Instructions for use of the drug Potassium Orotate - indications for athletes, bodybuilders and children

Description:

Round flat-cylindrical tablets of white color with a chamfer and a score.

Pharmacotherapeutic group:

metabolic agent.

ATX code:

A05VA

Pharmacological properties:

Pharmacodynamics

Orotic acid is one of the precursors of pyrimidine nucleotides that are part of nucleic acids that are involved in the synthesis of protein molecules, and therefore, salts of orotic acid are considered as anabolic substances and are used for protein metabolism disorders, to stimulate them. The potassium salt of orotic acid (potassium orotate) is usually used. Potassium orotate stimulates the synthesis of nucleic acids, albumin production in the liver (especially under conditions of prolonged hypoxia), increases appetite, and has diuretic and regenerating properties.

Pharmacokinetics

After oral administration, 10% of the ingested dose is absorbed in the gastrointestinal tract. Converts to orotidine 5-phosphate in the liver. Excreted by the kidneys (30% in the form of metabolites).

Potassium Orotate in bodybuilding

According to instructions and reviews, it is allowed to take Potassium Orotate orally for athletes. In bodybuilding, the drug is used to eliminate intoxications, dermatoses, progressive muscular dystrophy, and spastic conditions. It is recommended to take it when the body is exposed to increased physical activity, because the medication quickly restores the body and helps build muscle mass.

Before training, bodybuilders combine the medication with Riboxin and other vitamins (Sportvik), which increases the intensity of muscle growth. At the physiological level, potassium ions accelerate metabolism, improve appetite, strengthen the heart, and stimulate reparative processes. Take the drug half an hour before meals in the amount of one tablet, or after four hours from the moment of eating. The tablet is chewed and washed down with water. The maximum dose is 6 pieces per day, the average amount is 3-5. The course of treatment lasts a month, then a break is observed for two months.

Directions for use and doses

Should be taken orally 1 hour before meals or 4 hours after meals. Adults: 250-500 mg 2-3 times a day. The course of treatment lasts on average 20-30 days. If necessary, treatment can be repeated after 1 month. In exceptional cases, the dose for adults can be increased to 3 g per day. Children - 10-20 mg/kg body weight per day, divided into 3-4 doses (for example, if the child’s body weight is 25 kg, then the allowed dose is from 25 x 10 = 250 mg (1/2 tablet) to 25 x 20 = 500 mg (1 tablet per day, divided into 3-4 doses). Course of treatment is 3-5 weeks. If symptoms of the disease persist, consult your doctor

special instructions

Instructions for use of Potassium Orotate contain a special instructions section, which indicates the following important points for taking the drug:

• does not cause drowsiness, does not affect the speed of psychomotor reactions, the speed of muscle contraction;
• when treating with medication, diet is required;
• A promising direction in cardiology is the use of Potassium Orotate in combination with magnesium;
• Contraindicated in chronic renal failure, liver cirrhosis with ascites.

During pregnancy

Women carrying a child often experience swelling, so the use of the medication during pregnancy is justified. It helps remove excess fluid from the body and replenish potassium deficiency. The daily dose for pregnant women is one tablet 2-3 times a day. During therapy, you should constantly monitor the daily amount of fluid you drink and urine output.

For children

The use of Potassium Orotate in childhood is possible according to the dosage regimen. Indications for use are anemia, nutritional-infectious and nutritional dystrophy, convalescence. The daily dose is divided into 2-3 times and is 0.01-0.02 g per kilogram of the child’s body weight. The course of treatment is about 3-5 weeks, depending on the doctor’s prescription.

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Release form

Tablets 500 mg.

10 tablets in a contoured cell-free packaging made of paper with a polymer coating or from a combined film material.

10 tablets in a blister pack made of polyvinyl chloride film and printed varnished aluminum foil.

30, 40 or 50 tablets in polymer jars or polymer bottles. Each jar, bottle, or 1, 2, 3, 4 or 5 contour cell packaging or contour cellless packaging, along with instructions for use, will be placed in a cardboard pack.

Drug interactions

The same annotation on the use of potassium salt speaks of its drug interactions with other drugs:

• reduces the toxicity of cardiac glycosides;
• increases the effect of magnesium and calcium preparations, improves ion tolerance;
• astringents and enveloping agents reduce the absorption of potassium from the gastrointestinal tract;
• cardiologists recommend combining the drug with magnesium;
• not intended for use as a potassium-containing drug in potassium replacement therapy;
• slows down the absorption of sodium fluoride, iron, tetracyclines;
• its effectiveness is reduced when combined with oral contraceptives, diuresis, muscle relaxants, insulin, and glucocorticosteroid drugs.

Transfer and synthesis

Transfer and synthesis are two key principles for understanding the mechanisms of energy production in muscles. The key source of energy for our bodies is ATP (adenosine triphosphate), and its transmission produces activity in the muscles. Only from the energy released as a result of the destruction of this connection can cells perform work. Synthetic systems are pathways in which the energetic action of ATP or similar energy releases are supported through compounds that aid in their regeneration.

