokinetics of this drug.

Indications for use

What does Triderm ointment and Triderm cream treat and for what? Indications for use of Triderm ointment:

• infections associated with microorganisms sensitive to the drug and frolicking against the background of dermatoses , or suspicion of them, including atopic , allergic and simple dermatitis , diffuse and limited neurodermatitis , dermatomycosis ( candidiasis , dermatophytosis , pityriasis versicolor ), eczema ;
• lichen simplex of a chronic nature.

Which is better: Triderm or CANDIDERM

Cream CANDIDERM.
Photo: socialochka.ru Both drugs are not analogues of each other. The active ingredients of Triderm are Betamethasone, Gentamicin and Clotrimazole. The drug CANDIDERM replaces Betamethasone with Beclomethasone, the content of which in the drug is lower than the concentration of Betamethasone. Triderm is produced in the form of cream and ointment for external use. Release form CANDIDERMA is only a cream for external use. Indications for use:

• dermatoses complicated by secondary infection;
• athlete's foot;
• dermatomycosis (including localized in the groin area) caused by pathogens sensitive to the drug.

In pediatrics, the drug Triderm is approved for use from 2 years of age; CANDIDERM cream is recommended from 7 years of age. Both drugs are over-the-counter!

The country of origin of Triderm is Germany. CANDIDERM is produced in India. CANDIDERM is cheaper in cost than Triderm.

Contraindications

• skin symptoms of syphilis ;
• chicken pox;
• lupus ;
• post-vaccination skin reactions;
• herpes simplex;
• hypersensitivity to the components of the drug;
• age less than 2 years.

It is recommended to use the drug with caution for long-term therapy, in children over 2 years of age, during pregnancy, on large areas of skin or in the presence of wounds, when applying occlusive dressings.

The difference between Triderm and AKRIDERM GK

AKRIDERM GK.
Photo: petroapteka.com The drugs are analogues of each other. The active ingredients are the same in concentration (Betamethasone, Gentamicin and Clotrimazole). They differ in the composition of excipients. Both drugs are approved in pediatrics from 2 years of age. There is also a difference in the purchase of the substance: Triderm components from Spain, Singapore and China; the substances of the drug ACREEDERM GC are produced in China, India, Italy, and Malaysia. Both drugs are over-the-counter!

The country of origin of Triderm is Germany. AKRIDERM GK is produced in Russia. In terms of cost, AKRIDERM GK is cheaper than Triderm. Price per package from 355 rub.

Side effects

• Local phenomena: erythema , burning sensation, pigmentation disorder, exudation , itching.
• Side effects after using local glucocorticosteroids : itching, burning sensation, folliculitis , dry skin, hypertrichosis, hypopigmentation, acne, allergic contact dermatitis , skin maceration, perioral dermatitis , atrophy , secondary infection, prickly heat , stretch marks .
• Side effects after using clotrimazole : urticaria , tingling sensation, erythema , peeling, blistering, itching, local swelling, irritation.
• Side effects after using gentamicin : temporary erythema and itching, which does not require discontinuation of therapy.

Description

Triderm® cream works in three directions at once:

Anti-inflammatory

1. Has an anti-inflammatory effect, helps reduce swelling and relieve symptoms such as itching, irritation, redness and peeling;

Antibacterial

2. Fights bacterial infection caused by gram-negative and gram-positive bacteria;

Antifungal

3. Suppresses the growth of pathogenic fungi.

Thanks to its complex action, Triderm® cream fights infections that complicate:

• simple and allergic dermatitis;
• atopic dermatitis;
• eczema;
• neurodermatitis;
• dermatomycosis.

The cream gives the best results for acute inflammation, which may be accompanied by swelling, blistering, redness and severe itching. It is more suitable for oily or baby skin6.

Tolerability of Triderm was rated by patients as excellent (40%) and good (60%)8.

Instructions for use of Triderm (Method and dosage)

Triderm ointment, instructions for use

The ointment is for external use only.

The use of Triderm ointment is carried out in the following way: a thin layer is applied to the affected and surrounding skin twice a day (morning and evening). To ensure a therapeutic effect, the product must be applied regularly. The duration of treatment depends on the size and location of the lesion, as well as the response to therapy.

If improvement is registered after 4 weeks of treatment, you should consult a doctor and clarify the diagnosis.

Triderm cream, instructions for use

The cream is for external use only. The method of application and dosage when using the cream are completely consistent with those when using the ointment.

Which is better: Triderm cream or ointment

The cream is intended for acute inflammation; ointment is indicated for chronic inflammation.

