The drug Ornidazole is a drug with antibacterial and antiprotozoal action.
It has a detrimental effect on anaerobic bacteria and protozoan parasites. Aerobic parasites are not susceptible to the action of this medicine. The following parasites are highly sensitive to the drug: Trichomonas, ticks, Giardia, Ureaplasma, Gardnerella, dysenteric amoebas. Clinical studies have also revealed the susceptibility of certain strains of parasites that cause gastric ulcers.
In this article we will look at why doctors prescribe Ornidazole, including instructions for use, analogues and prices for this drug in pharmacies. Real REVIEWS of people who have already used Ornidazole can be read in the comments.
Pharmacodynamics and pharmacokinetics
This antiprotozoal and antimicrobial agent is a derivative of 5-nitroimidazole. Its action is aimed at the biochemical restoration of the 5-nitro group of ornidazole, thanks to the intracellular transport proteins of anaerobic microorganisms and some protozoa. As a result of reduction, the 5-nitro group of ornidazole interacts with the DNA cells of microorganisms, inhibits the synthesis of nucleic acids, having a detrimental effect on bacteria.
Thus, the activity of the drug is manifested against a number of known bacteria, obligate anaerobes and gram-positive microorganisms. At the same time, aerobic microorganisms are not sensitive to Ornidazole.
This antibiotic is characterized by good absorption from the gastrointestinal tract, with a bioavailability of about 90%. Plasma protein binding is 15%.
Metabolism occurs in the liver through hydroxylation, subsequent oxidation and glucuronidation of the drug. Its components are found in breast milk and tissues, penetrate the blood-brain barrier and the placenta. Excretion occurs in metabolites in urine and feces, and partly in unchanged form.
Indications for use
The drug is prescribed for:
- trichomoniasis;
- amebiasis, for example, amoebic dysentery, extraintestinal amebiasis;
- giardiasis;
- prevention of infections caused by anaerobic bacteria;
- operations in the colon area;
- treatment of gynecological diseases .
Contraindications
The use of the drug is not recommended for:
- hypersensitivity;
- early pregnancy;
- lactation;
- childhood.
The drug is prescribed with caution in the treatment of diseases of the nervous system, epilepsy, multiple sclerosis , liver diseases, alcoholism , and during pregnancy.
Side effects
When treated with Ornidazole, side effects may occur in the form of: drowsiness, headache , gastrointestinal disturbances, dizziness, tremors, muscle rigidity , convulsions, fatigue, temporary loss of consciousness, allergic manifestations, and so on.
Side effects
When using the drug, patients may develop the following side effects:
- From the central and peripheral nervous system: headache, dizziness, tremor of the extremities, impaired coordination of movements, peripheral neuropathy.
- From the gastrointestinal tract: nausea, vomiting, dry mouth, changes in taste, metallic taste, pain in the epigastric region, stool disorders.
In isolated cases, mainly when using high doses of the drug, patients may develop seizures and confusion. From the hematopoietic system: leukopenia, neutropenia. Allergic reactions: skin rash, itching, urticaria, Quincke's edema.
Instructions for use of Ornidazole (Method and dosage)
According to the instructions for use of Ornidazole, this drug is presented in several pharmacological forms. The tablets are taken orally, preferably after meals. It is also possible to prescribe an intravenous solution or vaginal tablets.
The dosage, therapeutic regimen and duration of use depend on the type of disease.
For example, during the treatment of trichomoniasis, tablets may be prescribed orally or for intravaginal administration. In this case, the therapeutic regimen includes 2 oral tablets and one vaginal tablet at night for 5 days.
Treatment of amoebic dysentery is carried out within 3 days. In this case, the dosage of the drug depends on body weight. Therefore, patients weighing over 35 kg are prescribed a single daily dose of 1.5 g, and over 60 kg, 2 g.
The course of treatment for other forms of amoebiasis is usually 5-10 days, and giardiasis – 1-2 days.
During the prevention of infections that can be caused by anaerobic bacteria, 0.5-1 g of the drug is prescribed before surgery, and 0.5 g after surgery, taken 2 times a day for 3-5 days.
Composition and release form
Clinical and pharmacological group: antiprotozoal drug with antibacterial activity.
- Ornidazole contains the active substance of the same name and is available in the form of white tablets with a slight yellowish tint. One tablet contains 500 mg of the active ingredient Ornidazole, as well as auxiliary ingredients: lactose, microcrystalline cellulose, povidone, sodium lauryl sulfate, calcium stearate, aerosil, primellose, hypromellose, macrogol 4000, titanium dioxide, talc.
One package contains 10 tablets. The drug is also available in capsule form, the number of capsules per package is 10. The solution for intravenous administration of the drug is available in 100 milliliter containers.
Ornidazole analogs
Level 4 ATC code matches:
Batsimex
Ornisol
Meratin
Metronidazole
Ornidazole-Vero
Klion
Tinidazole
The main analogues of Ornidazole: Orgil, Meratin, Ornisid, Tiberal, Lornizol, Metronidazole, Trichopolum, Dazolic and Metrogil.
Which is better - Ornidazole or Tiberal?
