Description and composition
Magne B6 tablets are one of the effective remedies used for adults, children and pregnant women. The drug can be used for a variety of conditions of the body, diseases of the central nervous system. This remedy has a positive effect on metabolic processes, increases immunity, improves sleep, heart function, and liver function. Reviews about the drug are quite good. Many note that after taking the drug their condition improved, increased anxiety and irritability disappeared, sleep improved, and they managed to cope with depressive disorders.
The drug contains:
- magnesium lactate 2-water;
- vitamin B6 (pyridoxine hydrochloride);
- Excipients.
Interactions of the drug Magne-B6
not recommended combinations : should not be prescribed simultaneously with preparations of phosphates or calcium salts (inhibit the absorption of magnesium in the digestive tract); combinations requiring caution when using : use oral tetracyclines with caution, since magnesium reduces the absorption of tetracyclines in the stomach and intestines. When used simultaneously with oral tetracyclines, the use of Magne-B6 should be delayed for at least 2 hours.
Pharmacological group
Magne B6 is a highly effective drug that corrects magnesium deficiency in the body. Basically, a person receives magnesium through food, but when the diet is unbalanced, the need for it increases. Most often, magnesium deficiency occurs during pregnancy, with increased mental stress and stress. The use of the drug eliminates magnesium deficiency and has a positive effect on bones, muscle structure, internal organs and systems. The instructions for the drug indicate that taking Magnesium B6 tablets allows you to have the following effects on the body:
- maintains cholesterol levels;
- regulates phosphorus metabolism;
- participation in neuromuscular excitation;
- improves the functioning of the heart muscle;
- takes part in fat, protein and carbohydrate metabolism;
- has a neuroprotective effect;
- synthesizes enzymes;
- stimulates the production of blood cells.
Thanks to the unique composition of the drug, its use allows it to improve the functioning of the whole organism, eliminate pathological processes, and reduce the risk of developing serious diseases.
Signs of intoxication
In case of magnesium poisoning, signs of acute and chronic phases are distinguished. Chronic intoxication occurs due to prolonged use of high concentrations of the substance. The mineral accumulates in tissues, hence a certain symptom:
- The hair on the head becomes dry and brittle;
- The mood is complete apathy;
- There is a constant sleepy state;
- Nausea occurs periodically;
- Disorders in the digestive process are observed.
A single high dose of the drug can lead to acute poisoning of the body. Often this form is provoked by a failure of the organs of the excretory system.
Symptoms of magnesium overdose:
- A sharp attack of nausea with a gag reflex;
- Failure of the digestive organs;
- The intestinal mucosa is irritated, resulting in diarrhea;
- Blood pressure drops to critical levels;
- Slowness or complete absence of reflexes;
- Uncontrolled muscle and facial movements;
- Heart rate increases to 100-130 beats per minute;
- Sometimes coma and death occur.
Excess of the compound has a negative effect on all body systems. Signs appear depending on the damage to a specific organ or system.
Reaction of the nervous system to mineral surplus
The nervous system reacts acutely to an excess of the drug:
- Unconditioned reflexes appear slowly or are absent;
- The skin and limbs lose sensitivity;
- Disturbances in the respiratory system - difficulty breathing, suffocation;
- Prolonged deep fainting;
- Muscle paralysis;
- Sometimes a coma and a state of lethargic sleep may occur.
Muscle activity in magnesium overdose
When poisoned by a substance, impulses from the nerve centers travel to muscle tissues with disturbances. This provokes a decrease in overall tone, the contraction function is absent or appears late, which leads to paralysis. Often the situation manifests itself in a disorder of intestinal motility - intense diarrhea, lack of tone and reflexes.
Cardiovascular system with an overdose of the element
Excess magnesium causes a relaxed state of the heart muscle, causing a decrease in heart rate.
Signs of heart damage:
- Blood vessels begin to rapidly expand;
- Heart rate is reduced to a minimum;
- Blood pressure drops to the limit;
- Nerve impulses from the atria do not reach the ventricles of the heart;
- Possible cardiac arrest.
The cardiac system usually suffers in elderly people when receiving a high dose of the substance.
