Movasin injections: instructions for use, composition, analogues and contraindications

• October 27, 2018
• Other drugs
• Gladkikh Asya

In this article we will look at the instructions for use for Movasin injections.

It is an antirheumatic and anti-inflammatory drug based on meloxicam. Used to eliminate symptoms and treat ankylosing spondylitis, osteoarthritis and rheumatoid arthritis.

The drug is produced by a Russian pharmaceutical company.

special instructions

The drug is used with extreme caution in patients who have a history or suspicion of such diagnoses as gastrointestinal ulcer, as well as during concurrent or recent anticoagulant therapy. In this case, the risk of developing erosive and ulcerative lesions increases significantly

Also, the medication can be used extremely carefully in the following patients:

• Elderly;
• With chronic heart failure;
• Liver cirrhosis;
• Hypovolemia caused by surgery;
• For phenomena associated with circulatory failure, against the background of heart problems.

In case of renal failure, if creatinine is approximately 25 ml/min or more, then no adjustment of the dosage regimen is required. At the same time, if the patient is on dialysis, then the dose of the drug in such a situation does not exceed 7.5 mg per day.

When using Movasin and diuretics simultaneously, it is necessary to adjust the water balance by increasing water intake. If allergic conditions develop, you should consult a doctor about discontinuing or replacing the composition.

Important! Movasin is capable, like other NSAIDs, of masking the symptoms of infectious pathologies.

Meloxicam may have some effects on fertility. Accordingly, women who are trying to become pregnant should refrain from using this drug.

Precautions for people and bees

Novosil belongs to substances of IV (minimal) hazard group, that is, it is practically harmless to people and the environment, however, it should be used carefully. You should use protective equipment - clothing, gloves, glasses, and refrain from eating and smoking while working. In case of contact with the skin, wash off the substance with soap; in case of contact with the eyes, rinse them with plenty of water.

As for bees, although no proven facts of their death from Novosil have been recorded, it is advisable to limit their flight for 12 hours. And if there is an apiary nearby, it is better to treat plants in the evening, after the end of the flight.

special instructions

Caution should be exercised when using the drug in patients with a history of gastric or duodenal ulcers, as well as in patients on anticoagulant therapy. Such patients have an increased risk of ulcerative-erosive diseases of the gastrointestinal tract

Caution should be exercised and monitoring of renal function indicators when using the drug in elderly patients, with chronic heart failure with symptoms of circulatory failure, with cirrhosis of the liver, as well as with hypovolemia as a result of surgical interventions. In patients with renal failure, if creatinine Cl is more than 25 ml/min, no dosage adjustment is required

In patients with renal failure, if creatinine Cl is more than 25 ml/min, no dosage adjustment is required.

In patients on dialysis, the dosage of the drug should not exceed 7.5 mg/day.

Patients taking diuretics and meloxicam simultaneously should take sufficient fluids.

If allergic reactions (itching, skin rash, urticaria, photosensitivity) occur during treatment, you should consult a doctor to decide whether to stop taking the drug.

Meloxicam, like other NSAIDs, can mask the symptoms of infectious diseases.

The use of meloxicam, like other drugs that block the synthesis of PG, can affect fertility, so the drug is not recommended for women wishing to become pregnant.

Driving vehicles, servicing machines and mechanisms.

The use of the drug may cause undesirable effects such as headache, dizziness, and drowsiness. You should refrain from driving vehicles, servicing machines and mechanisms, and other activities that require concentration.

Side effects

The use of Movasin may cause the following side effects:

• Central nervous system: vertigo, dizziness, disorientation, tinnitus, headache, confusion, drowsiness, emotional lability.
• Digestive system: dyspepsia, transient increase in the activity of liver enzymes, belching, stomatitis, esophagitis, hyperbilirubinemia, gastroduodenal ulcer, gastrointestinal perforation, gastritis, colitis, bleeding from the gastrointestinal tract (including hidden), hepatitis.
• Cardiovascular system: palpitations, peripheral edema, flushing of the face, increased blood pressure.
• Urinary system: increased serum urea levels and/or hypercreatininemia, albuminuria, acute renal failure, hematuria, interstitial nephritis.
• Respiratory system: bronchospasm.
• Skin: skin rashes and itching, urticaria, bullous rashes, erythema multiforme (including Stevens-Johnson syndrome), photosensitivity, toxic epidermal necrolysis.
• Hematopoietic organs: thrombocytopenia, anemia, leukopenia.
• Sense organs: visual impairment (including blurred vision), conjunctivitis.
• Local reactions: pain and swelling at the injection site.
• Allergic manifestations: anaphylactic/anaphylactoid reactions, angioedema.