The basis of the drug Tiberal is the substance ornidazole . Therefore, the indications for use of these drugs are the same. The differences between these drugs are the cost and the manufacturing company. If Ornidazole is a Russian drug, then Tiberal is produced by the Swiss company F. Hoffmann-La Roche. In any case, it is no less effective, which is confirmed by many clinical studies.
For what diseases is it used?
What Ornidazole helps you can find out from the annotation to it.
The instructions for the drug include all indications and contraindications, as well as side effects and dosages. Its use in practical medicine has caused a great resonance, and you can find not only reviews from patients, but also reviews from doctors about it. The range of applications of Ornidazole is quite large; it is used in gastroenterology, dermatovenereology, gynecology and surgical practice. This is due to its antiprotozoal and antimicrobial effects against:
- pathogens of protozoal infections;
- anaerobic microorganisms;
- microaerophiles.
Ornidazole is available in tablet form
Indications for use:
- Amoebiasis, including its extraintestinal forms (Entamoeba hystolitika).
- Giardiasis (Giardia lamblia).
- Trichomoniasis (Trichomonas vaginalis).
- Demodicosis (Demodex folliculorum).
In addition, the instructions indicate its bactericidal effect against leishmaniasis and balantidiasis.
Ornidazole has no effect on other parasites and worms.
Therefore, before you start using the drug, you should find out what it treats, look at the reviews below.
In surgical practice, indications for use are different; Ornidazole is used to prevent postoperative or post-traumatic anaerobic infections, since it destroys bacteroides, clostridia, and peptococci. Of the microaerophiles, Helicobacter pillory and Gardnerella vaginalis are sensitive to Ornidazole.
Reviews of Ornidazole
This drug is especially often prescribed for the treatment of trichomoniasis or giardiasis. Although it is widely used in clinical practice, patients are often interested in whether it is an antibiotic or not?
Numerous reviews of Ornidazole on forums include therapeutic regimens that are prescribed for various diseases. It should be noted that the effectiveness of the reception has significant differences and is not always positive. However, for some, tablets help better, while for others, suppositories for intravaginal administration. Also, varying degrees of effectiveness are manifested when Ornidazole and Ornidazole-Vero , and sometimes other analogues of the drug, are used.
However, this does not mean that any of these forms or drugs are worse or better. During the treatment period, it is important to follow the prescribed regimen and dosage, especially when antibiotic therapy is administered.
It is always necessary to first identify the causative agent of the infection, then determine its sensitivity to a particular antibiotic. Only then will the treatment be guaranteed to be effective.
As practice shows, this approach when prescribing treatment is not always carried out. Therefore, in most cases, standard therapy is prescribed, which cannot act equally on all patients.
Features of the drug
Contraindications to the use of Ornidazole include:
- pregnancy (first trimester);
- lactation;
- increased sensitivity;
- some organic lesions of the nervous system.
Use of the drug may cause dizziness
Side effects of the drug can be both from the gastrointestinal tract (metallic taste, nausea, abdominal pain, vomiting) and from the nervous system (dizziness, headaches, convulsions, paresthesia, tremors, neuritis). They are especially pronounced in case of overdose, but since there is no antidote, symptomatic treatment of seizures, depression and peripheral neuritis is carried out.
Unlike other drugs, Ornidazole does not affect liver alcohol dehydrogenase. If Metronidazole, Tinidazole and their analogues are used, the use of alcohol with them can lead to teturam-like reactions, but Ornidazole with alcohol does not cause such a complication.
Ornidazole price, where to buy
The price of Ornidazole in tablets is from 128 rubles for 10 pieces.
The price of Ornidazole suppositories varies between 140-290 rubles.
Price Ornidazole 500 mg in Ukraine – from 54.4 UAH.
- Online pharmacies in RussiaRussia
- Online pharmacies in UkraineUkraine
ZdravCity
- Ornidazole tab.
p/o captivity. 500 mg No. 10 Ozon LLC 166 rub. order - Ornidazole tablets p.p.o. 500 mg 10 pcs. Vertex JSC
RUB 216 order
- Ornidazole-OBL tablets p.p.o. 500 mg 10 pcs. JSC Obolenskoe farm. company
RUR 557 order
- Ornidazole-Vero tablets p.p.o. 500 mg 10 pcs. JSC Veropharm
RUB 199 order
Pharmacy Dialogue
- Ornidazole tablets 500 mg No. 10 Berezovsky plant
110 rub. order
- Ornidazole tablets 500 mg No. 10Vertex
RUB 226 order
- Ornidazole tablets 500 mg No. 10 Obolenskoe pharmaceutical company.
RUR 581 order
- Ornidazole tablets 500 mg No. 10Ozon LLC
177 RUR order
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Pharmacy24
- Ornidazole-KV 0.5 g No. 10 tablets PAT "Kiev Vitamin Plant", Kiev, Ukraine
58 UAH. order - Ornidazole 500 mg No. 10 capsules TOV Astrapharm, Ukraine
55 UAH order
- Ornidazole 0.5% 100 ml No. 1 solution ZAT “Infusion”, Ukraine
98 UAH order