An example of this action can be seen in muscle tissue, where we find high rates of ATP transfer, but low rates of purine synthesis. Although the concentration of high-energy compounds such as ATP was low and transport was high in places, the reverse synthesis rates were just the opposite. An excellent example of this is the heart (myocardium) - uracil and cytosine (pyrimidine bases) have a turnover of about 7 and 14% per hour with adenine nucleotides such as ATP having a turnover of only 2%.

Increasing muscle demand for ATP reduces total adenine nucleotide and total pyrimidine synthesis where metabolites are located. These metabolic reservoirs can be significantly reduced as a result of myocardial or skeletal muscle ischemia (insufficient blood supply), and certain metabolic diseases. But they are most important for athletes trying to reach the next level with repeated, high-intensity exercise.

Synthesis of orotic acid and carnosine

The effects of carnosine on pH (muscle acidity) control and the associated enhancement of high-intensity exercise have been well studied. During exercise, excessive lactate production is part of the process of extreme fatigue. However, the protons produced at the same time limit further action. As a result of the research work, a clear pathway was identified for the conversion of potassium orotate to β-alanine and carnosine in skeletal muscle tissue.

Analogs

The following analogues of Potassium Orotate are similar in their therapeutic effect on the body, chemical composition and active substance:

• Riboxin solution and tablets;
• Alpha lipone;
• Mildrocard;
• Vasomag;
• Valikar;
• Vitaden;
• Glycine Ozone;
• Gepadif;
• Farkovit B12;
• Energin.

Price for Potassium Orotate

You can buy the drug at an online pharmacy or order it from an online pharmacy. The cost depends on the pricing level of enterprises and the form of release of the medicine. Approximate prices:

Substance activity during physical activity

Two large studies have demonstrated the real impact of potassium supplementation on exercise capacity and biochemical markers, muscle growth (cortisol) and recovery (white blood cells).

This suggests that there is a mechanism for increased force production following the addition of orotate , as well as many other beneficial effects. This is good news for all powerlifters!

So what might be its potential uses and combinations as a dietary supplement?

One possible use in combination with creatine is the undisputed champion in sports nutrition. Creatine is a vital component for the regeneration and maintenance of ATP during intense muscle contractions. Its effect on improving performance has been shown in peer-reviewed studies.

The most effective nutrients that work well with orotate are magnesium . The mineral magnesium appears to be deficient in humans, and increased losses through sweat and urine production increase the incidence of deficiency in those who exercise regularly.

Basic mechanisms of orotic acid, according to instructions

1. Improvement and maintenance of SPS swimming pools
2. Increased glucose intake.
3. Enlarged ribose moieties, resulting in increased ribose formation.
4. Increased carnosine capacity.
5. Supports and enhances muscle hypertrophy (via supporting RNA synthesis during growth).
6. Increases uridine levels at the base of DNA, which increases muscle contractility.

Orotate: beneficial properties

1 Potassium, magnesium, calcium orotate is the best form to compensate for the deficiency of these minerals

One of the discoverers of the beneficial properties of potassium orotate is Dr. Nieper HA, who devoted many years of his life to studying its beneficial properties.

His works focus on the transport function of orotates of various minerals (potassium, magnesium, calcium). The doctor calls potassium orotate the best potassium preparation in terms of absorption .

Why? Because the potassium orotate molecule easily penetrates into cells (including muscle cells) and releases potassium ion in the place where it is needed, which improves the delivery of this important mineral 2,3.

Potassium itself is found in the body as a positively charged ion, which makes it difficult to penetrate the cell membrane. The orotate molecule is neutral.

If Dr. Nieper's hypothesis is correct, then potassium orotate is one of the best drugs for replenishing potassium deficiency .

Orotates of other minerals (calcium, magnesium, lithium) are also very effective in terms of absorption.

In sports and bodybuilding, under certain conditions, the risk of potassium deficiency is very high.

To understand which ones, it is necessary to understand the role of potassium in the body of athletes.

Potassium orotate is one of the most effective forms of potassium supplements in absorption and can be indicated for use in sports and bodybuilding in case of potassium deficiency

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Useful properties of Potassium in bodybuilding

The mineral potassium plays an extremely important role in internal metabolism. How important is clear from the following example: potassium deficiency, which often occurs when taking diuretics in bodybuilding while drying the body, can lead to death due to cardiac arrest.

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For this reason, simple diuretics or diuretics are considered one of the most dangerous pharmacological drugs in bodybuilding . To some extent, even more dangerous than steroids and growth hormone.

Potassium is present in the body in very large quantities inside cells (including muscle cells) and in the intercellular space. Together with some other minerals (calcium, magnesium, sodium), potassium regulates the level of fluids in the body and the balance of electrolytes, ensures the propagation of nerve impulses and muscle contraction.

