Side effects of the drug Terzhinan - everyone needs to know this

70% of women have experienced thrush at least once. The incidence rate is increasing every year. The drugs of choice are combination agents with a wide spectrum of antibacterial, anti-inflammatory, and antifungal effects. One of these is the French medicine Terzhinan, available in the form of vaginal tablets.

The cost of treatment varies depending on the duration (6–10 days) and the price per package - from 470 to 660 rubles. There are many analogues of Terzhinan tablets - they all differ in the effect they provide or the combination of medicinal properties, the included substance, the release form, the manufacturer, and the price. Some of them are allowed during pregnancy. Before replacing the drug and purchasing, consult a specialist.

The effectiveness of the drug Terzhinan in the treatment

Often, in the treatment of various vaginal diseases, an effective patented combination French remedy, Terginan, developed by the pharmaceutical company Laboratoris Bouchara Recordati, is used.

This drug has successfully passed numerous clinical trials and is effectively used in the treatment of diseases in the field of gynecology. Most often, Terzhinan is involved in the treatment of various inflammatory and infectious processes.

It has been established that the drug Terzhinan is an excellent remedy in the fight against thrush, which often attacks the delicate vaginal mucosa. This disease is caused by the candida fungus, which periodically “wakes up” and begins to actively multiply for various reasons. Most women encounter this diagnosis at least once in their lives. Due to changes in hormonal levels during pregnancy, three-quarters of women in an “interesting situation” suffer from thrush.

Vaginal suppositories Terzhinan prevent the development of the disease, reducing the number of candida fungi to a minimum. Their safety of use during pregnancy has been proven through long-term experience. Therefore, you can absolutely safely use this medicine in any position and age.

The wide scope of application of Terzhinan is such that, in parallel with the treatment of thrush, other infectious diseases of the vagina can be cured. The drug affects infection and fungi without penetrating into the blood, having a local effect.

Using Terzhinan suppositories in the fight against candidiasis (thrush), you can achieve restoration of the biocenosis of the birth canal in a minimum period of time.

The drug Terzhinan completely combines the following features of a universal drug used in the treatment of vaginal diseases:

• Wide range of effects
• Performance
• Pathogenetic, etiological and anti-inflammatory effects
• Use at any period of life
• General tolerability and safety
• Minimal side effects
• Minimal use
• Ease of use
• Affordable price
• Possibility of use for prevention

But you should always remember that self-medication is unacceptable, especially during pregnancy. The instructions supplied with the drug are not an indication for use, but are only for informational and advisory purposes. The prescription is determined by the doctor.

Get detailed information about the drug Terzhinan from the proposed video.

Composition and properties of the drug

Terzhinan contains several active ingredients.

These components together determine the effect of the drug:

• Neomycin sulfate is a broad-spectrum antibiotic substance from the group of amine glycosides. The component is active against various gram-positive and gram-negative bacteria.
• Trenidazole is an imidazole derivative that has an antitrichomoniacal effect and is active against anaerobic microorganisms. This antifungal agent changes the structure and properties of cells.
• Nystatin is an antibiotic component of polyenes that is effective in combating Candida fungi, slowing their growth and stopping their development by changing the permeability of cell membranes.
• Prednisolone is a hormonal substance that is a dehydrated analogue of hydrocortisone, relieving inflammation, irritation, and allergic reactions.

Suppositories for ureaplasma: diagnosis and treatment of pathology

The remaining substances included in the Terzhinan vaginal suppositories are auxiliary components that do not have a therapeutic effect, but protect the vaginal mucosa from the negative effects of the environment.

Terzhinan or Hexicon

Manufacturer: Hemofarm or Nizhpharm, Russia
Release form: vaginal tablets and suppositories

Active ingredient: chlorhexidine

Synonyms: Chlorhexidine, Hexicon D

Hexicon is an antimicrobial and antiseptic drug for intravaginal use, produced by a domestic pharmaceutical company. Contains chlorhexidine.

