pharmachologic effect
Tailed Mint is an anti-allergic drug. The active substance in this drug is nedocromil. When used systematically, it leads to a reduction in the symptoms of allergic inflammation in the respiratory system. Nedocromil is a stabilizer of mast cell membranes, inhibits both the early and late stages of the allergic reaction, preventing degranulation of mast cells and the release of inflammatory mediators from them (histamine, bradykinin, slow-reacting substance, leukotrienes, prostaglandin D2). Thanks to these properties , Tailed Mint prevents bronchospasm caused by contact with an allergen or other provoking factor (cold air, physical stress, stress). In patients with bronchial asthma, nedocromil suppresses antigen-induced allergic reactions of immediate and delayed types, and also reduces bronchial hyperreactivity. When applied topically at the level of the bronchial tree, it has an anti-inflammatory effect. Long-term continuous use reduces bronchial hyperreactivity, improves respiratory function, reduces the intensity and frequency of asthma attacks and the severity of cough. It is more effective for mild and moderate forms of asthma. When taken, nighttime symptoms are reduced and the need for daytime bronchodilator drugs is reduced. The therapeutic effect develops by the end of the first week.
Composition, packaging, form
What is the medicine "Tailed Mint"? The instructions for use state that this is a medicinal product produced in the form of an aerosol (dosed) for inhalation. The active element of this product is sodium nedocromil. It also contains excipients in the form of povidone K30, macrogol (polyethylene glycol) 600, levomenthol and propellant HFA-227.
The medication in question is placed in aluminum aerosol cans that have a dosing device. Each container contains up to 112 medicinal doses.
Pharmacokinetics
After administration by inhalation, about 10% of the dose enters the respiratory tract, and the rest settles in the oral cavity or nasopharynx and is then swallowed. However, the absorption of nedocromil from the gastrointestinal tract is low (about 2%), so nedocromil detected in plasma after inhalation mainly enters there as a result of absorption from the respiratory tract. Cmax of nedocromil is reached after approximately 60 minutes, and its half-life is 1-2 hours. Nedocromil is moderately (up to 89%) and reversibly bound to plasma proteins in humans. Nedocromil is not metabolized. It is excreted unchanged from the body in urine (approximately 70%) and feces (approximately 30%).
Using an inhaler
How should I use Tiled Mint aerosol? Reviews (this product is also purchased for children) report that before the first use, the inhaler should be shaken vigorously and also press the metering valve 4 times (that is, idle). If the aerosol has not been used for a week or more, then it is also necessary to bring it into working condition by performing two idle runs.
When using the drug in question, you must adhere to the following requirements:
- Remove the protective cap and inspect the outer and inner surfaces of the inhaler body to ensure they are clean.
- Shake the can vigorously, holding it upright and placing your thumb on the base.
- Exhale deeply, and then place the mouthpiece in the oral cavity between the teeth, but without biting it, but tightly clasping it with your lips.
- Inhaling air through your mouth, press the balloon so as to spray the medicinal substance while continuing to breathe deeply and calmly.
- Holding your breath as much as possible, remove the aerosol from your mouth.
- After completing the procedure, the cylinder body should be thoroughly rinsed and dried. You also need to cover the mouthpiece with a protective cap.
Dosage regimen
The drug is intended for regular daily use.
The drug is not intended for the relief of acute bronchospastic attacks.
Adults (including the elderly) and children over 2 years of age
The recommended dose of Tailed Mint is 2 inhalations 2-4 days a day. Once symptom control is achieved, the dose is gradually reduced to a maintenance dose. The usual maintenance dose of the drug is 2 inhalations 2 days a day. In severe cases, as well as with a high concentration of allergens, the dose of the drug can be increased to two inhalations 4 days a day. An additional dose of the drug in the form of two inhalations (4 mg) once can be taken immediately before physical activity to prevent exercise asthma or before contact with suspected allergens. The daily dose of the drug should not exceed 8 inhalations.
The therapeutic effect develops by the end of the first week.
If the use of a bronchodilator is prescribed at the same time, it is recommended to use it before using Tailed Mint .
The addition of Tailed Mint to the treatment of patients receiving GCS may allow the maintenance dose of GCS to be reduced or discontinued completely. During a reduction in the dose of steroids, strict monitoring of the patient is necessary; A weekly dose reduction of 10% is suggested. If reducing the dose of GCS is impossible, then Tailed Mint until GCS coverage is restored.
Using an inhaler
When using for the first time, shake the inhaler and press the metering valve 4 times (idle). If the inhaler has not been used for 7 days or more, it is necessary to bring it into working condition by pressing the metering valve twice (idle).
