How to use Korneregel eye drops: instructions and reviews

Ophthalmic problems are encountered at an early age. Eye strain is not limited to studying and reading—they spend a lot of time playing with various gadgets. Korneregel eye drops - made in Germany - eliminate irritation, help get rid of burning and itching in the area of ​​the conjunctiva and eyeball, and eliminate redness.

Release form and composition

The drug is most often packaged in tubes of 5 and 10 g. The packaging is cardboard - each comes with instructions for use. Structure - light, gel-like, fluid; color - transparent, colorless, slightly opalescent. There is no smell.

The active substance in the composition is dexpanthenol, auxiliary components: cetrimide, disodium edetate, carbomer, sodium hydroxide, water for injection.

Another form of Cornegel in the form of eye drops is available under the trade name Fluid Udo (CORNEREGEL FLUID EDO AUGENTROPFEN). The solution is packaged in mini bottles, designed for single use, with a volume of 0.6 ml. The tubes are packaged in bags of 10 pieces. The composition differs slightly:

• active ingredient - dexpanthenol;
• auxiliary components - disodium edetate, disodium hydrogen phosphate, hypromellose, sodium dihydrogen phosphate, water for injection.

At the pharmacy you can buy a package with one, three or six currency.

Analogs

Korneregel eye drops have many analogues. Medicines similar in principle of action and composition are prescribed to accelerate the restoration and healing of corneal tissue. Analogues of Korneregel include:

• Solcoseryl - it is an interchangeable drug, although it is obtained from animal blood;
• Systane;
• Dexagentamicin;
• Okoferon;
• Ophthal;
• Visine;

• Hilo Chest;
• Emoxybel;
• Khilozar-Chest of drawers;
• Quinax, etc.

Analogs cheaper than Korneregel are Betamycil and Solcoseryl, Lacropos or VitA-POS. You cannot replace Korneregel eye drops with an analogue on your own; an ophthalmologist must select an alternative medication, taking into account the characteristics of the patient’s condition.

Action

The main active component of the cornea protector is dexpanthenol, a derivative of pantothenic acid, a water-soluble vitamin that accelerates regeneration processes at the cellular level. The substance spreads quickly and is absorbed by all parts of the organ of vision. Thanks to carbomer, characterized by large structural components, dexpanthenol is not absorbed into the eyeball, does not penetrate the systemic bloodstream, but forms a strong protective film on the surface, increasing the viscosity of tears.

The drug activates metabolic processes, improving the supply of oxygen and nutrients to all parts of the eye. This accelerates the restoration of the mucosa in case of microtraumas and damage.

Due to the peculiarity of the chemical composition, Kornegel’s contact with eye tissues is prolonged.

Pharmacological action of Korneregel

The instructions for Korneregel say that this drug is used for local use in ophthalmology. The peculiarity of the product is that it is characterized by the phenomenon of regeneration.

The main active ingredient of Korneregel drops is dexpanthenol. The active elements of dexpanthenol after decomposition are similar in structure to pantothenic acid, however, unlike it, they penetrate much better into epithelial tissue. Korneregel takes part in metabolic processes, and also promotes rapid healing and restoration of not only the mucous membranes of the eye, but also all skin tissues.

Instructions - indications and contraindications for the use of the drug

Kornegel is prescribed for the treatment and prevention of irritations:

• for corneal pathologies—erosions, dystrophic changes;
• with keratopathy or dry keratoconjunctivitis;
• with thermal and chemical damage to parts of the eye;
• to accelerate recovery during infectious processes of various etiologies.

The drug is introduced into the therapeutic course after surgery on the organs of vision to accelerate the healing of the cornea. When used, the risk of clouding and perforation is reduced, and rough scars are not formed that interfere with the clarity of vision.

The drug is recommended for those who wear contact lenses to protect their eyes from mechanical damage. Udo fluid is additionally used to eliminate dry eye syndrome for therapeutic and preventive purposes.

Despite the fact that the amount of substances absorbed into the bloodstream is minimal, during pregnancy and lactation the possibility of using eye drops should be discussed with your doctor, taking into account the risks due to possible absorption.

Contraindications: individual intolerance to the main or auxiliary components. It may occur immediately after the first use or appear during the course of treatment. If unpleasant symptoms occur after administering the drops, you should notify your ophthalmologist.

