Corvalol is a medication based on a derivative of bromine and phenobarbital, which has a sedative (calming), antispasmodic (vasodilator) and mild hypotensive (lowering blood pressure) effect, which is prescribed for neurotic conditions, insomnia, sinus tachycardia and heart pain of neurogenic origin.
According to specialized studies, this is a medicine with extremely questionable clinical effectiveness. At least if we consider it from the perspective of treating diseases of the cardiovascular system.
Therefore, the limits of its use are small, which does not change the fact that neither patients nor even doctors realize its inferiority as a medicine.
Compound
Composition of Corvalol in tablets: ethyl bromizovalerianate , phenobarbital and peppermint leaf oil in proportions of 12.42, 11.34 and 0.88 mg/tab, respectively, as well as excipients - lactose (in the form of monohydrate), β-cyclodextrin, acesulfame K, Mg stearate.
Composition of Corvalol in drops: ethyl bromizovalerianate, phenobarbital and peppermint leaf oil in proportions of 20, 18.26 and 1.42 mg/ml, respectively, as well as 96% ethanol, purified water, stabilizer. One milliliter of solution is 26 drops.
The composition of drugs from different manufacturers may differ slightly. For example, the composition of Corvalol N (not available in tablets, only in the form of oral drops) in addition to the indicated active ingredients also includes hop oil (concentration - 0.2 mg/ml). Excipients of the drug: sodium acetate trihydrate, diluted acetic acid, purified water, 96% ethanol.
Pharmacodynamics and pharmacokinetics
What is Corvalol?
Corvalol is a drug that has an antispasmodic and sedative effect , and also facilitates the onset of natural sleep.
phenobarbital drops/tablets included in the composition (drugs from the group of barbiturates ), ethyl bromizovalerianate (sedative) and peppermint leaf oil.
Pharmacodynamics
ethylbromoisovalerate contained in tablets/drops is similar to the effects of valerian (Valeriana), and its antispasmodic effect is realized due to irritation mainly of the receptors of the nasopharynx and oral cavity, increasing inhibition in the nerve cells of the cerebral cortex, as well as in its subcortical structures, reducing reflex excitability in the central parts of the somatic nervous system and the activity of the vasomotor center, a direct antispasmodic effect (local) on smooth muscles.
The latter manifests itself in the form of a decrease in tension in the walls of blood vessels and internal organs, local anesthetic and vasodilating effects .
Phenobarbital suppresses the activating influence on the cerebral cortex of the centers of the reticular formation located in the midbrain and medulla oblongata, thus reducing the flow of excitatory influences on the subcortical regions and cerebral cortex.
This in turn causes a calming , tranquilizing or sedative effect (the severity of the effect depends on the dose).
Corvalol reduces the stimulating effects on the centers of the central nervous system, which take part in the regulation of vascular tone, as well as on peripheral and coronary vessels, while reducing total blood pressure and vascular spasms, primarily those of the heart.
Peppermint leaf oil contains a large amount of essential oils (including menthol (about 50%) and menthol esters (4 to 9%)), which have the ability to irritate thermoreceptors (cold) of the oral cavity and reflexively dilate blood vessels (mainly the brain and heart), while relieving smooth muscle spasms, and have a slight choleretic and sedative effect .
Peppermint oil also has antiseptic and the ability to eliminate flatulence by irritating the receptors in the mucous membrane of the digestive canal and enhancing intestinal motility.
Pharmacokinetics
Absorption of the drug after sublingual administration begins in the oral cavity. The active substances of Corvalol are characterized by high bioavailability, which varies from 60 to 80%.
A faster development of the effect (within five to ten minutes) is facilitated by holding the tablet in the mouth or taking drops on a piece of sugar.
Corvalol begins to act in 15-45 minutes, the effect lasts for three to six hours.
In persons who have previously taken barbituric acid , the duration of the effect is reduced due to the accelerated metabolism of phenobarbital in the liver ( barbiturates induce the activity of liver enzymes ).
Reduced metabolism of Corvalol is observed in patients with liver cirrhosis and the elderly. In this regard, their half-life of the drug is prolonged, which requires increasing the intervals between taking tablets/drops or reducing the dosage.
Component Properties
Corvalol eliminates spasm of smooth muscles, has a sedative effect and can help with mild sleep disorders. The therapeutic effect of the drug is determined by its components.
