Rules for using the drug Nise: exact dosage, side effects

Release form

Nise is prescribed for internal and external use:

1. White tablets with a yellowish tint have been released. They are distinguished by a smooth, convex surface on both sides. Most of its contents are represented by the active substance Nimesulide, supplemented by other components.
2. For a medicine released in the form of a suspension, the ratio of the main component is 50 mg per 5 ml.
3. For external use, the drug is prepared in the form of a gel. The share of active substance in it is only 10%. In appearance it is transparent, free from extraneous additions. Subject to technology, its color ranges from light yellow to yellow.

Nise: prices in online pharmacies

Nise 1% gel for external use 20 g 1 pc.

Nise 100 mg tablets 20 pcs.

Nise gel 1% 20g

Nise 100 mg 2 g 9 pcs.

Nise tablets 100 mg 20 pcs.

Nise granules for Prig Susp. for internal approx. 100 mg pack. 2g 9 pcs.

Nise 100 mg tablets 30 pcs.

Nise tablets 100 mg 30 pcs.

Nise 1% gel for external use 50 g 1 pc.

Nise gel 1% 50g

Nise 1% gel for external use 100 g 1 pc.

Nise gel for external use approx. 1% 100g

Information about the drug is generalized, provided for informational purposes and does not replace official instructions. Self-medication is dangerous to health!

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When is the medicine prescribed?

This medication in one of its forms can be prescribed for:

• arthritis of rheumatoid or psoriatic type;
• articular syndrome, manifested as a consequence of an aggravated state of gout;
• ankylosing spondylitis;
• osteochondrosis with radicular syndrome;
• osteoarthritis;
• rheumatic or non-rheumatic myalgia;
• inflammation in ligaments, tendons, bursitis;
• post-traumatic inflammation in soft tissues;
• pain regardless of nature;
• fever;
• Sciatica;
• Lumbago;
• Bekhterev's disease;
• gout

The use of Nyzma can reduce pain and relieve inflammation. At the same time, it has almost no effect on the development of the underlying disease.

Description

It is a non-steroidal anti-inflammatory drug and is widely used to relieve pain syndromes of various origins, however, there are a number of contraindications, and in case of some diseases, it is necessary to give your child medications for toothache with extreme caution.

The tablets are white or light yellow, odorless. The surface is smooth, biconvex.

Each pack contains blisters of 10 tablets. The package may contain one, two or ten blisters. Cardboard packaging.

Prohibition on the use of medicine

All forms of the drug have a large number of restrictions on use. These include:

• bronchial asthma, recurrent nasal polyposis and hypersensitivity to acetylsalicylic acid in any combination;
• gastrointestinal problems associated with the risk of internal bleeding;
• inflammation in the intestines in the acute phase;
• hemophilia and other problems affecting blood clotting;
• with decompensated heart failure;
• for acute liver problems;
• the likelihood of developing a hepatotoxic reaction;
• combination with medications leading to hepatoxic reactions;
• with kidney pathology in the progress stage;
• with sensitivity to the components of the drug;
• addiction to alcohol or drugs.

Therefore, it is forbidden to take the drug before carefully reading the instructions and without the knowledge of the attending physician.

Adverse reactions of tablets and suspensions

Violations of the rules for taking Nise lead to side effects of various types. Allergies occasionally manifest as urticaria or anaphylactic edema. The epidermis produces:

• Rash;
• Itching;
• Erythema;
• Eczema;
• dermatitis.

Sometimes the process is accompanied by increased sweating.

A person taking Nise infrequently may suffer from dizziness, fear, and nervousness. Very rarely, drowsiness or encephalopathy occurs. More often, patients experience abnormalities in the gastrointestinal tract: diarrhea, nausea, vomiting, flatulence and symptoms of gastritis. In a number of situations, a decrease in visual acuity and the formation of a clinical picture of hepatitis, choleasis, asthma, bronchispasm and hypothermia were diagnosed.

Operating principle

The analgesic effect is due to the ability of active substances to suppress the synthesis of prostaglandins in the inflammatory focus. The drug also selectively inhibits COX2 (cyclooxygenase). It is possible that prostaglandins in healthy cells may be inhibited, but this is rare.

