Tablets "Laktinet": reviews from doctors, instructions, side effects

The problem of control over the birth of children in modern times is the most pressing. After all, a woman’s health depends on how correctly she approaches the issue of planning pregnancies, maintains the optimal period for the body to recover after childbirth, and does not have further abortions. Of course, not only she herself, but also her husband should take care of the health of the expectant mother. However, as practice shows, it is women who think more about contraceptive measures. After all, the consequences of intimate relationships largely concern their future life rather than their sexual partner.

Modern realities are not encouraging with abortion statistics, especially between the ages of 15 and 30. Despite the fact that after an abortion you may not have children at all, many people decide to have the operation. Unwanted pregnancies often result in abandoned children, which increases the number of orphans in orphanages.

That is why medical experts are sounding the alarm, drawing attention to the fact that women must use the most effective contraceptives. Of course, the first thing on the list is always a condom. However, it is not always in your pocket at the right moment when the desire to make love arises. And the presence of it in many cases does not guarantee one hundred percent protection of the female body from sperm entering it, since not everyone knows how to use it correctly.

Another thing is the use of contraceptive mini-pills. This method of protection against unwanted pregnancy is by far the most effective if you adhere to certain simple rules of administration.

Compound

One tablet of Lactinet contains 0.075 mcg of desogestrel and a number of auxiliary components:

• colloidal silicon dioxide (Silicii dioxydum colloidale);
• D,L-α-tocopherol (dl-alfa-Tocopherol);
• stearic acid (Acidum stearicum);
• magnesium stearate (Magnesium stearate);
• povidone K30 (Povidonum K30);
• potato starch (Amylum solani);
• lactose monohydrate.

The film shell with which the tablets are coated contains:

• talc (Talcum);
• macrogol 3000 (Macrogolum 3000);
• titanium dioxide CI 77891 (Titanium Dioxide);
• Opadry II White;
• polyvinyl alcohol (Spiritus polyvinylicus).

Pharmacodynamics and pharmacokinetics

Film-coated contraceptive pills Lactinet are a contraceptive based on the third generation progestogen desogestrel .

The high degree of affinity of the substance for progesterone ensures reliable contraception even when used in low doses. Its main advantage is that it has virtually no effect on the lipid spectrum of the blood . carbohydrate metabolism and hemostasis .

These beneficial qualities of desogestrel are the key to the safety (taking into account contraindications to their use) of modern low-dose oral contraceptives , which include Lactinet.

Since no other hormonal components are used as an active substance except progestogen , Lactinet tablets are safe for women who are breastfeeding , as well as for women who have contraindications or do not want to take estrogen-containing drugs.

The mechanism of action of desogestrel is determined by inhibition of ovulation , which is confirmed by the absence of a follicle ultrasound diagnostic procedure , as well as by indicators of low levels of luteotropic (lactogenic) hormone .

The effectiveness of desogestrel is also confirmed by the low concentration of progesterone in the middle of the menstrual cycle .

Another equally important property of the substance is the ability to increase the density and viscosity of cervical mucus, which is produced by the glands of the cervix . This in turn creates a barrier to the passage of sperm and prevents fertilization of the egg .

The Pearl index for the drug is 0.4. This indicator reflects the number of pregnancies in a group of thousand women during the year without using contraceptives , as well as the level of reliability of the contraceptive . The lower it is, the more effective the contraceptive .

With regard to Lactinet, the Pearl index is similar to the indicator established for combined type contraceptives .

Data from a comparative study showed that when taking missed pills a maximum of three hours after the proper time, in the group of women taking the drug, the Pearl index remained unchanged - 0.4. The Pearl index for levonorgestrel increased to 1.6.

desogestrel tablet per os, it is quickly absorbed from the stomach and intestines . The average maximum concentration of the substance in the circulating blood is observed after 1.8 to 2 hours. The bioavailability rate is within 70%.

Under the influence of enzymes, desogestrel undergoes hydroxylation and dehydrogenation , as a result of which it is biotransformed to etonogestrel , which is its main metabolite . Further metabolization of etonogestrel is completed by the formation of glucuronide and sulfate conjugates .

Etonogestrel , which is the most active metabolite of desogestrel , has the ability to bind to plasma proteins by 95.5-99%. This applies to a greater extent to albumins , and to a somewhat lesser extent to globular proteins ( globulins ), which are responsible for the binding of sex hormones .