Ethylbromoisovalerate and alcohol affect the receptors of the inner lining of the mouth and pharynx, reduce the excitability of the central nervous system, and provoke an inhibitory effect on the cerebral cortex and subcortical nerve centers. Thanks to these substances, the drug has an antispasmodic and sedative effect similar to Valerian tincture. In large dosages, the sedative exhibits a pronounced hypnotic effect.
Phenobarbital has a sedative effect; this substance inhibits the transmission of nerve impulses to the cortex and subcortex of the brain. This component helps relieve irritation, under its influence the patient feels drowsiness, and the reaction rate decreases. The degree of suppression of excitatory impulses depends on the portion of drops: the recommended dose will have a calming effect, and in case of an overdose, a pronounced hypnotic effect will appear.
Corvalol has a sedative, antispasmodic, vasodilator effect
The components of Corvalol inhibit the activity of the vasomotor (vasomotor) center. Phenobarbital relaxes vascular smooth muscle, resulting in a moderate hypotensive effect of the drug. However, when blood pressure increases, it is recommended to take other medications; Corvalol is not suitable for this purpose. The drops slightly reduce blood pressure, but they are not able to eliminate the excessive increase in blood pressure during a hypertensive crisis.
Menthol oil is an antispasmodic, promotes vasodilation, enhances intestinal motility, eliminating excess gas formation. Thanks to peppermint oil, the drops have a pleasant refreshing taste and a disinfecting effect.
The tincture is taken before meals, first dissolved in a small dose of filtered water or by dropping the required portion onto refined sugar.
Many patients are interested in the question of how long it takes for Corvalol to work. The therapeutic effect appears 20 minutes after administration and lasts for 3–6 hours. Most of the medicine begins to be absorbed through the oral mucosa.
In patients who have previously taken medications with barbituric acid, the therapeutic effect is reduced due to the rapid metabolism of phenobarbital in the liver.
Indications for use of Corvalol
Indications for use of Corvalol tablets
Corvalol tablets are prescribed for the treatment of:
- neuroses with increased irritability;
- VSD and hypertension (used in complex therapy);
- insomnia;
- tachycardia and spasm of coronary vessels (provided that these conditions are not pronounced);
- caused by neurovegetative disorders .
Corvalol - what do drops help with?
Drops, like tablets, are used for disorders of the central nervous system , which are accompanied by increased irritability, in the early stages of the development of hypertension , for neurocirculatory dystonia , insomnia , moderate tachycardia , as well as to reduce the symptoms of coronary vasospasm , provided that they are not bright expressed.
Contraindications
The manufacturer's instructions list the following contraindications for the use of the drug:
- intolerance to the components of oral drops/tablets;
- increased sensitivity to bromine;
- severe forms of CHF;
- hepatic porphyria.
Preparations containing phenobarbital myocardial infarction (in the acute stage of development), severe arterial hypotension , myasthenia gravis , depression , diabetes mellitus , drug or drug addiction, alcoholism, obstructive syndrome , diseases of the respiratory tract with shortness of breath .
Caution should be exercised when prescribing the drug to patients diagnosed with epilepsy or liver pathologies .
Effect of the drug on blood pressure
The effect of active substances on blood pressure can also be quite dangerous. This applies to patients who have hypotension, because Corvalol provokes a decrease in blood pressure (BP). It is for this reason that it is sometimes used for hypertension. However, it is recommended to use specially designed medications for this purpose.
Corvalol lowers blood pressure
Doctors allow taking drops in emergency cases, when blood pressure rises sharply and there are no means at hand to lower it. The recommended dose is 45 drops per 100 ml of hot boiled water. The medicine must be taken quickly. The therapeutic effect appears after half an hour. Thus, Corvalol will help not only calm the nerves, but also save a person from a hypertensive crisis.
Side effects
Side effects of Corvalol appear as:
- digestive disorders (heaviness in the epigastric region, constipation ; during long-term treatment with the drug nausea , liver dysfunction, vomiting are possible);
- disorders of the nervous system ( ataxia , nystagmus , weakness, impaired coordination of movements, slow reactions, fatigue, paradoxical arousal, hallucinations , mild dizziness , cognitive impairment , headaches , drowsiness , confusion, decreased concentration);
- hypersensitivity reactions (including angioedema );
- skin manifestations of allergies ;
- changes in the blood ( agranulocytosis , thrombocytopenia , anemia );
- difficulty breathing;
- arterial hypotension , bradycardia .