Negative manifestations

Clinical trials indicate that the medication can provoke the development of the following negative reactions:

1. Confusion, emotional lability, headache, dizziness, vertigo, disorientation, drowsiness, tinnitus from the central nervous system.
2. Colitis, gastrointestinal perforation, Bleeding in the gastrointestinal tract, gastroduodenal ulcer, hyperbilirubinemia, stomatitis, gastritis, increased liver transaminases, constipation, esophagitis, belching, flatulence, vomiting, abdominal pain, diarrhea, nausea, hepatitis - from the gastrointestinal tract.
3. Increased blood pressure, peripheral edema, palpitations, hot flashes from the heart and blood vessels.
4. Thrombocytopenia, anemia, leukopenia from the hematopoietic system.
5. Epidermal necrolysis of a toxic nature, erythema multiforme, bullous rashes, photosensitivity, itching of the skin, skin rash, urticaria of the skin.
6. Bronchospasm from the respiratory system.
7. Visual impairment, conjunctivitis from the sensory organ system.
8. Hematuria, albuminemia, interstitial nephritis, increased urea levels, hypercreatininemia, acute forms of renal failure from the urinary system.
9. Anaphylactoid reactions, anaphylactic shock, angioedema as an allergic reaction.
10. Soreness, swelling at the injection site.

Side effects

Movasin can cause the following adverse reactions:

• dyspepsia, including abdominal pain, nausea, vomiting, constipation, bloating, loose stools, increased activity of liver enzymes, belching, bleeding from the digestive tract, stomatitis, esophagitis, increased bilirubin levels, gastroduodenal ulcers, intestinal inflammation, hepatitis, gastritis, gastrointestinal perforation;
• decrease in all blood cells;
• itching, rashes, including bullous ones, urticaria, photosensitivity, erythema multiforme, toxic epidermal necrolysis;
• bronchospasm;
• dizziness, headaches, ringing in the ears, drowsiness, impaired consciousness, disorientation in time and space, emotional lability;
• peripheral edema, increased blood pressure, palpitations, hot flashes;
• increased creatinine and urea in the blood serum, acute renal failure;
• the appearance of protein and blood in the urine, interstitial nephritis (the connection between taking meloxicam and the occurrence of these effects has not been established);
• conjunctivitis, vision problems;
• allergy.

When Movasin is prescribed with other NSAIDs, the likelihood of developing erosive and ulcerative lesions and bleeding from the digestive tract increases.

Meloxicam may reduce the effectiveness of antihypertensive drugs and increase the likelihood of lithium accumulation, which will cause an overdose.

When named in combination with Movasin:

• methotrexate increases the likelihood of undesirable effects from hematopoiesis and the appearance of anemia and leukopenia;
• diuretics and cyclosporine increases the likelihood of renal failure;
• intrauterine contraceptives may reduce their effectiveness;
• anticoagulants, thrombolytic drugs increase the risk of bleeding;
• cholestyramine increases the excretion of meloxicam through the digestive tract;
• selective serotonin reuptake blockers increase the likelihood of bleeding from the digestive tract.

When using the drug

From the central nervous system: headache, dizziness, tinnitus, disorientation, confusion, sleep disturbance.

From the organs of vision: conjunctivitis, blurred vision.

From the skin: itching, skin rash, urticaria, exudative erythema multiforme (incl.

From the hematopoietic system: anemia, leukopenia, thrombocytopenia.

Allergic reactions: anaphylactoid reactions (including anaphylactic shock), swelling of the lips and tongue, allergic vasculitis.

Other: fever.

When using the drug simultaneously

with other NSAIDs, incl. with acetylsalicylic acid, the risk of erosive and ulcerative lesions and bleeding in the gastrointestinal tract increases;

with lithium preparations, it is possible to develop the accumulation of lithium and increase its toxic effect (monitoring the concentration of lithium in the blood is recommended);

with methotrexate, the latter’s side effect on the hematopoietic system increases (the risk of anemia and leukopenia, periodic monitoring of a general blood test is indicated);

with intrauterine contraceptives, the effectiveness of the latter may decrease;

with anticoagulants and antiplatelet agents (heparin, ticlopidine, warfarin), as well as with thrombolytic drugs (streptokinase, fibrinolysin), the risk of bleeding increases (periodic monitoring of blood clotting parameters is necessary);

with cholestyramine, as a result of the binding of meloxicam, its excretion through the gastrointestinal tract is enhanced.