The average half-life of desogestrel metabolites is approximately 30 hours. Moreover, its duration does not change depending on whether the drug was taken once or in a course (multiple doses).

Equilibrium concentration is observed 4-5 days after starting to take the tablets.

Excretion of metabolites in the form of conjugates and free steroid hormones is carried out mainly by the kidneys with urine. To a much lesser extent, they are excreted in the intestinal .

In breastfeeding women, etonogestrel passes into the milk. The milk/blood plasma ratio is 0.37/0.55. This, and also the fact that on average a child receives about 150 ml of breast milk per kilogram of his weight during the day, he can also receive from 0.01 to 0.05 mcg of etonogestrel .

Mechanism of action and indications

The contraceptive effect of Lactinet is ensured by the following mechanisms:

• inhibition of the ovulation process;
• increasing the viscosity of cervical mucus, which makes it impermeable to sperm and prevents their penetration into the uterine cavity.

Lactinet is prescribed to prevent unwanted pregnancy, especially during lactation or in case of contraindications to the use of combined hormonal contraceptives.

Contraindications

Contraindications to the use of the drug are:

• thromboembolism (history or current);
• severe liver pathologies (contraindication remains until liver function tests return to normal);
• dysfunction, as well as liver failure ;
• the presence or suspicion of the presence of a hormone-dependent malignant neoplasm ;
• vaginal discharge of unknown origin;
• pregnancy or suspicion of it;
• lactose intolerance;
• lactase deficiency;
• glucose-galactose malabsorption;
• forced immobilization for a long period of time;
• hypersensitivity to the active substance or any of the auxiliary components.

Cautions and Recommendations

It must be remembered that taking Lactinet does not protect against infection with HIV and other diseases that can be sexually transmitted.

If any undesirable effects appear while taking the drug, you should consult a doctor to decide whether to stop or continue the course.

In the first months of using Lactinet, patients with diabetes mellitus should be under medical supervision.

It must be taken into account that taking Lactinet lowers estradiol levels in the body to values ​​that correspond to the early follicular phase.

Chloasma can sometimes occur, especially for women who had chloasma during pregnancy. Patients with a tendency to chloasma should avoid direct sunlight while taking Lactinet.

Despite the fact that Lactinet inhibits the ovulation process, it is necessary to take into account the possibility of an ectopic pregnancy during the diagnosis of abdominal pain or amenorrhea.

Women who are sensitive to lactose should take into account that 1 tablet of Lactinet contains 67.45 mg of lactose monohydrate. The drug is contraindicated in women with rare hereditary diseases associated with lactose intolerance or deficiency or glucose-galactose malabsorption.

Lactinet does not affect concentration, the ability to drive vehicles or carry out complex work that requires the speed of psychomotor reactions.

Side effects

Studies of the drug Lactinet and its active substance have shown that the most common adverse reaction to taking the drug is disruption of the regularity of the menstrual cycle .

Approximately half of women taking the drug experience non-cyclical bloody vaginal discharge . In every third to fifth woman, while taking the pills, menstruation becomes less frequent (even to the point that it completely disappears over time) or, on the contrary, becomes more frequent.

In some cases, an increase in the duration of menstrual bleeding . However, as a rule, after two months of use, menstruation becomes less frequent.

To increase the degree of safety and reduce the risk of side effects, a woman taking Lactinet is recommended to regularly visit her gynecologist, inform him of all changes in her condition, and also keep a diary of menstrual flow.

The category of effects most often occurring while taking gestagen-containing oral contraceptives includes:

• attacks of nausea;
• the appearance of acne ;
• mood lability;
• decreased sex drive;
• soreness in the mammary glands ;
• weight gain;
• headache.

Slightly less common:

• increased fatigue;
• vomit;
• hair loss ( alopecia );
• increased level of intracranial pressure ;
• inflammatory processes of the vaginal mucosa ;
• cystic formations in the ovaries;
• infectious diseases of the vagina;
• increased severity of pain in the lower abdomen during menstrual bleeding .

Quite rarely, phenomena such as skin rashes, erythema nodosum , redness of the skin, and urticaria . Some women may experience breast discharge . In rare cases, ectopic pregnancy .

