- October 31, 2018
- Other drugs
- Gena Poddubny
Biosulin R is human insulin and has a short action. Next, consider the instructions for using this medicine.
According to the instructions for use, Biosulin R is produced in the format of an injection solution. It is completely transparent.
The medicine is supplied in 3 milliliters in glass cartridges for use with a syringe pen for Biosulin R. The main active ingredient is human genetically engineered insulin (soluble). There are 100 units in 1 milliliter of the drug. The auxiliary components are metacresol along with glycerin and water for injection.
The syringe for administering the drug is called “Bioinsulin Pen”.
Pharmacodynamics and pharmacokinetics
Pharmacodynamics
Insulin Biosulin is human insulin , which is obtained using recombinant DNA . There are three types of bioinsulins : 30/40 (biphasic), medium-acting and short-acting soluble. All types of genetically engineered insulins interact with the cell membrane receptor and form a complex. It is he who stimulates intracellular processes and the synthesis of basic enzymes. A decrease in glucose content is associated with an increase in its absorption and assimilation.
Biosulin N has an average duration of action. Its action profile is subject to significant fluctuations even in the same person. With subcutaneous injection, the onset of action is observed after approximately 1-2 hours, after 5 and 12 hours the maximum effect is achieved, and the duration of action varies between 19-24 hours.
Biosulin R has a short action. When injected subcutaneously, it takes effect within 30 minutes, the maximum effect is within 2-4 hours, and the duration is 7-8 hours.
Pharmacokinetics
The onset of the effect of any insulin depends on the dose, site of administration, and concentration of the drug. Injected insulin is distributed unevenly throughout the tissues. Destroyed by insulinase in the kidneys and liver.
Biological effects - how the substance affects the body
When penetrating tissue, medical insulin has the following effects:
- Regulates carbohydrate metabolism. It helps accelerate the transport of glucose through cells and the production of liver glycogen.
- Breaks down fats, reduces the entry of fatty acids into the blood.
- Blocking ketones.
- Promotes the formation of coenzyme.
- Increases the rate of transfer of amino acids into cells that produce peptides, accelerates protein metabolism, as it contains protamine.
- Inhibits enzymes.
Insulin is used to treat any type of diabetes. Treatment is always prescribed individually, depending on the degree of the disease, its duration and characteristics of the body. Lantus, a substance containing insulin, is often prescribed in complex therapy. Biosulin R is most often administered subcutaneously, in rare cases it is prescribed intramuscularly.
Side effects
- increased sweating, pallor, headache , palpitations, hunger, tremor , paresthesia , agitation;
- hypoglycemic coma;
- Quincke's edema , skin rash, anaphylactic shock ;
- swelling;
- refractive errors;
- hyperemia at the injection site, lipodystrophy (with long-term use).
Injection procedure
The injection procedure itself is as follows:
- Use two fingers to gather the fold, then insert a needle into its base at an angle of about forty-five degrees and deliver insulin under the skin.
- After performing the injection, the needle must remain under the skin for at least six seconds to ensure that the insulin has been completely injected.
- If, after removing the needle, blood appears at the injection site, the patient should press the area with a finger.
- The injection site should be changed.
Biosulin, instructions for use (Method and dosage)
Biosulin N is used for subcutaneous administration. Used alone or in combination with other insulins . The dose is determined by the doctor. The average daily dose is 0.5 to 1 IU per kg of weight. Most often, the injection is performed in the thigh or anterior abdominal wall. To prevent the appearance of lipodystrophy, you need to change injection sites.
Biosulin R is used subcutaneously, intramuscularly and intravenously. The average daily dose is also calculated. Administered 30 minutes before meals.
In monotherapy, the drug is administered 3 times a day (sometimes 6 times). The patient performs subcutaneous injections himself, while intramuscular and intravenous injections are performed only in medical institutions under the supervision of a physician. Dose adjustment is carried out in case of infectious diseases, fever , before surgery, as well as with a significant increase in physical activity. The transition from one drug to another is carried out under the control of blood sugar levels.
Both drugs are administered using insulin syringes, and the syringe pen for Biosulin allows the use of only 3 ml cartridges. Biomatic Pen syringe pen and strictly follow the instructions for its use. The cartridge is intended for individual use and cannot be refilled.
Injection technique when it is necessary to mix two types of insulin
In the event that a patient needs to mix two types of insulin:
- It is necessary to disinfect the rubber membrane on the bottle.
- Before taking the kit, roll the bottle of long-acting insulin between your palms until the substance becomes white and cloudy evenly.
- Draw air into the syringe in a volume that corresponds to the dosage of cloudy insulin. Then they insert it into the bottle and remove the needle.
- Draw air into the syringe in a volume that corresponds to the dose of short-acting insulin. Now they inject it into a bottle of insulin, which is transparent. Turn the vessel and syringe upside down and draw out the required amount of clear insulin. Remove the needle and remove any remaining air from the syringe. Check the correct dosage.
- Insert the needle into the vial of insulin, which is cloudy, turn it upside down along with the syringe and draw out the required dosage of insulin. Remove air from the syringe, checking that the dosage is correct. Immediately perform an injection of the collected insulin mixture.
