Buy Medichronal Darnitsa

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Active ingredients

Glycine
Povidone
Glucose monohydrate
Sodium formate

Disease class

Mental and behavioral disorders caused by alcohol consumption - dependence syndrome

Clinical and pharmacological group

Not indicated. See instructions

Pharmacological action

Detoxifying

Pharmacological group

Means for the correction of disorders in alcoholism, toxic and drug addiction in combinations

pharmachologic effect

The complex action product is quickly absorbed into the intestines and has almost 100% bioavailability for the body. The components of the drug easily penetrate the blood and tissues and reduce the concentration of alcohol breakdown products and their toxicity. The product is also effective against acetaldehyde, which is a product of ethanol oxidation.

In addition to detoxification, the drug also helps to improve metabolic processes in the body and enhance the production of catecholamines, which stimulate the functioning of the cerebral cortex.

The drug also has a positive effect on the liver, reducing the degree of damage from ethanol. Improves sleep quality and overall well-being after intoxication. A decrease in the manifestations of alcohol intoxication, depending on its intensity, is observed after 20–30 minutes.

Granules for the preparation of oral solution Medichronalum

Instructions for medical use of the drug

Description of pharmacological action

Medichronal-Darnitsa is a combined drug that helps reduce the accumulation of toxic alcohol metabolites in the body, in particular acetaldehyde (a product of ethanol oxidation). The drug has a detoxification effect, improves metabolic processes in the body, enhances the synthesis of catecholamines, especially norepinephrine, which improves neuromediation processes, stimulates the limbic-reticular complex, and increases the functional activity of the cerebral cortex. The drug Medichronal-Darnitsa has a positive effect on liver function, and also improves sleep and overall well-being. A decrease in the symptoms of acute alcohol intoxication and symptoms of mild and moderate withdrawal syndrome occurs within 20–30 minutes after taking the drug. Aminoacetic acid is quickly absorbed into the gastrointestinal tract. Has almost 100% bioavailability. Easily penetrates into most body fluids and tissues. It is destroyed in the liver by the enzyme glycine oxidase. Sodium formate is quickly absorbed into the gastrointestinal tract. In the systemic bloodstream and body tissues, it reacts with acetaldehyde to form conjugates that take part in the tricarboxylic acid cycle, increasing the formation of high-energy compounds.

Indications for use

Alcohol intoxication, withdrawal symptoms; to improve the effectiveness of other therapy methods; prevention of intoxication; secondary prevention of alcoholism.

Release form

Granules, sets of packages No. 1 and No. 2, No. 1, 7 and 21.

Pharmacodynamics

Pharmacokinetics

Aminoacetic acid is quickly absorbed into the gastrointestinal tract. Has almost 100% bioavailability. Easily penetrates into most body fluids and tissues. It is destroyed in the liver by the enzyme glycine oxidase. Sodium formate is quickly absorbed into the gastrointestinal tract. In the systemic bloodstream and body tissues, it reacts with acetaldehyde to form conjugates that take part in the tricarboxylic acid cycle, increasing the formation of high-energy compounds.

Contraindications for use

Hypersensitivity to the components of the drug; severe forms of diabetes mellitus, arterial hypotension.

Side effects

All components of Medichronal-Darnitsa are natural metabolites, so it is well tolerated. In some cases, the following adverse reactions are possible: from the nervous system: headache, tension, irritability, deterioration in concentration; from the gastrointestinal tract: nausea; from the immune system: hypersensitivity reactions, including rash, itching, urticaria.

Directions for use and doses

The drug Medichronal-Darnitsa is used in adults after meals, after dissolving the contents of both packets in ½–¾ cup (200 ml) of warm water. A single dose is 28.5 g (the total weight of the components of both packages). To improve the taste, the contents of the packages can be dissolved in non-carbonated drinks (juice, compote, etc.). To eliminate acute alcohol and withdrawal conditions, the drug is used on the first day 1-2 times (every 10-12 hours) at a dose of 28.5 g, in the next 2-3 days - 28.5 g 1 time per day. In combination with other drugs in the treatment of chronic alcoholism and, if secondary prevention is necessary, this drug is taken daily in one package (28.5 g) for 7 days in the form of 3 courses with a 3-day break between them. To prevent relapses, 1–1.5 months after the course of treatment with Medichronal-Darnitsa, it is recommended to undergo a repeated 30-day course of therapy. It is also possible to use 1 to 3 repeated short-term preventive courses of treatment (7–14 days each) throughout the year. To prevent intoxication, you must take a single dose (contents of packages No. 1 and No. 2) 30 minutes before drinking alcoholic beverages.

Overdose

There is no information about the clinical manifestations of overdose. In case of overdose, digestive disorders (nausea, bloating, diarrhea) and increased manifestations of adverse reactions are possible. Therapy is symptomatic.

