Compound
Vaginal cream contains:
- nystatin , nifuratel ;
- glycerin , sodium methyl parahydroxybenzoate, propylene glycol, triethanolamine 30%, xalifin, sodium propyl parahydroxybenzoate, 70% sorbitol solution, water.
Vaginal suppositories include:
- nystatin, nifuratel;
- glycerin, titanium dioxide, sodium ethyl parahydroxybenzoate, gelatin, yellow iron oxide.
Release form, composition and packaging Makmiror Complex candles
The drug Macmiror Complex is available in the form of suppositories for vaginal administration. Suppositories are an oblong gelatinous substance with a pointed end, yellow in color with a brownish tint. Candles are packaged in cellular contour packs of 8 or 12 pieces in a cardboard box.
Vaginal soft gelatin suppositories, egg-shaped, yellow with a brown tint; the contents of the suppositories are a yellow oily suspension. 1 sup: nifuratel 500 mg; nystatin 200 thousand. Excipients: dimethylpolysiloxane AK 1000 (dimethicone) 960.0 mg.
Shell composition: gelatin 351.0 mg, glycerin (glycerol) 171.0 mg, sodium ethyl parahydroxybenzoate 1.8 mg, sodium propyl parahydroxybenzoate 1.0 mg, titanium dioxide 0.4 mg, yellow iron oxide 2.4 mg. Packing: 8 pcs. - blisters (1) - cardboard packs; 12 pcs. - blisters (1) - cardboard packs.
Pharmacodynamics and pharmacokinetics
Macmiror Complex is a combined local antifungal drug. Nifuratel effectively fights many types of bacteria, fungi and protozoan microorganisms (for example, Trichomonas vaginalis ).
Nystatin is an antifungal antibiotic. It disrupts the permeability of the fungal membrane, after which the cell is destroyed. Particularly effective against Candida albicans .
The combination of nystatin and nifuratel makes it possible to increase the effectiveness of the antifungal action and expand the range of indications for use.
McMikor Complex has low toxicity, due to which it does not destroy the physiological flora, does not cause dysbacteriosis and quickly restores vaginal normocenosis.
Medicine Macmiror: indications for use
The drug is active against a large number of protozoa and other pathogenic flora. The drug Macmiror is well tolerated. According to the results of clinical studies, the drug causes much fewer complications than other antibacterial agents.
An example is the examination of 120 patients with severe bacteriuria. They were divided into two groups, half took penicillin antibiotics, which are considered the least toxic, and the other took the drug Macmiror. Among the first group of patients, the occurrence of side effects was noted in 40% of patients, and among the second - only in 15%, which indicates a low risk of adverse reactions.
Given the wide range of therapeutic effectiveness of the active substance, the drug Macmiror is prescribed for the treatment of the following diseases:
- acute amoebiasis; giardiasis;
- indigestion and gastroenteritis of bacterial origin;
- trichomoniasis of the genital organs and urinary tract;
- peptic ulcer of the stomach and duodenum;
- pathologies of the upper digestive tract caused by Helicobacter pylori;
- cystitis; urethritis;
- bacterial kidney damage, including pyelonephritis and tubulointerstitial nephritis;
- vaginitis, vulvitis and vulvovaginitis, provoked by sensitive flora (medicine Macmiror Complex is used topically);
- candidiasis aggravated by a secondary bacterial infection;
- cholecystopancreatitis; enterocolitis;
- gastroduodenitis; gastroesophageal reflux;
- bacteriuria of unknown etiology.
Candles and cream Macmiror Complex, instructions for use
The drug is used intravaginally .
Every day for 8 days before bedtime, apply 2.5 g of cream using an applicator. The instructions for Macromir Complex suppositories are the same as for the ointment; 1 suppository should be administered per day. To maximize the effect, the suppository is inserted into the upper part of the vagina. After menstruation, treatment can be repeated if necessary.
In childhood, vaginal suppositories are not used; in such cases, it is recommended to use a cream with an applicator .
Pharmacological properties of the drug Makmiror Complex suppositories
Macmiror Complex is an antimicrobial agent for topical use. The active components included in the drug have a pronounced antifungal, antiparasitic and antibacterial effect on the female pelvic organs.
Nifuratel, which is part of the suppository, is a derivative of Nitrofuran and exhibits high therapeutic activity against bacteria, fungi and Trichomonas. Macmiror Complex suppositories are prescribed to women and girls over 18 years of age for the treatment of vaginitis and vulvovaginal infections of various origins.
The combination of two active components of the drug Macmiror Complex allows you to achieve the most pronounced therapeutic effect in relation to pathogens of female genital infections.
Nystatin belongs to the polyene group of antibiotics. The drug acts directly on the pathogen cells, disrupting their permeability and causing their death. Nystatin exhibits high activity against yeast-like fungi of the genus Candida.
Under the influence of Makmicor Complex suppositories, the physiological microflora of the vagina is not disturbed, which makes it possible to avoid dysbiosis of the genital tract and restore the natural pH environment of the vagina in the shortest possible time.
Indications for use of Macmiror Complex suppositories:
- chlamydia; trichomoniasis;
- fungal diseases, in particular thrush caused by fungi of the genus Candida;
- vaginal dysbiosis.
Price for McMirror Complex, where to buy
The cream in Russia costs 465 rubles, in Ukraine – 172 UAH.
