Pharmacodynamics and pharmacokinetics
The active substance of the drug belongs to the group of fusidines , which are antimicrobial compounds whose action is associated with disorders of protein synthesis in bacterial cells.
Fusidic acid blocks the elongation of factor G, preventing its connection with ribosomes and guanosine triphosphate , helping to interrupt the release of energy needed for protein synthesis and destroying bacterial cells.
The action of fusidic acid is aimed at microorganisms that often cause the development of eye infections: Haemophilus influenzae, Staphylococcus aureus and Streptococcus pneumoniae.
It should be noted that Enterobacteriaceae and Pseudomonas remain resistant to the action of the active substance.
Fucithalmic eye drops have a certain viscosity, which ensures a long-lasting effect of the drug on the conjunctiva. The therapeutic effect is achieved after 1 hour and lasts for 12 hours.
pharmachologic effect
Eye drops based on fusidic acid lead to disruption of the synthesis of protein molecules in the cells of pathogenic microorganisms, so the death of microbes occurs. Fucithalmic is active against the following bacteria:
- pneumococci;
- hemophilus influenzae;
- Staphylococcus aureus.
However, pseudomonas and enterobacteriaceae are resistant to eye drops. There is no evidence of cross-resistance to fusidic acid.
Thanks to the viscous structure of the drug Fucithalmic, it was possible to achieve optimal contact of the active ingredient with the conjunctiva and increase the concentration of the main component of eye drops in the tear fluid.
The therapeutic effect develops 1 hour after instillation of the medicinal composition and persists for 12 hours.
The substances that make up Fucithalmic are excreted through bile. Only a small amount of fusidic acid is excreted by the kidneys.
Side effects
This drug is usually well tolerated by patients. However, in rare cases, when using Fucithalmic eye drops or gel, you can expect the development of allergic reactions , for example, swelling of the follicles in the transitional fold of the conjunctiva, urticaria, itching, burning, conjunctival hyperemia, pain, lacrimation, swelling of the eyelids, exacerbation of conjunctivitis .
As a rule, all these unwanted symptoms disappear after stopping treatment.
Possible side effects
Systemic adverse reactions rarely develop during treatment with Fucithalmic. This is associated with the lack of absorption of the active substance into the bloodstream. Therefore, the drug is widely used to treat newborns.
In rare cases, eye drops provoke the development of local side effects:
- burning, itching and redness of the conjunctiva;
- local allergic reaction, which leads to swelling, soreness and itching of the conjunctiva;
- exacerbation of conjunctivitis symptoms;
- soreness and swelling of the eyelids;
- increased lacrimation.
Experts recommend stopping use of Fucithalmic if you develop any symptoms of hypersensitivity to the ingredients in the eye drops.
Analogues of Fucithalmic
Level 4 ATC code matches: Colbiocin
Gentamicin
Tetracycline ointment
Levomycetin
Tobrex
The main analogues of this drug: Fusiderm, Diethanolamine Fusidate, Fusidate Sodium, Fuzidin, Fuzidin Sodium, Fusidanate, Fusidic acid and Fucidin.
special instructions
To prevent lens clouding, it is recommended not to use them during Fucithalmic therapy. A long course of treatment with eye drops can provoke the development of superinfection, the causative agents of which are pathogenic microorganisms that are resistant to fusidic acid.
During therapy, any contact of the tip of the aluminum tube with eye tissue or other surfaces should be avoided. Fucithalmic must be stored in a dark place out of reach of children. The temperature should not exceed 300 C. After opening the tube, eye drops should be used within 30 days.
Reviews about Fucithalmic
Quite often, discussions of this drug are found on forums related to children's topics. When Fucithalmic is prescribed to newborns, reviews about it contain only positive opinions from their mothers. They say that they use the drug for suppuration of the eyes, in combination with massage and rinsing with herbal decoctions.
Fucithalmic usually helps eliminate inflammation and suppuration of the eyes, even in difficult cases, within one week. Many mothers recommend using this product for their babies.
However, it must be remembered that the effect of this drug does not apply to all pathogens of eye infections. Therefore, if treatment does not provide relief within a week, you should consult your doctor about prescribing appropriate therapy.
Indications for use
Fucithalmic is widely used for the treatment of infectious eye diseases caused by drug-sensitive pathogenic microorganisms:
- conjunctivitis;
- dacryocystitis;
- keratitis;
- blepharitis.
The drug has positive reviews that confirm the high effectiveness of eye drops.
Fucithalmic price, where to buy
The price of Fucithalmic in Russian pharmacies varies between 376-430 rubles.
- Online pharmacies in RussiaRussia
ZdravCity
- Fucithalmic eye drops 1% 5gLEO Laboratories Limited
RUB 302 order
Contraindications
It is recommended to stop using Fucithalmic in the following situations:
- presence of hypersensitivity to any ingredient of the drug. It is important to consider that benzalkonium chloride is a preservative that may be a potential allergen;
- period of pregnancy and lactation. No studies have been conducted in pregnant women. Therefore, the possibility of using eye drops should be determined exclusively by the attending physician, who will be able to correlate the benefits and harms of eye drops for the expectant mother and child.
