Functional disruptions in the functioning of the autonomic nervous system are accompanied by spasms of smooth muscle muscles. It is the lining of the vascular wall of arteries and capillaries. Because of this, a person suffers from high blood pressure. The drug Papazol normalizes blood pressure by eliminating spasm and expanding the lumen of blood vessels.
Pharmacodynamics and pharmacokinetics
The effect of the drug on the body is due to the combination of two active ingredients bendazole and papaverine . Papaverine reduces vascular resistance and blood pressure due to the fact that it blocks the enzyme phosphodiesterase and creatine phosphokinase in blood vessels. The amount of calcium inside the cell decreases, cyclic AMP , this causes the vasodilator effect of the drug. Papaverine has an antispasmodic effect on the gastrointestinal tract and bile - and urinary tract.
Bendazole directly affects imidazole receptors of vascular smooth muscles (their walls). Thus, like papaverine, it relieves spasms, lowers blood pressure, and reduces the amount of calcium inside the cell. The substance also stimulates the activity of the spinal cord and, when taken for a long time, acts as an immunomodulator . The processes of protein and nucleic acid , antibody and phagocytosis .
What is the medicine used for and for what?
The drug has a vasodilator, antispasmodic, and vasodilator effect . In large doses it has a mild sedative effect .
Does the drug increase or decrease blood pressure?
Papazole reduces blood pressure by reducing the resistance of the vascular walls.
Instructions for use
Papazol is a combination product that includes 2 active ingredients:
1. Bendazole is an antispasmodic drug with a myotropic effect. It is capable of having the following effects on the body:
- Hypotensive;
- Vasodialatating;
- Stimulating spinal functions;
- Moderately stimulating immunity.
2. Papaverine is an antispasmodic drug with a hypotensive effect, acting on the body as follows:
- Inhibits PDE;
- Favors the concentration of cAMP in the cell;
- Reduces the content of calcium ions inside the cell;
- Reduces tone and relaxes smooth muscles of the intestines and stomach, respiratory system and genitourinary system;
- Relaxes and reduces the tone of vascular smooth muscles.
Long-term use of the drug has an immunomodulatory effect, accelerates the formation of interferon, favors the production of antibodies, and enhances the activity of phagocytes.
With a large dosage of the drug, a slowdown in intracardiac conduction and suppression of cardiac excitability are observed.
The effect of using Papazol is as follows:
- In lowering blood pressure;
- Dilatation of cardiac and cerebral vessels;
- Relaxation of smooth muscles of the intestines and stomach.
Indications for use
Papazol is recommended for use in the following cases:
With spasm of peripheral arteries and vessels in the brain;- In the presence of residual manifestations of poliomyelitis;
- During labile arterial hypertension;
- During peripheral facial palsy.
With spasm of smooth muscles of the gastrointestinal tract, including ulcerative manifestations in the stomach and duodenum, intestinal colic, spastic colitis, pyloric spasms, cholecystitis.
Mode of application
For adult patients, Papazol is prescribed 1 tablet. up to 3 times a day. The drug is taken 2 hours before or after meals. For children (from 1 year), the drug is prescribed in exceptional cases. During the course of taking the medication, drinking alcohol is not allowed.
The duration of use of the drug is determined by a specialist individually for each patient, based on his condition, severity of symptoms, medical history, and test results. The maximum duration of taking Papazole cannot last more than 3-4 weeks. At the end of the course of treatment, if the desired effect is not achieved, continuation of treatment is allowed after a break of 1-2 weeks.
Release form, composition
Papazol tablets are sold by pharmacy chains without a prescription. The drug is packaged in blisters of 10 pieces, which contain:
- Active ingredients: bendazole and papaverine hydrochloride (0.03 g each).
- Excipients: calcium stearate, potato starch, lactose.
Interaction with other drugs
Papazol interacts with other drugs as follows:
- Simultaneous use of Papazole with sedatives, antispasmodics, procainamide, diuretics, reserpine, quinidine, tetracyclic antidepressants can enhance the severity of the hypotensive effect;
- When taking the drug simultaneously with coatings, astringents and adsorbents, its absorption in the gastrointestinal tract is reduced;
- The drug weakens the effect of anticholyesterase drugs on smooth muscles (Physiostigmine, Galantamine, Proserin).
Contraindications
- drug allergy;
- respiratory depression and epilepsy ;
- children under one year old;
- AV conduction disorder;
- liver and kidney diseases;
- hypothyroidism and head injury;
- decreased intestinal motility , some diseases of the prostate gland .
The medicine is prescribed with caution for traumatic brain injury and for pregnant and lactating mothers.
Method and features of reception
Adult patients take one Papazol tablet 2 or 3 times a day two hours before or two hours after meals.
The duration of treatment depends on the individual characteristics of the patient and the nature of the disease. As a rule, reviews of Papazole confirm this; it lasts from 2 to 4 weeks (in adults).
The dosage of the drug and the duration of treatment in children are determined by the attending physician.
The safety of Papazole for pregnant and lactating women has not been established.
Indications for Papazol are determined by the attending physician.
During treatment with the drug, alcoholic beverages should be avoided.
Interaction
Combination with adsorbents, astringents and drugs that coat the gastrointestinal tract .
The effect of the medicine will be enhanced when combined with sedatives , tricyclic antidepressants , antispasmodics , novocainamide , diuretics , reserpine .
