- October 14, 2018
- obstetrics and gynecology
- Gladkikh Asya
In this article we will look at the instructions for use for the drug “Progestogel”.
This remedy, the main active component of which is progesterone, is the hormone of the corpus luteum. It blocks estrogen receptors, promoting better absorption of fluid from the tissue and reducing compression of the milk ducts of the mammary gland. Progesterone also has a blocking effect on prolactin receptors, which reduces milk production in the breast.
Pharmacodynamics and pharmacokinetics
This ointment is intended for external use in the treatment of mastodynia . The active substance progesterone has a blocking effect on estrogen receptors, which improves the absorption of fluid from tissues, reducing the compression of the milk ducts. At the same time, blocking of prolactin receptors in the mammary gland was noted, leading to a decrease in lactopoiesis . In general, Progestogel begins to act due to an increase in the concentration of the active substance in the tissues of the mammary gland .
The use of the drug, even when creating a high concentration of progesterone at the site of application, does not cause systemic action or undesirable effects.
Some natriuretic effects as a result of inhibition of tubular reabsorption and increased cellular filtration, which prevents fluid retention during secretory transformations of the glandular component of the mammary gland and pain syndromes.
With the transdermal method of administering gestagen , there is a noticeable effect on the state of the vascular network and glandular epithelium, due to this, capillary permeability decreases, swelling of the breast tissue decreases, and the symptoms of mastalgia are eliminated.
The transdermal method of using the gel promotes rapid penetration into the tissue of the mammary glands, bypassing the process of destruction in the liver and without leading to the development of undesirable systemic effects in the body. In this case, the absorption of progesterone is about 10% of the dose and lasts for at least an hour from the moment of application of the drug, without changing the hormonal level.
With the help of cutaneous applications in the mammary glands, a high concentration is created at the site of application, even with a reduced dose.
Secondary metabolism of the drug occurs in the liver. In this case, conjugates with sulfuric and glucuronic acid are formed. In addition, the participation of the CYP2C19 isoenzyme was noted.
The drug is excreted mainly through the kidneys - about 50-60%, and a small amount through bile, about 10%. The number of metabolites that are excreted through the kidneys depends on the phase of the corpus luteum.
Use during pregnancy and lactation
No data on negative effects on the fetus have been established. But, despite this, it is not recommended to use Progestogel during pregnancy, especially in the 2nd and 3rd trimester.
The drug is contraindicated during breastfeeding, as it passes into breast milk. The exception is lactostasis. But at the same time, an integrated approach to therapy is used. The gel is combined with Bromocriptine, and an hour after taking the drug, milk is expressed. After some time, its quantity will be restored to the level necessary for feeding the child.
Indications for use
Gel Progestogel is prescribed in complex therapy:
- with fibroadenoma;
- for mastodynia and some other diseases of breast tissue.
Before you start using this product, you can see a photo of how to apply the gel to the affected area.
special instructions
The drug "Progestogel" is used for mastodynia caused by the use of oral contraceptives, premenopause, puberty, and premenstrual tension syndrome.
The product should be applied with a dispenser applicator to the skin of the mammary gland, without massaging or rubbing. It is advisable to avoid direct sun rays after applying the cream.
Studies regarding the possible effect of the drug on the ability to operate machinery and drive a car have not been conducted.
Contraindications for use
It is not recommended to use this external remedy if:
- nodular forms of fibrocystic mastopathy;
- tumors and tumor-like formations in the mammary glands of unknown origin;
- monotherapy for breast or genital cancer;
- II and III trimesters of pregnancy ;
- intolerance or sensitivity to the drug, and so on.
The gel should be used with caution in patients who have liver or kidney failure, bronchial asthma, epilepsy, migraine, depression, ectopic pregnancy, a tendency to thrombosis, acute forms of phlebitis, diabetes mellitus, arterial hypertension and some other diseases or special conditions.
Estrogens and mastopathy
Estrogens are the main ovarian hormones, divided into several dozen fractions, the main ones of which are estrone, estradiol and estriol. Different fractions of estrogens perform different functions. With a lack of estrogen, a woman’s appearance and mood changes, and an excess of estrogen provokes the formation of tumors and the development of hormone-dependent diseases, such as mastopathy.
Estrogens are formed from testosterone and androstenedione under the control of the aromatase enzyme. Cholesterol and luteinizing hormone are also involved in this process. Estrogen synthesis is impossible without male sex hormones - androgens.
The role of estrogen in the body:
- estradiol is the main estrogen, it acts in the body from the onset of puberty to menopause;
- estrone becomes dominant during the postmenopausal period;
- estriol is considered the weakest fraction; its activity increases during pregnancy.
The action of estrogens is possible only when they bind to receptors. They affect not only functions unique to the female body, but also many organs. In particular, estrogens protect against pathological processes, which becomes especially noticeable during menopause, when the concentration of hormones decreases and a woman’s health weakens.
An increase in estrogen levels is called hyperestrogenism. The cause of this condition may be obesity, polycystic ovary syndrome, use of contraceptives, hypothalamic dysfunction, liver disease. Estrogen levels can increase with excessive consumption of beer, fatty foods of animal origin, soy and legumes.