With long-term use of the drug, osteogenesis and the development of manifestations of bromism : central nervous system depression, ataxia , conjunctivitis , rhinitis , depression , lacrimation, purpura or acne , confusion.
As a rule, these symptoms disappear after reducing the dose or stopping treatment with Corvalol.
Precautionary measures
As indicated in the instructions for use of Corvalol in drops, the drug is prohibited in the following cases:
- Intolerance to the ingredients of the drug.
- Allergy to bromine.
- Chronic heart failure (severe).
- Hepatic porphyria.
Corvalol is contraindicated in case of allergies not to its components
In addition, drugs containing phenobarbital are prohibited from being taken by patients with heart attack (acute form), low blood pressure, stress, or diabetes. The use of Corvalol is contraindicated in patients with dependence on drugs, medications, or alcoholic beverages. This restriction applies to patients with impaired air flow through the bronchi due to narrowing or blocking of the air ducts, as well as for diseases of the respiratory organs with shortness of breath.
Under the supervision of a doctor, patients with epileptic seizures and severe liver diseases take a sedative. The tincture is allowed to be given to children only for medical reasons, and it is important to constantly monitor their condition.
Negative effects of tincture on humans:
- epigastric discomfort, difficulty defecating, nausea, vomiting, impaired liver function;
- neuromuscular disorders, involuntary eye movements of high frequency, slow reaction speed, dizziness, hallucinations, etc.;
- allergic reactions (including angioedema);
- disturbance of blood composition (decrease in the concentration of granulocytes, platelets, anemia);
- difficulty breathing;
- hypertension, bradycardia.
Long-term use of Corvalol is harmful to health, in which case the likelihood of osteogenesis imperfecta (impaired bone formation) and the manifestation of symptoms of bromism (chronic bromine poisoning) increases: inhibition of the nervous system, stress, ataxia, disorientation, etc. If such signs appear, you should stop taking it drops and consult a doctor.
Instructions for use of Corvalol
How to take the drops?
According to the instructions for use, Corvalol drops are taken by mixing the drug with 50 ml of water or on a piece of sugar. The optimal time to take it is half an hour to an hour before meals.
How many drops of Corvalol you need to drip depends on the indications. The standard single dose is from 15 to 30 drops. In case of spasm of coronary vessels or severe tachycardia, it is allowed to increase the single dose to 40-50 drops.
Recommendations on how to drink Corvalol for insomnia are as follows: add 30 drops of the drug to warm water (50 ml) and take half an hour before bedtime.
How to take the pills?
Corvalol tablets are taken orally or sublingually. Sublingual administration is preferable when you need to achieve the fastest possible effect.
The instructions for use of Corvalol in tablets indicate that the standard daily dose of the drug is 2-3 tablets. Single dose - 1 tablet.
If necessary (for example, to relieve spasm of coronary vessels ), the dose is increased to 3 tablets per dose. The permissible upper limit of the daily dose is 6 tablets.
How many times a day can you take the drug?
When asked how often you can take Corvalol, doctors answer that the frequency of use depends on the indications. In some cases, a single dose of medication is sufficient; in some cases, tablets/drops should be taken up to 3 times a day.
The duration of the course is determined depending on the tolerability and therapeutic effectiveness of the drug.
Is there a lethal dose?
The active substances of Corvalol are of plant origin, therefore they are safe, however, the use of high doses of the drug is accompanied by the risk of complications.
It is believed that the lethal dose of the drug is 120-150 drops in one dose (240 tablets, respectively). The maximum permissible concentration of the drug differs in each individual case, depending on age, the state of the enzyme systems of the liver and kidneys (for alcoholics, the toxic dose is higher, up to 200 drops).
Death occurs due to cardiac and respiratory arrest. Intensive therapy requires the administration of detoxification drugs and cardiotonic agents.
Overdose of Corvalol
Overdose is a consequence of uncontrolled (frequent or too long) use of the drug. Permanent/long-term treatment can lead to drug dependence, psychomotor agitation, and withdrawal syndrome .
Symptoms of an overdose of Corvalol:
- CNS depression;
- dizziness;
- confusion;
- drowsiness (up to deep, pathologically long sleep);
- ataxia.
In severe cases, the following are observed: arrhythmia , tachycardia , breathing disorders, drop in blood pressure. The most serious consequences of an overdose: collapse , coma , death.