Drug interactions

In order for the chosen treatment tactics to be effective and beneficial for the body, you need to approach treatment responsibly. It should be borne in mind that the simultaneous use of several medications can lead to changes in the chemical composition of the blood, which causes certain reactions.

Try to remember the following rules:

• If you take Movasin and acetylsalicylic acid, the risk of internal bleeding from the gastrointestinal tract will be extremely high;
• You should not take Movasin together with drugs that lower blood pressure, because its active ingredients completely reduce their effectiveness;
• You should not take Movasin with lithium drugs at the same time - this can provoke certain chemical reactions, which will cause toxic effects on the body;
• You should not take Movasin with methotrexants - this significantly increases the likelihood of side effects, which disrupts the chemical composition of the blood;
• The development of renal failure can be provoked by the simultaneous use of Movasin and diuretics based on cyclosporine;
• Movasin therapy changes the level of fertility, which changes the effectiveness of intrauterine contraceptives. This must be taken into account to prevent unwanted pregnancies;
• You should not take Movasin simultaneously with anticoagulants, as this significantly increases the risk of bleeding. With long-term use, it is necessary to constantly monitor the rate of blood clotting.

Important instructions

During the entire course of treatment, it is very important to constantly monitor the condition of the kidneys and liver. To minimize the likelihood of adverse reactions, it is recommended to start treatment with the lowest possible dosage

It can be increased only if there is an urgent need.

Please note that for injections, the medicine "Movasin", the indications for use of which are described in this article, is administered only intramuscularly. Under no circumstances should you administer the injection solution intravenously.

If you are also taking diuretics at the same time as this drug, make sure your body gets enough fluids every day.

Be aware that using this drug may affect your nervous system, causing headaches and drowsiness. Therefore, during the course of treatment, it is strongly recommended not to drive a vehicle or operate other serious machinery.

Environmental impact

Thanks to the natural components, the impact of the stimulant on the environment is minimal - Novosil spilled on the ground does not require measures to remove it, and its use is permissible even in the fishery protection coastal zone of water bodies.

Minimal impact of the stimulant on the environment

How to take the medicine

At the beginning of treatment of the disease, the doctor prescribes injections of the drug Movasin. The instructions for use stipulate the possibility of using this dosage form for the first 2 or 3 days, and then you should switch to therapy with the tablet form of the drug.

The daily dosage of injections is set at 7.5 or 15 mg, it all depends on the level of the pain symptom and the intensity of the inflammatory reaction. The solution is administered in one go, making a deep intramuscular injection. If we talk about another method of administering the drug Movasin, intravenous injections are prohibited.

If after using the drug there is a risk of undesirable consequences, dosages greater than 7.5 mg should not be used.

After three days of treatment with injections of the drug "Movasin", the use of this drug is possible only in tablet form.

The tablets are taken once a day with food, the daily dosage ranges from 7.5 mg to 15 mg, depending on the severity of the disease.

Osteoarthritis is treated with a daily dosage of 7.5 mg; if the effect of such therapy is not observed, the dosage is increased by another 7.5 mg.

Treatment of ankylosing spondylitis requires taking 15 mg tablets once a day.

If the patient uses tablets and injections at once, the highest dosage in total is 15 mg.

In persons with insufficient renal function and those prescribed hemodialysis, the dosage of the drug for intramuscular or oral administration is prescribed no more than 7.5 mg.

Use of the medication

Injectable Movasin should be used for therapy only in the first three days of therapy with this drug, after which it is recommended to continue treatment using oral forms of the drug.

The recommended daily dose is 7.5 or 15 mg. The drug is administered once a day. The dose should be determined exclusively by the doctor, since when determining it, the type of pathology, the intensity of the pain syndrome, and the type of inflammation process should be taken into account.

Administration is carried out exclusively intramuscularly, and quite deep into the muscle tissue. Intravenous administration of the drug based on meloxicam is prohibited.

According to the instructions for use and reviews, Movasin injections intramuscularly are sometimes very painful.

If a patient has a tendency to develop negative effects from using the drug, it is recommended to administer no more than 7.5 mg.

The same dose of injectable Movasin is recommended for administration to patients on hemodialysis who have minor or moderate impairments in renal function and suffer from end-stage renal failure.

The injection drug is approved for practical use for the treatment of only adult patients, so doses for adolescents and children have not been determined.

A maximum of 15 mg of Movasin per day is allowed.

If combination therapy is carried out with meloxicam preparations that have different pharmacological forms (plasters, tablets, suppositories, injections), then the total amount of meloxicam taken per day should be no more than 15 mg.

