The drug Omnic is a specific blocker of α1-adrenergic receptors; these receptors are located directly in the smooth muscles of the prostate gland, as well as parts of the urinary tract that come into contact with the prostate and the bladder neck. The drug Omnic is a urodynamic corrector, and is also in the group of alpha-blockers and belongs to drugs that affect the metabolic processes occurring in the prostate.
This medicine is used during the treatment of certain types of prostatitis, for example, atonic.
Pharmacological authorities
Pharmacodynamics.
Omniq® selectively and competitively blocks postsynaptic α1-adrenergic receptors, α1A and α1D, which are located in the smooth muscles of the anterior pelvis, the cervix and the prostatic part of the urethra. This leads to a decrease in the tone of the smooth muscles of the anterior pelvis, the neck of the mikhur and the prostatic part of the urethra and the swelling of the visible section. Symptoms of obstruction and irritation associated with benign hyperplasia of the anterior gland suddenly change (difficulty in cutting, weakening of the cut, stinging after completion of cutting, in іndings of the uneven sporulation of the secho, parts of the deposit before the release, put before the release at night, the difficulty of release) .
These effects are preserved for a long time with long-term debridement and are significantly followed by surgical operation or catheterization.
Antagonism of α1-adrenergic receptors may reduce arterial pressure as a result of a decrease in peripheral vascular tone. During the study period, no clinically significant decrease in arterial pressure was observed with Omniq®.
Pharmacokinetics.
Installation:
Tamsulosin is readily absorbed from the colonic-intestinal tract, and its bioavailability is as high as 100%. The absorption of tamsulosin is even more effective after taking it. However, the new level of infusion is achieved when the patient takes Omnic® at the same hour after taking it. The pharmacokinetics of tamsulosin is linear.
After taking a single dose of Omniku®, the peak concentration of tamsulosin in the blood plasma is reached after approximately 6 years, and a stable concentration is maintained until after the drug has been consumed. Cmax is approximately two-thirds higher than that achieved after taking a single dose.
Rozpodil:
In humans, tamsulosin is approximately 99% bound to plasma proteins. The dose volume of the drug is insignificant (approximately 0.2 l/kg).
Metabolism:
tamsulosin hydrochloride is not subject to the first-pass effect and is extensively metabolized in the liver with the release of pharmacologically active metabolites, which maintain high selectivity for α1-adrenergic receptors. Most of the active speech is present in the blood of an unchanged appearance.
Elimination:
It is important for tamsulosin and its metabolites to be excreted from the body. Approximately 9% of the dose is lost from apparently unchanged active speech.
After a single dose of Omniku® after eating at a stable blood plasma concentration, the recovery period is approximately 10 to 13 years.
Action without problems
When using Omnic capsules to solve urological problems, it is important to remember that it may not be combined with all medications. In particular, the minimal consequence of taking the drug together with diuretics (for example, with Furosemide) may be a decrease in its therapeutic effect, and when used simultaneously with antiulcer drugs (in particular with Cimetidine), it may increase its effect.
The components of Omnic can be eliminated from the body before their maximum beneficial concentration is reached if the patient simultaneously takes drugs such as Diclofenac and Warfarin.
Side effects in the form of a noticeable decrease in blood pressure can be caused if Omnic is taken simultaneously with other types of alpha1-blockers.
The Omnic Okas form does not recommend driving a vehicle after taking it
Interactions with other medicinal drugs and other types of interactions
The study of mutual interactions was observed only in adults.
When tamsulosin hydrochloride was ingested for one hour with atenolol, enalapril, nefedipine or theophylline, no drug interactions were observed. At the same time, treatment with cimetidine increases, and with furosemide, it reduces the concentration of tamsulosin in the blood plasma, otherwise the fragments are lost within the normal range, there is no need for special correction of tamsulosin dosing and.