Death occurs when taking 0.1-0.3 mg/kg of the drug. Intoxication from taking more than 150 drops of an oral solution.
It should be noted that for children and the elderly the toxicity threshold of Corvalol is much lower.
Use in pediatrics
Most pediatricians do not recommend prescribing Corvalol to children under 12 years of age. Sometimes in emergency situations it is allowed to take the drug once a day, the dose is determined by the doctor. For the treatment of nervous disorders, sleep disorders and other conditions requiring the use of sedatives and sedatives, a special form of medication was developed - Corvalol Kids. This medication, which includes herbal ingredients, does not contain chemical or toxic additives.
Important! Corvalol Kids has passed all the necessary quality tests, does not cause side effects, and can be prescribed to children of all ages.
Interaction
The effect of Corvalol is enhanced by simultaneous use with drugs of a central inhibitory type, alcohol, and valproic acid preparations .
Phenobarbital , inducing liver enzymes, thereby accelerates the metabolism of drugs that are biotransformed in the liver, including: cardiac glycosides, indirect anticoagulants; antifungal, antiviral, antimicrobial, antiepileptic, psychotropic, anticonvulsant, hormonal, oral hypoglycemic, cytostatic, immunosuppressive, antihypertensive and antiarrhythmic drugs.
Phenobarbital potentiates the action of local anesthetics and analgesics .
Prolongation of the effects of Phenobarbital is facilitated by the simultaneous use of MAOIs. To reduce their severity - take Rifampicin .
When using Phenobarbital in combination with gold drugs, the risk of kidney damage increases, with NSAIDs (with long-term use) - the risk of ulceration of the gastric mucosa and the development of bleeding, with Zidovudine - the toxicity of both drugs increases.
Corvalol enhances the toxic effects of Methotrexate.
special instructions
phenobarbital in Corvalol can cause the development of Lyell's syndrome or Stevens-Johnson syndrome , which is most likely in the first weeks of using the drug.
The drops contain phenobarbital and ethanol (56 vol.%). The alcohol concentration in the minimum dose of the drug (15 drops) is 254 mg, which corresponds to 2.7 ml of wine or 6.4 ml of beer.
When taking these substances, the following are possible:
- coordination problems;
- impaired speed of psychomotor reactions;
- dizziness;
- drowsiness.
In this regard, the answer to the question whether you can drink Corvalol while driving is unequivocal - you can’t. During treatment with the drug (in any dosage form), you should also avoid working with mechanisms and activities that require increased attention and high speed of motor and mental reactions.
Is Corvalol harmful - the benefits and harms of the drug
Everyone knows what Corvalol is needed for. The effectiveness of the drug is evidenced by a fairly large number of reviews left by patients. However, recently more and more information has appeared that the drug can not only treat, but also cause harm to the body.
So, why is Corvalol harmful? Contained in tablets and drops, ethyl bromizovalerianate is an antispasmodic , which, depending on the dose taken, can have a sedative or hypnotic effect . The dose required to develop a hypnotic effect depends on the individual characteristics of the body.
Phenobarbital entering the body when taking a standard dose of Corvalol (15-20 drops) provokes vasodilation and causes a mild sedative effect , without having a hypnotic effect .
Peppermint oil causes a reflex vasodilation and antispasmodic effect , however, when consumed in a dose exceeding 25 mg, it inhibits intestinal motility and causes constipation.
In most countries, substances that provide the therapeutic effect of Corvalol are considered controlled substances (in the Russian Federation included in List III, which is the basis for restricting its circulation) and are prohibited for import. In particular, the drug is prohibited for import and sale in the United States and Lithuania.
According to some narcologists, phenobarbital is a drug, and its use should be avoided if possible due to the risk of developing addiction and dependence on the drug.
When used regularly in high doses, phenobarbital causes cognitive impairment (speech impairment, short-term memory impairment, unsteadiness of gait), serious neurological disorders and withdrawal symptoms , and suppresses sexual function.
Long-term use of Corvalol is also dangerous due to the risk of possible accumulation of bromine in the body and the development of bromine poisoning.
Symptoms of poisoning can be mild, moderate or severe. The lungs manifest themselves in the form of: general weakness, drowsiness, lethargy, decreased muscle strength, absent-mindedness, blurred speech, confusion, apathy, ataxia, conjunctivitis, depressive mood, the appearance of purpura and acne , runny nose .