Not everyone knows why Movasin injections help.

Analogues of Movasin

There are an abundance of similar drugs on the pharmaceutical market with the active ingredient meloxicam.

One of the most expensive is Movalis; the pharmaceutical company that produces it is the direct developer of the meloxicam formula and has a patent on the medicine.

This suggests that different excipients are possible in other drugs.

When combining Movasin with other NSAID drugs, the likelihood of bleeding in the gastrointestinal tract and the appearance of ulcerative and erosive lesions increases.

Parallel use with antihypertensive drugs leads to a decrease in the therapeutic effect of the latter.

Parallel use with methotrexate leads to changes in the hematopoietic system, the development of leukopenia, and anemia.

When combined with cyclosporines and diuretics, the risk of developing renal failure increases.

Movasin can reduce the therapeutic effectiveness of intrauterine contraceptives.

When taken in parallel with cholestyramine, the excretion of meloxicam increases.

In the instructions for use, analogues of Movasin in injections are not presented.

Reviews from patients indicate that Movasin is an effective drug for pain relief. In most cases, the administration of the drug can successfully relieve painful manifestations of the musculoskeletal system. In addition, it is noted in reviews of Movasin injections that, in comparison with NSAIDs of previous generations, it does not provoke many negative effects.

That is why it is important to remember that only a specialist should prescribe the drug, its dosage and regimen. Only in this case can harm to the body be eliminated and therapy be made as effective as possible.

We reviewed the instructions for use and reviews of Movasin in injections.

Pharmacodynamics, pharmacokinetics

Meloxicam, in addition, can have an effect on COX-1, but to a lesser extent. COX-1 activates the process of biosynthesis of prostaglandins, which protect the mucous membranes of the gastrointestinal tract and contribute to the regulation of blood flow in the renal structures.

What is the course of Movasin injections according to the instructions for use? We'll talk about this below.

The bioavailability of the drug when administered by injection reaches 100%. A minute after intramuscular administration of 5 mg of the drug, the concentration of the active substance in the blood reaches its maximum and is 1.52 mcg/ml.

The maximum therapeutic effect is observed after 3-5 days of using Movasin. It is worth noting that the concentration of the substance in the blood remains at a stable level even after a year of use. Meloxicam is 99% bound to albumin and other plasma proteins. With a single dose of the drug per day, the range of differences between the maximum and basal concentrations of the substance remains small.

The instructions for Movasin injections must be strictly followed.

The main active component has the ability to penetrate the histohematic barrier; in the synovial fluid, the concentration of meloxicam reaches 50% of the total concentration in the blood. Interindividual variation is about 30-40%, the substance has a low volume of distribution, which is about 11 liters.

Meloxicam is completely metabolized in liver tissue to form four pharmaceutically inactive metabolites. Studies show that the main role in the metabolism of meloxicam is played by the CYP2C9 isoenzyme, and the CYP3A4 isoenzyme plays an auxiliary function.

When Movasin is used in injections for the treatment of elderly patients, a decrease in the clearance of meloxicam is observed.

Moderate impairment of the liver and kidneys does not significantly affect pharmacokinetics.

The main part of meloxicam is absorbed in the gastrointestinal tract. When eating at the same time as the drug, absorption does not change.

The absolute bioavailability of Movasin is 89%. 99% percent binds to blood proteins. Equilibrium concentration occurs after 3-5 days.

With long-term use of the medication (more than a year), its concentration in the body is similar to that achieved after the first doses of the medication and occurs within 5 days.

Metabolism is carried out in the liver with a volume close to 100%. It is excreted from the body everywhere with feces and urine. The twentieth part is excreted in the feces in its original state, but only traces of the drug are observed in the urine.

Instructions for use of tablets

Using Movasin tablets is extremely simple; everything is described in detail in the instructions for use. It says that it is best to take them during meals, with plenty of water. This significantly reduces the pathogenic effect on the mucous membrane of the stomach and the entire gastrointestinal tract.

Movasin tablets should be used as follows:

1. For rheumatoid arthritis – 1 tablet 2 times a day. In the future, the dose is reduced by 2 times and the capsule is taken once;
2. For osteoarthritis, take 1 tablet once a day. If this does not help get rid of discomfort, the dosage is doubled;
3. For ankylosing spondylitis - take 1 tablet 2 times a day for several months.

Please note that you need to take Movasin with extreme caution. Any wrong action can provoke the development of side effects. People who are at high risk should be especially careful.