In vitro studies
Diazepam, propranolol, trichlormethiazide, chlormadinone, amitriptyline, diclofenac, glibenclamide, simvastatin and warfarin do not interfere with the free fraction of tamsulosin in human plasma. Similarly, tamsulosin does not change the level of free fractions of diazepam, propranolol, trichlormethiazide and chlormadinone in human blood plasma.
Diclofenac and warfarin may increase the rate of elimination of tamsulosin.
Acute administration of tamsulosin hydrochloride with strong CYP3A4 inhibitors may result in increased influx of tamsulosin hydrochloride. Acute administration of ketoconazole (a known strong CYP3A4 inhibitor) increased AUC and Cmax to 2.8 and 2.2 bp.
Tamsulosin hydrochloride should not be used in combination with strong CYP3A4 inhibitors in patients with low CYP2D6 metabolism.
Tamsulosin hydrochloride should be used with caution when combined with strong and moderate CYP3A4 inhibitors.
Acute administration of tamsulosin hydrochloride and paroxetine (a strong CYP2D6 inhibitor) increased Cmax and AUC to 1.3 and 1.6%, but not clinically significant.
Short-term use of other α1-blockers may enhance the hypotensive effect.
What is the drug
Omnic capsules are combined drugs from the group of alpha-1-adrenergic blockers, the task of which is to influence urination disorders in the most common diseases of the prostate gland - prostatitis and adenoma (benign hyperplasia).
The dosage form of the product is a capsule of halves of orange and olive colors, with granular contents in shades from white to pale yellow.
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The composition of the drug Omnic includes the main active ingredient called tamsulosin hydrochloride. This drug ingredient in official medical documentation is called a competitive selective blocker (inhibitor) of postsynaptic alpha-1-A and alpha-1-D adrenergic receptors. The substance, when it begins to act, affects the normal contraction of the smooth muscles of the neck and body of the bladder, the prostate and the part of the urethra located in close proximity to this organ. Component performance results:
- decrease in the tone of smooth muscle cells (in these pelvic organs);
- improving the functioning of the detrusor (the muscular lining of the bladder, the contraction of which carries out the process of urination);
- “neutralization” of irritation in the genitourinary system and obstruction associated with prostate adenoma.
Also, the composition of each Omnic capsule includes a certain amount of inactive components, including: talc, iron (yellow and red oxide), as well as other excipients that do not cause any particular harm.
Omnic should be taken with caution and only after consultation with your doctor.
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The composition of the drug is strong and effective enough (the effect becomes noticeable after about 14 days) to take Omnic with caution and only after consultation with your doctor.
Features of good stagnation
As with other α1-blockers, in some cases, when taking Omniku®, there may be a decrease in arterial pressure, which can sometimes lead to loss of fluidity. When the first signs of orthostatic hypotension (confusion, weakness) appear, the patient must take a sitting or lying position until symptoms disappear.
Before starting treatment with Omniq®, you should undergo medical treatment to identify other concomitant illnesses that may cause the same symptoms as benign hyperplasia of the anterior gland. Before harvesting, it is necessary to perform a rectal stripping of the ear and, if necessary, a test for the level of specific antigen (PSA) before the ear and at intervals between an hour and an hour before the harvest.
It is necessary to prescribe the drug to patients with a severe form of nitric deficiency (creatinine clearance <10 ml/min) with special care, since clinical studies of Omniku® administration to such patients have not been carried out.
In some patients who have taken or are taking tamsulosin, during surgical treatment of actuated cataracts and glaucoma, there is atonic zone syndrome (IFIS, a variant of atonic zone syndrome), which This may cause an increase in the amount of folding in the hours or hours after such an operation.
As a rule, 1 or 2 days before surgery for cataracts and glaucoma, it is recommended to administer treatment with tamsulosin; the risk of pain associated with treatment with tamsulosin has not been clearly established to date. Atonic zone syndrome was also reported in patients who were treated with tamsulosin for three hours before cataract surgery.
Patients before elective cataract or glaucoma surgery are not recommended to start taking tamsulosin hydrochloride. In preparation for surgery, surgeons and ophthalmologists may want to know whether the patient is taking (or is taking) tamsulosin in order to prevent possible complications associated with IFIS.