The drug helps slow down lipid peroxidation. Nise does not affect hemostasis (preservation of the liquid state of blood) and phagocytosis (the process of capture and digestion of solid particles, that is, nutrients, by cells).

When taken orally, Nise is well absorbed from the gastrointestinal tract, reaching maximum concentration after 1.5-2.5 hours. The main metabolic product is the active hydroxynimesulide. The components of Nise are excreted by the kidneys and do not accumulate with long-term use.

Nise in gel form has a local analgesic and anti-inflammatory effect. The drug is able to eliminate swelling and stiffness of the joints (mainly in the morning). It also eliminates joint pain. If there is pain in the teeth, do not use the gel.

Adverse reactions from the gel

Local use of Nise is fraught with fewer dangers compared to internal use. A negative reaction to a medication in this form is often presented as:

• itching;
• hives;
• transient change of skin.

More serious side effects are expected if the drug is used for a long time or over a large area of ​​skin. In this case, a person exhibits signs of heartburn, fluid retention, hematurgy, thrombocytomy, anemia, leukopenia, vomiting, diarrhea, and decreased blood clotting ability. If there is any deterioration in health, treatment is stopped.

Why is it dangerous?

Most often, side effects occur during the first week of therapy:

• skin rash or itching, increased sweating, swelling of the face, angioedema;
• abdominal pain, nausea, flatulence, gastritis, vomiting, diarrhea, constipation, rarely - stomatitis, ulcers or bleeding from the stomach or intestines;
• drowsiness, dizziness, headache, pressure fluctuations, blurred vision;
• nervousness, anxiety, nightmares;
• urinary retention, edema, kidney failure;
• changes in blood composition;
• bronchospasm, asthma.

Such reactions are typical for taking the drug orally, but can also occur if the dosage or time of treatment with the gel is exceeded. Also, when applied topically, peeling and burns of the skin and changes in its color may occur.

How to take pills correctly

For a number of diseases there are no strict restrictions on Nise therapy. However, treatment with this drug requires great caution when:

• IHD;
• congestive heart failure;
• dyslipidemia;
• gastrointestinal ulcers;
• diabetes mellitus;
• problems with peripheral arteries;
• somatic disorders.

The doctor can also warn about possible dangers when prescribing medication for older people. Taking Nise poses a potential danger to smokers and people taking NSAIDs for a long time.

In case of severe kidney problems, the specialist will prescribe the drug in minimal dosages. If during treatment the patient feels a decrease in visual acuity, the drug should be stopped. Similar actions are required if signs of liver dysfunction are visible. Since Nise may cause fluid retention, it is used with caution in the treatment of persons suffering from hypertension. All these factors are taken into account when determining the possibility of carrying out therapy, the duration of the course and dosages of tablets.

Where to buy and what analogues are there

This drug belongs to the over-the-counter group of drugs. Therefore, it is available for free retail sale. However, you should not “prescribe” it yourself, especially for a long time. If the drug “Nise” is not available in the pharmacy chain, you can purchase its analogue:

• "Nimesan";
• "Nimesulide";
• "Nemulex";
• "Aponil."

These medications also contain nimesulide as the main active ingredient. However, how to take them and the dosage should be clarified in the official instructions or with your doctor.

"Nise" is an effective anti-inflammatory drug, which additionally has an analgesic and antipyretic effect. It allows you to quickly eliminate the symptoms of the disease and improve the patient’s well-being. However, before starting treatment, you need to make sure that there are no contraindications to the use of nimesulide, and if necessary, consult a doctor.

Instructions for use of tablets

Since Nise has an irritating effect on the gastrointestinal tract, tablets are taken on a full stomach:

1. The medicine needs to be dissolved in a certain amount of liquid.
2. After this, the composition is thoroughly stirred, taken and washed down with water, juice or tea.
3. The dosage for a teenager over 12 years of age and an adult will be 50-100 milligrams per day. In this case, the daily consumption of the drug is not higher than 400 milligrams.
4. This medicine is usually not prescribed for younger children. Occasionally, it can be used strictly as prescribed by the pediatrician.