Taking Lactinet can become a provoking factor for the development or increase in the severity of angioedema , as well as for its exacerbation, if the latter is congenital.

There are cases where women who took oral contraceptives experienced more serious consequences. These include the formation of hormone-dependent cancer tumors and the development of thromboembolism (venous or arterial) .

special instructions

As the instructions say, Lactinet is prohibited from taking in the following cases:

• Blockage of leg veins with blood clots.
• Blockage of arteries in the lungs with blood clots.
• Functional liver failure.
• Hormone-dependent neoplasms.
• Uterine bleeding.
• Hypolactasia.
• Lactase deficiency.
• Glucose-galactose malabsorption.
• Hypersensitivity to the main or auxiliary components.
• Pregnancy.

Women with refractory arterial hypertension, chloasma, and diabetes mellitus should take the drug with caution. This limitation applies to patients with porphyrin disease and lupus erythematosus.

The most common side effect after taking Lactinet is a violation of the periodicity or duration of the menstrual cycle. Lactating mothers experience acyclic bleeding, periods become less frequent or disappear completely, and in some cases their frequency becomes more frequent. Sometimes the duration of menstruation increases. To control your menstrual cycle, keep a menstrual diary. The doctor must monitor the patient’s condition while taking the mini-pill.

In rare cases, the following side effects occur after taking the drug:

• nausea;
• acne;
• mood swings;
• decreased sexual desire;
• chest pain;
• weight gain;
• headache.

If the dosage is unreasonably exceeded, nausea, vomiting, and uterine bleeding of varying intensity occur. These symptoms can be eliminated with symptomatic therapy.

Instructions for use of Lactinet: method of administration and dosage of the drug

If a woman has not taken any oral contraceptives , the pills should be taken from the first day of the cycle. The daily dose of the drug is 1 tablet.

At the same time, it is recommended to take it exactly at the same time, maintaining an interval of 24 hours and following the instructions indicated on the package. When taking Lactinet, there is no need to take intervals between each two courses.

If a woman has not previously used hormonal contraception (at least in the previous month), pills should be taken on the first day after the end of menstrual bleeding . Auxiliary barrier contraceptives are not needed.

If the drug is started between 2 and 5 days after the end of menstrual bleeding , in this case birth control pills are supplemented with barrier contraceptives .

If it is necessary to replace another combined contraceptive with Lactinet, it is recommended to do this the very next day after stopping the previously used drug. There is no need to use additional protective equipment.

If it is necessary to replace another monocomponent drug containing a progestogen with Lactinet, taking tablets is also started immediately after discontinuation of the previously used drug, be it mini-pills , progestogen-containing injections , intrauterine contraceptives or implants .

In each case, during the first week, for greater reliability of contraception barrier contraceptives along with pills .

After an abortion , as well as after a spontaneous abortion in the first three months of pregnancy , it is recommended to start taking the drug immediately after termination of pregnancy . need for additional methods of contraception .

After termination of pregnancy between 13 and 24 weeks, as well as after childbirth , Lactinet is prescribed no earlier than 21-28 days later. If you plan to start the course later, then in the first seven days the tablets are combined with the use of barrier contraceptives .

In situations where unprotected sexual relations took place before starting the course of taking the drug, the woman is advised to exclude the possibility of pregnancy or is advised to shift the first day of starting to use the pills to the first day of the next menstrual cycle .

If the previous dose of the pill was missed, but less than twelve hours have passed, the contraceptive effect of the drug remains unchanged, further administration is continued in accordance with the usual regimen, without using additional methods of protection against unwanted pregnancy .

If from twelve hours to three days have passed, then the reliability of contraception decreases significantly. The drug continues to be taken according to the usual regimen, however, it is supplemented with the use of other methods of contraception .

vomiting begins a few hours after taking the tablet , this is evidence that complete absorption of the active substance of the drug has not occurred. In this case, the instructions for Lactinet recommend resorting to countermeasures similar to those used if the next dose was missed. To replenish the missing tablet, it is taken from the next package of the drug.

menstrual irregularities while taking the pills (for example, excessively frequent, prolonged, painful or irregular bleeding), you should consider changing the drug. If the symptoms do not disappear even after this, a thorough examination is necessary to determine the exact cause of its occurrence.