Read more Phenylephrine - eye drops for children

Korneregel – a new stimulator of reparative regeneration

Rybakova EG, Yegorova GB, Kalinich NI Authors represent the results of treatment of anterior eye chamber diseases, following by various corneal disorders, and patients with keratoconus, developed because of hard contact lenses, using the new stimulator of reparative regeneration Corneregel. Comparative trials showed that Corneregel turned out to be more effective than Solcoseryl in the treatment of erosions and traumatic keratitis, eye burns, in combined treatment of epithelial–endothelial dystrophy in conjunction with therapeutic contact lenses and in improvement of tolerance of hard contact lenses in patients with keratoconus II–III. Currently, traumatic injuries and diseases of the cornea remain a pressing problem in ophthalmology and are a common cause of decreased vision and blindness. Despite the abundance of means and methods for conservative treatment of corneal injuries, the clinical results of their use are not always satisfactory. In this regard, the search and study of new means that promote the regeneration of corneal tissue in case of damage and diseases is an important task and is of significant scientific and practical interest. Currently, the arsenal of means that enhance the processes of reparative regeneration includes drugs such as 20% solcoseryl ophthalmic gel, 1% emoxipine solution, 4% taufon solution. The action of these drugs is based on the activation of oxygen metabolism and energy metabolism at the cellular level. An increase in the processes of reparative regeneration was noted with the use of peptide bioregulators (cytomedins) thymalin and thymogen. A fairly effective remedy is methyluracil, which is widely used in the clinic in the form of a 10% ointment, and is also included in ophthalmic medicinal films and sponges (gentamecon, meturacol). Nucleic acid preparations, such as encad, vitasik (a complex of nucleotides), have a multifactorial effect on all stages of the reparative process and also accelerate wound epithelization. The new drug Korneregel - 5% dexpanthenol gel containing pantothenic acid, is an effective stimulator of regeneration processes in the cornea. Pantothenic acid, as a component of coenzyme A, is present in all living tissues, and damage to them sharply increases the need for it. The use of D-panthenol stimulates mitosis and reduces the time of epithelization. Histochemical studies have shown that Korneregel enhances the proliferative activity of epithelial cells and also stimulates cell migration, promoting faster epithelization of the wound defect. It should be noted that by stimulating the processes of migration of epithelial cells under the influence of cornegel, earlier re-epithelialization of the wound surface occurs, the gates to infection are closed and the percentage of transparent healing of the cornea increases. A clinical study of topical use of Corneregel was conducted for corneal erosions and traumatic keratitis (41 eyes), eye burns (31 eyes), epithelial endothelial corneal dystrophy (12 eyes), herpetic keratitis (24 eyes), as well as in patients with keratoconus 2– 3 stages while wearing hard contact lenses (10 eyes). The control group consisted of 40 patients receiving solcoseryl. The criterion for the clinical effectiveness of treatment was the onset of epithelization, which was monitored using a fluorescein test. Other criteria were also taken into account: the severity and duration of corneal syndrome and inflammatory changes in the eye (edema of the eyelids, conjunctival injection, edema of the corneal stroma, descemetitis). The effect of the drugs was assessed during treatment using drugs that, if necessary, were prescribed additionally in each specific case. The pronounced effect of Corneregel was noted in the treatment of erosions and traumatic keratitis. Its use in combination with the main treatment complex made it possible to increase the effectiveness of treatment. Epithelization of corneal defects in this pathology occurred on average within 3–5 days. The acceleration of epithelization compared to the control group of patients receiving solcoseryl gel was 3–4 days. The administration of Korneregel did not cause any adverse reactions, including allergic ones. With superficial traumatic keratitis, no corneal opacities were observed; with deep keratitis in both groups, the outcome of the process was opacification of varying degrees of intensity, but