Bellataminal

Pharmacodynamics and pharmacokinetics

Bellataminal is a combination medicine, the effectiveness of which is determined by the effect on the human body of each component. Therefore, ergotamine and belladonna alkaloids exhibit a slight antispasmodic effect. Phenobarbital reduces the excitability of peripheral nerve endings due to the presence of a calming effect.

Typically, the therapeutic effect is felt after long-term use of the drug - at least one month. The organs of the excretory system are responsible for removing the drug from the body.

Bellataminal®

Bellataminal® is a combination drug. It has α-adrenergic blocking, m-anticholinergic and sedative effects, and has antispasmodic properties. The drug reduces the excitability of the central and peripheral adrenergic and cholinergic systems of the body, has a calming effect on the central nervous system (CNS), and has some antispasmodic effects.

The pharmacological properties of the drug are determined by the action of the components included in its composition.

Belladonna sum of alkaloids

(alkaloids of the atropine group) has an m-anticholinergic and antispasmodic effect. Interferes with the stimulating effect of acetylcholine; reduces the secretion of the salivary, gastric, bronchial, lacrimal, sweat glands, and the exocrine function of the pancreas. Reduces the tone of the muscles of the gastrointestinal tract, bile ducts and gallbladder, but increases the tone of the sphincters; causes tachycardia, improves atrioventricular conduction. Dilates the pupils, impedes the outflow of intraocular fluid, increases intraocular pressure, causes paralysis of accommodation, etc.

Phenobarbital

belongs to the group of barbiturates. It interacts with the barbiturate portion of the benzodiazepine-γ-aminobutyric acid receptor complex, thereby increasing the sensitivity of γ-aminobutyric acid receptors to γ-aminobutyric acid, leading to the opening of neuronal channels for chloride ions, which leads to an increase in their entry into the cell.

Suppresses the sensory zones of the cerebral cortex, reduces motor activity, and inhibits cerebral functions, including the respiratory center. Reduces the tone of the smooth muscles of the gastrointestinal tract. Has a sedative effect.

Ergotamine

- ergot alkaloid. Affects various organs and systems of the body, incl. on the central nervous system; increases the tone of the uterus. It has been established that ergotamine is characterized by α-adrenergic blocking activity in combination with a pronounced direct vasoconstrictor effect on the smooth muscles of peripheral and cerebral vessels. In this regard, against the background of the action of ergotamine, despite its α-adrenergic blocking activity, the tonic effect on peripheral vessels and cerebral vessels predominates. It has a direct stimulating effect on the smooth muscles of the vessels of the skull, causing their constriction due to binding to 5-HT1-serotonin receptors, which leads to their activation.

Contraindications to the use of Bellataminal

high sensitivity;
during pregnancy and labor;
angina pectoris;
angle-closure glaucoma;
pronounced degree of atherosclerosis and so on.

In addition, patients should take into account that the drug is recommended to be taken with caution while driving a vehicle, engaging in dangerous activities that require high attention, rapid reaction and good vision.

Contraindications

Before you start using this remedy in the fight against neurological pathologies, you should familiarize yourself with the contraindications. The drug is not prescribed to patients in the following cases:

age under 18 years;
pregnancy;
breastfeeding period;
severe atherosclerosis;
hypersensitivity to the components of the drug;
brain injuries;
angle-closure glaucoma;
pathologies of the kidneys, liver (with caution).

Overdose

In case of an overdose , dizziness, general lethargy of the body, tachycardia , accommodation paresis , problems with urination, intestinal atony , convulsive and even coma occur.

Recommended treatment: gastrointestinal lavage, taking activated charcoal or other symptomatic therapy.

Drug interactions

Before starting treatment for nervous system disorders, it is important to inform the doctor about what medications the patient is taking in parallel. Bellataminal may reduce the effectiveness of oral contraceptives. Adrenergic stimulants (Dopamine, Dopexamine and others) can enhance the sedative effect of tablets on the body. The dosage and course of therapy should be prescribed taking into account drug interactions.

Bellataminal's analogs

Level 4 ATC code matches:
Corvalol

Belloid

Corvaldin

Bellaspon

Korvaltab

Reladorm

Valocordin

Popular analogues are Reladorm , Bellalgin and Bellastesin . In addition, there are herbal remedies and sedatives of synthetic origin have been developed - bromides , for example, sodium or potassium bromides and bromocamphor . These components are taken either independently or included in some sedatives.

As for the cost of analogues, they can be purchased in pharmacies in a wide price range - 82-250 rubles.