Terzhinan's analog Hexicon is active against bacteria, protozoa and the herpes virus. It is used for the treatment of vaginitis and colpitis, prevention of infection before childbirth, during pregnancy, before diagnostic and surgical interventions, and during inflammation.

Unlike Terzhinan, the analogue has an additional indication - the prevention of sexually transmitted infections (STDs).

Terzhinan is prescribed once a day at night for 6–10 days. The analogue has a different scheme - a course of 7-10 days, 1 candle 2 times.

Both drugs Hexicon and Terzhinan are allowed during pregnancy.

Terzhinan suppositories for intravaginal use have a greater spectrum of action than Hexicon and are available with a doctor’s prescription. Not suitable for self-medication.

Hexicon is an over-the-counter analogue of Terzhinan, used for preventive and therapeutic purposes. The cost of one package of medicine is lower. However, a course of 7–10 days requires 14–20 tablets, which is approximately the same cost as a small package of Terzhinan.

When to use

The medicine does not have a general effect on the body, since it is not absorbed into the blood. Based on this fact, which is associated with low absorption, studies on the pharmacokinetics of the drug have not been conducted.

Terzhinan is used in the treatment and prevention of various diseases caused by microorganisms sensitive to the drug and its components.

These tablets are used in the following cases:

• Vaginitis provoked by pyogenic microflora (banal bacterial vaginitis)
• Recurrent nonspecific vaginitis (colpitis)
• Trichomonas vaginitis
• Candidiasis (thrush)
• Bacterial vaginosis
• Mixed vaginal infection
• Vaginal dysbiosis and dysbiosis

The drug is often used for preventive measures:

• On the eve of childbirth or gynecological surgery
• Before hysterography
• Before and after installation of an intrauterine device
• Before and after cauterization of the cervix
• To avoid complications during antibiotic therapy

Terzhinan's analogs

The drug is available by prescription, the cost ranges from 470 to 660 rubles. The composition includes several components that have anti-inflammatory, antibacterial, antifungal and antiprotozoal effects.

On the one hand, the content of several components is an advantage. On the other hand, if the causative agent of the disease is identified, single drugs can be used; the risk of individual intolerance and side effects will be much lower.

Analogues of Terzhinan differ in composition, price, dispensing procedure (with or without a prescription), manufacturer and effect(s).

List of analogues

Diflucan

Manufacturer: Fareva Amboise, France
Release form: capsules, powder for suspension

Active ingredient: fluconazole

Synonyms: Fluconazole, Mikosist, Flucostat, Diflazon, Mikomax, etc.

For genital infections caused by fungi, treatment is necessary for both partners. An analogue of Terzhinan for men and women in capsules is the original Diflucan. Effective against candida, taken once. The disadvantage is the high cost.

The main difference between the analog and Terzhinan is the composition. Diflucan contains only an antifungal component and is used orally. Terzhinan tablets are a complex product used intravaginally.

The Terzhinan analogue Diflucan serves as an adjunct to treatment with antibiotics (for example, Clindamycin, Dalacin).

Depanthol

Manufacturer: Nizhpharm, Russia
Release form: vaginal suppositories

Active ingredient: dexpanthenol, chlorhexidine

The Russian analogue of Terzhinan suppositories is the drug Depantol. Contains chlorhexidine, which has an antiseptic and antimicrobial effect, and the regenerating component dexpanthenol.

Just like Terzhinan, Depantol can be used in the treatment of vaginitis, before surgical and diagnostic interventions, for prophylactic purposes during pregnancy. To do this, it is prescribed 1 suppository intravaginally twice a day for 7–10 days. The analogue is better tolerated and side effects occur less often. Available without a doctor's prescription, it belongs to the expensive segment.

Betadine

Manufacturer: Egis, Hungary
Release form: vaginal suppositories

Active ingredient: povidone-iodine

An analogue of Terzhinan, Betadine suppositories have an antiseptic effect based on povidone-iodine. They are used for various forms of vaginitis; they are not recommended for treatment and prevention during pregnancy and pregnancy. The course is determined by the doctor and ranges on average from 7–14 days, 1–2 suppositories per day.