The average price of McMirror Complex candles in Russia is 491 rubles, in Ukraine – 109 UAH.
- Online pharmacies in RussiaRussia
- Online pharmacies in UkraineUkraine
ZdravCity
- Macmiror Complex vaginal capsules.
200000IU + 500 mg 8 pcs. Doppel Pharmaceutical S.r.L. RUR 775 order - Macmiror Complex cream vaginal. 30gDoppel Pharmaceutical S.r.L.
RUB 809 order
Pharmacy Dialogue
- Macmiror Complex (cream vaginal tube 30g)Doppel
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Pharmacy24
- Macmiror Complex 30 g cream Doppel Pharmaceutical Srl, Italy
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Use of Macmiror suppositories during pregnancy
Hormonal changes during pregnancy lead to a decrease in immunity, so viruses and bacteria begin to attack the woman’s body with redoubled force, causing, first of all, changes in the microflora. This leads to the development of inflammatory processes in the genital organs.
To eliminate negative consequences, Macmiror is often prescribed during pregnancy, reviews of which are mostly positive. This is an antibacterial drug that has a gentle effect on the vaginal microflora and does not cause the development of dysbacteriosis.
One of the main active ingredients of the drug is nifuratel, which is effective against various bacterial pathogens. This substance itself is not particularly safe and has some side effects.
Thanks to recent pharmacological developments, it has been possible to minimize negative effects, resulting in the appearance of this drug, Macmiror, which can also be used during pregnancy.
Macmiror, while maintaining high efficiency, practically does not provoke the occurrence of complications. In addition, nifuratel is not addictive, so the drug can be used for relapses of the disease.
Indications for use of Macmiror suppositories during pregnancy
Despite the fact that the Macmiror suppositories used during pregnancy have mostly positive reviews, they should only be prescribed by the attending physician; self-medication is unacceptable. Before prescribing therapy, the specialist will conduct a comprehensive examination in order to make an accurate diagnosis and select the optimal course of treatment.
Macmiror during pregnancy is prescribed for infectious diseases of the genital tract, as well as for preventive purposes. Therapy will be effective only if the pathological microorganisms are sensitive to the active components of the drug.
The main indications for the use of Macmiror suppositories during pregnancy are:
- chlamydia, trichomoniasis;
- fungal infections: candidiasis; infectious inflammatory processes; bacterial infections of the genital organs;
- prevention of genital infections.
"Makmiror" during pregnancy: instructions for use
Having previously carried out a bacteriological examination of vaginal discharge, the doctor will prescribe a drug in the form of suppositories or vaginal cream, depending on the nature of the pathology and the patient’s condition.
Vaginal suppositories are inserted deep into the vagina once a day, preferably before bedtime. Before using the drug, you must wash your hands and genitals well. The course of treatment with Macmiror suppositories during pregnancy is no more than eight days.
In some cases, the doctor may recommend continuing therapy for up to 10-14 days. The unpleasant manifestations of the disease will disappear within a few days. The drug "Makmiror" has earned positive reviews from both doctors and patients, which indicates its high effectiveness.
But if you have vaginal discharge, itching and burning sensations, you should not prescribe treatment with the drug yourself, especially while pregnant.
Women who use it are confident that the product has helped them overcome various pathologies of the genital area. At the first unpleasant symptoms, consult a doctor, this will protect both yourself and the child from negative consequences.
Side effects when using Macmiror suppositories during pregnancy
If pronounced side effects occur, you should consult a doctor to rule out a severe form of allergy. The doctor will also determine the advisability of further treatment with the drug. Negative manifestations disappear almost immediately after discontinuation of the medication.
Patients note another minor drawback of the drug. Brightly colored suppositories stain underwear. But this problem is not difficult to eliminate if you use panty liners during therapy. In addition, not everyone is happy with the considerable price of the product.
When using the drug, side effects may occur in the form of:
- allergic reactions, itching, rash, redness of mucous membranes;
- general deterioration of health, headaches;
- disorders of the gastrointestinal tract, nausea, diarrhea.
Contraindications Macmiror suppositories during pregnancy
According to the instructions, Macmiror suppositories are approved for use during pregnancy. The exception is individual intolerance to individual components of the product, and the drug is not used if the pathogenic microflora is not sensitive to it.
Conducted studies prove the safety of the drug for a pregnant woman and fetus. Although, according to some experts, drug therapy for a long time can cause premature birth or miscarriage. But such information has no clinical confirmation.
Special instructions for use and precautions
- During the treatment period, it is recommended to abstain from sexual intercourse .
- To achieve the desired effect, you should treat your sexual partner using the drug in the form of a cream.
- During the course of treatment with Macmiror suppositories, it is recommended to stop drinking alcohol .
- Macmiror suppositories do not affect the ability to drive a car or engage in activities requiring high concentration.
The drug is available with a doctor's prescription .
Analogs of Makmiror Complex candles
Before replacing the prescribed drug with one of the listed analogues, you should definitely consult your doctor.
These drugs have different compositions, indications, contraindications and therapeutic activity against infectious agents in comparison with the Macmiror Complex suppository.
The following drugs are similar in their therapeutic effect to Macmiror Complex suppositories:
- Hexicon suppositories; Diflucan suppositories;
- Livarol suppositories; Clotrimazole vaginal tablets, cream;
- Nystatin tablets for oral use;
- Pimafucin suppositories.