Triderm cream:

• absorbs easily and quickly without leaving a greasy film;
• wet, inflamed areas dry out;
• bubbles with liquid decrease in size;
• the skin cools slightly;
• the skin becomes less red;
• the skin becomes less swollen.

Triderm ointment:

• absorbs completely after some time, forming a film that protects the skin;
• the skin becomes less dry;
• the skin warms up slightly;
• the skin becomes softer;
• cracks in the skin become less painful.

Overdose

Signs of overdose with local glucocorticosteroids : with long-term use in large doses, suppression of adrenal function with the appearance of adrenal insufficiency and hypercortisolism .

An overdose of clotrimazole when applied locally does not lead to the development of any symptoms.

In case of an overdose of gentamicin, no symptoms are detected either. Long-term treatment with gentamicin in large doses may cause the appearance of insensitive flora.

Overdose therapy: symptomatic. Acute hypercortisolism is usually reversible. If necessary, correct electrolyte imbalance. In case of chronic overdose of local glucocorticosteroids, slow withdrawal is recommended.

Triderm ointment for external use, 15g tube 44743

Description

Ointment: translucent white ointment containing no visible particles. Cream: soft consistency white or almost white homogeneous cream that does not contain foreign inclusions. Triderm® ointment and cream combine the anti-inflammatory, antipruritic, antiallergic and antiexudative effect of betamethasone dipropionate with the antifungal activity of clotrimazole and the broad antibacterial effect of gentamicin sulfate. Clotrimazole has an antifungal effect (inhibits the synthesis of ergosterol in the cell membrane of fungi). Active against Trichophyton rubrum, Trichophyton mentagrophytes, Epidermophyton floccosum, Microsporum canis, Candida albicans, Malassezia furfur (Pityrosporum orbiculare). Gentamicin sulfate, a broad-spectrum antibiotic from the aminoglycoside group, is bactericidal and provides highly effective local treatment of primary and secondary bacterial skin infections. Active against gram-negative microorganisms: Pseudomonas aeruginosa, Aerobacter aerogenes, Escherichia coli, Proteus vulgaris, Klebsiella pneumoniae; gram-positive microorganisms: Streptococcus spp. (susceptible strains of alpha- and beta-hemolytic streptococcus of group A), Staphylococcus aureus (coagulase-positive, coagulase-negative and some strains that produce penicillinase). Cannot be used in ophthalmic practice. Prolonged topical use of antibiotics can sometimes lead to the growth of resistant microflora. In this case, as well as if irritation, sensitization or superinfection develops during the use of Triderm®, treatment should be interrupted and appropriate therapy should be prescribed. Cross-allergic reactions with aminoglycoside antibiotics have been observed. Any side effects that occur with the use of systemic corticosteroids, including suppression of the function of the adrenal cortex, can also be observed with local use of corticosteroids, especially in children. Systemic absorption of GCS or gentamicin when applied topically will be higher if treatment is carried out over large surfaces of the body or when using occlusive dressings. Avoid applying gentamicin to open wounds or broken skin. Appropriate precautions should be taken in such cases, especially when treating children. It is recommended to discontinue the drug after long-term use gradually. Use in pediatrics Children from 2 years of age are prescribed only according to strict indications and under medical supervision, because Systemic side effects associated with betamethasone may develop. When using Triderm®, like many other topical corticosteroids on large surfaces and/or with an occlusive dressing, the function of the hypothalamic-pituitary-adrenal system may be suppressed, a decrease in the excretion of growth hormone, as well as an increase in intracranial pressure may be observed.

Compound

Ointment 1 g betamethasone 0.5 mg (in the form of betamethasone dipropionate 0.64 mg) clotrimazole 10 mg gentamicin 1 mg (1000 IU) (in the form of gentamicin sulfate) excipients: liquid paraffin; white petroleum jelly in tubes of 15 g; 1 tube in a box. Cream 1 g betamethasone 0.5 mg (in the form of betamethasone dipropionate 0.64 mg) clotrimazole 10 mg gentamicin 1 mg (in the form of gentamicin sulfate) excipients: liquid paraffin; white petroleum jelly; cetostearyl alcohol; propylene glycol; cetomacrogol−1000; benzyl alcohol; sodium dibasic phosphate dihydrate; phosphoric acid; sodium hydroxide (to establish the required pH value); purified water (qs ad 1000 mg) in tubes of 15 g; 1 tube in a cardboard box.

