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Manufacturers: Poli Industria Chimica SpA
Active ingredients
- Nystatin
- Nifuratel
Disease class
- Urogenital trichomoniasis
- Candidiasis of the vulva and vagina (N77.1*)
- Other inflammatory diseases of the vagina and vulva
Clinical and pharmacological group
- Not indicated. See instructions
Pharmacological action
- Antifungal
- Antiprotozoal
- Antibacterial
Pharmacological group
- Other synthetic antibacterial agents in combinations
pharmachologic effect
Antimicrobial drug for topical use.
It has antiprotozoal, antifungal and antibacterial effects. Nifuratel, a nitrofuran derivative, is highly active against
a number of bacteria, fungi and protozoa (including Trichomonas vaginalis).
Nystatin is an antifungal antibiotic of the polyene group. By binding to sterols in the cell membrane of fungi, it disrupts its permeability, which leads to cell death. Highly active against
Candida albicans.
The combination of nifuratel and nystatin allows one to achieve a more pronounced antifungal effect and significantly expand the spectrum of antimicrobial action. The high efficiency and low toxicity of the components of the drug determine a wide range of its clinical use in the treatment of vaginitis of mixed etiology, in particular, use for the prevention of mycoses caused by the specific treatment of trichomoniasis.
Macmiror complex does not disturb the physiological flora, which allows you to avoid the development of dysbacteriosis and quickly restore vaginal normocenosis.
McMiror complex
Macmiror Complex is a combined antibacterial agent for the treatment of vulvovaginitis caused by microorganisms sensitive to the active components of the drug (including trichomonas, candida, chlamydia). The most common causes of vaginitis are infestations of Trichomonas, Candida, and Gardnerella. The main complication of such infections is recurrence, which disrupts the well-being of both the woman herself and the couple as a whole. With trichomoniasis, there is a high risk of an asymptomatic course of this disease in the partner, who, due to the latency of the pathological process, in most cases is not inclined to undergo treatment. In this regard, in such situations, when it is impossible to accurately diagnose the pathogen, the prevalence of mixed infections and the likelihood of recurrence should be taken into account when choosing treatment tactics. For this reason, today the standard treatment for mixed vulvovaginitis is the use of combination drugs that act on bacteria, fungi, and protozoa. A drug that meets this criterion is Macmiror Complex, which contains two active components: nifuratel and nystatin. The first exhibits a pronounced trichomonadocidal effect, which is more powerful than metronidazole. Nifuratel also has fungicidal and antibacterial effects. In turn, nystatin increases the permeability of the fungal membrane and, even in low doses, can have an antimycotic effect.
Nystatin does not have a bactericidal or bacteriostatic effect. Nifuratel and nystatin potentiate the antimycotic effect of each other. Nystatin also potentiates the antibacterial and antiprotozoal effects of nifuratel. In clinical studies, Macmiror Complex demonstrated effectiveness in 60-100% of cases, depending on the causative agent of the infection. A repeated medication course brought the desired result in 85-100% of cases. Both dosage forms of the drug - cream and suppositories - showed equal effectiveness. The drug is well tolerated by patients, incl. pregnant women. Suppositories are used in the evenings before going to bed for 8 days (by agreement with the doctor, a different duration of pharmacotherapy is possible). After menstruation, the medication course can be repeated. The suppository is inserted into the upper area of the vagina. In pediatric practice, suppositories are not used, preferring cream. Single dose of cream – 2.5 g. Frequency of use – 1-2 times a day. Duration of treatment – 8 days. The cream is applied using the graduated applicator included in the package. The drug has a favorable safety profile: only in rare cases are side effects possible in the form of dermatological manifestations (itching, rash). Due to the risk of repeated microbial invasion, it is recommended to simultaneously treat the sexual partner.
Instructions for use / dosage
The drug is intended for topical use for gynecological or venereal diseases.
Vaginal suppositories
1 vaginal suppository is administered daily in the evening before bed for 8 days or as recommended by your doctor. If necessary, treatment can be repeated after menstruation.
To achieve the maximum therapeutic effect, the suppository should be inserted into the upper part of the vagina.
Suppositories are not used for treatment in children. For this category of patients, it is recommended to use vaginal cream complete with an applicator (graduated syringe).
Vaginal cream
Prescribe 2.5 g of cream 1-2 times a day. (morning or evening) for 8 days.
The required dose of cream should be administered using a graduated applicator.
Instructions for use of the graduated applicator
Screw the graduated applicator onto the tube of cream. Take the required amount of cream (in accordance with the scale lines indicating the amount in grams) by pressing on the tube. Disconnect from the tube, insert into the vagina, squeeze out the contents of the applicator, pressing on the rod.
The presence of a special nozzle allows you to introduce the cream without damaging the hymen. To do this, you need to remove the cannula from the top of the shaft and screw it onto the head of the syringe from the opposite side before inserting the cream into the vagina.
Release forms, composition and packaging
The drug "Makmiror" is an antiprotozoal and antibacterial agent; It can be purchased in the following forms:
- White tablets intended for oral administration. Sales are carried out in cardboard boxes containing blister packs of 10 tablets.
- Suppositories intended for vaginal administration; are used mainly for the treatment of gynecological diseases of infectious origin. One package contains 8 candles.
- The cream is prescribed for vaginal administration using a special applicator for the treatment of sexually transmitted or gynecological diseases. One tube contains 30 grams of the drug.
The active substance that provides the pharmacological effect of Macmiror is nifuratel: its content in each tablet is 200 mg, in a suppository - 500 mg, in 1 g of cream - 100 mg.