When inhaling, you should adhere to the following instructions:
Remove the dust cap. Inspect the inside and outside of the plastic casing of the inhaler to make sure they are clean. Shake the inhaler vigorously. Hold the inhaler upright with your thumb on the base of the canister. Exhale as completely as possible, then insert the mouthpiece into your mouth between your teeth (without biting it) and close your lips tightly. As you begin to inhale through your mouth, press down on the base of the can to release a dose of Tailed Mint ; At the same time, continue to breathe calmly and deeply.
Hold your breath and remove the inhaler from your mouth. Continue to hold your breath as much as possible.
The plastic body of the inhaler should be washed and thoroughly dried at least once every three days.
After inhalation, always close the mouthpiece with a dust cap.
Care instructions
To prevent powder particles from blocking the mouthpiece opening, keep the plastic body of the inhaler clean. At least once every 3 days, it must be washed and left to dry overnight. Cleaning the plastic case is carried out as follows:
1. Remove the plastic dust cap and remove the metal can from the plastic device.
2. Rinse the plastic device thoroughly under hot running water (+45°C) for 1 minute.
3. Turn the plastic device over and rinse it from the other end under hot running water for 1 minute.
4. Shake any remaining moisture out of the plastic device by tapping it on a hard surface.
5. Leave the plastic device to dry overnight. If the package contains two devices, use them alternately to keep them clean and dry.
6. Insert the metal can into the plastic casing, making sure it is completely dry and the rubber ring is firmly seated on the metal can.
If the spray outlet from the inhaler is blocked, remove the dust cap, take out the metal can (see step 1) and place the plastic case in hot water for 20 minutes. Then follow the steps described above in steps 2-6.
Before using the inhaler, you should always make sure that the plastic casing is completely dry. Under no circumstances try to clean the inhaler outlet with a needle or sharp object, as this will damage the inhaler. Do not place the metal can into water or remove the rubber ring from it.
The drug "Tailed Mint": instructions for use
The medication in question is intended for daily use. However, it is prohibited to use it to relieve an acute bronchospastic attack.
For adults, children over 2 years of age and the elderly, Tailed Mint is prescribed in a dose of two inhalations 2-4 times a day. After achieving control over the signs of the disease, a gradual reduction in dosage to maintenance is carried out. As a rule, it is 2 inhalations twice a day.
In more severe cases, as well as with regular contact with allergens, the amount of the drug used is increased to 2 inhalations four times a day. It should also be noted that an additional dose of the drug in the form of 2 single inhalations (that is, 4 mg) can be taken before physical activity in order to prevent physical exertion asthma, as well as before expected contact with the allergen. It is strictly forbidden to exceed the daily dose of the medication, which is 8 inhalations.
As mentioned above, the therapeutic effect after regular use of the drug in question develops only by the end of the first week.
If the patient was simultaneously prescribed a bronchodilator, it is recommended to use it before Tailed Mint.
According to experts, the use of this medicine for the treatment of patients who are already receiving GCS makes it possible to reduce the maintenance dosage of GCS or even cancel them altogether.
In the process of reducing the dose of steroids, regular monitoring of the patient is required. In this case, a weekly reduction in the amount of the drug by 10% is proposed.
special instructions
It is very important that patients who benefit from Tailed Mint use it regularly, daily, even if they have no symptoms. Patients should also be advised that because multiple doses may be required to achieve beneficial effects, relief may not be immediate and that it may take several weeks to achieve benefits.
As with any inhalation therapy, bronchospasm may unexpectedly develop immediately after inhalation. This condition requires immediate treatment with a short-acting inhaled bronchodilator and immediate medical attention should be sought. Tailed Mint therapy should be discontinued immediately and alternative treatment initiated.
In case of recurring bronchospasm, a bronchodilator is first inhaled, and the cough is calmed by drinking water immediately after inhalation.
If there is a need to discontinue the drug, it should be done gradually over one week, but asthma symptoms may return.
The drug is not intended for the relief of acute attacks of bronchial asthma.
Protect from direct sunlight. Do not refrigerate or freeze.
Indications
For what diseases is the patient prescribed Tailed Mint? Reviews from doctors report that this remedy is very effective in the following cases:
- with bronchospastic syndrome, which was caused by the following factors: inhaled allergens, cold air, atmospheric pollution (in adult patients and children over 2 years old);
- for the prevention and treatment of bronchial asthma of various origins, including physical exertion asthma.
It should also be noted that “Tailed Mint” can be additionally prescribed in combination with other existing treatment regimens for bronchial asthma.
Similar medications and reviews
What can replace the medication in question? Unfortunately, this product has practically no analogues. In some cases, it is replaced with the drug "Intal".
Most consumer reviews about the product in question are positive. Patients claim that this is a very powerful and effective medicine that is suitable not only for adults, but also for children aged 2 years and older.
The only drawback of this medicine is its high cost. In some pharmacies, one cylinder costs about 2,100 rubles. If there is no financial opportunity, patients buy Intal, which also effectively fights allergic diseases of the respiratory tract.