Tamsulosin hydrochloride should not be used in combination with strong CYP3A4 inhibitors in patients with low CYP2D6 metabolism.
Tamsulosin hydrochloride should be used with caution in combination with strong and moderate CYP3A4 inhibitors (section “Interactions with other medicinal products and other types of interactions”).
Occasions of allergic reactions to tamsulosin have been reported in patients with a history of allergy to sulfonamides. Caution should be exercised when taking tamsulosin hydrochloride in patients who have previously been allergic to sulfonamides.
Suspension during pregnancy and breastfeeding.
Omniq® is not indicated for use in women.
Fertility
During clinical studies of tamsulosin, impairments in ejaculation were observed over a short period of time. Episodes of impaired ejaculation, retrograde ejaculation and insufficient ejaculation were observed during the post-acute period.
This is due to the fluidity of the reaction during treatment with vehicles or other mechanisms.
Testing of the infusion of the drug for delivery of ceruvate by motor transport or other mechanisms was not carried out. However, patients may be warned about the possibility of guilt confusion.
Method of congestion and dosage
The recommended dose for adults is 1 capsule, either after a meal or after the first meal. The capsule must be kept intact, without breaking or becoming pink, so that any fragments will interfere with the modified content of the active ingredient.
Patients with nitric deficiency do not require dose adjustment. Patients with mild to moderate severity of liver failure do not require dose adjustment (div. also “Contraindicated”).
Children.
The drug should not be given to children.
The safety and effectiveness of tamsulosin administration in children (age 18 and under) have not been assessed.
Omnic drug: Instructions for use
Appearance and release form
The Latin name of the drug is Omnic. The main active ingredient is tamsulosin hydrochloride . Additional substances include the following elements:
- MCC;
- methacrylic acid copolymer;
- triacetin;
- polysorbate 80;
- talc;
- sodium lauryl sulfate;
- indigotine;
- calcium stearate;
- red iron oxide;
- yellow iron oxide;
- gelatin;
- titanium dioxide.
It is manufactured and sold in capsule form , which is universal and convenient, in particular during the treatment of a disease such as prostatitis. Capsules have a volume of 400 mg and are usually green-yellow in color. In pharmacies, this product can be purchased in cardboard packs in quantities of 10 and 30 capsules.
Pharmacological effect after use
During a course of treatment of prostatitis with Omnic, the tone of the bladder, urethra and smooth muscles of the prostate gland decreases. All this significantly improves urine flow. The active component tamsulosin hydrochloride is characterized by increased selectivity, which explains why this drug does not affect smooth muscle fibers in the walls of blood vessels. However, this effect does not lead to a systemic decrease in blood pressure.
During the treatment of prostatitis, Omnic is characterized by high absorption properties into the intestines. It must be said that after eating, the absorption of tamsulosin hydrochloride slows down. After using the drug, its highest concentration in the blood is achieved within 7-8 hours . Excretion of the drug mainly occurs in the urine.
Directions for use and dosage
The medicine is taken orally. As a rule, the drug is taken in the morning, after meals. You can take only one capsule per day (volume 400 mg), wash it down with plenty of water. We must remember that the capsule must not be chewed while taking it.
Omnic: indications for use
The drug is indicated for dysuric disorders, benign prostatic hyperplasia, and also as an auxiliary drug for the symptomatic treatment of certain types of prostatitis.
The drug "Omnic" may be useful for a man suffering from benign prostate hyperplasia. Hyperplasia is an enlargement of the prostate gland. It is explained by the aging process of men; it is found in the majority of people over the age of 55. This disease is in no way associated with malignant processes, its symptoms do not constantly progress, but on the contrary, hyperplasia responds quite well to drug treatment.
Overdose
Symptoms
Overdose of tamsulosin hydrochloride can potentially cause severe hypotensive effects. Severe hypotensive effects were observed at various stages of overdose.
Likuvannya.