Other analogues of Terzhinan

1. Trichopolum (Metronidazole) – tablets and vaginal suppositories with antimicrobial and antiprotozoal effects;
2. Viferon and Genferon - preparations in the form of suppositories, stored in the refrigerator and containing interferon;
3. Zalain is an antifungal drug used for the treatment of candidiasis with a course of 1 day;
4. Macmiror complex - vaginal capsules with an antimicrobial effect, affecting fungi, protozoa and bacteria;
5. Dalatsin, Clindacin and Clindamycin - 3 drugs contain one antibiotic, available in the form of vaginal suppositories;
6. Laktozhinal - capsules for restoring the normal microflora of the vulva and vagina and suppressing the proliferation of pathogenic microorganisms, the drug is stored in the refrigerator.

How Terzhinan suppositories can be replaced depends on the type of pathogen, manifestations of the disease (acute form or has become chronic), the individual characteristics of the patient (pregnancy and breastfeeding, other medications used, intolerance or allergy to components, budget). This issue should be discussed with your doctor without self-medicating.

Instructions for use

The usual way of using Terzhinan is one vaginal tablet per day, used at night. The duration of treatment is from 6 to 10 days, but in some cases it is possible to increase the duration to 20 days. Mycosis may be an indication for this. During menstruation, therapy is not stopped.

On the eve of inserting the drug into the vagina, it is recommended to hold the tablet in water for 30 seconds. The vaginal tablet is then inserted deep into the vagina. After administration, you need to lie down for 10 minutes.

After administration of the tablet, an increased secretion of a yellowish secretion may occur within a few hours. This is normal during treatment.

Terzhinan - instructions for use

The drug is available with a doctor's prescription and is used intravaginally as prescribed. Course – 6 or 10 days, 1 vaginal tablet at night, before bed.

Important! During menstruation, treatment should continue.

During treatment, you must carefully follow the personal hygiene recommendations:

• refuse sanitary tampons;
• wear cotton underwear;
• wash regularly, use panty liners and change them every 2 hours;
• avoid factors that provoke thrush and other infectious diseases of the urogenital tract, for example, hypothermia.

Both partners must undergo treatment - the woman must undergo Terzhinan or approved analogues, the man - drugs in the form of capsules for oral administration, creams and ointments.

Side effects of the drug Terzhinan

Side effects of the drug Terzhinan are possible in rare cases if there are allergic reactions to the components of the drug.

There is a possibility of local reactions occurring at the beginning of therapeutic intervention. Usually this is a burning sensation, tingling, slight itching or irritation of the vaginal mucosa. There may be swelling of the vagina and a feeling of pain.

Systematic side effects occur extremely rarely, in isolated cases. There are rare phenomena of slowing down the processes of scarring and healing of wounds, cracks, abrasions, which is associated with the presence of corticosteroids in the drug.

Terzhinan or Clotrimazole

Manufacturer: Akrikhin, Sedate, Shreya, Teva, etc., Russia, Germany, India or Romania
Release form: cream, vaginal tablets, ointment, spray, vaginal cream

Active ingredient: clotrimazole

Synonyms: Candide

Terzhinan and Clotrimazole are analogues used for thrush from different price segments. The cost of treatment for the first starts from 450 rubles, for the second – from 30 rubles.

Terzhinan is a combination drug that fights inflammation and infections of fungal, parasitic and bacterial nature. It does not have a systemic effect, so overdose and serious side effects are not observed.

Clotrimazole is a cheap analogue used in gynecology and dermatology for fungal skin diseases. May cause allergic reactions, nausea and dizziness.

According to clinical studies, Terzhinan is safer and is an alternative treatment for pregnant women.

Interaction with alcohol and other drugs

It is known that drugs and alcohol are incompatible, especially if the drug is an antibiotic. Accordingly, when using the drug Terzhinan you should not drink alcohol.