Analogs

If the patient is allergic to the components of the drug or the required medicine is not available in the pharmacy, you can purchase one that is similar in composition or action. Before choosing and starting to use a Bellataminal analogue, it is recommended to consult a doctor. Popular drugs with similar composition or action are presented below:

Reladorm is produced on the basis of diazepam, calcium cyclobarbital. A drug is prescribed to reduce spinal reflexes, nervous excitability, and eliminate sleep problems. Cost: 450-650 rubles.
Bellasthesin is produced on the basis of belladonna extract and benzocaine. The use of the drug provides an analgesic and antispasmodic effect. Price: 55 rubles.
Potassium bromide. The product is made on the basis of hydrobromic acid and potassium. The medicine helps relieve seizures, stabilizes the functioning of the central nervous system, enhances inhibition processes in the patient’s cerebral cortex, and eliminates sleep disorders. Cost: 45 rubles.

Reviews about Bellataminal

This drug is often used in clinical practice, so reviews of Bellataminal are mostly positive. At the same time, doctors claim that the effectiveness of the drug is manifested even in the treatment of skin itching of various origins.

Some patients report that they experienced a variety of side effects during treatment. There are also often cases of drug overdose. Therefore, experts recommend taking Bellataminal correctly, for which they prescribe the appropriate prescription. When side effects occur, you must immediately inform your doctor so that the drug can be changed.

Bellataminal (belladonna alkaloids + ergotamine tartrate + phenobarbital) is a combination drug that combines the properties of an alpha-blocker, an m-anticholinergic blocker and a sedative. The list of indications for taking bellataminal has a wide therapeutic range: from increased irritability and sleep disorders to skin diseases and menstrual disorders. The drug has proven itself in the relief of post-concussion syndrome (PCS), a pathological condition that occurs in people who have suffered a traumatic brain injury. Headaches, vertigo, memory and attention disorders, depressive and anxiety states are quite common post-traumatic phenomena. As a rule, brain functions are restored within 2-3 months and the above symptoms disappear. However, in some cases, signs of ACL persist for a longer time. As some sources indicate, manifestations of ACL six months after a mild traumatic brain injury occur in 15–30% of patients. The optimal treatment strategy for patients with ACL is still a matter of debate. Clinicians are in a very difficult situation: on the one hand, they need to eliminate the cognitive, affective and autonomic symptoms of PCS, on the other hand, they need to avoid oversaturating the patient with sedatives that depress cognitive functions. In this regard, the domestic drug bellataminal is of particular interest. Russian scientists conducted a study of its effectiveness in patients with ACL. The study assessed the effect of the drug on the severity of the main symptoms of PCS and its safety. Two groups of patients were formed: participants in one of them took bellataminal 1 tablet 3 times a day for 30 days, participants in the other formed a control group. The severity of clinical and subjective symptoms was assessed using a specially developed scale before and at the end of pharmacotherapy. By the end of the 1st month of treatment, a statistically significant decrease in the severity of ACL symptoms was recorded in the experimental group compared to the initial level.

Compared with the control group, patients taking the drug had lower rates of headache, vertigo, nausea, sensitivity to light, emotional instability and irritability. Thus, in the experimental group, improvement was noted more often than in the control group, and a pronounced regression of symptoms due to bellataminal was observed twice as often as in the comparison group. In addition, the drug showed good results in terms of safety for patients: minor side effects such as dry mouth, drowsiness, lethargy and headache were observed in only 7% of patients. However, in none of the cases was it necessary to discontinue bellataminal.

The drug can also be effective in the treatment of dermatological diseases. Previously, bellataminal was quite actively used to reduce psycho-emotional overload in atopic dermatitis, dyshidrotic eczema, and itchy dermatoses. In recent years, due to global warming, the problem of treating prickly heat has become particularly relevant. Considering the presence of sedative and m-cholinergic effects in bellataminal, clinicians have proposed this drug as a means of direct and indirect reduction of excessive sweating. A study conducted at the Department of Dermatovenereology and Cosmetology of the Institute of Pedagogy of the Federal Medical and Biological Agency of Russia confirmed the effectiveness of bellataminal in the complex treatment of prickly heat.

Bellataminal is available in tablets. The drug is taken 1 tablet 2-3 times a day after meals. The duration of the drug course varies from 2 to 4 weeks with the possibility of a second course after agreeing on this issue with the attending physician. Bellataminal contains potent components, so it is not superfluous to know the symptoms of a drug overdose: lethargy, tachycardia, impaired accommodation, lack of normal intestinal tone, convulsions. The action of bellataminal is potentiated by nicotine, alpha and beta adrenergic agonists.

Bellataminal price, where to buy

In different pharmacies, the price of Bellataminal varies depending on the number of tablets in the package. Thus, you can buy these tablets in Moscow at a cost of 153 to 216 rubles.

Online pharmacies in RussiaRussia

ZdravCity

Bellataminal tablets p.p.o.
30 pcs. CJSC "Pharmcenter VILAR" 124 RUR. order