Nise can be taken orally for 7-10 days. Depending on the characteristics of the body, correction of the period is permissible. With a longer course, there is a possibility of developing negative reactions.

Advantages of the drug

When a toothache occurs, it is important for many to quickly eliminate these unpleasant sensations. The main advantage of this remedy is that it can reduce discomfort within 20-30 minutes after taking the first tablet. But it is worth remembering that the period of action depends on the individual characteristics of each person’s body, on the degree of dental damage, as well as on the intensity of the pain syndrome.

In addition, among the advantages of this tool, several important qualities can be identified:

• This product can be purchased at almost any pharmacy. You do not need a doctor's prescription to purchase it.
• Low cost. A package of the drug with 20 tablets costs no more than 200 rubles
• It can be taken together with other medications. Can be used with antihistamine medications, as well as with some broad-spectrum antibiotics and anti-inflammatory drugs

Instructions for the gel

This form is released exclusively for external use:

1. Before applying the product, ensure that the treated area is clean and dry.
2. From the tube you need to squeeze out a column of gel of approximately 3 centimeters.
3. It must be applied to the skin without rubbing up to four times a day.

If a large area of ​​skin needs to be treated, the use of Nise gel should be reduced. It is important to avoid getting the product into the mucous membrane area. The therapeutic course is up to 10 days.

Contraindicated for whom

Any form of medication is prohibited for the following conditions:

1. intolerance to the components of the composition or other NSAIDs;
2. exacerbation of ulcers or gastrointestinal bleeding;
3. severe renal or liver failure;
4. pregnancy (especially the third trimester) and lactation;
5. children under 2 years of age (for oral use) and up to 7 years of age (for gel) - treatment is possible strictly according to indications.
6. dermatoses, damage or infections of the skin in the area of ​​gel treatment.

Hepatotoxic drugs, analgesics, other NSAIDs, and alcohol should not be used at the same time.

Drug interactions

If it is necessary to combine Nise with other medications, several factors should be taken into account:

• the drug, when mixed with drugs containing lithium, reduces the effectiveness of the latter;
• when used together with hypoglycemic drugs, sugar level control is required;
• combination with antihypertensive drugs is likely to sharply reduce blood pressure;
• Nise is not used together with anticoagulants and non-steroidal anti-inflammatory drugs due to the high risk of bleeding.

Therefore, when determining the course of treatment, it is necessary to notify the attending physician about all medications used.

special instructions

Nise is used as part of complex therapy. Moderate doses of nimesulide are prescribed together with other medications with caution and under the supervision of a physician.

Drug interactions

Nise enhances the effect of medications that help reduce blood clotting. When treated simultaneously with lithium preparations, the risk of liver and kidney intoxication increases. The medicinal effect of furosemide is weakened.

If treatment with glucocorticosteroids and serotonin reuptake blockers is started, the use of Nise should be discontinued. This will protect the patient’s body from gastric and intestinal bleeding.

When used with Warfarin and acetylsalicylic acid, there is a high risk of bleeding. The medicine should not be used simultaneously with Digoxin, Phenytoin, since under the influence of each other the therapeutic effect of the drugs is reduced.

When using this drug together with hypoglycemic drugs, patients should constantly monitor their blood sugar levels. When treated with antihypertensive drugs, the patient's blood pressure may decrease, so this interaction is undesirable. The simultaneous use of nimesulide and cyclosporine has a detrimental effect on the kidneys.

After two weeks of using the drug, you need to take a blood test and monitor liver function indicators. Nise retains fluid in organs and tissues, so people with hypertension and cardiac disorders should use the medicine with caution.

It is not recommended to take this drug with other non-steroidal drugs. If signs of liver damage appear (itching, yellowing of the skin, nausea, stomach pain), stop taking Nise.

The drug affects the reaction, so during treatment it is not recommended to drive a car or engage in activities that require high concentration. With long-term or constant use of Nise, monitoring the condition of the kidneys, liver, stomach and intestines is necessary. The compatibility of Nise and alcohol has a toxic effect on organs.