Interactions with other drugs

The active ingredient of the drug - glycine - reduces the toxicity of anticonvulsants, antipsychotics, antidepressants, and anticonvulsants. When taken in combination with tranquilizers, hypnotics and antipsychotics, the effect of central nervous system inhibition is enhanced. Medichronal-Darnitsa can be used in conjunction with other drugs for the treatment of alcohol dependence, except for disulfiram. The use of disulfiram is possible after courses of treatment with Medichronal-Darnitsa, if necessary.

Special instructions for use

Medichronal-Darnitsa can be used both independently and in complex treatment. When prescribing treatment, it is necessary to use an individual approach, which may include changing the duration of treatment or increasing the number of repeat courses throughout the year. In patients prone to arterial hypotension, it is necessary to monitor blood pressure levels and, if necessary, adjust the dose of the drug (prescribed in lower doses, subject to regular blood pressure monitoring). If blood pressure drops below normal levels, the drug is discontinued. Since the drug contains glucose, its use is limited to conditions accompanied by hyperglycemia. Use during pregnancy and lactation. Strictly controlled and adequate studies on the effectiveness and safety of the drug in pregnant and breastfeeding women have not been conducted, so use during pregnancy is possible if the benefit to the mother outweighs the potential risk to the fetus. The ability to influence reaction speed when driving vehicles or working with other mechanisms. During treatment, care should be taken when driving vehicles and working with complex mechanisms. Children. No studies have been conducted on the effectiveness and safety of the drug in children.

Storage conditions

In original packaging at a temperature not exceeding 25 °C.

Best before date

24 months

ATX classification:

N Nervous system

N07 Other drugs for the treatment of diseases of the nervous system

N07B Drugs used for psychological or physiological dependence on various substances

Contraindications

Restrictions on the use of the drug require strict adherence. They are not numerous, they are:

Diabetes mellitus - since the drug contains glucose, it is prohibited for persons suffering from this pathology, like any other product with sugar. In mild cases of the disease, the use of Medichronal may be considered on an individual basis.
Moderate and severe hypertension - the drug has an effect on blood vessels, which can lead to an additional increase in blood pressure.
Allergic reaction to any of the components in the composition.
Pregnancy period - there is no data on how the drug affects the development of the fetus and whether it penetrates the placental barrier.
Breastfeeding period - there is no data on the effect of the drug on the child through mother's milk.
Ages up to 18 years - no studies have been conducted on the effect of the medicine on children.

special instructions

The drug Medichronal-Darnitsa is used as monotherapy or simultaneously with other drugs. The prescription is made taking into account the individual characteristics of the patient, which provides for the possibility of changing the duration of therapy or increasing the number of repeated courses throughout the year.

If you are prone to arterial hypotension, you need to monitor your blood pressure level and, if necessary, adjust the dose of the drug (Medichronal-Darnitsa is taken in smaller doses with regular blood pressure monitoring). If blood pressure drops below normal levels, treatment should be discontinued.

Since the drug contains glucose, treatment is limited to conditions accompanied by the development of hyperglycemia.

When using the drug, care must be taken when driving vehicles and performing work with complex mechanisms.

Side effects

Side effects while taking the drug are rare. They may appear as follows:

headache;
feeling of tension and fullness in the head;
increased irritability;
decreased concentration;
nervousness;
nausea to the point of vomiting;
skin rashes like urticaria.

If side effects occur, you must stop taking the drug and consult the doctor who prescribed the drug. At his discretion, the dosage is adjusted or the medication is replaced.

Drug interactions

Glycine (one of the active components of the drug Medichronal-Darnitsa) reduces the toxicity of anticonvulsants and antipsychotics, antidepressants and anticonvulsants.

The effect of inhibition of the central nervous system is enhanced by simultaneous use with tranquilizers, antipsychotic and hypnotics.

When treating alcohol dependence, Medichronal-Darnitsa can be taken together with other medications (with the exception of disulfiram, which, if necessary, is prescribed at the end of the course of therapy).

Use of the drug

How to take Medichronal is described in instructions that should be strictly followed. In this case, the drug has a noticeable effect after 2 doses. Method of administration: oral. Take the medicine after meals. The contents of both packets are dissolved in a glass of water and drunk. It is allowed to use non-carbonated drinks instead of water. For acute alcohol poisoning, take the drug once every 12 hours on the first day and then once a day on days 2 and 3.

When treating alcoholism, in complex therapy, the drug is drunk once a day for a week. The medicine is also used when prevention of secondary alcoholism is necessary. A total of 3 courses are required, with a break of 3 days between them. You can take courses 3 times a year.

In order to prevent intoxication, the drug is taken once 30 minutes before drinking alcohol. Does Medichronal help? Patient reviews can be found in many sources.