Electrolytes are understood as liquids that fill cells and the spaces between them, saturated with ions of various microelements (potassium, sodium, calcium, magnesium, etc.). With the help of such an ionic mechanism, the transmission of nerve impulses between cells and the contraction of muscle cells .

The effect on fluid levels in the body implies the ability of potassium to lower blood pressure 4, and therefore the risk of stroke 5. A diet high in potassium strengthens the blood vessels of the brain and makes them able to withstand heavy loads 6.

Potassium ensures the functioning of the autonomic nervous system, which controls heart rate and brain function.

Together with calcium, it participates in the creation of bone tissue , determining the strength of bones and reducing the risk of fractures 7.8.

A deficiency of potassium in the body can increase the sensation of muscle soreness after exercise, lead to decreased muscle strength and endurance, and may also cause muscle cramps .

In the given example with diuretics, their use leads to the “washing out” of potassium from the body with urine, as a result of which the propagation of nerve impulses preceding the contraction of the heart muscle is disrupted, which can cause its spasm or arrhythmia with subsequent arrest.

Potassium is one of the minerals that ensures the propagation of nerve impulses in the body and the contraction of muscle cells. Its deficiency can cause muscle cramps and pain, as well as heart rhythm disturbances.

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2 Anabolic properties of Orotate

There is no scientific research into the benefits of taking potassium orotate in sports and bodybuilding for building muscle mass. Moreover, almost all conclusions about its benefits and harms are made on the basis of experimental studies on mice.

One of the important properties of orotic acid is its participation in protein synthesis in the body 9.

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It was first discovered in cow's milk, and later it was found that women's milk also contains it. This indirectly indicates an important role in ensuring the growth of cubs.

Indeed, experiments on mice have shown that when they are fed food enriched with potassium orotate, their growth is significantly accelerated . Scientists attribute this to an increase in the level of oxygen consumed due to an increase in breathing rate and heart rate 10.

At the same time, the combination of orotate, typical for bodybuilding, with different types of proteins in food (casein, egg protein, soy and wheat protein) does not affect the rate of weight gain in adult mice .

Moreover, when the diet is based on orotate and egg or wheat protein, the body weight of mice can decrease 11.

This indicates the likely uselessness of potassium orotate in bodybuilding for gaining muscle mass. Although, of course, more thorough research is required.

Orotate is involved in the creation of proteins in the body, but the benefits of taking it for gaining muscle mass in bodybuilding are questionable

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3 Benefits of Potassium and Magnesium Orotate for Heart and Cardiovascular Health

Scientific research shows the benefits of potassium and magnesium orotate for heart and vascular health 12.3.

Dr. Nieper himself was a practitioner and studied in clinical settings the effectiveness of orotates (potassium, calcium, magnesium) for the treatment of cancer, cardiovascular and some other diseases.

Nipper has found that potassium orotate is very effective in reducing the severity of heart disease, especially when combined with magnesium orotate. But even alone, it significantly accelerates the recovery of the heart muscle after a heart attack 13.

Scientists note the ability of orotate to “fix” magnesium in cells, which explains its benefits for heart health, in particular for the treatment of arrhythmia.

When taking orotate, the energy supply to the heart muscle improves 9.

All this together makes the heart capable of withstanding heavy loads in sports and is the basis for its use in sports medicine 9,14.

Orotate and especially magnesium orotate improves the health of blood vessels, reduces the level of bad cholesterol in the blood, reducing the risk of atherosclerosis 15.

Potassium and magnesium orotate improves the functional reserve of the cardiovascular system and helps withstand heavy loads in sports

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4 Some other beneficial properties of Orotate

Among other properties of orotate, the scientific literature mentions a protective effect on nerve cells, an anti-stress effect and effectiveness in the treatment of various nervous disorders 9.

Orotic acid is also involved in the creation of blood cells (erythrocytes and leukocytes) 9 and accelerates wound healing 16.

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The latter property theoretically makes it useful for accelerating recovery after training, during which microtraumas usually form in the muscles.

Orotate speeds up wound healing and may be useful for faster recovery after exercise

Drugs

Potassium orotate tablets are classified as metabolic drugs. They can only be purchased in pharmacies with a doctor's prescription. In terms of composition and pharmacological properties, all domestic analogs are identical and are interchangeable.

Table - Potassium orotate preparations produced in the Russian Federation

These drugs are used as stimulants of protein synthesis in a hospital setting and on an outpatient basis under the supervision of a physician.

Reviews about the application

You can leave a review about potassium orotate treatment and share your experience of using it in sports in a special form:

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Potassium orotate

Average rating: Number of reviews: 0

Based on customer reviews, we have identified the main advantages and disadvantages.

Pros:

• the drug is well tolerated;
• suitable for children;
• it can be used during pregnancy (in some cases).

Minuses:

• purchase by prescription;
• long wait for the effect.