Pharmacodynamics and pharmacokinetics
imidazoline derivative , is an alpha-adrenergic agonist and has a local vasoconstrictor effect on the vessels of the nasal cavity.
the arterioles located in its mucous membrane are narrowed , due to which exudation , hyperemia and swelling , discharge from the nasal cavity is reduced, and normal nasal breathing is restored.
Oxymetazoline also helps to reduce swelling of the mucous membrane that envelops the passages of the Eustachian tube , thereby facilitating drainage in otitis media and tubo-otitis ( eustachitis ).
Additional effects of essential oils included in the spray are expressed in eliminating irritation of the nasal mucosa and protecting it from excessive drying.
The development of local vasoconstriction , occurring in the nasal mucosa and paranasal sinuses, is observed 5-10 minutes after using the spray and, in accordance with the individual response of the human body, can last for 10-12 hours.
Knoxprey Malyuk
Children's Noxprey Malyuk can be used even during the treatment of newborns. The medicine is presented in the form of nasal drops, colorless or yellowish. When used topically in the optimal therapeutic concentration, the drops do not cause irritation of the nasal mucosa or the development of hyperemia. The medicine does not have a systemic effect on the body.
Peculiarities
The instructions for children's Noxprey say that you should refrain from prolonged use of the medicine due to the risk of addiction, atrophy of the nasal mucosa, as well as reactive hyperemia with the subsequent development of drug-induced rhinitis.
In case of overdose, mydriasis, nausea, vomiting, arrhythmia, tachycardia, vascular insufficiency, decreased blood pressure, and respiratory disorders may develop. In severe cases, the functioning of the central nervous system is suppressed, followed by the development of coma.
In case of overdose, you should rinse the stomach, take a medicine with an absorbent effect and immediately consult a doctor for symptomatic therapy.
Instructions and dosage
The instructions for Noxprey Malyuk describe the following recommendations regarding the dosage regimen:
- For newborns up to 1 month, instill 1 drop into each nostril up to 2 times a day.
- Children from 1 to 12 months - 1 drop in each nasal passage up to 3 times a day.
The duration of use of the medicine should not exceed 7 days.
Indications for use
Noxprey is indicated for:
- treatment of acute rhinitis caused by an allergic reaction or infection ;
- therapy for tubootitis ( eustachitis ), sinusitis , otitis media ;
- prevention of difficult nasal breathing and nasal congestion in diseases of cold etiology;
- facilitating the process of rhinoscopy and other diagnostic procedures in the nasal cavity.
Contraindications
The use of Noxprey is contraindicated in:
- pregnancy;
- diagnosed atrophic rhinitis ;
- breastfeeding;
- personal hypersensitivity to oxymetazoline and/or other components of the drug;
- under the age of 6 years.
Noxprey can be used with caution when:
- severe atherosclerosis ;
- angle-closure glaucoma;
- CHF;
- thyrotoxicosis;
- arrhythmias;
- prostate hyperplasia , which occurs with clinical symptoms;
- arterial hypertension;
- diabetes mellitus;
- chronic renal failure;
- parallel therapy using tricyclic antidepressants or MAO inhibitors .
Side effects
With the recommended dosage regimen, the following was occasionally observed:
- sneeze;
- itchy nose;
- a feeling of dryness or burning of the inner membranes of the nose;
- formation of reactive hyperemia .
With repeated uncontrolled use, the following was sometimes noted:
- nausea;
- tachycardia;
- headache;
- insomnia;
- increased blood pressure ;
- feeling of anxiety .
Very rarely, when using the spray, the formation of severe hypersensitivity reactions, including Quincke's edema .
If side effects are detected, use of the drug should be stopped immediately and consult a doctor.
Noxprey, instructions for use
The instructions for Noxprey involve injecting the contents of the bottle into the nasal cavity. To do this, you need to unscrew the cap of the bottle, insert its sharp tip into each nasal passage one by one and, by pressing sharply once on the bottle itself, inject the spray into the nostril. While performing this procedure, you should forcefully draw in air through your nose. There is no need to turn the bottle over or tilt your head back.
The dosage regimen recommends that patients over 12 years of age take 1-2 injections (6-12 years - 1 injection) twice a day into each nasal passage. The duration of use of Noxprey should be limited to 7 days.
Pharmacological authorities
Pharmacodynamics.
Noxprey for children is an α-adrenergic agonist, similar to imidazoline, and belongs to the group of local vasodilatory agents. It sounds like a sound in the place of application, changes the swelling of the mucous membrane of the nose and upper respiratory tract, changes the vision from the nose. Renews nasal breathing. Reduced nasal mucosa leads to renewed aeration of the paranasal sinuses, emptying of the middle ear, which prevents the development of bacterial complications. Oxymetazoline has antiviral, anti-inflammatory, immunomodulatory and antioxidant effects. This combined mechanism resulted in a more effective reduction of symptoms of acute rhinitis (nasal congestion, rhinorrhea, coughing, low self-esteem). In case of local nasal infusion in therapeutic concentrations, it does not irritate the nasal mucosa and does not cause hyperemia. Essential oils, which are added to the preparation, soothe the nasal mucous membranes and protect them from excessive dehydration.
Pharmacokinetics.
The withdrawal period is approximately 35 years after the drug has been infused. 2.1% of the drug is excreted in alcohol, about 1.1% is excreted in feces. The shelf life of oxymetazoline is up to 12 years.