Consequences of moderate poisoning: pathological increase in sleep duration, drooling, increase in muscle weakness up to the development of paresis , decrease in blood pressure, decrease in the volume of urine excreted, dilated pupils.
, barbituric coma develops . A person develops respiratory failure, reflexes become undetectable, there is no consciousness, and acute cerebrovascular insufficiency develops, the signs of which are:
- drop in blood pressure;
- the appearance of wheezing in the lungs audible at a distance;
- tachycardia;
- increasing bluishness of the skin, which spreads from the tips of the ears, nose, nasolabial triangle and ends with general cyanosis .
The progression of heart failure often ends with pulmonary edema .
The lethal dose of the drug is 0.1-0.3 g/kg (on average about 20 g). of phenobarbital is fatal .
In case of mild poisoning, it is enough to rinse the patient’s stomach (to clean rinsing water), give him an enterosorbent (any, if he is not intolerant) in a dose equal to a third of the highest daily dose. It is also advisable to use saline laxatives, a cleansing enema, and take an enveloping drink.
Due to the danger of a rapid increase in the severity of the condition, you should definitely call an ambulance.
In case of severe intoxication, when the patient has signs of lack of cardiac activity, an indirect cardiac massage is performed and artificial respiration is performed before the doctor arrives.
The consequences of poisoning, even with timely assistance, can be quite serious - from severe forms of dermatitis to acute cardiac, respiratory or renal failure .
The largest number of deaths due to drug poisoning is observed precisely from drugs that contain barbituric acid . The severity of the consequences is determined by the dose of the substance taken, the severity of the poisoning, and the timeliness of the measures taken.
Does Corvalol reduce blood pressure?
When it comes to treating patients suffering from blood pressure fluctuations, the question “Does Corvalol increase blood pressure or decrease it?” very relevant.
Research by scientists has shown that Corvalol lowers blood pressure. Therefore, in emergency situations, it can be used as an alternative to special medications that are intended for the treatment of arterial hypertension .
How to drink and how many drops to measure at high blood pressure?
If your blood pressure has risen sharply and there is no other antihypertensive drug in the house, doctors recommend measuring 45 drops of Corvalol oral solution in 100 ml of hot water and drinking this medicine in one gulp. Improvement is usually noted after about half an hour.
How to prepare a remedy for heart and vascular diseases at home?
valerian , Corvalol, hawthorn, motherwort, mint and eucalyptus are very effective for heart pathologies , hypertension
To prepare the medicine, alcohol tinctures are used in the following proportions: tinctures of valerian, motherwort, peony and hawthorn - 100 ml each, tincture of eucalyptus - 50 ml, tincture of mint - 25 ml, Corvalol - 30 ml, clove spice - 10 columns.
All ingredients are poured into a dark glass bottle, the bottle is sealed and placed in a dark place for 2 weeks. The medicine should be infused at room temperature.
Take the product 3-4 times a day, half an hour before meals, 30 drops for each dose, after diluting the indicated dose in 0.5 glasses of water. The last dose should be before bedtime. They take the medicine in courses lasting 30 days, with weekly intervals between them. Treatment is continued until improvement appears.
The combination of motherwort , hawthorn and valerian helps improve cerebral circulation , eliminate the consequences of stroke and heart attack , improve hematopoiesis, and also prevent blood clots .
Analogs
Level 4 ATC code matches:
Belloid
Corvaldin
Bellaspon
Korvaltab
Bellataminal
Reladorm
Valocordin
Analogs with a similar mechanism of action: Amizil , Bromizoval , Valemidin , Valerian , Valocordin , Doppelgerts Melissa , Potassium bromide , Corvaldin , Novo-Passit , Notta , Passifit , Persen , Sympatil , Songa Knight , Bromcamphor , Circulin , Dexdor .
Which is better: Corvalol or Valocordin?
Valocordin is a drug based on ethyl bromizovalerianate (18.4 mg/g), phenobarbital (18.4 mg/g), mint oil (1.29 mg/g), hop oil (0.18 mg/g), 96% th ethanol (469.75 mg/g), purified water (411.97 mg).
It can be noted that the difference in the composition of Valocordin and Corvalol is very insignificant. The only difference is that the first contains a small amount of hop oil, which has a calming and antispasmodic effect .
Experts, when asked how Valocordin differs from Corvalol, answer that the drugs are absolutely identical. Both of them quickly eliminate discomfort and pain in the heart, and, if used in a timely manner, can prevent an attack of angina and myocardial infarction .