Application

reduction of inflammatory manifestations of dermatoses complicated by primary and secondary infection (simple and allergic dermatitis, atopic dermatitis, diffuse neurodermatitis, limited neurodermatitis); athlete's foot; pityriasis versicolor; simple chronic lichen; dermatomycosis (including inguinal and in large folds of the skin), caused by pathogens sensitive to the drug: dermatophytosis, candidiasis; lichen versicolor. The use of Triderm® during pregnancy is possible only if the expected benefit to the mother outweighs the potential risk to the fetus. It is not known whether the components of the drug are excreted in breast milk. Therefore, when prescribing Triderm® during lactation, the issue of stopping breastfeeding should be decided. Local reactions: burning sensation, erythema, exudation, pigmentation disorders, itching. Adverse reactions caused by betamethasone: burning sensation, itching, irritation and dry skin, folliculitis, hypertrichosis, acne, hypopigmentation, perioral dermatitis, skin maceration, secondary infection, skin atrophy, stretch marks, prickly heat. Adverse reactions caused by clotrimazole: erythema, peeling, local swelling, itching, urticaria, skin maceration, paresthesia. Adverse reactions caused by gentamicin: hyperemia, itching. Drug interactions are not described. Local. The ointment or cream is applied in a thin layer to the entire affected surface of the skin and surrounding tissue 2 times a day (morning and night). To ensure the effectiveness of treatment, the drug must be used regularly. The duration of therapy depends on the size and location of the lesion, as well as the patient's response. If clinical improvement has not occurred after 3–4 weeks, this may be a reason to clarify the diagnosis. With long-term use of GCS in high doses, symptoms of hypercortisolism, including Cushing's syndrome, may develop. The use of clotrimazole when applied topically does not lead to the development of overdose symptoms. Long-term treatment with gentamicin in high doses can lead to the growth of insensitive flora. increased sensitivity to any of the components of the drug; lupus; skin manifestations of syphilis; chicken pox; herpes simplex; skin post-vaccination reactions; age up to 2 years.

Possible product names

• Triderm ointment for external use, tube 15g No. 1
• TRIDERM OINTMENT 15.0
• (Triderm) Triderm ointment for external use 15g tube No. 1

special instructions

Triderm ointment and cream are not intended for use in ophthalmic practice.

Prolonged use of local antibiotics in some cases can lead to the emergence of resistant microflora. In such a case, as well as in case of sensitization , irritation or superinfection , Triderm therapy should be stopped and symptomatic treatment should be started. Cross allergic phenomena with aminoglycoside antibiotics cannot be excluded .

All side effects that occur when taking systemic glucocorticosteroids , including suppression of the adrenal cortex, can also develop when using local glucocorticosteroids , especially in children.

The absorption of active substances into the systemic circulation when applied topically is enhanced if treatment is carried out with the application of occlusive dressings or over large areas of the skin, especially during prolonged treatment or when the skin is wounded. It is strongly recommended to avoid contact of gentamicin with open wounds or broken skin, as this may cause adverse reactions characteristic of systemic use of gentamicin .

With long-term use of the drug, its withdrawal should be carried out slowly.

There was no effect of the drug on the ability to drive vehicles.

Which is better: Triderm or AKRIDERM

ACREEDERM.
Photo: socialochka.ru The drugs are not analogues of each other. Triderm is a combination drug with the active substances Betamethasone, Gentamicin and Clotrimazole. It has anti-inflammatory, antiallergic, antibacterial and antifungal effects. Release form: cream and ointment for external use. The drug ACRIDERM is a one-component glucocorticosteroid for external use with the active ingredient Betamethasone. Available in the form of cream and ointment. Indications:

• atopic dermatitis;
• allergic contact dermatitis;
• eczema (various forms);
• contact dermatitis (including occupational) and other non-allergic dermatitis (including solar and radiation dermatitis);
• reactions to insect bites;
• psoriasis;
• bullous dermatoses;
• discoid lupus erythematosus;
• lichen planus;
• exudative multimorphic erythema;
• skin itching of various etiologies.

The spectrum of activity of Triderm is higher than that of AKRIDERM. Triderm is approved for use in children from 2 years of age, and AKRIDERM - from 1 year.

The country of origin of Triderm is Germany. AKRIDERM is produced in Russia. AKRIDERM is cheaper in cost than Triderm.

Triderm's analogs

Level 4 ATX code matches:
Rederm

Losterine

Akriderm SK

Akriderm

Akriderm GK

Akriderm Genta

Elokom S

Diprosalik

Belosalik

Kanizon Plus

Betasalik

Triacutan

Momat-S

Analogues of Triderm cream and ointment: Akriderm (Russian substitute), Kanizon , Triakutan, Betazon Ultra, Lokoid, Diprosalik, Betasalik.