Excessive synthesis of estrogens in women of reproductive age provokes endometrial hyperplasia of the uterus, mastopathy, endometriosis, and cycle disorders. The intensity and pain of menstruation increases, and infertility is possible. In addition, with an excess of estrogen, blood pressure increases and blood clots form. In this state, excess weight appears faster, acne occurs, and hair falls out. The woman becomes irritable, sleeps poorly, and suffers from migraines.
Mastopathy is hyperplasia of breast tissue, a violation of the ratio of connective and epithelial tissue. In the first phase of the cycle, estrogen fractions provoke the proliferation of the mammary epithelium, but this process is soon blocked by another hormone - progesterone. With an excess of estrogen, breast tissue continues to grow, the structures become deformed, cysts, fibroadenomas and scars form. Progesterone (from the group of gestagens) can block the activity of estrogen. Sports and diet have a slight effect on estrogen concentrations.
Side effects
In rare cases, the use of the gel can cause disturbances in the functioning of the reproductive system, for example:
- increased tenderness of the mammary glands;
- strong flushes of blood;
- decreased libido;
- metrorrhagia.
In addition, allergic manifestations are not excluded - irritation at the site of application, swelling of the lips and neck, fever, headaches, nausea, and more.
Necessary Precautions
Under no circumstances should the dosage form be used without medical advice and prior measurement of the hormone level in the blood. The drug is sold in almost every pharmacy, and in most cases without a prescription, however, its independent use can lead to undesirable consequences, especially if there are undiagnosed tumor cells in the body.
You cannot use a drug that has expired, and even more so, it is prohibited to take it if the drug package has been opened. It should be stored out of reach of direct sunlight, in a specially designed place where children do not have access, at a temperature not exceeding +25.
Self-medication, or use of this medicine after the expiration date indicated on the package, can cause damage to health and cause negative consequences.
The use of any hormonal drug without appropriate indications, or for other purposes, can cause hair growth, contribute to changes in appearance, disrupt the natural level of hormones in the body, and lead to disruptions in hormonal function.
Instructions for Progestogel (Method and dosage)
This ointment is administered transdermally. To calculate the daily dose, use a special plastic dispensing spatula. When you need to apply Progestogel gel, the instructions for use advise pressing on the tube in a place above the line of the spatula. One dose corresponds to a column of gel along the length of the indentation on the ruler. Usually a tube is enough for 30 doses.
The squeezed product is applied to the skin surface of each breast . Often women doubt the accuracy of applying this product and would like to see a video “How to apply Progestogel correctly . However, there is nothing complicated in this process. This procedure must be performed daily, regardless of the frequency of the menstrual cycle or on the days established by a specialist. After application, the gel should be completely absorbed into the skin. The average duration of treatment is 3 months. A doctor's prescription is required for re-therapy.
Instructions for use
According to the instructions for use of Progestogel, the gel should be used as prescribed by a doctor. He calculates single and daily dosages and determines the duration of the upcoming treatment. The drug can be used in several ways depending on the diagnosed disease:
- daily;
- in the second phase of the menstrual cycle.
The rules and procedure for taking the drug are prescribed by a doctor.
Using Progestogel is quite simple. Each package contains an applicator for convenient dosing. With its help, you can correctly measure the required amount of gel for a one-time application to the mammary glands. Before the procedure, wash the skin and dry it with a cotton towel. Then you need to distribute a thin layer of the product on the mammary glands and rub in with massaging movements.
Progestogel should be applied up to 2 times a day. It is advisable to smear it before bed after hygiene procedures. At night, all biochemical processes in the body accelerate. The duration of the therapeutic course does not exceed 1 month. After consultation with a doctor, it can be extended for a few more weeks.
Overdose
Since progesterone enters the systemic bloodstream in low concentrations, no cases of overdose have been observed. If Progestogel gets inside, digestive and peristaltic disorders may occur. You should quickly rinse your stomach, take enterosorbent (activated carbon, Smecta) and seek medical help.
Side effects
More often, side effects of Progestogel are observed when the dosage regimen is violated or long-term treatment. Clinically, they are manifested by decreased sexual desire and irregular uterine bleeding. There may be increased discomfort in the mammary glands and slight enlargement of the lymph nodes. Allergic reactions, both local and systemic, are less commonly diagnosed. Their development is indicated by headaches, fever, facial swelling, and gastrointestinal disorders.
The drug has side effects
special instructions
Progestogel is a hormonal drug, so it should be used with caution. If any side effect occurs, stop using the gel and consult a doctor. He will adjust the dosage regimen or prescribe a drug with a different active ingredient.
A doctor’s consultation is also required if Progestogel is unsuccessful for 5-7 days. If the severity of pain does not decrease, the gel can be excluded from the therapeutic regimen. If it is necessary to use a hormonal drug, the doctor may prescribe drugs with an analgesic effect.
The use of progesterone does not affect memory, attention, or concentration. Therefore, there is no need to give up driving during Progestogel therapy. The instructions for use recommend not to stay in the open sun for a long time during the treatment period.
