To successfully resist the constant attacks of surrounding viruses, it is necessary to create a list of proven drugs. It is recommended to include “Isoprinosine” in this list; for HPV, such a remedy will be simply irreplaceable. Its properties correspond to those stated in the annotation - an immunomodulatory and antiviral drug. Of the large number of similar drugs, only a few have undergone actual clinical trials to confirm their effectiveness. Among them was Isoprinosine.
Isoprinosine: properties and functions
The drug Isoprinosine is characterized by the following properties: - increases the functional activity of lymphocytes in an immunosuppressive state; — helps to increase the functionality of membrane T-helper receptors; - prevents a decrease in the activity of lymphocyte cells due to the influence of glucocorticosteroids; - promotes the functionality of cytotoxic T-lymphocytes and cells - natural killers, T-suppressors, T-helpers, interleukins 1 and 2, interferon gamma; - increases IgG production; - reduces the synthesis of cytokines, which are anti-inflammatory in nature; - potentiates the chemotaxis of monocytes, neutrophils and macrophages.
pharmachologic effect
The active substance Isoprinosine has an antiviral effect and immunostimulating activity. Reduces the clinical manifestations of viral diseases and blocks the reproduction of various viruses.
Isoprinosine also helps speed up recovery and increase the body's resistance to various herpes viruses (Epstein-Barr, Varicella-Zoster), measles, mumps viruses and others. When prescribed with other antiviral drugs (zidovudine and acyclovir), it enhances the effect of interferon.
According to reviews, Isoprinosine is usually well tolerated and approved for use in pediatrics.
Isoprinosine: indications and contraindications
Isoprinosine, the use of which is due to the above properties, is indicated for use in the following diseases: - ARVI and influenza; — infectious diseases caused by herpes virus (Herpes simplex) types 1,2,3,4. These include chickenpox, herpetic keratitis, labial and genital herpes, herpes zoster; — cytomegalovirus; - Infectious mononucleosis; - acute form of measles; - papillomavirus of an infectious nature (genital papillomavirus in women and men, laryngeal papilloma, etc.) - molluscum contagiosum.
Adverse reactions
A medicinal substance can have a negative effect on the body only if it was taken in the wrong dosage or if it was self-medicated, ignoring visits to a pediatrician or therapist.
List of possible adverse reactions of the body to the drug:
- pain in the upper abdominal cavity, under the solar plexus;
- feeling of nausea, urge to vomit;
- the occurrence of skin itching;
- frequent urination;
- general weakness of the body, fatigue, lethargy;
- constipation, diarrhea (gastrointestinal disturbances);
- dizziness;
- severe pain in the musculoskeletal system (knees, joints, bone aches).
Note!
After completing a long course of treatment, after 14 days, you should definitely get a referral from your doctor to take a general blood test. This is done to assess liver health indicators, uric acid and bilirubin levels in the body.
If adverse reactions occur while taking isoprinosine, you should contact a specialist to promptly discontinue the drug or switch to more gentle analogues.
Isoprinosine: instructions for use
Isoprinosine instructions for use, which recommends taking the drug after meals, be sure to drink enough water.
For children over 3 years of age, with a body weight of at least 15 kg, as well as for adults, Isoprinosine is recommended to be used in a daily dose, depending on the calculation made, 50 mg per kg of body weight. The drug is taken in 3-4 doses, which is 6-8 tablets for adults, and ½ tablet per 5 kg of the child’s body weight for children.
In severe and acute forms of infectious diseases, it is possible to increase the dose to 100 mg per kg of body weight per day, which should be taken in 4-6 doses. In such cases, children need to take Isoprinosine at a rate of 50 mg per kg of body weight per day. For adults, the daily dose will be 3-4 g.
The duration of taking the drug for acute diseases in both adults and children is from 5 to 14 days. The use of the drug Isoprinosine, the instructions for which are included in the kit, is quite simple and is recommended until the symptoms of the disease completely disappear. The use of the drug can be extended, but only if there are medical recommendations, the drug should be taken under the supervision of an experienced doctor.
For chronic relapses in adults and children, treatment with Isoprinosine is carried out in several courses (5-10 days each) with mandatory breaks of 8 days.
For maintenance therapy, the dose of the drug is 1-2 tablets (500 - 1000 mg) throughout the day for a month.
Isoprinosine for infectious herpes is used for 5-10 days until all symptoms of the disease disappear, 1-2 tablets per month.
When infected with papillomavirus, adults are prescribed 2 tablets 3 times a day, and children are prescribed ½ tablet per 5 kg of body weight per day in 3-4 doses. This course of treatment takes place in the form of monotherapy and lasts for 14-28 days.
In case of relapse of genital warts, adults are recommended to take 2 tablets 3 times a day, and children - 1/2 tablet per 5 kg of body weight in 3-4 doses throughout the day. It is necessary to continue the course of treatment for 14-28 days, and then repeat the course of therapy three more times with monthly breaks.
For cervical dysplasia, Isoprinosine is recommended to take 2 tablets, 3 times for 10 days, and then the course of treatment is repeated 2-3 more times with intervals of 10-14 days.