The price of analogues of Triderm ointment, which are listed above, is an order of magnitude lower than the price of the product itself.

Which is better: Triderm or PIMAFUCORT

Cream PIMAFUCORT.
Photo: pimafucort.ru The drugs are not analogues of each other. Both are tripartite drugs. Active ingredients Triderma: Betamethasone, Gentamicin and Clotrimazole. Release form: ointment and cream for external use. The drug PIMAFUCORT includes Natamycin, Neomycin and Hydrocortisone, which causes fungicidal, antibacterial and anti-inflammatory effects. Available in the form of cream and ointment for external use. Indications: dermatoses amenable to GCS therapy, complicated by secondary bacterial and/or fungal infection (especially caused by Candida spp.). Triderm cream/ointment is applied up to 2 times a day; The drug PIMAFUCORT is used 2-4 times a day. Both drugs are approved in pediatrics: Triderm from 2 years, and PIMAFUCORT from 1 year. The drugs are dispensed without a doctor's prescription!

The country of origin of Triderm is Germany. PIMAFUCORT is produced in Italy. In terms of cost, PIMAFUCORT is cheaper than Triderm.

For children

The medicine is prescribed only to children over 2 years of age, according to strict indications and under the supervision of a doctor, since it is possible that systemic side effects associated with betamethasone appear in this category of patients more often than in adults. Such side effects include: Cushing's syndrome , inhibition of the pituitary-hypothalamic-adrenal system , growth retardation, increased intracranial pressure (as a consequence, headache, swelling of the optic nerve and bulging of the fontanelles), slower growth of body weight.

Features of treatment

Triderm® cream is well tolerated by patients who have no contraindications. Allergic reactions and other side effects may occur in case of hypersensitivity to the components, during prolonged use or in case of overdose. Therefore, when consulting with your doctor, be sure to talk about your previous reaction to corticosteroids and antibiotics, and discuss possible side effects.

The cream should not be used during breastfeeding. The cream can be used during pregnancy only after the recommendation of a doctor who will conduct an examination and make an informed decision on optimal therapy.

Reviews about Triderm

Reviews of the cream, as well as reviews of Triderm ointment, report rare cases of ineffectiveness and even more rarely undesirable effects (mainly itching). Otherwise, 90% of reports give an excellent rating to the drug. Due to the complex composition and the possibility of severe side effects, it is not recommended to use this medicine independently and unsupervised.

Is Triderm ointment hormonal or not?

The ointment and cream of the same name contain the hormonal component betamethasone , so they can be called hormonal.

Triderm and balanoposthitis

Despite the good results of treating balanoposthitis with this remedy, many doctors do not recommend its use for this pathology, due to the high probability of damage to the skin of the genitals under the influence of hormones.

Cream or ointment: which is better?

Reviews do not reveal any significant correlation between the effectiveness of these forms of release of the drug.

Triderm price, where to buy

The price of Triderm ointment 15 g in Russia is 570-680 rubles, and cream 15 g costs 580-640 rubles. Buying a cream in Moscow (like ointment) will cost a large amount; here its cost reaches 820 rubles.

Ointment 15 g costs 230-300 hryvnia in Ukraine. The price of Triderm cream 15 g is on average 230-290 hryvnia.

• Online pharmacies in RussiaRussia
• Online pharmacies in UkraineUkraine
• Online pharmacies in KazakhstanKazakhstan

ZdravCity

• Triderm cream 15gSchering-Plough Labo NV
  RUB 703 order
• Triderm ointment 15g Schering-Plough Labo NV

  RUR 683 order

Pharmacy Dialogue

• Triderm ointment (tube 15g)Shering-Plough

  RUR 764 order

• Triderm cream tube 15gShering-Plough

  RUR 777 order

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PaniPharmacy

• Triderm cream Triderm cream 30g Belgium, Schering-Plough Labo
  295 UAH.order
• Triderm cream Triderm cream 15g Belgium, Schering-Plough Labo

  187 UAH order

• Triderm ointment Triderm ointment 15g Belgium, Schering-Plough Labo

  190 UAH order

• Triderm ointment Triderm ointment 30g Belgium, Schering-Plough Labo

  345 UAH. order

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Cost of medicines

Prices for analogues of the drug Triderm depend on the generic manufacturer and on the country in which the analogues were produced. The cost of imported substitutes is in the same price segment as Triderm, and Russian analogues are much cheaper in price than the original drug.