Any change in dosage must be discussed with your doctor

People who are at high risk should be especially careful. Any change in dosage must be discussed with your doctor.

Indications for use

The main indications for use are:

• rheumatic diseases of various origins, which are accompanied by pain, swelling and difficulties with movement;
• development of osteoarthritis;
• development of ankylosing spondylitis or ankylosing spondylitis;
• development of rheumatoid arthritis.

Overdose and additional instructions

In patients with a history of peptic ulcer disease, as well as those taking anticoagulants, there is a high likelihood of erosive and ulcerative lesions of the digestive tract.

Patients taking both diuretics and meloxicam should drink enough fluids.

Movasin may mask signs of infection.

During therapy, undesirable reactions from the central nervous system may occur, such as dizziness, drowsiness, so you should refrain from driving.

In case of an overdose of Movasin, the following symptoms are observed: nausea, loss of consciousness, epigastric pain, vomiting, asystole, bleeding in the gastrointestinal tract, acute renal or liver failure, cardiac arrest.

Treatment in cases of overdose is symptomatic and requires urgent hospitalization of the patient. Within an hour after taking a critical dose, gastric lavage and activated charcoal are taken.

Hemodialysis, forced diuresis and other similar procedures are usually ineffective because meloxicam has a high degree of binding to blood protein.

Side effects

Common (1 case in 100):

• headache;
• peripheral edema;
• anemia;
• itching, rash;
• vomiting, nausea;
• dyspepsia.

Sometimes (1 word out of 1000):

• drowsiness;
• hives;
• increased blood pressure;
• rush of blood to the skin of the face.

Rarely (1 word out of 5000):

• hypercreatininemia;
• stomatitis;
• heartbeat;
• esophagitis;
• belching;
• photosensitivity.

Very rare (1 word out of 10,000):

• disorientation;
• angioedema;
• conjunctivitis;
• bronchospasm;
• hepatitis;
• gastritis;
• Stevens-Johnson syndrome.

special instructions

If persistent side effects occur, stop taking the drug immediately and consult your doctor.

Drug and alcohol

It is strictly not recommended to take alcohol-containing products along with medication.

Firstly, the inhibitory effect on the kidneys and liver increases, which, with long-term co-administration, leads to acute kidney and liver failure, hepatitis, and cirrhosis of the liver.

Secondly, with a large dose of alcohol, internal bleeding may occur. If you are drunk, late diagnosis of this bleeding can be fatal.

If it is absolutely necessary to take the drug during acute renal failure, hemodialysis should be performed in parallel.

It is not advisable to take it together with diuretics, as it has an extremely depressing effect on the kidneys. Taking the drug with methotrexate increases the possibility of anemia.

When taking drugs containing lithium simultaneously, the toxic effect on the body may increase; this should be taken into account when calculating the dosage and duration of taking the drug.

It is prohibited to take the drug during pregnancy and breastfeeding.

Women planning a pregnancy should be aware that Movasin reduces fertility.

Tablets can be prescribed to children from 12 years of age, adjusting the dosage depending on weight.

The genetic pathology of syndactyly of the toes and hands is curable with surgical intervention. To find out how effective Miracle Hash ointment is, its pros and cons and other useful information about this medicine, look here.

Signs of overdose

Cases of overdose with Movasin are extremely rare, especially if an injection solution is used. Injections are performed by qualified specialists in a medical facility. Therefore, when treated with injections, overdose practically does not occur.

If the patient uses oral forms of the drug for treatment, an overdose may occur if the treatment regimen is not followed.

The key signs of exceeding the specified doses of Movasin are:

1. confusion;
2. attacks of nausea or vomiting;
3. pain in the epigastric region;
4. development of gastric or intestinal bleeding;
5. development of acute failure of kidney and liver function;
6. disruption of the heart.

If an overdose of Movasin occurs, symptomatic therapy is necessary. You must definitely call an ambulance. In this situation, gastric lavage and the use of enterosorbents - smecta, sorbex, polypefan, activated carbon - are indicated. All these procedures must be performed as quickly as possible, no later than one hour after taking the medicine.

To speed up the breakdown of drug components and remove them from the body as quickly as possible, Cholisteramine is used. In such a situation, a procedure such as hemodialysis will not bring any results.

Pharmacokinetics

Suction.

After taking the drug orally, meloxicam is well absorbed from the gastrointestinal tract, with its absolute bioavailability being 80%. Taking simultaneously with food does not affect absorption. The concentration of meloxicam when taking the drug orally in doses of 7.5 and 15 mg is proportional to the dose.