Immunomodulatory agent
Good day to all!
I’ll tell you how my acquaintance with this “miracle remedy” took place and how it ended for me. In December 2013, I underwent a full examination in the field of gynecology, I was given a not very good diagnosis and prescribed for surgery. My gynecologist, a conscientious guy, was not in a hurry in his actions and checked my general background of the body as a whole.
And he said: “Maybe stop smoking already?!!” =)))) In short, I have a very weak immune system. Because remembering my bad habit + the lack of PP and sports in my life as such – nothing surprising! It was decided that first we would boost our immunity with this very Isoprinosine course of 10 days, 5 tablets per day.
At this time, I was strongly recommended to reduce the number of cigarettes I consumed, or rather to minimize it and not take alcohol for a while in order to enhance the effect. Frightened by my serious diagnosis, angry at myself for my laziness and unreasonable waste of health on all sorts of bullshit, I rushed home.
I purchased this drug at the Gemini pharmacy at a price of 1,175 rubles. per piece It contains 50 tablets. And, starting from the notorious Monday, I rushed to boost my immunity. Hmmm... I took the pills 5 times a day: 08:00, 12:00, 15:00, 18:00, 21:00, i.e. every 3 hours.
My enthusiasm lasted for 7 days, then, with angry tirades and whining, I reached the finish line, but, by the way, I was still on schedule. There were definite improvements, which later turned out to be temporary (the effect lasted for 2 weeks) The only improvements were: that my gynecology test was good.
I won’t describe it, because men read the reviews here too =)) We quickly did a couple of procedures with the gynecologist and decided with satisfaction that I would repeat the course in 2 months. I repeated it, but there was no result or even effect like the previous time! But these are still flowers!
A small digression =))
Like all girls in the final grades of school, when you want to be fashionable at any cost (and to the point of complete cretinism!), I wore 20 den caprons until the temperature was +5, and sometimes even at zero degrees outside)) Well, I earned it as a “bonus” “a very unpleasant thing called CYSTITIS! I think the ladies know what kind of rubbish this is, but the guys don’t even need to know =))) Somehow I was tormented by it for 3 days and calmed down. He made himself known again around the age of 21, when I was at a barbecue in the forest in the winter and apparently caught a little cold. He didn't mention himself anymore.
Now to the point!
Let me make a reservation right away: I was examined in the field of the genitourinary system, or rather, it was computer diagnostics in general. I didn’t have any problems with my kidneys or my bladder…. What do we end up with? I live in Samara, in February 2014 we had frost down to -35 degrees.
Well, no matter how much I wrap myself up (the childish nonsense has flown out of me a long time ago), I get an attack of cystitis. I treat it safely with Manural and forget about it.
In March I started taking the notorious 2nd course of Isoprinosine and then it became generally fun =))) Until August 2014, I was picked up twice by an ambulance and taken to the hospital! I learned, sorry, to sleep on the toilet! I am a seasoned person, I was not afraid (!) to walk barefoot on a cold floor or sleep with a window even in winter, but now...
My cystitis, which literally develops into pilonephritis within a day, showed me such tricks, you’ll rock yourself! I endured hellish pain in the lower back, liters of antibiotics went through me, handfuls of pills + a completely upset intestine, a shattered nervous system and the gynecology limped even more! This story ended in August, fortunately my “joy” began to torment me less and less. With my next rendezvous at the hospital, I took an ambulance to see a nice old urologist (I’m lucky to have male doctors =))))), who asked what medications I had taken in general over the last year. Having heard about Isoprinozine, he smiled like a Cheshire cat and said: “How you all got me!” Well, this is still in a mild form)) It turns out that this drug puts a huge burden on the kidneys, which was not reported to me. I ran in a wild rage to my gynecologist and expressed what I thought about his treatment, to which he told me that you don’t have kidney or bladder diseases. You can blame the doctor, of course, but... He's right!
Conclusions:
Isoprinosine does not cure and cripples. If someone thinks the effect of 2 weeks is the result, excuse me)) How much I suffered later, it’s just tough. Thank God, now I don’t suffer so much anymore. If I had known that this dummy would have such a side effect, I would have run as fast as I could.
In general, I don’t recommend it to anyone. Good luck to you =)))
Source: https://irecommend.ru/content/izoprinozin-istoriya-o-tom-kak-ya-chut-ne-popala-v-bolnitsu
Isoprinosine: cost and sale
Ioprinosine, the price of which is about 600 rubles for 20 tablets, is a drug that is widely used in Russia. Since the drug is often used in medical practice, you can buy Isoprinosine in almost any pharmacy or by ordering online. But we should not forget that popular drugs, which include Isoprinosine, are much more often counterfeited. In order to save both money and health when purchasing a drug, it is necessary to check the product’s certificate of conformity, and, of course, do not buy any medicines second-hand or from strangers.
Isoprnosine has received good reviews from patients, but nevertheless has side effects. Therefore, before deciding to use this drug, you should think it over carefully, consult with your doctor and study the manufacturer’s instructions, since this instruction is provided with the purpose of familiarizing the consumer with this drug.