Alcohol and treatment are incompatible things. After all, alcohol reduces the effect of the drug. Terzhinan is no exception.

No clinical interactions with other drugs have been identified; however, the simultaneous use of Terzhinan and other vaginal products is not recommended.

What is castor oil obtained from: properties, contraindications

Terzhinan or Neo-penotran

Manufacturer: Ekseltis Ilach San.ve Tik.A.S. / Turkey
Release form: vaginal suppositories

Active ingredients: miconazole, metronidazole

Synonyms: Metromicon neo, Neo-Penotran forte

According to clinical studies, Terzhinan and Neo-Penotran are approximately equal in strength. Both medicines contain an antifungal and antiprotozoal component.

Terzhinan is used once a day for 6 or 10 days. The course of treatment with the Neo-Penotran analogue is 7 or 14 days.

Terzhinan is safer, approved during pregnancy and does not have a systemic effect.

Terzhinan and intimacy

When using Terzhinan, it is advisable to avoid intimacy, since in most cases it can intensify the signs of the underlying disease.

When the doctor allows you to have sex during therapy, sexual contact is possible only with the use of a condom.

If after intimate intimacy one of the partners or both of them experience increased itching and burning, then you need to refuse sexual contact until complete recovery.

Terzhinan for erosion

One of the methods for treating erosion is diathermocoagulation of the cervix. During the procedure, the pathology site is cauterized with high-frequency current. With diathermocoagulation there is a high risk of infection, which can cause infertility in the future.

To prevent this from happening, you need to undergo treatment with an antimicrobial agent before and after the procedure. Therefore, Terzhinan is recommended before and after surgery to prevent pathologies of the reproductive system. Doctors usually recommend using the drug for 6 days before the procedure and then for another 6 days after cauterization of the erosion.

Terzhinan or Pimafucin - which is better for thrush

Manufacturer: Temmler Italia S.r.L., Italy
Release form: vaginal suppositories, cream, tablets

Active ingredient: natamycin

Synonyms: Ecofucin, Primafungin

Pimafucin is an analogue cheaper than Terzhinan in tablets, cream and vaginal suppositories, approved during pregnancy. Contains an antibacterial component that is not inferior in strength to nystatin in Terzhinan.

Of the two analogues - Pimafucin and Terzhinan, the second is more effective due to its complex therapeutic effect and combined composition. If the causative agent of vaginosis is identified and is sensitive to natamycin, you can get by with the one-component drug Pimafucin. One of the advantages of this analogue of Terzhinan suppositories is that it is up to 40% cheaper, it is used for 3 or 6 days, 1 suppository per day.

Analogue drugs

At the moment, there are no analogues to the drug Terzhinan. There are drugs that contain the same active substances that make up Terzhinan, but they are present in other drugs in the wrong volume and composition. The manufacturing company strictly monitors compliance with the monopoly ownership of the patent.

Analogues of Terzhinan include drugs with similar, but not identical, effects.

Among them:

• Meratin-combi
• Neotrizol
• Pimafucin
• Polygynax
• Clotrimazole

All of them have a powerful therapeutic effect, but only on certain types of diseases, and not on several diseases at the same time. Thus, Clotrimazole and Pimafucin can cure fungal diseases, but will not help if a patient has trichomoniasis or vaginitis with a mixed type of infection.

Meratin-combi is a complex antibiotic drug, however, it is powerless against candidiasis, and Polygynax, which has power against many vaginal infections and fungal diseases, is powerless against trichomonas colpitis. Terzhinan is unique both in its composition and in its principle of action.

Terzhinan or Elzhina – which is better?

Manufacturer: Vertex, Russia
Release form: vaginal tablets

Active ingredients: ornidazole, neomycin, prednisolone, econazole

Elzhin candles are a domestic analogue of Terzhinan, with a similar composition. They also contain an antibiotic, antifungal and antiprotozoal component, and a glucocorticoid. Unlike Terzhinan, the analogue is not used during pregnancy and lactation.