Indications for use
Indications for the use of the drug are considered to be various dysfunctions of the central nervous system, which manifest themselves against the background of magnesium deficiency in the body.
For adults
- sleep disturbance;
- increased fatigue;
- physical or mental fatigue;
- increased irritability;
- muscle pain and spasms;
- feeling of anxiety.
For children
Children can take Magnesium B6 from 6 years of age with the following disorders:
- increased nervous excitability;
- sleep problems;
- unreasonable fears and worries;
- mental stress;
- acidosis.
For pregnant women and during lactation
The drug is considered especially useful for women during pregnancy. Taking the drug allows you to protect the nervous system and eliminate the deficiency of useful components. Magnesium is extremely important for a pregnant woman, since its lack can lead to the development of hypoxia. The following complaints may be indications for prescribing the drug:
- mood swings;
- increased irritability;
- insomnia;
- increased fatigue;
- severe toxicosis;
- risk of miscarriage;
- cramps of the calf muscles;
- hair loss.
Magnesium can be prescribed at any stage of pregnancy, but its use must be agreed with your doctor.
Magnesium Dosage to Regulate Blood Sugar Levels
People with diabetes may be more likely to have low magnesium levels (, ).
High blood sugar can increase the loss of magnesium through urine, causing low blood magnesium levels.
Research has shown that magnesium supplements may help regulate blood sugar levels by managing the action of insulin ().
Insulin is a hormone that helps control blood sugar levels by signaling your cells to consume sugar from your blood.
One study found that taking 2,500 mg of magnesium daily in a magnesium chloride solution improved insulin sensitivity and blood sugar levels in people with type 2 diabetes and low magnesium levels at baseline ().
However, another study found that people who received 20.7 mmol of magnesium oxide daily had no improvement in blood glucose regulation.
However, it should be noted that those who received a higher dose of magnesium oxide (41.4 mmol per day) experienced a decrease in fructosamine, an average measure of a person's blood sugar level, over about 2 to 3 weeks ().
The researchers concluded that long-term magnesium supplementation at higher than usual doses may help control blood glucose levels, but further research is needed ().
Summary:
Very high doses of magnesium supplements (2500 mg per day) have been found to improve blood glucose levels in patients with diabetes, but more research is needed.
Applications and dosages
The instructions for use contain standard doses of the drug, but the doctor must prescribe it individually for each patient.
For adults
The drug tablets should be taken with a sufficient amount of water. The daily dose for an adult is 6 – 8 tablets. The therapeutic course is 30 days.
For children
Children over 6 years old are prescribed 1 tablet twice a day. The tablets must be swallowed whole, but if the child has difficulty swallowing the tablet, it can be crushed and mixed with a small amount of water.
For pregnant women and during lactation
During pregnancy, the daily dose of the drug should not exceed 4 - 6 tablets. The dose should be determined by the doctor based on the general condition of the pregnant woman.
Contraindications
Sometimes taking this pharmacological agent is prohibited. The instructions indicate that it is not recommended for use if you are hypersensitive to the components contained in the composition. Under the age of 6 years, the drug can be prescribed only in case of emergency.
In this case, it is better to give preference to the liquid form of the medication, which contains less magnesium and pyridoxine.
If the patient has lactose deficiency, then the attending physician should prescribe a similar drug, but with a different composition. Use with caution in patients with renal failure and phenylketonuria.
Side effects
Magnesium B6 is well tolerated, but in a number of exceptions, after taking the medicine, adverse reactions of the body may occur:
- skin rashes;
- bronchospasm;
- nausea;
- abdominal pain;
- stool disorder;
Adverse reactions after taking the drug are very rare, but if they develop, you should stop taking the drug as soon as possible and consult a doctor. The doctor may be able to stop taking the drug or reduce the dose of the drug.
Magnesium Dosage to Improve Athletic Performance
Various studies on the effects of magnesium supplementation on physical performance have shown that the potential for improvement is largely based on dosage.
For example, two studies that used doses of 126–250 mg of magnesium per day found no significant changes in physical performance or muscle mass gain.
The researchers concluded that any beneficial effects from taking magnesium at these doses were not strong enough to be detected (, ).