when treated with Corneregel, the opacification was not intense, mainly in the form of a “cloud”. A pronounced positive effect of Corneregel on the course and outcome of the burn process has been established. This drug, in combination with complex treatment, helped to reduce the severity and shorten the time of relief of the inflammatory reaction, which was expressed in a decrease in pain and corneal syndromes, edema and descemetitis. Along with this, patients experienced complete epithelization of the burn surface in a shorter period of time. The period of epithelialization, depending on the severity of the burn, ranged from 3 to 16 days, while in the control group when using solcoseryl they ranged from 6 to 24 days. A positive effect of Corneregel on preventing the formation of symblepharons, especially in severe chemical burns, was noted. For herpetic keratitis, Korneregel was used only as an addition to specific treatment. However, in cases of superficial herpetic lesions, its effectiveness was quite pronounced: the use of Corneregel led to the completion of epithelization by the end of the first week of treatment. For epithelial-endothelial dystrophy, Korneregel was used in combination with soft therapeutic contact lenses. In the presence of bullous changes in the cornea, it is advisable to use therapeutic contact lenses, while wearing them, a gradual flattening and reduction of bullous elements occurs. Then it is possible to cancel the therapeutic soft contact lens with the simultaneous administration of disinfectants in combination with Corneregel. The administration of this drug led to the epithelization of epithelial defects and to a significant improvement in the condition of the corneal surface. Patients noted a decrease in pain and corneal syndromes, and in some cases, a complete disappearance of painful sensations. The positive effect of Corneregel is very valuable in the event that a patient loses a lens and cannot quickly replace it, or in other circumstances when it becomes necessary to cancel a contact lens. In the presence of bullous changes in the cornea, the use of Corneregel alone did not give such a positive effect. However, all patients noted some subjective improvement in the form of a decrease in pain and photophobia. All patients with epithelial endothelial dystrophy had previously used solcoseryl gel, which did not give such a noticeable effect. Korneregel was also used in patients with stage 2–3 keratoconus while wearing hard contact lenses. The gel was prescribed twice a day: in the morning 15 minutes before putting on the contact lens and at night after removing it. In all patients, the selection of hard contact lenses was difficult due to the complex shape of the cornea. Patients, for various reasons, refrained from surgical treatment and continued to wear rigid contact lenses, despite the fact that the fit of the lenses was unsatisfactory. All patients periodically complained of discomfort when wearing contact lenses, redness of the eyes, and fogging. Objectively, biomicroscopy revealed signs of epithelial edema and multiple surface defects stained with fluorescein. More pronounced changes were noted in the area of ​​the apex of keratoconus. In one case, in a patient with a downwardly displaced apex of keratoconus and a low-fitting contact lens in both eyes, diffuse staining of the corneal epithelium was noted under the entire surface of the contact lens. After prescribing Corneregel, all patients noted an improvement in the tolerability of contact lenses from the first day of using the drug. After a week of treatment, all patients' complaints of discomfort when wearing lenses disappeared. Only one patient noted discomfort and fatigue at the end of the day. Objectively, during biomicroscopy and fluorescein testing after 7 days of using Corneregel, no swelling or epithelial defects were observed in 4 patients. One patient had minor symptoms of epitheliopathy, but against the background of a significant subjective improvement in the tolerability of hard contact lenses. Thus, the high efficiency of topical application of Corneregel - a new stimulator of reparative regeneration - allows us to recommend this drug for inclusion in a complex of medications for the treatment of traumatic, inflammatory diseases of the cornea, eye burns, as well as epithelial-endothelial dystrophies in combination with the use of therapeutic contact lenses and for prevention of corneal damage when wearing hard contact lenses.