Side effects of Fucithalmic
According to reviews, Fucithalmic does not cause systemic side effects, which is due to the lack of absorption of the active substance into the systemic bloodstream.
In some cases, Fucithalmic, according to reviews, can lead to disorders of the visual organs, which manifest themselves as:
- Burning, itching and hyperemia of the conjunctiva;
- Allergic reactions - swelling of the follicles of the transitional fold of the conjunctiva;
- Exacerbation of conjunctivitis;
- Watery eyes, soreness and swelling of the eyelids.
The use of eye drops should be interrupted if any signs of hypersensitivity to one of the components of the drug appear.
To avoid lens clouding, it is not recommended to wear them during Fucithalmic treatment.
Analogs
Several other drugs have similar effects to Fucithalmic:
- Fusiderm ointment and cream. The active ingredient of the drug is fusidic acid, the drug has an antimicrobial effect. The average price is 160 rubles, depending on the country of origin.
- Floxal ointment and drops. A drug of the antibiotic group, the active substance is ofloxacin. You can purchase the product in pharmacies for 250 rubles.
- The drug Tobrex is produced in the form of drops and ointments. This is an antibiotic with a wide spectrum of effects on bacteria. The average price of drops in pharmacies is 200 rubles, ointment costs no more than 180 rubles.
Tobrex has properties similar to Fucithalmic.
- Vitabact eye drops are an antimicrobial agent for topical use. The price of the drug is about 200 rubles.
Composition and effect of the drug
Fucithalmic is prescribed for the treatment of diseases caused by Staphylococcus aureus, pneumococcus or Haemophilus influenzae. It is these bacteria that are sensitive to the active ingredient of the drug.
The main component of the drug is fusidic acid. This is a natural antibiotic produced by the fungus Fusidium coccineum. Under the influence of fusidic acid, protein formation in bacterial cells is disrupted, which leads to their death.
The drug also contains excipients that act as preservatives and stabilizers. They can cause an allergic reaction during treatment.
Pharmacological action of Fucithalmic
Fusidic acid disrupts the process of protein synthesis in the cell of a pathogenic microorganism, which leads to its death. Bacteria that cause infectious inflammation of the eyes are sensitive to the active substance Fucithalmic: Haemophilus influenzae (Haemophilus influenzae), Streptococcus pneumoniae (pneumococcus), Staphylococcus aureus (Staphylococcus aureus).
Pseudomonas and enterobacteria are resistant to the action of Fucithalmic. The viscous structure of eye drops promotes optimal contact of fusidic acid with the conjunctiva, thereby ensuring a sufficient concentration of the main active ingredient Fucithalmic in the tear fluid. The required content of fusidic acid in the intraocular and tear fluid is achieved approximately one hour after application of the drops and is maintained for about twelve hours.
Content
- Characteristics of fucithalmic (tube 1% 5g (eye drops))
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Composition: Active substance - fusidic acid.
Pharmacological Action: Antibacterial.
It disrupts the protein synthesis of microbial cells and, depending on the dose, has a bacteriostatic or bactericidal effect.
Active against gram-positive bacteria, including staphylococci resistant to penicillin and other antibiotics.
When used externally, systemic absorption is negligible.
The effective concentration in the intraocular and tear fluid, which far exceeds the MIC, persists for at least 12 hours.
It is quickly absorbed and is not destroyed in the stomach.
The maximum concentration in the blood is observed after 2-3 hours and remains at a therapeutic level for 24 hours.
Penetrates into the lungs, liver, kidneys, pleural exudate, bones, cartilage and connective tissue, skin, subcutaneous fat; in smaller quantities, but sufficient for a therapeutic effect, enters the cerebrospinal fluid.
It is excreted from the body mainly with bile and in small quantities with urine.
With repeated doses, accumulation of the drug is possible, and with prolonged use, local accumulation may occur.
Indications for Use: Skin and soft tissue infections (impetigo, carbuncles, boils, infected wounds, hidradenitis, folliculitis, paronychia, sycosis, erythrasma, acne).
Bacterial eye infections (conjunctivitis, blepharitis, barley, keratitis, dacryocystitis, infections associated with the removal of a foreign body from the conjunctiva and cornea).
Method of Application: Conjunctivally.
1 drop 2 times a day into the affected eye.
After normalization of the eye condition, treatment is continued for another 2 days.
Interaction: No data available.
Side Effects: Externally: allergic reactions.
When instilled into the eyes: a short-term burning sensation.
When taken orally: belching, abdominal pain, nausea, vomiting, diarrhea.
To reduce side effects, the drug is taken with liquid food or milk.
Contraindications: Hypersensitivity.
Overdose: No data.
Special Instructions: Apply the ointment around the eyes with caution, as sodium fusidate causes irritation of the conjunctiva.