However, another study found that volleyball players who took 350 mg of magnesium per day showed improved athletic performance compared to the control group ().
Summary:
Taking magnesium in doses of 350 mg or higher per day may improve physical performance.
special instructions
- Take the drug with caution if you have diabetes, since the outer shell of the tablet contains sucrose.
- The tablets are intended only for adults and children over 6 years of age.
- Before taking the medicine, you should study the instructions for use.
- Children under 6 years of age are recommended to take other forms of the drug: injections, suspension.
- It is prohibited to exceed the daily dose of the drug.
- Do not take the drug without first consulting your doctor.
- If after 2 weeks of taking the medicine there are no positive results from the treatment, tell your doctor.
Magnesium dosage to improve sleep
Adequate magnesium levels are important for good sleep. Magnesium can help your brain relax and your body achieve deep, restorative sleep.
In fact, studies in rats showed that suboptimal magnesium levels resulted in poor sleep quality ().
Currently, a limited number of studies have examined the effects of magnesium supplementation on sleep quality, making it difficult to recommend a specific daily dose.
However, in one study, older adults who received 414 mg of magnesium oxide twice daily (500 mg magnesium per day) had better sleep quality compared to adults who received a placebo ().
Summary:
Based on limited research, taking 500 mg of magnesium per day may improve sleep quality.
Analogs
Instead of Magnesium B 6, the following medications can be used:
- Magnelis B6 is a complete analogue of the drug Magnesium B6. It is produced in tablets that can be used in patients over 6 years of age, including during pregnancy. It is not advisable to take the medicine during lactation.
- Magnistad is a medicine from the Shtad company, which is a complete analogue of Magnesium B6. It is produced in enteric-coated tablets. They can be used to treat patients over 6 years of age, including pregnant patients. Magnesium is excreted through the mammary glands, so the medicine is not recommended for breastfeeding women.
- Magnesium plus B6 is a complete analogue of the drug Magnesium B6. The medicine is produced by Valenta Pharmaceuticals PJSC, Russia. Both drugs are similar, have similar indications and limitations, causing the same side effects.
- Magnesium Plus is a combined medication containing magnesium carbonate and lactate, pyridoxine, cyanocobalamin, and folic acid as active ingredients. It is sold in effervescent tablets. They are allowed to be drunk by persons over 6 years of age, including during pregnancy.
Types of Magnesium Supplements
There are many forms of magnesium supplements available on the market today.
The most important thing to consider before deciding to take a supplement is its absorption rate, or how well it is absorbed into your body.
Here are brief descriptions of the most common magnesium supplements.
Magnesium gluconate
Magnesium gluconate is produced from the magnesium salt of gluconic acid. In rat studies, this form of magnesium was found to have the highest absorption rate of any other type of magnesium supplement ().
Magnesium oxide
Magnesium oxide contains the largest amount of elemental or actual magnesium by weight. However, it is poorly absorbed. Research has shown that magnesium oxide is practically insoluble in water, making the absorption rate low (, ).
Magnesium citrate
Magnesium citrate combines magnesium in salt form with citric acid. Magnesium citrate is relatively well absorbed by the body and is highly water-soluble, meaning it mixes well with liquids ().
Magnesium citrate comes in tablet form and is commonly used as a saline laxative before a colonoscopy or surgery.
Magnesium chloride
Like magnesium gluconate and citrate, magnesium chloride is well absorbed by the body ().
It is also available as an oil that can be applied topically, but further research is needed to fully understand how well magnesium in this form is absorbed through the skin ().
Magnesium hydroxide
Magnesium hydroxide, also known as milk of magnesia, is commonly used as a laxative to treat constipation, and some antacids to treat heartburn (,).
Magnesium aspartate
Magnesium aspartate is another common magnesium supplement that is well absorbed by the human body (,).
Magnesium glycinate
Magnesium glycinate has been found to have a relatively good absorption rate with less laxative effect.
This is likely due to the fact that it is absorbed in a different area of the intestine compared to many other forms of magnesium supplements ().
Summary:
There are many forms of magnesium supplements available on the market today. It is important to consider the absorption rate of the supplement before making a purchase.