Release form and composition

Medichronal-Darnitsa is available in the form of granules: white with a yellowish tint or white, odorless (in bags No. 1 and No. 2, 1, 7 or 21 sets of bags in a cardboard box).

Package No. 1 includes:

Active substance: glucose monohydrate – 17.5 g;
Auxiliary component: povidone.

Package No. 2 includes:

Active ingredients: glycine – 7 g, sodium formate – 3.5 g;
Auxiliary component: povidone.

Reviews and recommendations from doctors and patients

Reviews from doctors about the drug are positive. In their opinion, there are no analogues of the drug that have such a pronounced effect and at the same time with a minimum of side effects. Medichronal powder, the instructions for use of which require adjustments during long-term therapy, is suitable for patients of different ages and for chronic pathologies arising from alcohol dependence. Doctors also note the rapid effect of the drug in alcohol intoxication.

People who took Medichronal for a hangover are satisfied with the price and speak positively about the results of taking it. The drug allows you to avoid unpleasant consequences from drinking alcohol and maintain adequacy, even after significant doses of alcohol. The convenient form of release and availability in Good Day Pharmacies and on the Internet are also positively assessed in reviews.

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** The Drug Directory is intended for informational purposes only. For more complete information, please refer to the manufacturer's instructions. Do not self-medicate; Before starting to use the drug Medichronal, you should consult a doctor. EUROLAB is not responsible for the consequences caused by the use of information posted on the portal. Any information on the site does not replace medical advice and cannot serve as a guarantee of the positive effect of the drug.

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** Attention! The information presented in this medication guide is intended for medical professionals and should not be used as a basis for self-medication. The description of the drug Medichronal is provided for informational purposes and is not intended for prescribing treatment without the participation of a doctor. Patients need to consult a specialist!

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Reviews

Mikhail, 43 years old “I used Medichronal to reduce the craving for alcohol. I took 3 courses, the results are satisfactory so far, my overall health has improved.”

Marina, 39 years old “I bought Medichronal for my husband to relieve a hangover. It works much better than other analogue drugs, and there were no side effects.”

Alexander, 51 years old “After every feast I suffered from a severe hangover, until I found Medichronal. I drink the solution every time before drinking alcohol, and the next morning I feel just fine.”

Active components

The effectiveness of the drug is determined by the concentration of active and auxiliary substances in the composition.

They must be taken into account especially for patients with intolerances, diseases and various types of disorders:

Glucose. Participates in many metabolic processes in the body, common as a powerful source of energy and stabilizer of normal sleep. However, in cases where the patient has conditions that are accompanied by hyperglycemia, then one should refrain from using the medicine.
Glycine. Normalizes thought processes, activates important functions of the nervous system. However, in case of simultaneous use with antidepressants or anticonvulsants, it should be taken into account that it reduces their effectiveness.

The composition also includes a small amount of excipients - povidone and sodium formate. Since the composition is quite simple, the drug can be safely used as a complex therapy in the fight against alcoholism or withdrawal syndrome.

Indications for use

It is recommended to use the drug Medichronal only in the cases described below:

Intoxication with alcoholic beverages;
Preventive anti-alcohol procedures;
Withdrawal symptoms (hangover);
Prevention of intoxication.

Indications The drug is effective even in the case of an already existing hangover.
Medichronal can also be used as a drug that enhances the therapeutic effectiveness of other methods of combating alcoholism or other drugs of analogue action. The main feature of the drug is that it can be used both before the upcoming feast to reduce the severity of the hangover, and after.

Cost of the drug

The drug Medichronal is offered in several dosages: 1, 7 and 21 packets.

The cost also varies depending on the number of packages:

1 package – about 300 rubles;
7 packages – about 700 rubles;
21 packages - about 2000 rubles.

Accordingly, the more packages you purchase, the better the price. At the same time, experts recommend first trying to use 1 packet of Medichronal to make sure that it is well tolerated by the body.

Analogue tools

In Russia, if necessary, you can select the following most popular and effective analogs of the drug Medichronal:

Metadoxyl. Available in the form of an injection solution or tablets. The drug helps well with serious alcohol intoxication and is a good addition to the complex treatment of alcohol dependence and hangover relief. The active component of the composition is metadoxine.
Proprothene. The drug is available in the form of drops and lozenges. It is recommended to be used as an element of monotherapy in the fight against alcohol syndrome, as well as to reduce the psychopathological disorders that accompany a hangover. The drug is also suitable for normalizing the general condition of the body after alcohol intoxication. The active component of the composition is antibodies to the brain-specific protein S-100.
Biotredin. It is produced only in the format of sublingual tablets, which ensures the fastest possible delivery of active substances into the blood. It has a greater effect on stabilizing the patient’s mental state, improves mood, helps focus attention and normalize mental activity.

The use of analogue drugs cannot fully replace Medichronal. To obtain the full range of effects that this drug has, it will require a comprehensive replacement with several medications.