Both drugs are available on prescription and are in the high-end segment with good reviews. They serve as the drugs of choice for infectious, fungal and protozoal infections of the vagina.

Prices in pharmacies

The cost of the drug depends on the quantity and the specific pharmacy.

Table 1. Price of the medicine.

Video about if discharge appears after taking it:

Patient reviews

The uniqueness of the drug is confirmed not only by the conclusion of the pharmaceutical company and biochemical studies. This is confirmed by patient reviews.

Pain-relieving ointments for feet: features of the use of external agents

Based on numerous comments, some conclusions can be drawn:

• Efficacy of the drug
• Effective from the first use
• Ease of use
• Short duration of treatment
• Relief of symptoms and signs of the disease in a short time
• Possibility of use during pregnancy
• Therapeutic effects during menstruation
• No age dependence
• Not high cost
• Possibility of use for preventive purposes

All these are only positive reviews. The only disadvantages of the drug include the rare occurrence of side effects, the formation of discharge during therapy and the inconvenience of opening the package.

Against the background of continuous positivity, the final touches indicating the shortcomings of the drug Terzhinan seem very unfounded and unimportant.

Reviews of discharge during Terzhinan

In patient reviews, you can find information that vaginal discharge appears during treatment with the drug:

• The doctor prescribed Terzhinan to me for vaginitis. During the first two days, when the drug was administered into the vagina, I felt a strong burning sensation. Also, during treatment, I noticed that there was a pinkish discharge from the genital tract. I informed the doctor about this, he reassured me and explained that a burning sensation occurs if the medicine is used during the acute period of the disease. I noticed that if you insert the tablet and don’t move after that, there will be no burning sensation. And the pink tint of the discharge is due to the fact that the components of the vaginal tablet oxidize in air. It happens that due to oxidation they become reddish or brownish. After finishing the course, I took another smear test, and everything was fine. /Maria, Volzhsk/
• The gynecologist prescribed Terzhinan for colpitis during pregnancy. I had a thin discharge while using the medication. The doctor explained that this is not a reason to discontinue the drug and that after completing the course of therapy they will disappear. I did not notice any side effects from Terzhinan. After completing the course of treatment, the tests returned to normal. /Lyudmila, Omsk/
• The doctor prescribed Terzhinan to me to prevent infectious complications during diathermocoagulation. I didn't have any burning or discomfort. The only thing is that in the morning after the pill I had a yellow discharge that lasted for 2 hours. These were the auxiliary components of the drug. The erosion was cauterized for me successfully and Terzhinan prevented infection and the development of complications. The tablets themselves are very fragile and break easily, so they should not be thrown. Otherwise, you won’t be able to insert the broken tablet correctly. /Rozalia, Kazan/
• I took a vaginal smear, it wasn’t very good, and the doctor prescribed Terzhinan. During the entire time I was using the medication, I had bloody vaginal discharge. The gynecologist said that many people have them and ordered not to interrupt the course of treatment. After 10 days of using the medicine, the vaginal microflora returned to normal. /Anastasia, Moscow/

Vaginal tablets Terzhinan are a unique combination of components, ease of use, short course of treatment and effectiveness. Vaginal diseases of infectious and fungal etiology recede before this drug. However, the use of Terzhinan is carried out as prescribed by a doctor.

Feb 16, 2016Violetta Lekar

Terzhinan or Klion D – which is better?

Manufacturer: Gedeon Richter-Rus, Russia
Release form: vaginal tablets

Active ingredients: metronidazole, miconazole

When choosing between Terzhinan and Klion D, the first drug is preferable:

• a wider spectrum of action and effectiveness against many pathogens, while Klion D is effective against Candida and Trichomonas;
• safety – allowed during pregnancy, fewer list of contraindications;
• four components that have anti-inflammatory, antibacterial, antifungal and antiprotozoal effects.

What to choose - Terzhinan or Klion D - is determined by the gynecologist based on the results of a smear and a survey of the patient. Both medications are available by prescription.