Literature 1. Egorov E.A., Kalinich N.I., Kiyasov A.P. New stimulators of reparative regeneration of the cornea. – Bulletin of Ophthalmology. – 1999, t. 115, no. 6. pp. 13–16. 2. Egorova G.B. Increasing tolerance to hard contact lenses using solcoseryl. – Ophthalmological Journal. – 1983, No. 4. P. 198–200.

Application and dosage

Before instillation, you must wash your hands. If you wear contact lenses, they are removed and can be put back in place no sooner than after 10-15 minutes. The composition does not cause clouding of the material, but vision correction agents make distribution difficult, reducing the therapeutic effect.

The tube is held vertically so that the tip of the tip does not touch the skin. The conjunctival sac of the lower eyelid is pulled back and 1 drop of solution is injected into it approximately in the center. The eye is closed, and then the position of the eyeball is changed several times, moving it to the right and left so that the medicine is distributed evenly.

Dosage and frequency of instillations - based on the clinical picture and type of pathology:

• for preventive purposes to eliminate irritation due to the use of contact lenses - 1 drop before bedtime in each eye;
• for lesions of a different nature - administered 3-5 times in the same dosage;
• After surgery, you can drip up to 6 times during the day.

Korneregel Fluid Udo eye drops are used in the same dosage, according to a similar principle. The cap of the mini bottle is removed immediately before instillation.

The packaging is single-use, designed for administration into the conjunctival sacs of both eyes. Even if a little solution remains inside, it cannot be used again during the day. The bottle is disposed of.

Interaction

Korneregel goes well with any ophthalmic medications, however, when using them you need to follow certain rules. Korneregel should be applied to the conjunctival sac last.

After using the last drug, at least 5 minutes should pass, and it does not matter what exactly the patient used - gel, ointment, ophthalmic drops, etc.

Side effects

No overdose was detected. In rare cases, after administration of the drug, the following were noted: itching, burning, mild pain, blurred vision, foreign body sensation. If the discomfort is short-lived and disappears within a few seconds, continue use.

If pain after the first or second instillation persists for more than 15 minutes, you should notify your doctor. In this case, analogues of Korneregel in drops are usually selected.

Adverse reactions

In the instructions, the manufacturer warns that the use of Korneregel can provoke allergic skin rashes, hyperemia and burning, itching on the skin surface, and urticaria. Patients may also be bothered by lacrimation, conjunctival swelling or a feeling of specks in the eyes, etc.

In very rare cases, patients experience eye irritation that occurs at the site of contact of the gel with mucous tissues. If this phenomenon is temporary, then there is nothing to fear, but if this sensation occurs frequently, you should consult a doctor to discontinue the drug.

Immediately after using the drug, patients experience visual blurriness, similar to fogging, it is safe and goes away on its own after a short time.

But in general, the gel is well tolerated by patients and causes adverse reactions extremely rarely. There is no data on an overdose of the drug, however, the absence of such information does not mean that you can use the medicine with any frequency and in any quantity without fear of exceeding the dose of the active ingredient.

The product should be used only according to indications and as prescribed by an ophthalmologist.

special instructions

It is impossible to cure infectious inflammatory processes in the organ of vision with the help of Kornegel. The active substance does not suppress the activity of pathogenic microorganisms. In this case, the drug is introduced into the therapeutic course only to accelerate corneal regeneration and eliminate unpleasant symptoms.

The preservative in the solution is cetrimide. It can provoke the development of allergic reactions if it persists for a long time. Therefore, even when no side effects occurred in the first days of treatment, but later they appeared, it is necessary to contact an ophthalmologist to select an analogue.

With systematic instillations of Kornegel, it is better to temporarily replace the lenses with glasses, even if there is no incompatibility of the solution composition with the material of the correction accessories. This is necessary to speed up recovery.

Use during pregnancy and lactation

When applied topically, a small amount of dexpanthenol is absorbed through the mucosal epithelium and is transformed into pantothenic acid. Metabolites cross the placenta and are excreted in breast milk. When applied topically, the amount of absorbed active component is negligible, but since there is no data on how this affects the development of the fetus or baby, the doctor must be informed about the “special situation” before instillation.

In pediatric ophthalmology

There are no restrictions when introduced into pediatric practice. The dosage and frequency of use depends on the age of the child and the reasons for which the drug is prescribed. From the age of 5-6 years, instillations are carried out 2-3 times a day, the dosage is the same as for adults, 1 drop in each eye.

Read more Zinc sulfate-dia drops: instructions for use and reviews

Drug interactions

When introduced into a treatment course or used against the background of the need for regular use of pharmacological drugs orally or in the form of injections, no undesirable effects of Kornegel were described. But the instructions indicate that when instilled together with eye drops or ointments, the drug can enhance their effect. Therefore, it is recommended to administer it last, with an interval of 10-15 minutes.

Impact on machine control

After administration of the solution, a thin film is formed on the cornea, which causes short-term vision impairment - a veil may appear before the eyes or blurred contours of objects. At this time, the reaction rate decreases. Therefore, working with machinery or driving vehicles should be interrupted for 10-15 minutes until clarity of vision is restored.