Analogs

Instead of the original medicine, analogues are often used. Some patients find Nise in the form of tablets or gel expensive, so they are looking for alternative treatment options. Sometimes it is necessary to replace the drug due to contraindications. The pharmaceutical industry produces various analogues of the drug:

• Actasulide.
• Aertal.
• Brustan.
• Aponil.
• Nimesulide.
• Nimesil.
• Nurofen.
• Nimulid.
• Voltaren.
• Fastum-gel.
• Rofecoxib.
• Ibuprofen.
• Ketanov, Ketorol.

Nimesil contains the active component nimesulide. Indications for use and list of contraindications are the same as for the drug Nise. The medicine is released in powder form and sold in packaged form.

Ketanov is available in tablets and contains the main component - ketorolac. Refers to non-steroidal anti-inflammatory drugs, which are derivatives of pyrrolysine-carboxylic acid. Relieves pain, inflammation and reduces temperature during fever. Like any drug from this group, Ketanov has a number of contraindications and adverse reactions.

Ketorol contains ketorolac and replaces Nise in all clinical characteristics. The drug is produced in tablets, gel and injection solution. Children under 16 years of age are prohibited from using this product. The gel is contraindicated in the last trimester of pregnancy, and other forms cannot be used throughout the entire period of bearing a child.

The combined drug Brustan is a substitute for Nise in many respects. The drug is available in the form of a suspension and tablets. The drug contains ibuprofen and paracetamol. Children from two years of age are allowed to use a suspension with an acceptable concentration of active ingredients. However, it is not recommended for pregnant women in the last trimester.

Nimulide has the same therapeutic effect as Nise because it contains nimesulide. The list of contraindications is similar. During inpatient treatment, the doctor prescribes injections with the same active substance. The solution is packaged in 2 ml vampules containing 75 mg of the substance.

Novigan tablets relieves pain of various types, inflammation and muscle spasms. It is forbidden to use by pregnant women and children under 16 years of age.

The drug Aceclofenac is an analogue of Nise with the same list of indications for use. Available in tablet form. Not approved for use by children under 18 years of age, with diseases of the stomach and intestines, after aortic bypass surgery and heart failure, during the period of bearing and feeding a child.

Ibuprofen-Hemofarm replaces Nise for therapeutic reasons. Produced in effervescent tablets, water-soluble and film-coated tablets. The effervescent medicine can be used by children from 6 years of age as an analgesic and anti-inflammatory agent. Regular tablets are used from 12 years of age. The exception is the category of expectant and nursing mothers.

Airtal tablets belong to the group of non-steroidal drugs and are used in complex therapy. Relieves pain and inflammation in damaged tissues of the musculoskeletal system. Indications are arthritis of various forms, bursitis, osteoarthritis, osteochondrosis, menstrual pain, toothache and headache. The active ingredient is aceclofenac. Available in tablets, suspension and gel. After 40-50 minutes it penetrates to the source of pain.

Voltaren Emulgel of domestic production contains diclofenac diethylamine (equal to 2 g of diclofenac). A nonsteroidal anti-inflammatory drug characterized by analgesic and anti-inflammatory effects. The gel is used to lubricate sore and swollen areas.

The drug Rofecoxib is a non-steroidal drug and a cyclooxygenase II inhibitor. Sold in the form of tablets, suppositories, gel and injections. The composition includes rofecoxib, which has analgesic, antipyretic and anti-inflammatory effects. The list of indications is the same as for drugs with nimesulide.

Nise helps with various pathologies of the musculoskeletal system, inflammation, fever and other ailments. A doctor's supervision and monitoring of blood and urine test results are required.

Possibility of overdose

Ignoring the consumption rate and duration of the therapeutic course of Nise can lead to side effects in an acute condition. Particularly affected by:

1. Gastrointestinal tract, up to the risk of internal bleeding.
2. Functioning of the liver, kidneys and respiration.

The consequences of an overdose can be eliminated with activated carbon or another absorbent. Further assistance is provided in a hospital setting in accordance with the symptoms that appear. External use of the drug rarely causes an overdose.