Distribution.

An equilibrium state is achieved within 3–5 days of regular use. With long-term (more than 1 year) use of the drug, the concentration of meloxicam is similar to the CSS, which was established after the first achievement of a steady state of pharmacokinetics. Plasma protein binding is more than 99%. When taking the drug 1 time, CSSmin and CSSmax differ to a small extent and are 0.4–1.0 mcg/ml when taken at a dose of 7.5 mg, and 0.8–2.0 when taken at a dose of 15 mg. µg/ml respectively. Meloxicam penetrates histohematic barriers, the concentration in synovial fluid reaches 50% of Cmax in plasma. The volume of distribution (Vd) is on average 11 l.

Metabolism.

Meloxicam is almost completely metabolized in the liver to form four pharmacologically inactive metabolites.
The main metabolite is 5′-carboxymeloxicam, which is formed by oxidation of an intermediate metabolite (5′-hydroxymethylmeloxicam). In vitro
studies have established that biotransformation occurs with the participation of CYP2C 9; the CYP3A4 isoenzyme is of additional importance. Peroxidase is involved in the formation of the other two metabolites, the activity of which probably varies individually.

Excretion.

It is excreted equally in feces and urine, mainly in the form of metabolites (5′-carboxymeloxicam - up to 60%, 5′-hydroxymethylmeloxicam - 9%, and the other 2 - 16 and 4%, respectively). Less than 5% of the daily dose is excreted unchanged in feces; the drug is found unchanged in urine only in trace amounts. T1/2 - 15–20 hours. Plasma clearance averages 8 ml/min.

Pharmacokinetics in special clinical cases.

In elderly people, drug clearance is reduced.

In patients with moderate hepatic or renal impairment, the pharmacokinetics of meloxicam does not change significantly.

Release form and composition

Dosage forms of Movasin:

• Tablets: pale yellow, flat-cylindrical, round, with a chamfer and a score (for a dosage of 15 mg), slight marbling on the surface is acceptable (10 pcs. in a blister pack, 1 or 2 packs in a cardboard pack; 20 pcs. per polymer jar, 1 jar in a cardboard pack);
• Solution for intramuscular administration: transparent or slightly opalescent, yellow with a greenish tint (1.5 ml in a glass ampoule, 3 or 5 ampoules in a strip pack, 1 pack in a cardboard box).

Active substance: meloxicam – 7.5 or 15 mg per tablet; 10 mg in 1 ml of solution (15 mg in 1 ampoule).

Additional components:

• Tablets: lactose monohydrate, povidone 12600, crospovidone (kollidon CL-M), talc, potato starch, microcrystalline cellulose, magnesium stearate;
• Solution: meglumine, glycofurol, glycine, sodium chloride, poloxamer 188, sodium hydroxide, water for injection.

Mechanism of action

The drug belongs to a number of oxicams, that is, NSAIDs. Accordingly, the composition has anti-inflammatory properties and also helps eliminate pain. The composition can also have an antipyretic effect.

All these effects are achieved by inhibiting the active action of COX-2 enzymes. The latter take part in the synthesis of prostaglandins. They are the ones who provoke the development of the inflammatory process. Movasin is somewhat less able to have an effect on COX-1, which is actively involved in the production of prostaglandins.

These elements protect the mucous membranes in the gastrointestinal tract, and also participate in the normalization and maintenance of processes in the blood flow of the kidneys. Accordingly, the drug does not produce a large number of intense side effects, like its non-structural analogues.

The composition is well absorbed through the gastrointestinal tract, entering the bloodstream in a volume of 80%. Complete distribution of the substance throughout the body occurs approximately 3-5 days from the start of regular use of the product. Metabolism occurs mostly in the liver. Excretion is carried out by the gastrointestinal tract and kidneys.

For what crops is Novosil used?

Novosil is used to treat most agricultural and ornamental plants, with the exception of some trees and shrubs.

For vegetable crops

Vegetable crops are the main object of application of Novosil. You should start by soaking the seeds, which will significantly increase their germination. Consumption – 1 ml (about 30 drops) per 1 liter of water. Processing time – 6 hours. After processing, the seeds are washed with water.

Novosil is used for seedlings a day before planting in the ground, which allows plants to more easily withstand the stress of transplantation and protects them from most diseases. Consumption depends on the type of plant and is determined by the manufacturer's instructions.

Vegetable crops are usually processed twice. The exception is cucumbers, which it is advisable to process 4 times at intervals of a week.