Since Corvalol is a domestic drug, and Valocordin is produced by the German company Krewel Meuselbach GmbH, the former is a more affordable product (a bottle of Valocordin , depending on the container, costs from 130 to 300 rubles, while Corvalol drops can be bought for 11-40 rubles).
Similar means
There are a large number of medicines with similar properties. The most popular substitutes for Corvalol include:
- Novo-Passit;
- Valocordin;
- Persen;
- Notta;
- Barboval;
- Korvaldin, etc.
Read more Indications and instructions for use of Normax ear drops
Tinctures based on peony, valerian, motherwort, and hawthorn also have a similar effect.
Alcohol compatibility
Alcohol enhances the effect of Corvalol. The drug is harmful for alcoholic patients.
Corvalol and alcohol: consequences of simultaneous use
Concomitant use of the drug with alcoholic beverages primarily causes damage to hepatocytes and the development of a disulfiram-ethanol reaction.
Once in the blood, alcohol increases heart rate, increases blood pressure and excites the nervous system. Corvalol is taken to reduce high blood pressure and calm the heart. Thus, the combination of the active components of the drug with alcohol provokes an imbalance and overload of the body.
Peppermint oil has a vasodilating effect and reduces blood viscosity. Since alcohol enhances the effect of the drug, drinking it in large quantities after taking Corvalol can provoke the development of internal bleeding and hemorrhage in the brain.
Another possible consequence of using this combination is cardiac arrest.
Repeated mixing of Corvalol with alcoholic beverages can cause dependence, much stronger than just dependence on alcohol.
This is due to the fact that one of the components of the drug is phenobarbital barbituric acid derivatives , which, with prolonged use, is addictive and provokes the development of drug dependence.
Is it possible to drink Corvalol with a hangover?
If you have a hangover, the use of Corvalol is not only inappropriate, but also extremely dangerous. By accelerating the course of all metabolic processes in the body due to the active release of liver enzymes, the drug thereby promotes faster absorption of alcohol in the blood and enhances its destructive effect.
There is also an increase in the sedative effect, which in turn leads to a more pronounced hangover syndrome.
Drinking alcohol also worsens the symptoms characteristic of an overdose of Corvalol: severe weakness, inability to think coherently, apathy. The possibility of unexpected reactions cannot be excluded.
Description of the pharmaceutical form
Corvalol is available in the form of tablets and drops. The most popular form of medication is oral drops. They have a quick healing effect and are easy to use. The medicinal solution is colorless, but has a specific odor. The drops are packaged in dark glass dropper bottles. The cardboard package contains 1 bottle of 25 or 50 ml.
The composition of 1 ml of Corvalol solution includes the following active ingredients:
- phenobarbital is a synthetic psychotropic component that has a powerful sedative effect;
- ethyl bromoisovalerate – a synthetic component with antispasmodic, soothing, relaxing properties;
- Peppermint oil is a natural ingredient that gives the medicine an antiseptic, antispasmodic effect.
The medication contains auxiliary components - ethyl alcohol 95%, stabilizer, distilled water.
Corvalol during pregnancy and lactation
Is it possible to take Corvalol during pregnancy?
The annotation for the drug states that both tablets and drops are contraindicated for pregnant women.
The use of phenobarbital in the first three months of pregnancy can provoke fetal developmental abnormalities, and in the prenatal period it can cause respiratory distress syndrome in the newborn.
Another component of Corvalol - mint oil - can cause an increase in the tone of the uterine muscles.
If the question arises whether pregnant women can take Corvalol, doctors answer that during pregnancy one should, if possible, stop taking medications, and, if necessary, use the safest ones possible.
Corvalol during breastfeeding
The use of the drug during breastfeeding is contraindicated.
What restrictions exist?
Before therapy, a person needs to read the instructions, since Corvalol has certain contraindications. These include:
- Increased sensitivity to components.
- Lactation.
- Age up to twelve years.
- Myocardial infarction (one of the clinical forms of coronary heart disease, occurring with the development of ischemic necrosis of the area).
- Myasthenia gravis (an autoimmune disease that causes muscle weakness due to disruption of neuromuscular transmission).
- Diabetes mellitus (metabolic disorder characterized by increased blood sugar).
- Alcoholism.