Overdose
With uncontrolled excessive use of Noxprey or its accidental oral administration, the development of arrhythmia , miosis , nausea/vomiting, hyperthermia , cyanosis , tachycardia , arterial hypertension , vascular insufficiency, respiratory disorders, pulmonary edema, mental disorders, and cardiac arrest was noted.
There is isolated information about suppression of central nervous system functions followed by coma.
Therapy for such conditions requires treatment based on observed symptoms.
Overdose
Overdose may occur after nasal or intravenous oral administration. The clinical picture of intoxication by imidazole-related drugs may be unclear, and periods of stimulation may alternate with periods of suppression of the central nervous, cardiovascular, and respiratory systems.
Stimulation of the central nervous system may manifest itself in the appearance of anxiety, agitation, hallucination, and seizures.
Suppression of the central nervous system may manifest itself as a decrease in body temperature, lethargy, drowsiness, and possible development of coma.
The following symptoms may also occur: miosis, mydriasis, elevated temperature, increased sweating, pallor, cyanosis, accelerated heart rate, tachycardia, bradycardia, arrhythmia, cardiac arrest, arterial for hypertension, arterial hypotension right up to the development of shock, boredom, vomiting, respiratory failure and apnea , mental disorders.
Zocrem, in children, overdose can cause major effects on the side of the central nervous system: development of coma, bradycardia, apnea, as well as arterial hypertension with a possible transition to arterial hypotension.
Likuvannya.
In cases of severe overdose, intensive therapy is indicated. It is recommended to immediately take active vugill (absorbent), sodium sulfate (carrying agent) or rinsing the tube (in case of overdosing with a very strong drug), fragments of oxymetazoline may be quickly absorbed. Vasopressor agents are contraindicated. Non-selective alpha-blockers can be used as an antidote. If necessary, you can take steps to reduce body temperature, carry out anti-seizure therapy and ventilation.
special instructions
In order to prevent the spread of infectious diseases, one bottle of the drug is intended for use by only one patient.
Prolonged use of decongestants , as this can lead to a decrease in their effectiveness, as well as to the development of various negative phenomena associated with overdose.
Abuse of Noxprey can cause atrophy of the nasal mucosa and cause reactive hyperemia with parallel drug-induced rhinitis .
Avoid getting the contents of the bottle into your eyes.
Side effects
On the side of the dichotomy system:
discomfort in the nose, liver or dryness of the nasal mucosa, such as severe congestion in the nose (reactive hyperemia), coughing, nosebleeds, apnea in newborns and young children, especially in cases of overdose.
On the side of the nervous system:
headache, drowsiness, fatigue, lethargy, sleeplessness, restlessness, seizures (especially in children), hallucinations (especially in children), confusion, boredom, vomiting.
On the side of the cardiovascular system:
Local nasal administration of the drug may cause systemic effects (palpitation, tachycardia, arterial hypertension, arrhythmias).
On the side of the immune system:
Allergic reactions may occur, including hissing, itching, and angioedema.
Analogs
Level 4 ATX code matches:
Xymelin Eco
Xymelin
Nazivin
Galazolin
Lazorin
Nazivin Sensitive for children
Otrivin
Naphthyzin
Sanorin
For the nose
Lazolvan Rino
Afrin
Rhinorus
Eucazoline Aqua
Rinazolin
Grippostad Reno
Farmazolin
Xylometazoline
Nazol Advance
Nazol Baby
- For the nose;
- Galazolin;
- Xylene;
- Otrivin;
- Naphthyzin;
- Sanorin;
- Tizin Xylo;
- Rhinostop;
- Eucabalus;
- Farmazolin;
- Meralis;
- Eucazoline Aqua.
Reviews
There are a wide variety of and often conflicting reviews about Knoxprey, ranging from completely positive to completely negative. Some patients using this drug, after a certain time, discovered that they simply had a “painful” addiction to the spray and the impossibility of normal nasal breathing without its use. In fairness, it is worth noting that they all ignored the recommendations for its use and exceeded both the number of possible injections per day and the duration of treatment itself. On the contrary, when using the drug strictly in accordance with the instructions, no negative manifestations associated with its action were observed, and the effectiveness of the spray remained at a very high level.
Contraindicated
Increased sensitivity to the components of the drug, atrophic rhinitis, with stagnation of monoamine oxidase inhibitors (MAO) and for 2 years after administration of treatment with MAO inhibitors, as well as other drugs, what causes displacement of the arterial pressure, with a displaced internal eye pressure, especially with closed-cuta glaucoma, with severe forms Cardiovascular diseases (for example, ischemic heart disease, arterial hypertension), pheochromocytoma, metabolic disorders (hyperthyroidism, diabetic diabetes, porphyria), prostate hypertrophy. Do not stiffen after transphenoidal hypophysectomy or other surgical procedures for cerebral lining.
Noxprey price, where to buy
The price of Noxpreya fluctuates around 200 rubles.
- Online pharmacies in RussiaRussia
- Online pharmacies in UkraineUkraine
ZdravCity
- Noxprey nasal spray.
0.5 mg/ml 20 ml Sperko Ukraine SP 145 rub. order
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Pharmacy24
- Noxprey Baby nasal spray for children 0.025% 15ml Joint Ukrainian-Spanish enterprise "Sperko Ukraine", m. Vinnytsia, Ukraine
38 UAH. order - Noxprey 0.05% 10 ml spray Spilne Ukrainian-Spanish enterprise "Sperko Ukraine", m. Vinnytsia, Ukraine
40 UAH order
- Noxprey Active 0.05% 10 ml spray
45 UAH order