Reviews from doctors
Since Isoprinosine has low toxicity, it is sold without a prescription. Its analogues are groprinosin and sinupret. On the question of which is better, the opinions of doctors differed. Some drugs are cheaper. But according to experts, as confirmed by official statistics and clinical trials, this is an antiviral drug worthy of attention. At the same time, the domestic manufacturer bears full responsibility for its products.
Contraindications
Contraindications to taking Isoprinosine is an allergy to any of the components of the drug. It is also not recommended to prescribe antiviral treatment in the acute stage of parenteral hepatitis.
An absolute contraindication for use is insufficiency of humoral immunogenesis and pregnancy. In this case, the medicine will not be effective and dangerous. An important role in the prescription of the medicine is that while taking it, a delay in menstruation may occur, and those who have been helped by it say that it is a good alternative to more expensive antiviral drugs. Although it is banned in the USA.
Isoprinosine and Transfer Factor
A course of treatment with Isoprinosine for a patient will cost about 3000-3500 rubles. Although you will have to take about 8 tablets a day for 2 weeks, there is no guarantee that the result will be achieved, and the course of therapy may have to be repeated several times.
Transfer factor, which performs all the same functions, differs from Isoprinosine and other similar drugs in that it has no contraindications and does not cause any side effects. The cost of the drug is about 2000 rubles for 90 capsules. The components included in the drug are natural, and therefore Transfer Factor is easily accepted by the body. The unique properties of the drug are that Transfer Factor eliminates damage that occurs in the DNA structure, and thereby removes the cause of the disease. If you take Isoprinosine in combination with Transfer Factor, the latter will be able to neutralize the side effects of Isoprinosine and restore disturbances in the gastric microflora.
Substitute drugs
A direct analogue of Isoprinosine is Groprinosine, which is cheaper and is also used in the treatment of HPV. It contains the same active ingredient and in the same quantity. Groprinosin is produced by pharmaceutical companies in Poland and Hungary. However, the difference in price for a course of treatment is not significant. Manufacturers in the CIS countries produce cheaper analogues of the drug, but they are not generics of Isoprinosine.
Substitute drugs:
- "Allokin";
- "Lavomax";
- "Alizarin";
- "Hyporamine";
- "Panavir gel";
- "Tilaxin";
- "Tiloron";
- "Genferon";
- "Ferrovir";
- "Ergoferon".
Attention! Only a doctor who can comprehensively see the complexity of the development of the virus can replace the drug and prescribe its analogues.
Compound
The main active ingredient is Inosine Pranobex (or Isoprinosine). One tablet contains 500 mg, while 1 ml of syrup contains only 50 mg.
Excipients in tablet form are: wheat starch, povidone, mannitol and magnesium stearate.
The syrup contains: propylparaben, methylparaben, sucrose, sodium hydroxide, natural plum flavoring, sodium dihydrogen citrate and prepared water.
Drug interactions
When diuretics and Isoprinosine are taken simultaneously, a critical increase in the level of urea in the patient’s blood is observed. That is why the patient’s condition should be monitored or these medications should not be used together at all.
An antiviral agent is not prescribed in combination with immunosuppressants, as well as cytostatics, antibacterial medications. They weaken its effect and can cause complications. In addition, the tablets are not used in combination with medications that have immunostimulating properties.
It is allowed to combine the product with chondroprotectors, antipyretics and analgesics. Can be used in combination with vitamin complexes.
Release form
There are two forms of release of the drug:
- Isoprinosine - syrup for children. Transparent, almost colorless syrup with a light plum aroma.
- White tablets with an amine odor. They have an oblong convex shape with a chamfer on one side. Thanks to the presence of a separator, the tablet can be easily divided into two parts.
Analogs
If it is impossible to use the original medication, substitutes with similar therapeutic properties are prescribed.
The most popular analogues:
- Groprinosin – a Polish analogue of Isoprinosine with the same composition and principle of action. The drugs are considered synonymous, but Groprinosin contains more gentle auxiliary ingredients, therefore it is more often used in the treatment of children and elderly patients. The drug has pronounced antiviral and immunostimulating properties, quickly destroys viruses and strengthens the patient’s immunity.
- Amiksin is an antiviral and immunostimulating medicine based on tilorone, available in the form of tablets for oral administration. Prescribed for adults and patients over 7 years of age. Helps fight respiratory and viral diseases, strengthens the patient’s immunity, and promotes the formation of a large number of lymphocytes. The treatment regimen and dosage are determined individually, taking into account the purpose for which the medication is used.
- Arbidol is an immunostimulating and antiviral medication that is available in the form of capsules and tablets for oral use. The product is highly effective against the most well-known viruses and helps treat influenza and respiratory pathologies. Additionally, the medicine stimulates the formation of one’s own immunity in order to prevent re-infection. Prescribed for children over 3 years of age and adults.
Any of the analogues, except Groprinosin, cannot completely replace Isoprinosine. This is due to the fact that only these medications are active against the human papillomavirus. Despite this, analogs can be used for the prevention and treatment of children who often suffer from colds and viral diseases.