- Epilepsy (a chronic neurological disease manifested in the body’s predisposition to the sudden onset of seizures).
The drug can be used with extreme caution during pregnancy and attacks of bradycardia.
Reviews of Corvalol
Reviews of Corvalol in tablets and drops are generally good, because the effectiveness of the medicine has been tested by time. However, along with them you can also find negative reviews. They usually note that the drug is really good at calming, but at the same time it greatly dulls reactions and causes lethargy.
Most people know about Corvalol as a remedy for calming the heart and treating neuroses, but it turns out that it can also be used as a remedy for acne and herpes on the lips .
When acne appears, cosmetologists recommend Corvalol-based drops. To prepare it, grind 1 tablet of Aspirin , 1 tablet of Metronidazole (or Trichopolum ) and 1 tablet of Levomycetin , and then add the resulting powder to 50 ml of the drug.
Shake the mash well before use. It is recommended to wipe your face after washing, optimally before bed. If you believe the reviews, in order to remove inflammation, 3-4 days of using the product are enough.
Some Corvalol solution is applied to acne spots. In 3-4 procedures, acne noticeably dries out, and inflammation decreases.
For herpes on the lips, drops are best used as soon as unpleasant symptoms appear. The only disadvantage of this treatment is that the drug greatly dries out delicate skin, so when using Corvalol you should take extra care of it.
Is it possible during pregnancy?
Despite the fact that Corvalol is a mild sedative medicine, it is not recommended to take it while pregnant. The risk of developing negative consequences in this situation outweighs the benefits. In the first trimester of pregnancy, taking any sedatives is prohibited. The active components of the drug can negatively affect the developing nervous system of the fetus. In subsequent trimesters, the methods and dosage of taking the medication must be discussed with your doctor.
The prescription of Corvalol during pregnancy is carried out exclusively by a doctor.
How much do Corvalol drops and tablets cost?
The price of Corvalol tablets in Russian pharmacies is 100-150 rubles. for package No. 20. You can buy oral drops from 11 rubles.
In Ukraine, the price of Corvalol in tablets is from 8 UAH per package No. 10. The price of Corvalol in drops is 9-18 UAH.
- Online pharmacies in RussiaRussia
- Online pharmacies in UkraineUkraine
- Online pharmacies in KazakhstanKazakhstan
ZdravCity
- Corvalol tablets 20 pcs. Pharmstandard-Leksredstva OJSC
129 RUR. order - Corvalol drops for oral administration vial. 25ml RenewalАО Update PFK
71 RUR order
- Corvalol NEO drops for internal use. approx. fl.-dropper 50mlPharmstandard-Leksredstva OJSC
105 rub. order
- Corvalol tablets 20 pcs. YuzhPharm LLC
129 RUR order
- Corvalol phyto 1.16mg+28mg+16.4mg tab. No. 50Pharmstandard-Leksredstva OJSC
RUB 279 order
Pharmacy Dialogue
- Corvalol (tab. No. 20)Pharma Start
127 RUR order
- Corvalol (25ml bottle)Hippocrates
15 rub. order
- Corvalol (25ml bottle) MFF
22 RUR order
- Corvalol (25ml bottle) FS.-Leksredstva
18 rub. order
- Corvalol (tab. No. 20) FS.-Leksredstva
110 rub. order
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Pharmacy24
- Corvalol 25ml drops PAT "Farmak", Ukraine
10 UAH. order - Corvalol N 25 ml drops PAT "Farmak", Ukraine
10 UAH.order
- Corvalol K No. 30 capsules PAT "Farmak", Ukraine
32 UAH order
- Corvalol-Darnitsa 25 ml oral drops PrAT” Pharmaceutical company “Darnitsa”, Ukraine
10 UAH.order
- Corvalol No. 10 tablets PAT "Farmak", Ukraine
12 UAH order
PaniPharmacy
- Corvalol tablets Corvalol tablets. No. 30 Ukraine, Farmak OJSC
33 UAH order
- Corvalol liquid Corvalol-Darnitsa solution 25ml Ukraine, Farmak OJSC
13 UAH order
- Corvalol N liquid Corvalol N solution 25ml Ukraine, Farmak OJSC
13 UAH order
- Corvalol tablets Corvalol tablets. No. 10 Ukraine, Farmak OJSC
12 UAH order
- Corvalol K capsule Corvalol K capsule. No. 30 Ukraine, Farmak OJSC
38 UAH order
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