The drug weakens anticholinesterase drugs , levodopa , proserin .
The toxic effect on the liver when used with nitrofurantoin is enhanced.
pharmachologic effect
Bendazole in Papazole is an antispasmodic agent with myotropic action. It affects the body as follows:
- has a hypotensive effect;
- has a vasodilating effect;
- stimulates the functions of the spinal cord;
- moderately stimulates immune activity.
Papaverine is also an antispasmodic agent that has a hypotensive effect. According to the instructions for Papazole, papaverine:
- causes PDE inhibition;
- promotes the accumulation of cAMP in the cell;
- reduces Ca2+ content;
- helps reduce the tone and relax the smooth muscles of the stomach, intestines, as well as the organs of the genitourinary and respiratory systems;
- helps reduce tone and relax smooth muscles and blood vessels.
A large dose of Papazole suppresses the excitability of the heart muscle and helps slow intracardiac conduction.
The drug has virtually no effect on the central nervous system. A large dose may cause sedation.
The therapeutic effect of taking Papazol is:
- in dilation of blood vessels of the heart and brain;
- in lowering blood pressure;
- in relaxing the smooth muscles of the stomach and intestines.
Analogs
Level 4 ATX code matches:
Tornetis
Olmax Strong
Taxier
Dynamico
Revatio
Caverject
Levitra
Cialis
Tentex Forte
Rileys
Viagra
Sildenafil
Yohimbine hydrochloride
Zidena
Dibazol, duzopharm, enelbin 100 retard, papazol-lhfz, vinoxim MV, papazol-darnitsa.
Possible adverse reactions
During treatment with Papazol, there is a possibility of the following side effects:
- Rash on the skin like urticaria;
- Irregular heart rhythm (arrhythmia);
- Apathy, lethargy, decreased ability to work;
- Increased sleepiness during the day;
- Permanent lack of appetite;
- Nausea and vomiting;
- Excessive decrease in blood pressure;
- Problems with stool (diarrhea or constipation);
- Cardiopalmus;
- Increased sweating;
- Myocardial dysfunction
- Loss of strength, general weakness, malaise.
If you detect at least some of the undesirable reactions listed above, you must stop using the drug and seek professional medical advice! The specialist will prescribe symptomatic treatment and help you choose a suitable substitute.
Papazole price (where to buy)
The average price of Papazole and Papazole UBF for 10 tablets (1 tablet of the drug) ranges from 7 to 12 rubles.
- Online pharmacies in RussiaRussia
- Online pharmacies in UkraineUkraine
- Online pharmacies in KazakhstanKazakhstan
Pharmacy Dialogue
- Papazol (tab. No. 10) FS.-Tomskkhimpharm
10 rub. order - Papazol (tab. No. 10) DHF JSC
8 rubles order
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Pharmacy24
- Papazol-Darnitsa No. 10 tablets PrAT" Pharmaceutical company "Darnitsa", Ukraine
10 UAH. order
PaniPharmacy
- Papazol tablets Papazol tablets. No. 10 Ukraine, Darnitsa ChAO
11 UAH order
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Drug overdose
In case of an overdose of Papazol, the user experiences the following characteristic symptoms:
- Feverish state;
- A sharp decrease in blood pressure, up to a hypotensive crisis;
- Excessively intense sweating;
- Attacks of severe dizziness;
- Fainting conditions;
- Painful sensations localized in the temporal region;
- Darkening in the eyes;
- Nausea and bouts of vomiting.
If there are signs of an overdose, it is necessary to induce artificial vomiting in the patient, then give him a sorbent tablet and call an ambulance to provide professional medical care.
How can I replace Papazol?
The following analogues of Papazole can be found on the modern pharmaceutical market:
- Meverin;
- Dibazol;
- Analgin (solution for injection);
- No-shpa;
- Spasmalgon;
- Papaverine (tablets, suppositories, injection solution);
- Andipal;
- Duspatalin;
- Drotaverine;
- Vazaprostan.
The drugs listed above are not absolute analogues of Papazole, although they have a similar composition and have antihypertensive properties. Each medication has its own characteristics regarding dosage, dosage regimen, duration of treatment, and restrictions on use. For this reason, you should not independently replace Papazol prescribed by the doctor with another medicine. If you need to select an analogue, you need to consult a qualified specialist on this issue!
The drug Papazol is an effective medicine that helps normalize blood pressure and improve the general condition of the patient. However, despite the rather mild effect of the tablets, it is strongly recommended to consult with your doctor before starting a therapeutic course!
Storage, terms of sale, cost
To purchase this drug, you do not need to present a prescription form. Storage in a dark, cool place ensures the preservation of all positive qualities for a period of five years from the date of its release (the date is indicated on the packaging). It is important that the packaging with Papazol does not end up as a toy in children’s hands.
The estimated cost in the pharmacy chain for 10 tablet forms is within 25 rubles.
Release form and components.
The drug Papazol can be purchased in the pharmacy chain in foreign currency in 10 tablet forms. They are packaged in a pack with a detailed annotation.
Papaverine has a therapeutic effect due to the combination of 2 ingredients papaverine and bendazole.
To stabilize the composition, additional substances are used: potato starch and calcium sterate, povidone and lactose monohydrate.