In case of a sharp decrease in pressure following an overdose, supportive therapy should be carried out, aimed at restoring the normal function of the cardiovascular system (for example, the patient may assume a horizontal position). If this approach does not work, conduct infusion therapy and identify vasopressor functions. It is necessary to follow the function of the niroq and conduct supportive therapy. Due to the high degree of binding of tamsulosin to plasma proteins, hemodialysis is unlikely to be effective.
By using the method of further soaking the drug, you can individually vomit. When overdosing a significant amount of the drug, the patient must rinse the plug to remove contaminated active vugill and low-osmotic laxatives, such as sodium sulfate.
Side effects
| Body system | Often (>1/100, <1/10) | Uncommon (>1/1000, <1/100), | Rarely (>1/10000, <1/1000) | Very rare (<1/10000) | Unknown (impossible to estimate given the availability of data) |
| Neurological disorders | Confused (1.3%) | Head bill | Unpretentiousness | ||
| From the side of the organs | Clouded vision*, ruined vision* | ||||
| On the side of my heart | Feel the heartbeat | ||||
| Sudin's discord | Orthostatic hypotension | ||||
| Respiratory-mediastinal disorders | Rhinitis | Nosebleed* | |||
| Shlunkovo-intestinal disorders | Constipation, diarrhea, nausea, vomiting | Dry mouth* | |||
| Loosen the sides of the skin and mucous membranes | Visip, sverbizh, kropiv'yanka | Angioneurotic lesion | Steven's syndrome sa ̶ Johnson | Multiform erythema*, exfoliative dermatitis* | |
| Reproductive damage | Ejaculation disorders, including retrograde ejaculation and failure of ejaculation | Priapism | |||
| Zagalni discord | Asthenia |
*Was observed during the post-registration period
In the postoperative period, episodes of intraoperative instability of the iris of the eye (sound zone syndrome) during cataract and glaucoma drive surgery in patients who were admitted there were clearly described. sulozin (div. section “Peculiarities of stasis”).
Post-release report
: In addition to these reported adverse reactions, episodes of atrial fibrillation, arrhythmias, tachycardia and dyspnea were reported. Seizures have been reported spontaneously, and the frequency of reported seizures due to tamsulosin administration cannot be reliably determined.
In case of any side effects, please send information to the representative office of Astellas Pharma Europe B.V., at 04050 m. Kiev, vul. Pimonenka, 13, building 7-B, office 41, tel: 044 490 68 25, fax and national notification system.
Omnic or Omnic Okas
Often patients who are prescribed treatment for prostatitis or adenoma ask questions not only about what Omnic tablets are and what they help with, but also about the possibility of replacing this drug with a drug with a similar name - Omnic Okas? Is it possible to restore health and stop the prostate inflammatory process by taking a medicine with a slightly different name? The answer from the experts is as follows: Omnic Okas can be used in treatment, and it is even recommended in cases where patients suffer from side effects that this form of medicine can avoid.
The principle of operation of Omnic Okas, which is available in the form of tablets rather than capsules, is based on the controlled release of the main active substance (tamsulosin hydrochloride), which is realized through the use of a non-ionic gel in the product. The component is released in the body slowly and slowly, accumulating within 24 hours. Absorption of the drug occurs in the intestines (up to 57% absorption), this process is not affected by the daily routine or food intake, so the tablets can be taken at any time of the day.
Like the main medication, the Omnic Okas form does not recommend driving a vehicle or engaging in activities that require increased accuracy, attentiveness and speed of reactions after taking it. As for how much both types of the drug cost, it can be noted that in most pharmacies you can find the combined Omnic at a price 100-200 rubles cheaper than its long-acting version.
Getting rid of problems with urination due to hyperplasia or prostatitis within a matter of days - with the drug Omnic (and its “advanced” version Omnic Okas) everything is possible. The main thing is not to do this without the supervision of a doctor, who will conduct an examination, warn about potential side effects, and most importantly, tell you when you can stop taking the medication. And you also need to be able to stop in time to avoid the development of another disease - hypochondria.