In some cases, amenorrhea and other cycle disorders may occur as a result of improper use of the drug.

If pregnancy occurs , Lactinet should be stopped immediately.

Contraceptive pills "Laktinet": reviews

So, many oral contraceptive drugs contain female sex hormones - estrogen and progestin. They are more effective compared to the Lactinet mini-pills, reviews of which are also positive. It is these pills that gynecologists prescribe to their patients if, for some reason of poor health, oral combined contraceptives are not suitable for use as an effective method of contraception.

The Lactinet mini-pill is also an oral method of protection, but it contains microdoses of gestagen. This drug has a more gentle effect on the female body and does not cause most side effects, especially those related to the cardiovascular system.

It causes an increase in the viscosity of the mucus formed in the cervix, that is, it thickens, and this complicates the penetration of sperm into the cavity of the reproductive uterus, and also reduces the contraction of the fallopian tubes several times, which slows down the process of a mature or fertilized egg entering the uterine cavity. Mini-pills cause inhibition of ovulation.

Thus, it is possible to prevent unwanted pregnancy at the physiological level with the help of Lactinet tablets. Reviews about them, despite their supposed effectiveness, are varied. As already mentioned a little above, this drug is not without side effects, so for many it is not suitable as a method of contraception. We'll talk about the side effects of this contraceptive a little later.

Often reviews of Lactinet tablets from nursing women who take the drug after childbirth are positive. The only caveat is getting used to taking the pills every day. In order not to forget about your potential protection in the flow of daily responsibilities, you need to use reminders, for example, set an alarm on your mobile phone and take the drug at the same time, so as not to stray from the correct course.

Interaction

Concomitant use with drugs that induce microsomal liver enzymes may cause breakthrough bleeding and reduce the contraceptive effect of Lactinet.

Such drugs include hydantoin :

• phenytoin;
• carbamazepine;
• topiramate;
• griseofulfin;
• rifabutin;
• barbiturates;
• primidone oxcarbazepine.

If it is necessary to undergo treatment with these drugs, a woman is recommended to supplement her intake of birth control pills with the use of additional contraceptives throughout the course of treatment and for another seven days after its completion. After stopping rifampicin, to use barrier contraceptives for another 28 days.

The contraceptive effect of Lactinet is reduced by the simultaneous use of antibiotics , as well as during treatment activated carbon and drugs similar in action to it.

After taking activated carbon or its analogue, you should follow the recommendations regarding the dosage of the drug if you skip a pill.

Precautionary measures

The mini-pill should be taken with caution when:

• Development of resistant hypertension that arose while taking a hormonal contraceptive, or low effectiveness of antihypertensive treatment
• Diagnosing systemic lupus erythematosus
• Diabetes mellitus
• Severe chloasma or a tendency to develop it
• Herpetic rashes
• Porphyria.

It must be taken into account that one pill contains 67.4 mg of a substance such as lactose.

Analogs

Level 4 ATX code matches:
Eskinor-F

Microlute

Exluton

Postinor

Escapelle

Implanon NKST

Charosetta

Analogues of Lactinet are the drugs Charozetta and Desogestrel .

Use of Lactinet during breastfeeding and pregnancy

The use of Lactinet by pregnant women is prohibited. This is due to the results of preclinical studies showing that high doses of progestogens (one of which is the active substance of the drug) contribute to excessive masculinization of female fetuses.

As for epidemiological studies , they did not reveal an increased risk of congenital deformities in the child and any disorders of embryogenesis in newborn infants whose mothers took contraceptives before pregnancy or, unintentionally, in the first weeks after its onset.

Lactinet taken during breastfeeding does not affect the quantity of breast milk in a woman and its quality indicators. However, desogestrel has the ability to pass into milk in small quantities.

Observations of nursing women using Lactinet to prevent pregnancy while breastfeeding have confirmed that desogestrel does not provoke any disturbances in growth and development (both physical and mental).

However, for safety reasons, close monitoring of the child by a qualified pediatrician is recommended.

Taking the Lactinet mini-pill after childbirth

A woman can breastfeed her baby for two or two and a half years. But it is definitely impossible to say that she will not be able to get pregnant during this period. The most effective lactation period is maintained for up to six months, when the baby is not introduced to complementary foods. But when the number of breastfeedings decreases significantly, the lactation contraceptive method ceases to be effective. And the contraceptive Lactinet comes to the aid of many mothers. Feedback from nursing women is very positive. After all, this is practically the only reliable method of contraception after the barrier method.