Pregnancy and lactation
Progestogel can be used in the early stages of pregnancy, but only if safer means are ineffective. Before prescribing it, the benefits to the mother and the risk to the intrauterine development of the fetus are taken into account. It is prohibited for use in the 2nd and 3rd trimesters of pregnancy. The manufacturer did not provide clinical trial results confirming the absence of teratogenic effects.
Not suitable for use during pregnancy
In case of urgent need, Progestogel can be used during lactation. Therapy is carried out under medical supervision with constant laboratory monitoring of the condition of internal organs.
Storage conditions and periods
The shelf life of the drug is 3 years. Once the tube is opened, it is recommended to use it for several months. Progestogel should be stored at room temperature in a dark place. If the gel separates, the smell changes, or a yellowish tint appears, it is prohibited to use it for treatment. The hormonal drug should be inaccessible to small children.
Conditions for dispensing from pharmacies
Progestogel is dispensed from pharmacies upon presentation of a prescription from a doctor.
Drug interactions
The gel combines well with other drugs - vaginal suppositories, ointments, tablets, creams. It should be taken into account that when combining hormonal contraceptives with Progestogel, its effect is enhanced.
Analogs
Matches by level 4 ATX code:
Iprozhin
Utrozhestan
Crinon
Prajeesan
Progesterone
The main analogues of Progestogel: Utrozhestan, Progesterone, Endometrin.
Reviews about Progestogel
It should be noted that many patients use Progestogel gel, reviews of which are very varied. Women often report its effectiveness, for example, thanks to the use of this external remedy, “seals soften, pain decreases,” and the general condition of the female body improves. However, there are also reviews from patients when, as a result of treatment with the gel, they, on the contrary, began to feel severe pain, hardening and lumpiness in the area of application. Other ladies are simply afraid to use hormonal drugs, believing that they will further undermine their health.
At the same time, reviews from doctors show that when contacting a specialist, a full selection of complex therapy is carried out, which often includes Progestogel. If treatment is started in a timely manner, then in most cases it is highly effective. The main problem is the fact that women are in no hurry to see a doctor, trying to independently eliminate unpleasant symptoms using traditional medicine methods. It is this approach that causes severe consequences, with the development of pathologies that significantly complicate further treatment.
Use of the product for mastopathy
In women of reproductive age, cystic fibrous mastopathy occurs quite often. The pathology is benign, but often causes great concern to the patient.
The causes of the disease can be various factors: changes in hormonal levels and continuous depression, as well as the process of inflammation in the pelvic organs and very strong stress. The problem can be diagnosed by discomfort in the chest area. During palpation, a certain soreness is felt.
To eliminate the disorder, only drug treatment is prescribed. A specialist may prescribe oral medications intended for oral use. However, local medications also have a beneficial effect on eliminating swelling. It is one of the most effective drugs "Progestogel" for mastopathy. The opinions of patients indicate its rapid impact; experts note the presence of a hormone in the composition, which affects directly in the area of application.
The development of mastopathy is also facilitated by an increase in estrogen levels. The use of the drug in question makes it possible to reduce its production and increase the concentration of progesterone, thereby solving the problem.
In the mammary gland, with fibrotic disease, stagnation occurs, which leads to small compactions. The specific enzyme estradiol, which prevents this process, includes the drug “Progestogel”. Experts say that this component does not allow the development of oxidative processes and has a beneficial effect on the entire vascular system of the body. Patients using the product note that the pain, feeling of fullness and burning gradually go away.
Progestogel price, where to buy
As it turned out, the price of Progestogel in Moscow pharmacies varies between 445-577 rubles. Approximately the same price for Progestogel gel is observed in other Russian regions. A course of treatment may require 2-3 tubes of the drug.
- Online pharmacies in RussiaRussia
- Online pharmacies in UkraineUkraine
- Online pharmacies in KazakhstanKazakhstan
ZdravCity
- Progestogel gel 1% 80gBezen Manufacturing Belgium RUB
1,022 order
Pharmacy Dialogue
- Progestogel gel (tube 1% 80g)Besins Manufacturing Belgium
RUB 1,114 order
show more
Pharmacy24
- Progestogel 1% 80 g gel
219 UAH. order
PaniPharmacy
- Progestogel gel Progestogel gel 80g + spar. dosage No. 1 Belgium, Besins Manufacturing Belgium
261 UAH. order
show more
Packaging, composition and release form
According to the instructions, “Progestogel” is available in the form of a 1% gel for external use, which is translucent, colorless, slightly opalescent, there are no visible particles, with the aroma of alcohol.
The active ingredient in 100 grams is one gram of micronized progesterone. Auxiliary components:
- octyldodecanol;
- carbomer 980;
- macrogol glyceryl hydroxystearate (polyoxyl hydrogenated castor oil);
- triethanolamine (trolamine);
- 96% ethanol, purified water.
Available in 80 g aluminum tubes, the kit includes an applicator-dispenser. They are packed in cardboard boxes.