The main object of application of Novosila is vegetables

For berry crops

The use of Novosil in berry gardens not only increases the yield, but also improves the quality of the collected berries. Treated plants produce larger fruits with higher sugar content.

Strawberries (garden strawberries) require spraying three times - during the period of intensive flowering, after harvesting and after trimming the mustache. Consumption – 40 drops per bucket of water.

Berry bushes - raspberries, currants, gooseberries, etc. are processed twice. The first time after the formation of buds, and the second time after 14 days. The concentration of the solution is 12 drops per 3 liters. The grapes are treated in the same way, only with a more concentrated solution - 30 drops per 3 liters of water.

For indoor flowers

Indoor and ornamental plants are treated after the appearance of buds and at the time of flowering. It is also useful to treat them before transplanting. Before planting, seed and tuber treatment is necessary.

Analogs

If necessary, it can be replaced by one of the following structural or therapeutic analogues: “Liberum”, “Medsicam”, “Mesipol”, “Mirlox”, “Melox”, “Amelotex”, “Artrosan”, “Meloxicam”, “Movalis”, "Oxyten", "Piroxicam", "Lorakam". "Tenoctil", "Xefocam".

It is important to remember that any of the indicated analogues of Movasin in injections has a number of its own contraindications and can provoke a variety of negative effects. In this regard, it is important to agree on the possibility of changing the drug with your doctor.

You can replace Movasin with the following medications:

Movalis is an original drug containing meloxicam as an active ingredient. It is available in tablets, injections, rectal suppositories, and suspensions for oral administration. For juvenile rheumatoid arthritis, the drug can be used in children over 2 years of age. Movalis is prohibited from being prescribed to pregnant women and breastfeeding women.

OKI is a substitute for Movasin in the therapeutic group. The effect of the drug is explained by ketoprofen. The medicine is available in rectal suppositories, a solution for topical use, and granules for preparing a suspension for oral use. OKI is prohibited from use during pregnancy and breastfeeding.

The medicine can be prescribed to children over 6 years of age (topical solution may be used with caution in patients under 6 years of age).

Voltaren Rapid belongs to the Movasin substitutes in the pharmacological group. The medicine is available in tablets and powder for the preparation of an oral solution

A non-steroidal anti-inflammatory drug can be prescribed to patients over 18 years of age, including pregnant women. Breastfeeding should be interrupted during therapy.

Nalgesin is a substitute for the drug Movasin in the therapeutic group. The medicine is available in tablets that can be taken by children over 9 years of age. They are contraindicated for pregnant women and those supporting breastfeeding.

It is permissible to take an analogue instead of Movasin only after consultation with a specialist.

Technical characteristics of the product

Novosil fertilizer is a natural bioregulatory product with a pine scent. Used to protect plants and as a fertilizer.

Composition and appearance

In terms of its composition, the growth stimulator Novosil is a 5% or 10% aqueous emulsion of salts of triterpene acids (abiesonic and abiesolic) extracted from fir bark and pine needles.

Natural bioregulatory fertilizer Novosil

Properties and mechanism of influence on plants

The growth regulator Novosil provides plant protection due to the influence of the active substance directly on phytohormones responsible for plant growth and immunity. In addition, the growth stimulator Novosil, according to the instructions, has fungicidal and partially bactericidal properties.

Impact spectrum

The spectrum of action of the drug is quite wide, it provides:

• increasing seed germination;
• increase in yield up to 25%;
• increasing plant resistance to adverse climatic influences;
• protection against fungal, as well as some bacterial and infectious plant diseases.

Duration of the drug

The effect of the stimulant begins almost immediately after application, but the visible effect occurs after 2-3 days. After about 10 days, the effect of Novosil ceases due to the complete disintegration of the active substances.

Applications and dosages

for adults

The tablets should be taken with meals. The dosage of the drug is selected individually depending on the pathology:

• for rheumatoid arthritis, the medicine should be taken at a dose of 15 mg per day, which, depending on the therapeutic effect, can be reduced to 7.5 mg per day;
• for osteoarthritis, the medication is prescribed at 7.5 mg per day; if there is no effect, then the daily dosage of the medication is increased to 15 mg;
• for ankylosing spondylitis - 15 mg.

The maximum daily dosage should not exceed 15 mg.

If the patient is at high risk of developing adverse reactions, as well as in persons with severe renal failure who are not on hemodialysis, the daily dosage should not exceed 7.5 mg.

In injections, the medicine can only be administered deep intramuscularly; it cannot be administered intravenously. The medication can be administered in ampoules during the first 2-3 days. Then it is taken in tablets.

for children

After the baby is switched to the formula during breastfeeding, Movasin can be used as usual.