- Both types of insulin should always be taken in the same sequence, which was described above.
Overdose
Manifested by a hypoglycemic state: increased sweating, pallor, palpitations, hunger, tremor , paresthesia , agitation, headache . , hypoglycemic coma develops .
Treatment for mild hypoglycemia involves taking sugar, sweet tea, or carbohydrate foods (sweets, cookies, candy). In severe cases ( coma ), a 40% dextrose intravenously, and glucagon . After the patient regains consciousness, it is recommended to take carbohydrate foods.
Interaction
The effect of the drug is enhanced by: oral hypoglycemic agents, inhibitors of monoamine oxidase , carbonic anhydrase, angiotensin-converting enzyme , sulfonamides, non-selective beta-blockers , octreotide , bromocriptine , anabolic steroids, clofibrate , tetracyclines , ketoconazole , pyridoxine , cyclophosphamide , theophylline , hairdryer fluramine , lithium preparations, ethanol.
The effect of the drug is weakened by: glucocorticosteroids , oral contraceptives, heparin , thiazide diuretics, tricyclic antidepressants , danazol , clonidine , sympathomimetics, calcium channel blockers, morphine , phenytoin , diazoxide , nicotine . When using reserpine and salicylates, both a weakening and an increase in the effect are observed.
Reviews about Biosulin
The drug of choice in the treatment of patients with diabetes is genetically engineered human insulin, which is identical in chemical structure to human insulin. According to the International Diabetes Federation, these are the only insulins used throughout the world. Their advantage is their effectiveness and safety, and therefore the Ministry of Health of the Russian Federation recommends their use for the treatment of adolescents, children and pregnant women. The results of studies of such drugs showed that the content of liver enzymes, lipids, residual nitrogen, creatinine and urea remained within normal limits during their use. No one had any allergic reactions.
Another advantage (this applies to the long-acting drug) is that the protein protamine (the so-called NPH insulin ) is used as a prolongator, rather than zinc. NPH insulins can be mixed with short-acting drugs in the same syringe and this will not lead to a change in pharmacokinetics. Despite all the advantages, there are negative reviews and many patients prefer imported drugs ( Humalog , NovoRapid ).
- “... I’ve been injecting him for several months now. Everything is fine, but I think that there is nothing better than Humalog.”
- “... Grandmother on Biosuline. It’s possible to compensate for the sugar, but the vision decreases and the diabetic foot.”
- “... I’ve been on it for several days. Issued at the clinic. It got worse - sugar levels are over 20! Does not help!".
- “...Personally, Biosulin N does not help me, but Biosulin R works well.”
Injection technique when using insulin in cartridges with a syringe pen
The cartridge with the drug is intended for use with a syringe pen called “Biomatic Pen”. The patient must be warned about the need to carefully follow the instructions in the instructions for using a syringe pen to inject insulin.
Immediately before use, you should make sure that the medication cartridge is not damaged (for example, cracks). You cannot use it if there are any visible defects. After the cartridge is inserted into the pen, a colored stripe should become visible through its window.
After the injection, the needle should remain directly under the skin for at least six seconds. It is necessary to keep the button firmly pressed until the needle is removed from the skin. Thus, the correct dosage is administered, limiting the possibility of blood entering the needle. It is worth noting that the cartridge with this drug is intended for individual use only and cannot be refilled.
Biosulin price, where to buy
You can buy Biosulin N at any pharmacy. The cost of 1 bottle of suspension 100 IU 10 ml is 500-510 rubles, 5 cartridges of 3 ml each can be purchased for 1046-1158 rubles.
- Online pharmacies in RussiaRussia
ZdravCity
- Biosulin n suspension.
for s/c input. 100 IU/ml 3ml No. 5 (cartridge + syringe pen) Pharmstandard-Ufavita Ufimsky vitamin plant OJSC RUB 1,464 order - Biosulin R solution for in. 100 IU/ml 3ml 5 pcs Pharmstandard-Ufavita Ufimsky vitamin plant OJSC
RUB 1,096 order
- Biosulin N suspension. for s/c input. 100 IU/ml 3ml 5 pcs Pharmstandard-Ufavita Ufimsky vitamin plant OJSC
RUB 1,113 order
- Biosulin R solution for in. 100 IU/ml 10mlPharmstandard-Ufavita Ufa vitamin plant OJSC
RUR 515 order
Special conditions
Taking the drug necessarily implies a diet with a calorie range of 1700–3000 per day. This will give a good treatment result in a short time. You can take Biosulin N during pregnancy; no additional side effects have been identified. Taking this drug will be a good preventative measure during pregnancy.
For people over 65 years of age, those who suffer from kidney and heart diseases, as well as during an acute viral infection or cold, the dose of artificial insulin must be adjusted. After discontinuation of Biosulin R or N, you need to constantly monitor your blood glucose levels.
Like any other medications, the drug is not recommended to be taken with alcohol. While medical insulin is in effect, alcohol will not have its usual effect on the body.