Various forms of the drug contain other auxiliary components:
- In tablets : gelatin, starch, medical talc, polyethylene glycol, magnesium stearate and carbonate, titanium dioxide and sucrose.
- In suppositories : nystatin, wax.
- In the cream : sodium benzoate, xalifin, carbomers, sorbitol, glycerol, triethanolamine and propylene glycol.
Pills
Suppositories
Cream
special instructions
When using McMirror, the following points must be taken into account.
- Incompatibility with alcohol. While taking the drug, avoid drinking drinks and products containing alcohol. Otherwise, nausea and deterioration in well-being are possible.
- Treatment with a partner. For vaginal infections, it is necessary to take the drug to the sexual partner at the same time to prevent the possibility of re-infection.
- Intimate relationships. While using the drug, you must abstain from sexual contact or use barrier methods of contraception. During menstruation, vaginal suppositories and cream are not used.
- Diabetes. The medicine contains sucrose, which must be taken into account when prescribing it to those who suffer from increased blood glucose levels.
- Storage. The medicine should be kept in a place protected from light, at temperatures up to 25°C. The shelf life of the medicine is five years.
The drug "Makmiror" shows high effectiveness in the treatment and prevention of genitourinary pathologies (in both women and men), parasitic diseases and infections of the digestive organs (for example, when infected with Helicobacter pylori). The product has a minimal risk of side effects. Reviews from doctors prove the effectiveness and safety of the medicine. However, taking the drug must be agreed with your doctor. In some cases, the use of Macmiror cream is allowed in girls from three years of age in the treatment of vulvovaginitis.
Side effects
In rare cases, the use of Macmiror provokes the following side effects:
- The reaction from the digestive system can manifest itself in the form of a feeling of nausea and profuse vomiting, heartburn, diarrhea, discomfort in the epigastric region and the appearance of an unpleasant metallic taste in the mouth.
- Local allergic reaction in the form of dermatitis, itching and burning sensation, redness of the skin or mucous membranes.
Patient reviews
The variety of release forms and the minimum number of contraindications make Macmiror a fairly safe drug that can be used in various ways.
It demonstrates a high degree of effectiveness in the treatment of many inflammations caused by the activity of microorganisms, but prior consultation with a specialist and diagnostic testing are always required to make an accurate diagnosis and prescribe adequate treatment.
Marina Maksimova
Gastroenterologist, Candidate of Medical Sciences and editor of articles at gastro911.com. For more than 10 years I have been helping to recover from gastrointestinal diseases.
Pathologies for which the drug is prescribed
Indications for the use of Macmiror are as follows.
- Diseases of the urinary system. Cystitis, pyelonephritis, urethritis, pyelitis.
- Gynecological infections. Pathogens must be sensitive to nifuratel. These are chlamydia, fungi of the genus Candida with thrush, trichomonas, opportunistic microbes with their intensive reproduction and clinical manifestations of bakvaginosis.
- Parasitic and intestinal infections. Amebiasis, giardiasis, shigellosis, salmonellosis.
- Helicobacter Pylori infection. Peptic ulcer, chronic gastritis.
In suppositories and cream, the drug is used for local treatment of gynecological diseases. It is prescribed as part of the treatment of colpitis, cervicitis, endometritis, including when specific pathogens are detected.
Drug interactions
"Makmiror" can be used as part of complex therapy with permission from the attending physician. The drug does not enter into undesirable pharmacological interactions with other substances.
It is necessary to be careful and, if possible, avoid simultaneous use with drugs based on nystatin , since nifuratel can significantly enhance their therapeutic effectiveness.
McMiror and alcohol
There is no exact information about the interaction of nifuratel and ethyl alcohol.
Experts recommend refraining from the parallel use of Macmiror and alcoholic beverages.
This may lead to the following consequences:
- Reduced therapeutic effectiveness of Macmiror in the treatment of infectious diseases.
- Increased risk of side effects from the digestive system in acute form.
Impact on the ability to drive vehicles
The use of Macmiror in any form and dosage does not cause undesirable reactions from the nervous system.
For this reason, after taking the drug, no restrictions are introduced on the ability to drive vehicles, other mechanisms, or carry out other activities that require increased attention.
Is it possible for pregnant and lactating women
The active component of Macmiror tablets easily penetrates the placental barrier. Therefore, the drug can be used during pregnancy only in cases where the benefits to the woman’s health are higher than the possible risks to the fetus. And strictly as prescribed by the attending physician.
Nifuratel, when taken internally, passes into breast milk. Therefore, if there is a need to prescribe a tablet form of medication while breastfeeding, the baby should be switched to artificial formulas for the duration of treatment.
"Makmiror" in the form of cream and vaginal suppositories during lactation and pregnancy is not contraindicated. They are used to detect gardnerellosis, vaginal candidiasis, trichomoniasis, ureaplasmosis, and chlamydia.
Indications for use
The use of the drug "Makmiror" is prescribed in the presence of the following indications:
- Chlamydia.
- Vulvavaginal candidiasis.
- Lesions of the genitourinary system caused by the activity of Trichomonas vaginalis.
- Vaginal infectious diseases caused by bacteria and microorganisms that are sensitive to the drug.
- Gastritis in chronic form.
- Ulcerative lesions of the stomach and intestines.
- Gastroesophageal reflux disease.
- Amoebic dysentery.
- Inflammatory lesions of the mucous membranes of the renal pelvis of bacterial origin.
- Cystitis.
- Inflammation of the urethra.
- Acute inflammatory processes occurring in the upper gastrointestinal tract and caused by the activity of spiral-shaped bacteria.
- Lesions and disturbances in the functioning of the digestive system, the causative agent of which is Giardia.