Reviews

• Anna, 57 years old. I was diagnosed with rheumatoid arthritis about 15 years ago. All this time I tried to treat her, using different drugs. They were not always effective. Movasin helped get rid of severe joint pain, and walking became much easier. Now, with the help of this medicine, I can stop the seasonal exacerbation of my illness.
• Victor, 55 years old. Joint problems started recently. The doctor prescribed Movasin. The result pleased me. After three months of regular use, the joints stopped hurting. Now I am taking maintenance therapy. I hope that after completing the course of treatment I will be able to forget about my problem for a long time.
• Nikolai, 70 years old. The diagnosis of osteoporosis was made not so long ago. The shoulder began to hurt a lot, swell, and it was difficult to lift it. Even at night I couldn’t sleep properly because of the pain. The doctor prescribed various medications, but my shoulder hurt so much that I couldn’t lift my arm. After the Movasin injections it became much easier. The pain has decreased a little, and it has become easier to move my arm. Of course, there is still a long course of treatment ahead; the doctor prescribed Movasin tablets. I continue to undergo treatment, hoping for a good, lasting result.

Recommendations for use, warnings

The injectable drug can provoke undesirable reactions such as drowsiness, dizziness, and headache. In this regard, there is an assumption that the drug can influence the ability to drive vehicles, engage in potentially hazardous types of work, and perform work that requires increased attention and a high speed of psychomotor reaction.

It is important to exercise caution when prescribing Movasin to people suffering from ulcerative and erosive lesions of the gastrointestinal tract. Elderly patients, people suffering from chronic heart failure, disorders in the circulatory system, cirrhosis of the liver, hypovolemia (arising from surgical interventions) are recommended to use Movasin with extreme caution, as well as regularly monitor kidney function parameters

Elderly patients, people suffering from chronic heart failure, disorders in the circulatory system, cirrhosis of the liver, hypovolemia (arising from surgical interventions) are recommended to use Movasin with extreme caution, as well as regularly monitor kidney function parameters. With a moderate decrease in renal function, no dose adjustment is required

With a moderate decrease in renal function, no dose adjustment is required.

If allergic manifestations occur (photosensitivity, rash, urticaria, itching), you should immediately stop using the medication.

In accordance with the instructions for use, Movasin in injections, like other drugs of the NSAID group, can mask the symptoms of diseases of an infectious nature.

Contraindications for use

We told you what Movasin injections help with. The drug is contraindicated for use if the patient has the following physiological or pathological conditions:

1. Progressive kidney pathologies.
2. Chronic forms of renal failure requiring dialysis.
3. Severe forms of liver pathologies, severe liver failure.
4. Age less than 18 years.
5. Cerebrovascular bleeding, bleeding of another nature.
6. Intestinal diseases, inflammatory processes in the intestines, for example, Crohn's disease, ulcerative colitis.
7. Complete, incomplete combination of intolerance to acetylsalicylic acid, NSAIDs, with bronchial asthma and recurrent forms of polyposis of the mucous membranes of the nose or paranasal sinuses.
8. Presence of bleeding in the gastrointestinal tract.
9. Lesions of the mucous membranes of the stomach and duodenum of an erosive and ulcerative nature.
10. Decompensated form of heart failure.
11. Condition after coronary artery bypass surgery.
12. Lactation period.
13. Any trimester of pregnancy.
14. Increased individual susceptibility to any component included in the drug.

In accordance with the instructions for use for Movasin injections, it is important to exercise caution when prescribing the drug to patients in the following categories and having the specified pathologies:

1. Those receiving concomitant therapy with medications such as selective serotonin reuptake inhibitors, oral corticosteroids, anticoagulants, antiplatelet agents.
2. When affected by Helicobacter pylori infection.
3. In severe forms of somatic diseases.
4. Frequently drink alcoholic beverages.
5. Using NSAID therapy for a long time.
6. Having a history of information and the development of ulcerative lesions in the gastrointestinal tract.
7. For diseases in the peripheral arterial system.
8. With a compensated form of heart failure.
9. For hyperlipidemia, dyslipidemia.
10. For cerebrovascular diseases.
11. With ischemic heart disease.
12. Those who are elderly.
13. Suffering from diabetes.
14. Smokers.

To avoid the risk of negative manifestations from the gastrointestinal tract, it is recommended to use the drug in minimal effective doses for the shortest possible time.

As the instructions for use tell us, Movasin is administered intramuscularly in injections. More on this below.