Rules of application

To minimize the risk of adverse reactions and achieve the maximum possible therapeutic effect, Korneregel should be used according to certain rules:

1. Before applying the gel, be sure to wash your hands with soap and then sit in a comfortable position, preferably lying down.
2. You need to hold the tube in your hand a little so that its contents warm up to body temperature, then instillation will be as comfortable as possible.
3. The lenses must be removed, and they can be put on after instillation only after 15-20 minutes.
4. The drug should be applied only to the lower eyelid, not to the corneal tissue. In this case, it is unacceptable for the tip of the tube to touch the eyelids.
5. After instillation, you should sit with your eyes closed for a few minutes.
6. If visual blurriness is noted, then you can work with machinery or drive only half an hour to an hour after instilling the medicine.
7. According to the instructions, a printed tube of Korneregel drops should be stored for no more than one and a half months.

By following these rules, the risk of adverse reactions is minimized.

Terms of sale and storage

Eye gel, as well as the drug in drops Korneregel Fluid Udo, can be purchased without a prescription. The medicine can be ordered from an online pharmacy. The date of manufacture is indicated on the packaging. It should be stored in a place protected from light, out of reach of children, at a temperature not exceeding +25°C. After opening, the tube with the solution must be used within 6 weeks; mini bottles, as already mentioned, are designed for single use.

The price of an ophthalmic product in a tube is from 457 rubles. for 5 g. Price for Kornegel drops - from 1495 rubles. for 30 mini bottles.

Analogs

Substitutes for the original drug are selected if it is not possible to purchase it, the price is not suitable, or an allergic reaction to the active substance or auxiliary components has occurred. They have a similar effect:

1. Hilo-Komod for moisturizing the cornea with sodium hyaluronate - price for 10 ml from 600 rubles.
2. Eye drops Artelak and Artelax Splash with hyaluronic acid and hypromellose, protecting the cornea from damage. Price - 300-455 rubles. per bottle of 10 ml.
3. Emoxybel with methylethylpyridinol hydrochloride (emoxipine) for the treatment of corneal burns and elimination of redness, to prevent irritation from contact lenses. Cost from 200 rub. for 5 ml.
4. Ophtal - vasoconstrictor effect, eliminates redness. The active substance is tetrizoline hydrochloride. Price - from 40 rub. for 5 ml.
5. Visine with tetrahydrozoline hydrochloride eliminates irritation due to eye fatigue, due to lack of tear production, and allergic conjunctivitis. Price - from 300 rub. for 0.5 ml.
6. Systane eye drops with an active complex, which includes: propylene glycol, polyethylene glycol, hydroxypropyl, sorbitol, methylpropanol. Eliminates the symptoms of dry eyes, irritation, redness, and has a moisturizing effect. Price - from 180 rub. for 15 ml.

The pharmacy offers forms of the drug Systane, enriched with additional components: Ultra with Pyridoxine Thiamine (3 ml - 220 rubles); Ultra Plus with hyaluronic acid (10ml – 480 rub.); Balance with mineral oil and dimyristoyl phosphatidylglycerol (10 ml – 670 rub.); Systane Gel with edetate disodium and minomethylpropanol (10 ml – 620 RUR)

Read more Lecrolin eye drops – instructions, reviews

As a substitute, Solcoseryl gel can be prescribed, which accelerates the regeneration of epithelial tissues of the mucous membrane and cornea. The active component of the composition is a hemoderivat made from the blood of newborn calves. Cost - from 400 rubles. for 5 ml.

To find a replacement, it is not enough to read the instructions for Korneregel and find out the price. The selection of analogues should be entrusted to the attending physician. The effect of substitutes differs from the original product, which is why there is a high probability of making a mistake. This can lead to worsening of the condition and decreased visual function.

Description of the medicine

Due to its anti-inflammatory and wound-healing effects, Korneregel eye gel is widely used in ophthalmic practice.

The medication perfectly helps to cope with an insect or small speck that has gotten into the eye, causing irritation, and to speed up the healing of burn injuries.

Corneregel can quickly relieve inflammation, remove uncomfortable soreness and irritation of the eye mucous membranes.

Eye gel Korneregel effectively protects eye tissue from inflammatory lesions and accelerates their healing after ophthalmological surgery.

The product is often used by patients who wear contact lenses.

People often damage their eyes with lenses, which causes them to experience irritation and a feeling of excessive dryness in their eyes. The use of Korneregel provides hydration of the mucous membranes and ensures rapid healing of microdamages.