Negative tablets "Lactinet" cause reviews from those women who have encountered side effects caused by taking the drug. So this contraceptive, like many others, should be selected individually, taking into account the general physiological health of the woman both before and after childbirth, so as not to harm her normal well-being.

A lot of women have tried Lactinet tablets while breastfeeding. Reviews sometimes contain information that this contraceptive promotes weight gain. But a competent specialist always explains that changes in body weight do not depend on taking mili-pili, but are directly related to the special physiological state of the woman’s body during the period of feeding the baby.

Some complain of decreased libido. But the majority are still happy that today it is possible to effectively protect yourself and not strain your other half by thinking about constantly having condoms in your pockets.

Mini-pills are a reliable and inexpensive method of contraception.

This is how the Lactinet product is characterized by reviews from nursing mothers. The instructions for use must be carefully studied.

Reviews about Laktinet

Reviews from doctors about the drug are positive. Most experts note that if properly selected, taking into account all the recommendations and contraindications given in the instructions, it does not cause any serious side effects even with long-term use.

Another compelling argument in favor of the prescription is that Lactinet contraceptive pills are suitable for breastfeeding mothers, as well as for those who are contraindicated with combined oral contraceptives .

Reviews of Lactinet for breastfeeding indicate that the drug does not affect the taste or other qualities of milk and is considered safe for the health of the baby.

Reviews left by women who took this contraceptive are more contradictory. Many of them were satisfied with the tablets, emphasizing the ease of use and the absence of adverse reactions.

But along with this, there are also negative comments, which note that after taking the drug, the menstrual cycle ( bleeding became more frequent and heavy or disappeared altogether), hair began to fall out , and weight increased .

Some people also consider its relatively high cost to be a disadvantage of the drug.

On the pharmaceutical market of Russia and Ukraine, an analogue of Lactinet is the drug Charozetta , which is produced by ORGANON NV (Netherlands). When trying to decide which is better - Charozetta or Lactinet - you should take into account the fact that in terms of their properties, indications and composition they are almost identical, and the only significant difference is the price (Lactinet is somewhat cheaper than its analogue).

The drug "Lactinet": expert opinion

A competent gynecologist will never prescribe a contraceptive to a woman that will worsen her health. The individually selected drug “Laktinet” (doctors’ reviews say) helps her to have excellent physical shape and a stable psyche.

The issue of choosing a contraceptive drug should worry every woman, no matter how old she is - twenty, thirty, fifty... Lactinet tablets are designed for all females. But health conditions sometimes prevent them from being used.

Gynecologists prescribe this drug for painful menstruation and inflammation of the genital organs, since it performs a dual useful function - contraceptive and anti-inflammatory.

The majority of doctors’ opinion boils down to the fact that Lactinet tablets are a reliable and necessary contraceptive for females. It is included in the ranking of the most popular.

Lactinet price, where to buy

The average market price of Lactinet in Russia is 750 rubles per pack of 28 tablets. In Ukrainian pharmacies it sells for an average of 135 hryvnia.

• Online pharmacies in RussiaRussia
• Online pharmacies in UkraineUkraine
• Online pharmacies in KazakhstanKazakhstan

ZdravCity

• Lactinet tablets p.p.o.
  75mkg 28 pcs. JSC Gedeon Richter RUB 869 order

Pharmacy Dialogue

• Laktinet (No. 28 tablet p/o) Gedeon-Richter

  925 rub. order

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Pharmacy24

• Lactinet 0.075 mg N28 tablets VAT "Gedeon Richter", Ugorshchina
  294 UAH. order

PaniPharmacy

• Lactinet tablets Lactinet tablets. p/o No. 28 Hungary, Gedeon Richter

  298 UAH order

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When is additional contraception needed?

Additional, usually barrier, contraception is required in the following cases:

• break between taking pills for more than 36 hours;
• start taking after 28 days after birth or from 2-5 days of the menstrual cycle;
• vomiting or diarrhea within the next 4 hours after administration;
• lack of a permanent partner or lack of confidence in him, since Lactinet, like other oral contraceptives, does not protect against sexually transmitted infections and AIDS.